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Gene Review

TPT1P8  -  tumor protein, translationally-controlled...

Homo sapiens

Synonyms: FKSG2
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Disease relevance of FKSG2


High impact information on FKSG2


Biological context of FKSG2


Anatomical context of FKSG2


Associations of FKSG2 with chemical compounds


Physical interactions of FKSG2


Regulatory relationships of FKSG2


Other interactions of FKSG2


Analytical, diagnostic and therapeutic context of FKSG2


  1. The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein. Han, J., Sabbatini, P., Perez, D., Rao, L., Modha, D., White, E. Genes Dev. (1996) [Pubmed]
  2. Sparing of neuronal function postseizure with gene therapy. McLaughlin, J., Roozendaal, B., Dumas, T., Gupta, A., Ajilore, O., Hsieh, J., Ho, D., Lawrence, M., McGaugh, J.L., Sapolsky, R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. Dierlamm, J., Baens, M., Wlodarska, I., Stefanova-Ouzounova, M., Hernandez, J.M., Hossfeld, D.K., De Wolf-Peeters, C., Hagemeijer, A., Van den Berghe, H., Marynen, P. Blood (1999) [Pubmed]
  4. The apoptosis inhibitor protein survivin induces tumor-specific CD8+ and CD4+ T cells in colorectal cancer patients. Casati, C., Dalerba, P., Rivoltini, L., Gallino, G., Deho, P., Rini, F., Belli, F., Mezzanzanica, D., Costa, A., Andreola, S., Leo, E., Parmiani, G., Castelli, C. Cancer Res. (2003) [Pubmed]
  5. Antiapoptotic function of apoptosis inhibitor 2-MALT1 fusion protein involved in t(11;18)(q21;q21) mucosa-associated lymphoid tissue lymphoma. Hosokawa, Y., Suzuki, H., Suzuki, Y., Takahashi, R., Seto, M. Cancer Res. (2004) [Pubmed]
  6. Structure of Bax: coregulation of dimer formation and intracellular localization. Suzuki, M., Youle, R.J., Tjandra, N. Cell (2000) [Pubmed]
  7. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Roy, N., Mahadevan, M.S., McLean, M., Shutler, G., Yaraghi, Z., Farahani, R., Baird, S., Besner-Johnston, A., Lefebvre, C., Kang, X. Cell (1995) [Pubmed]
  8. IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival. Wu, M.X., Ao, Z., Prasad, K.V., Wu, R., Schlossman, S.F. Science (1998) [Pubmed]
  9. The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. Susin, S.A., Zamzami, N., Castedo, M., Daugas, E., Wang, H.G., Geley, S., Fassy, F., Reed, J.C., Kroemer, G. J. Exp. Med. (1997) [Pubmed]
  10. c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. Chang, D.W., Xing, Z., Pan, Y., Algeciras-Schimnich, A., Barnhart, B.C., Yaish-Ohad, S., Peter, M.E., Yang, X. EMBO J. (2002) [Pubmed]
  11. Regulation of survivin function by Hsp90. Fortugno, P., Beltrami, E., Plescia, J., Fontana, J., Pradhan, D., Marchisio, P.C., Sessa, W.C., Altieri, D.C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  12. Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways. Roth, W., Kermer, P., Krajewska, M., Welsh, K., Davis, S., Krajewski, S., Reed, J.C. Cell Death Differ. (2003) [Pubmed]
  13. A novel anti-apoptosis gene: Re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancers. Monzó, M., Rosell, R., Felip, E., Astudillo, J., Sánchez, J.J., Maestre, J., Martín, C., Font, A., Barnadas, A., Abad, A. J. Clin. Oncol. (1999) [Pubmed]
  14. Mammalian GADD34, an apoptosis- and DNA damage-inducible gene. Hollander, M.C., Zhan, Q., Bae, I., Fornace, A.J. J. Biol. Chem. (1997) [Pubmed]
  15. Dynamic intracellular survivin in oral squamous cell carcinoma: underlying molecular mechanism and potential as an early prognostic marker. Engels, K., Knauer, S., Metzler, D., Simf, C., Struschka, O., Bier, C., Mann, W., Kovács, A., Stauber, R. J. Pathol. (2007) [Pubmed]
  16. Inverse expression of bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes. Yoshino, T., Kondo, E., Cao, L., Takahashi, K., Hayashi, K., Nomura, S., Akagi, T. Blood (1994) [Pubmed]
  17. Identification of a cytotoxic T lymphocyte response to the apoptosis inhibitor protein survivin in cancer patients. Andersen, M.H., Pedersen, L.O., Becker, J.C., Straten, P.T. Cancer Res. (2001) [Pubmed]
  18. Enhanced lymphocyte longevity and absence of proliferation and lymphocyte apoptosis in Quilty effects of human heart allografts. Dong, C., Winters, G.L., Wilson, J.E., McManus, B.M. Am. J. Pathol. (1997) [Pubmed]
  19. Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation. Adida, C., Crotty, P.L., McGrath, J., Berrebi, D., Diebold, J., Altieri, D.C. Am. J. Pathol. (1998) [Pubmed]
  20. Abl expression in human fetal and adult tissues, tumours, and tumour microvessels. O'Neill, A.J., Cotter, T.G., Russell, J.M., Gaffney, E.F. J. Pathol. (1997) [Pubmed]
  21. Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis. Dou, Q.P., An, B., Will, P.L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  22. The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal. Vieira, H.L., Belzacq, A.S., Haouzi, D., Bernassola, F., Cohen, I., Jacotot, E., Ferri, K.F., El Hamel, C., Bartle, L.M., Melino, G., Brenner, C., Goldmacher, V., Kroemer, G. Oncogene (2001) [Pubmed]
  23. Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells. Mu, Y.M., Yanase, T., Nishi, Y., Tanaka, A., Saito, M., Jin, C.H., Mukasa, C., Okabe, T., Nomura, M., Goto, K., Nawata, H. Endocrinology (2001) [Pubmed]
  24. Protection from cell death in cultured human fetal pancreatic cells. Beattie, G.M., Leibowitz, G., Lopez, A.D., Levine, F., Hayek, A. Cell transplantation. (2000) [Pubmed]
  25. Expression of apoptosis-related oncoproteins and modulation of apoptosis by caffeine in human leukemic cells. Efferth, T., Fabry, U., Glatte, P., Osieka, R. J. Cancer Res. Clin. Oncol. (1995) [Pubmed]
  26. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Aita, V.M., Liang, X.H., Murty, V.V., Pincus, D.L., Yu, W., Cayanis, E., Kalachikov, S., Gilliam, T.C., Levine, B. Genomics (1999) [Pubmed]
  27. Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis factor-induced cell cycle arrest. Hu, X., Bryington, M., Fisher, A.B., Liang, X., Zhang, X., Cui, D., Datta, I., Zuckerman, K.S. J. Biol. Chem. (2002) [Pubmed]
  28. E1B-55-kilodalton protein is not required to block p53-induced transcription during adenovirus infection. Hobom, U., Dobbelstein, M. J. Virol. (2004) [Pubmed]
  29. Enhanced apoptosis under low serum conditions in human glioblastoma cells by connexin 43 (Cx43). Huang, R., Liu, Y.G., Lin, Y., Fan, Y., Boynton, A., Yang, D., Huang, R.P. Mol. Carcinog. (2001) [Pubmed]
  30. Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. Wistow, G., Bernstein, S.L., Wyatt, M.K., Behal, A., Touchman, J.W., Bouffard, G., Smith, D., Peterson, K. Mol. Vis. (2002) [Pubmed]
  31. Apoptosis: checkpoint at the mitochondrial frontier. Bossy-Wetzel, E., Green, D.R. Mutat. Res. (1999) [Pubmed]
  32. Immunohistochemical analysis of anti-Hu-associated paraneoplastic encephalomyelitis. Bernal, F., Graus, F., Pifarré, A., Saiz, A., Benyahia, B., Ribalta, T. Acta Neuropathol. (2002) [Pubmed]
  33. Expression of the apoptosis inhibitor, survivin, in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line. Grossman, D., McNiff, J.M., Li, F., Altieri, D.C. Lab. Invest. (1999) [Pubmed]
  34. Apoptosis and proliferation of fibroblasts during postnatal skin development and scleroderma in the tight-skin mouse. Pablos, J.L., Carreira, P.E., Serrano, L., Del Castillo, P., Gomez-Reino, J.J. J. Histochem. Cytochem. (1997) [Pubmed]
  35. Apoptosis inhibitor, survivin, in posterior uveal melanoma: comparison among primary tumors, tumors resistant to brachytherapy, tumors with liver metastases, and liver metastases. Ben Simon, G.J., Abulafia, A., Pe'er, J. Curr. Eye Res. (2006) [Pubmed]
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