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Gene Review

LIPG  -  lipase, endothelial

Homo sapiens

Synonyms: EDL, EL, Endothelial cell-derived lipase, Endothelial lipase, PRO719, ...
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Disease relevance of LIPG

  • To investigate the effects of EDL on binding and uptake of high-density lipoprotein (HDL), as well as on the selective uptake of HDL-derived cholesterol esters (CEs), HepG2 cells were infected with adenovirus coding for EDL [1].
  • Plasma EL concentrations were positively correlated with various indices of obesity, fasting plasma insulin, and plasma CRP, IL-6, and sPLA(2)-IIA concentrations [2].
  • Its tissue-restricted pattern of expression and its ability to be expressed by endothelial cells, suggests that endothelial cell-derived lipase may have unique functions in lipoprotein metabolism and in vascular disease [3].
  • Molecular analysis of the plasmid-encoded hemolysin of Escherichia coli O157:H7 strain EDL 933 [4].
  • A dose of 25 microg kg(-1) day(-1) of formoterol elicited greater EDL and soleus hypertrophy than salmeterol, but resulted in similar beta-adrenoceptor downregulation [5].

Psychiatry related information on LIPG

  • EDL and FDL display distinctive, individualized patterns of locomotor activity that may vary in a facultative manner or in different forms of locomotion (O'Donovan et al., 1980; Trank et al., 1996) [6].

High impact information on LIPG


Biological context of LIPG


Anatomical context of LIPG


Associations of LIPG with chemical compounds

  • EDL is a phospholipase with very little triacylglycerol lipase activity [1].
  • Inhibition of the enzymic activity with tetrahydrolipstatin (THL) significantly enhanced the effect of EDL, as reflected by a 5.2-fold increase in binding, a 2.6-fold increase in particle uptake and a 1.1-fold increase in CE selective uptake compared with incubations without THL [1].
  • In summary, EL mediates binding and uptake of plasma lipoproteins via a process that is independent of its enzymatic activity, requires cellular heparan sulfate proteoglycans, and is regulated by ligand clustering [14].
  • Inhibition of proteoglycan sulfation by sodium chlorate or incubation of cells with labeled lipoproteins in the presence of heparin (100 microg/ml) abolished bridging effects of EL [14].
  • In situ hybridization studies demonstrated intense EL mRNA staining of lutein cells in corpora lutei in ovaries, of spermatocytes in the late pachytene and diplotene stages in testes, and of principal cells in epididymis [15].

Other interactions of LIPG

  • Despite 1.7-fold higher binding and 1.8-fold higher holoparticle uptake, the selective CE uptake by MUT-EDL-expressing cells was comparable with EDL-expressing cells and was even decreased 1.3-fold with THL [1].
  • When entered into the model, LPL activity accounted for 16.1% (P < 0.0001) and plasma CRP concentrations accounted for 20.9% (P < 0.0001) of the variance in EL concentrations [2].
  • Like LPL but not HL, both lipase activities of EL were inhibited by 1 M NaCl [16].
  • Multiple regression analyses revealed that plasma CRP concentrations explained 14.5% (P = 0.0008) of the variance in EL concentrations [2].
  • Relative to the serum before overexpression of EL, the efflux potential of the serum via SR-BI decreased by 90% and ABCA1-mediated efflux increased by 63% [17].

Analytical, diagnostic and therapeutic context of LIPG


  1. Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity. Strauss, J.G., Zimmermann, R., Hrzenjak, A., Zhou, Y., Kratky, D., Levak-Frank, S., Kostner, G.M., Zechner, R., Frank, S. Biochem. J. (2002) [Pubmed]
  2. Endothelial lipase is associated with inflammation in humans. Paradis, M.E., Badellino, K.O., Rader, D.J., Deshaies, Y., Couture, P., Archer, W.R., Bergeron, N., Lamarche, B. J. Lipid Res. (2006) [Pubmed]
  3. Cloning of a unique lipase from endothelial cells extends the lipase gene family. Hirata, K., Dichek, H.L., Cioffi, J.A., Choi, S.Y., Leeper, N.J., Quintana, L., Kronmal, G.S., Cooper, A.D., Quertermous, T. J. Biol. Chem. (1999) [Pubmed]
  4. Molecular analysis of the plasmid-encoded hemolysin of Escherichia coli O157:H7 strain EDL 933. Schmidt, H., Beutin, L., Karch, H. Infect. Immun. (1995) [Pubmed]
  5. Systemic administration of beta2-adrenoceptor agonists, formoterol and salmeterol, elicit skeletal muscle hypertrophy in rats at micromolar doses. Ryall, J.G., Sillence, M.N., Lynch, G.S. Br. J. Pharmacol. (2006) [Pubmed]
  6. Correlations between neurograms and locomotor drive potentials in motoneurons during fictive locomotion: implications for the organization of locomotor commands. Hamm, T.M., Trank, T.V., Turkin, V.V. Prog. Brain Res. (1999) [Pubmed]
  7. A novel endothelial-derived lipase that modulates HDL metabolism. Jaye, M., Lynch, K.J., Krawiec, J., Marchadier, D., Maugeais, C., Doan, K., South, V., Amin, D., Perrone, M., Rader, D.J. Nat. Genet. (1999) [Pubmed]
  8. Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue. Kratky, D., Zimmermann, R., Wagner, E.M., Strauss, J.G., Jin, W., Kostner, G.M., Haemmerle, G., Rader, D.J., Zechner, R. J. Clin. Invest. (2005) [Pubmed]
  9. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Ma, K., Cilingiroglu, M., Otvos, J.D., Ballantyne, C.M., Marian, A.J., Chan, L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  10. Immunohistochemical localization of endothelial cell-derived lipase in atherosclerotic human coronary arteries. Azumi, H., Hirata, K., Ishida, T., Kojima, Y., Rikitake, Y., Takeuchi, S., Inoue, N., Kawashima, S., Hayashi, Y., Itoh, H., Quertermous, T., Yokoyama, M. Cardiovasc. Res. (2003) [Pubmed]
  11. Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans. Hutter, C.M., Austin, M.A., Farin, F.M., Viernes, H.M., Edwards, K.L., Leonetti, D.L., McNeely, M.J., Fujimoto, W.Y. Atherosclerosis (2006) [Pubmed]
  12. High-density lipoprotein-cholesterol, its subfractions, and responses to exercise training are dependent on endothelial lipase genotype. Halverstadt, A., Phares, D.A., Ferrell, R.E., Wilund, K.R., Goldberg, A.P., Hagberg, J.M. Metab. Clin. Exp. (2003) [Pubmed]
  13. Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression. Lindegaard, M.L., Damm, P., Mathiesen, E.R., Nielsen, L.B. J. Lipid Res. (2006) [Pubmed]
  14. Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway. Fuki, I.V., Blanchard, N., Jin, W., Marchadier, D.H., Millar, J.S., Glick, J.M., Rader, D.J. J. Biol. Chem. (2003) [Pubmed]
  15. Expression of the endothelial lipase gene in murine embryos and reproductive organs. Lindegaard, M.L., Nielsen, J.E., Hannibal, J., Nielsen, L.B. J. Lipid Res. (2005) [Pubmed]
  16. Characterization of the lipolytic activity of endothelial lipase. McCoy, M.G., Sun, G.S., Marchadier, D., Maugeais, C., Glick, J.M., Rader, D.J. J. Lipid Res. (2002) [Pubmed]
  17. In vivo modulation of HDL phospholipid has opposing effects on SR-BI- and ABCA1-mediated cholesterol efflux. Yancey, P.G., Kawashiri, M.A., Moore, R., Glick, J.M., Williams, D.L., Connelly, M.A., Rader, D.J., Rothblat, G.H. J. Lipid Res. (2004) [Pubmed]
  18. Endothelial and lipoprotein lipases in human and mouse placenta. Lindegaard, M.L., Olivecrona, G., Christoffersen, C., Kratky, D., Hannibal, J., Petersen, B.L., Zechner, R., Damm, P., Nielsen, L.B. J. Lipid Res. (2005) [Pubmed]
  19. Role of N-linked glycosylation in the secretion and activity of endothelial lipase. Miller, G.C., Long, C.J., Bojilova, E.D., Marchadier, D., Badellino, K.O., Blanchard, N., Fuki, I.V., Glick, J.M., Rader, D.J. J. Lipid Res. (2004) [Pubmed]
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