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Gene Review

CD1A  -  CD1a molecule

Homo sapiens

Synonyms: CD1, FCB6, HTA1, R4, T-cell surface antigen T6/Leu-6, ...
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Disease relevance of CD1A


High impact information on CD1A

  • RESULTS: Immunohistochemical analysis of 11 prospectively identified children showed a significantly greater number of mucosal CD3 and CD8 lymphocytes, as well as CD1a antigen-presenting cells compared with normal controls [6].
  • The genes are evenly spaced in the complex except for the distance between CD1D and CD1A, which is two to three times greater than the average [7].
  • Although in the case of CD1A only the transcript encoding the cell surface CD1a isoform is found, CD1C and -E produce complex intrathymic splicing patterns [8].
  • In the case of CD1A transfectants, we demonstrate that the major protein product is secreted and show by amino acid sequence analysis that this is derived from an unspliced transcript [8].
  • Immunohistochemical detection of CD1A antigen in formalin-fixed and paraffin-embedded tissue sections with monoclonal antibody 010 [9].

Biological context of CD1A

  • There are five closely linked CD1 genes in humans located in chromosome 1 (named CD1A, B, C, D, and E) all showing limited polymorphism in exon 2 which codifies for the alpha1 domain of CD1 molecules [10].
  • CD1A duplication in the porcine genome was estimated to have occurred after the divergence of the human and porcine [11].
  • Although a correlation between CD1E*01/01 genotype and recent C. jejuni infection or presence of antiganglioside antibodies was not found the overall findings indicate that susceptibility to develop GBS is associated with polymorphisms of CD1E and CD1A genes [10].
  • Our aim was to study possible allelic variations of exons 2 and 3, encoding for the alpha1 and alpha2 domains, respectively, of human CD1A, -B, -C and -D genes [12].
  • The CD1A and CD1E alleles were nominally identified as CD1A*01, CD1A*02, CD1E*01 and CD1E*02, and the control gene frequencies were found to be 5%, 95%, 67% and 33%, respectively [13].

Anatomical context of CD1A


Associations of CD1A with chemical compounds

  • The cDNAs encoding both wild type and mutant CD1A were cloned in the expression vector pSRalphaNeo and transfected into C1R and L721.221 cells [19].
  • We have previously described and partially characterized a new human CD1A allele differing from the wild type CD1A by a substitution of Cysteine by Tryptophan at position 52 in the alpha1 domain of the CD1A molecule [19].
  • Lesional cells expressing the CD1a molecule were enriched using either fluorescein-activated cell sorting or negative selection with indirect immunomagnetic beads, and functional activity was assessed using the 6-day primary allogeneic mixed-cell reaction [20].

Regulatory relationships of CD1A


Other interactions of CD1A

  • During the study, two strains (CD1A and CD4) extensively contaminated the CCH environment [23].
  • A significant inhibition of the mixed skin cell-lymphocyte reaction was obtained with BL6 and DMC1 monoclonal antibodies (MoAb), which recognize the same epitope on CD1a molecule [24].

Analytical, diagnostic and therapeutic context of CD1A


  1. Expression of B7 co-stimulatory molecules and CD1a antigen by alveolar macrophages in allergic bronchial asthma. Agea, E., Forenza, N., Piattoni, S., Russano, A., Monaco, A., Flenghi, L., Bistoni, O., Gillies, D.A., Azuma, M., Bertotto, A., Spinozzi, F. Clin. Exp. Allergy (1998) [Pubmed]
  2. Results of a phase I clinical study using autologous tumour lysate-pulsed monocyte-derived mature dendritic cell vaccinations for stage IV malignant melanoma patients combined with low dose interleukin-2. Nagayama, H., Sato, K., Morishita, M., Uchimaru, K., Oyaizu, N., Inazawa, T., Yamasaki, T., Enomoto, M., Nakaoka, T., Nakamura, T., Maekawa, T., Yamamoto, A., Shimada, S., Saida, T., Kawakami, Y., Asano, S., Tani, K., Takahashi, T.A., Yamashita, N. Melanoma Res. (2003) [Pubmed]
  3. Atypical generalized eruptive histiocytosis associated with acute monocytic leukemia. Klemke, C.D., Dippel, E., Geilen, C.C., Koenigsmann, M.P., Thiel, E., Orfanos, C.E., Goerdt, S. J. Am. Acad. Dermatol. (2003) [Pubmed]
  4. Hairy cell leukemia cells express CD1a antigen. De Panfilis, G., Manara, G.C., Ferrari, C., Torresani, C., Sansoni, P. Cancer (1988) [Pubmed]
  5. Expression of the CD1a molecule in B- and T-lymphoproliferative skin conditions. Pigozzi, B., Bordignon, M., Belloni Fortina, A., Michelotto, G., Alaibac, M. Oncol. Rep. (2006) [Pubmed]
  6. Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate. Teitelbaum, J.E., Fox, V.L., Twarog, F.J., Nurko, S., Antonioli, D., Gleich, G., Badizadegan, K., Furuta, G.T. Gastroenterology (2002) [Pubmed]
  7. A physical map linking the five CD1 human thymocyte differentiation antigen genes. Yu, C.Y., Milstein, C. EMBO J. (1989) [Pubmed]
  8. Alternative splicing generates secretory isoforms of human CD1. Woolfson, A., Milstein, C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  9. Immunohistochemical detection of CD1A antigen in formalin-fixed and paraffin-embedded tissue sections with monoclonal antibody 010. Krenács, L., Tiszalvicz, L., Krenács, T., Boumsell, L. J. Pathol. (1993) [Pubmed]
  10. Susceptibility to Guillain-Barré syndrome is associated to polymorphisms of CD1 genes. Caporale, C.M., Papola, F., Fioroni, M.A., Aureli, A., Giovannini, A., Notturno, F., Adorno, D., Caporale, V., Uncini, A. J. Neuroimmunol. (2006) [Pubmed]
  11. Analysis of the genomic structure of the porcine CD1 gene cluster. Eguchi-Ogawa, T., Morozumi, T., Tanaka, M., Shinkai, H., Okumura, N., Suzuki, K., Awata, T., Uenishi, H. Genomics (2007) [Pubmed]
  12. Single strand conformational polymorphism analysis of human CD1 genes in different ethnic groups. Oteo, M., Parra, J.F., Mirones, I., Giménez, L.I., Setién, F., Martínez-Naves, E. Tissue Antigens (1999) [Pubmed]
  13. CD1 genotyping of patients with Mycobacterium malmoense pulmonary disease. Jones, D.C., Gelder, C.M., Ahmad, T., Campbell, I.A., Barnardo, M.C., Welsh, K.I., Marshall, S.E., Bunce, M. Tissue Antigens (2001) [Pubmed]
  14. An optimised biphasic culture system for the generation of functional dendritic cells from patients with acute lymphoblastic leukaemia at presentation and in clinical remission. Blair, A., Rowbottom, A.W., Browne, S.J., Goulden, N.J., Steward, C.G., Oakhill, A., Pamphilon, D.H. Leukemia (2001) [Pubmed]
  15. Two novel CD1 E alleles identified in black African individuals. Tamouza, R., Sghiri, R., Ramasawmy, R., Neonato, M.G., Mombo, L.E., Poirier, J.C., Schaeffer, V., Fortier, C., Labie, D., Girot, R., Toubert, A., Krishnamoorthy, R., Charron, D. Tissue Antigens (2002) [Pubmed]
  16. Sustentacular cells in pulmonary neuroendocrine tumours. Gosney, J.R., Denley, H., Resl, M. Histopathology (1999) [Pubmed]
  17. Interferon gamma impairs the ability of monocyte-derived dendritic cells to present tumour-specific and allo-specific antigens and reduces their expression of CD1A, CD80 AND CD4. Rongcun, Y., Maes, H., Corsi, M., Dellner, F., Wen, T., Kiessling, R. Cytokine (1998) [Pubmed]
  18. Human CD1a molecule expressed on monocytes plays an accessory role in the superantigen-induced activation of T lymphocytes. Gregory, S., Zilber, M., Charron, D., Gelin, C. Hum. Immunol. (2000) [Pubmed]
  19. Structural characterization of two CD1A allelic variants. Oteo, M., Arribas, P., Setién, F., Parra, J.F., Mirones, I., Gómez del Moral, M., Martínez-Naves, E. Hum. Immunol. (2001) [Pubmed]
  20. Functional defect in cells involved in Langerhans cell histiocytosis. Yu, R.C., Alaibac, M., Chu, A.C. Arch. Dermatol. Res. (1995) [Pubmed]
  21. Functional CD86 (B7-2/B70) on cultured human Langerhans cells. Yokozeki, H., Katayama, I., Ohki, O., Matsunaga, T., Watanabe, K., Satoh, T., Azuma, M., Okumura, K., Nishioka, K. J. Invest. Dermatol. (1996) [Pubmed]
  22. The effect of trypsin on CD1a molecule of human thymocytes. Dezutter-Dambuyant, C., Staquet, M.J., Schmitt, D., Thivolet, J. Thymus (1990) [Pubmed]
  23. Difference in the incidence of Clostridium difficile among patients infected with human immunodeficiency virus admitted to a public hospital and a private hospital. Pulvirenti, J.J., Gerding, D.N., Nathan, C., Hafiz, I., Mehra, T., Marsh, D., Kocka, F., Rice, T., Fischer, S.A., Segreti, J., Weinstein, R.A. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (2002) [Pubmed]
  24. A potential role for CD1a molecules on human epidermal Langerhans cells in allogeneic T-cell activation. Moulon, C., Péguet-Navarro, J., Schmitt, D. J. Invest. Dermatol. (1991) [Pubmed]
  25. Expression of c-myc oncoprotein in chronic T cell leukemias. Maljaie, S.H., Brito-Babapulle, V., Matutes, E., Hiorns, L.R., De Schouwer, P.J., Catovsky, D. Leukemia (1995) [Pubmed]
  26. In situ behavior of human Langerhans cells in skin organ culture. Rambukkana, A., Bos, J.D., Irik, D., Menko, W.J., Kapsenberg, M.L., Das, P.K. Lab. Invest. (1995) [Pubmed]
  27. Analysis of CD1 molecules on haematological malignancies of myeloid and lymphoid origin. I. Cell surface antigen expression. Salamone, M.C., Roisman, F.R., Santiago, J., Satz, M.L., Fainboim, L. Dis. Markers (1990) [Pubmed]
  28. Stable expression of CD1a molecule in human epithelial cell lines shows temperature-dependent expression and affects cell morphology and growth. Yu, R.C., Kolettas, E., Kamalati, T., Chu, A., Buluwela, L. Arch. Dermatol. Res. (1997) [Pubmed]
  29. Eosinophilic granuloma of bone and biochemical demonstration of 49-kDa CD1a molecule expression by Langerhans-cell histiocytosis. Cambazard, F., Dezutter-Dambuyant, C., Staquet, M.J., Schmitt, D., Thivolet, J. Clin. Exp. Dermatol. (1991) [Pubmed]
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