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Gene Review

TMSB10  -  thymosin beta 10

Homo sapiens

Synonyms: MIG12, PTMB10, TB10, THYB10, Thymosin beta-10
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Disease relevance of TMSB10


High impact information on TMSB10


Chemical compound and disease context of TMSB10


Biological context of TMSB10

  • To identify the critical residues responsible for TB10-mediated apoptosis, we used a series of computational methods [1].
  • These results, together with primer extension experiments, suggest that the two thymosin beta 10 mRNAs are transcribed from the same gene through a combination of differential promoter utilization and alternative splicing [10].
  • The conserved 17LKKTET(22 motif region of TB10 was tested by Ala and Ser scanning mutagenesis using computational and biochemical methods, and 12 mutants were transfected into cancer cell lines and tested for their effects on growth arrest [1].
  • Immunohistochemical analysis showed that the protein was present in differentiating spermatids, suggesting that the testis-specific thymosin beta 10 mRNA is translated in haploid male germ cells [10].
  • Previously, we demonstrated that overexpression of TB10 in ovarian tumor cells increased the rate of cell death [11].

Anatomical context of TMSB10


Associations of TMSB10 with chemical compounds


Other interactions of TMSB10

  • Most frequent was the loss of 1 copy of TMSB10, observed in 11 of 12 SCV patients, followed by loss of CTNNB1 and BCL2, which occurred in 7 of 12 patients [19].
  • Among the 63 developmentally regulated genes, four exhibited the highest levels of expression (TMSB10, CTNNA1, NMP1, and CX3CL1) [20].
  • However, while thymosin beta-10 mRNA was undetectable (by northern blot analysis) in adult human brain, levels of thymosin beta-4 mRNA, although greatly reduced, were still present [14].
  • The upregulated genes included CD44, high mobility group protein-I, thymosin beta-10 and 27-kD heat shock protein, while the downregulated genes included NM23-H1, all of which are thought to be associated with the development or progression of carcinoma in the liver or other organs [21].
  • The expression of Tmsb10, S100a6 and Anxa2 coincided with heavy proteinuria [22].

Analytical, diagnostic and therapeutic context of TMSB10


  1. The identification of apoptosis-related residues in human thymosin beta-10 by mutational analysis and computational modeling. Rho, S.B., Lee, K.W., Chun, T., Lee, S.H., Park, K., Lee, J.H. J. Biol. Chem. (2005) [Pubmed]
  2. Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma. Weterman, M.A., van Muijen, G.N., Ruiter, D.J., Bloemers, H.P. Int. J. Cancer (1993) [Pubmed]
  3. Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma. Hall, A.K., Hempstead, J., Morgan, J.I. Brain Res. Mol. Brain Res. (1990) [Pubmed]
  4. Thymosin beta-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium. Santelli, G., Bartoli, P.C., Giuliano, A., Porcellini, A., Mineo, A., Barone, M.V., Busiello, I., Trapasso, F., Califano, D., Fusco, A. Thyroid (2002) [Pubmed]
  5. Thymosin beta-10 gene expression as a possible tool in diagnosis of thyroid neoplasias. Chiappetta, G., Pentimalli, F., Monaco, M., Fedele, M., Pasquinelli, R., Pierantoni, G.M., Ribecco, M.T., Santelli, G., Califano, D., Pezzullo, L., Fusco, A. Oncol. Rep. (2004) [Pubmed]
  6. Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis. Vasile, E., Tomita, Y., Brown, L.F., Kocher, O., Dvorak, H.F. FASEB J. (2001) [Pubmed]
  7. Thymosin beta-10 gene overexpression correlated with the highly malignant neoplastic phenotype of transformed thyroid cells in vivo and in vitro. Califano, D., Monaco, C., Santelli, G., Giuliano, A., Veronese, M.L., Berlingieri, M.T., de Franciscis, V., Berger, N., Trapasso, F., Santoro, M., Viglietto, G., Fusco, A. Cancer Res. (1998) [Pubmed]
  8. Retinoids and a retinoic acid receptor differentially modulate thymosin beta 10 gene expression in transfected neuroblastoma cells. Hall, A.K. Cell. Mol. Neurobiol. (1992) [Pubmed]
  9. Regulation of thymosin beta10 expression by TSH and other mitogenic signals in the thyroid gland and in cultured thyrocytes. Viglietto, G., Califano, D., Bruni, P., Baldassarre, G., Vento, M.T., Belletti, B., Fedele, M., Santelli, G., Boccia, A., Manzo, G., Santoro, M., Fusco, A. Eur. J. Endocrinol. (1999) [Pubmed]
  10. Cloning and characterization of a testis-specific thymosin beta 10 cDNA. Expression in post-meiotic male germ cells. Lin, S.C., Morrison-Bogorad, M. J. Biol. Chem. (1991) [Pubmed]
  11. The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture. Rho, S.B., Chun, T., Lee, S.H., Park, K., Lee, J.H. FEBS Lett. (2004) [Pubmed]
  12. Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pancreatic cancer. Alldinger, I., Dittert, D., Peiper, M., Fusco, A., Chiappetta, G., Staub, E., Lohr, M., Jesnowski, R., Baretton, G., Ockert, D., Saeger, H.D., Grützmann, R., Pilarsky, C. Pancreatology (2005) [Pubmed]
  13. Thymosin beta-10 gene overexpression is a general event in human carcinogenesis. Santelli, G., Califano, D., Chiappetta, G., Vento, M.T., Bartoli, P.C., Zullo, F., Trapasso, F., Viglietto, G., Fusco, A. Am. J. Pathol. (1999) [Pubmed]
  14. Expression of thymosin beta-4 and related genes in developing human brain. Condon, M.R., Hall, A.K. J. Mol. Neurosci. (1992) [Pubmed]
  15. Array analysis of the genes regulated during neuronal differentiation of human embryonal cells. Bani-Yaghoub, M., Felker, J.M., Ozog, M.A., Bechberger, J.F., Naus, C.C. Biochem. Cell Biol. (2001) [Pubmed]
  16. Profiling, comparison and validation of gene expression in gastric carcinoma and normal stomach. Oien, K.A., Vass, J.K., Downie, I., Fullarton, G., Keith, W.N. Oncogene (2003) [Pubmed]
  17. Isolation of cDNAs encoding cellular drug-binding proteins using a novel expression cloning procedure: drug-western. Tanaka, H., Ohshima, N., Hidaka, H. Mol. Pharmacol. (1999) [Pubmed]
  18. Thymosin gene expression is modulated by pregnant mare's serum gonadotropin, human chorionic gonadotropin, and prostaglandin F2 alpha in the immature rat ovary. Hall, A.K., Aten, R., Behrman, H.R. Endocrinology (1991) [Pubmed]
  19. Identification of individual genes altered in squamous cell carcinoma of the vulva. Kunjoonju, J.P., Raitanen, M., Grénman, S., Tiwari, N., Worsham, M.J. Genes Chromosomes Cancer (2005) [Pubmed]
  20. Identification of differentially regulated genes during elongation and early implantation in the ovine trophoblast using complementary DNA array screening. Cammas, L., Reinaud, P., Dubois, O., Bordas, N., Germain, G., Charpigny, G. Biol. Reprod. (2005) [Pubmed]
  21. Alteration in gene expression profile by full-length hepatitis B virus genome. Nakanishi, F., Ohkawa, K., Ishida, H., Hosui, A., Sato, A., Hiramatsu, N., Ueda, K., Takehara, T., Kasahara, A., Sasaki, Y., Hori, M., Hayashi, N. Intervirology (2005) [Pubmed]
  22. Glomerular crescent-related biomarkers in a murine model of chronic graft versus host disease. Ka, S.M., Rifai, A., Chen, J.H., Cheng, C.W., Shui, H.A., Lee, H.S., Lin, Y.F., Hsu, L.F., Chen, A. Nephrol. Dial. Transplant. (2006) [Pubmed]
  23. C-terminal truncation of thymosin beta10 by an intracellular protease and its influence on the interaction with G-actin studied by ultrafiltration. Huff, T., Müller, C.S., Hannappel, E. FEBS Lett. (1997) [Pubmed]
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