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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Hematologic Diseases

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Disease relevance of Hematologic Diseases


Psychiatry related information on Hematologic Diseases


High impact information on Hematologic Diseases


Chemical compound and disease context of Hematologic Diseases


Biological context of Hematologic Diseases


Anatomical context of Hematologic Diseases


Gene context of Hematologic Diseases

  • However, rare cases of childhood ALL and various other hematological diseases with t(1;19) lack the E2A-PBX1 fusion [26].
  • CONCLUSIONS: PNH, an acquired blood disease seen more often among adult males, can be diagnosed more sensitively by hemocyte member CD55 and CD59 tests and treated more effectively with adrenocortical hormone or low dose chemotherapy [27].
  • Interferon (IFN) has shown antiproliferative activity in several malignant hematologic diseases and potentially may be of benefit when administered early after BMT when the number of residual cells is minimal [28].
  • Conversely patients with the combination of AID and a severe blood disease (leukemia, aplasia) were cured of both diseases following allogeneic BMT, with the notable exception of a relapse in a patient with RA despite full donor engraftment [29].
  • The synergistic effect of histone deacetylase inhibitors, including phenylbutyrate (PB), in reactivating silenced genes encouraged clinical studies on the combination of PB and demethylating agents in hematological diseases, characterized by p15 silencing [30].

Analytical, diagnostic and therapeutic context of Hematologic Diseases


  1. Anemia and perinatal death result from loss of the murine ecotropic retrovirus receptor mCAT-1. Perkins, C.P., Mar, V., Shutter, J.R., del Castillo, J., Danilenko, D.M., Medlock, E.S., Ponting, I.L., Graham, M., Stark, K.L., Zuo, Y., Cunningham, J.M., Bosselman, R.A. Genes Dev. (1997) [Pubmed]
  2. After chronic myelogenous leukemia: tyrosine kinase inhibitors in other hematologic malignancies. Wadleigh, M., DeAngelo, D.J., Griffin, J.D., Stone, R.M. Blood (2005) [Pubmed]
  3. Increased risk of infection in marrow transplant patients receiving methylprednisolone for graft-versus-host disease prevention. Sayer, H.G., Longton, G., Bowden, R., Pepe, M., Storb, R. Blood (1994) [Pubmed]
  4. Group B streptococcal bacteremia in a community teaching hospital. Gallagher, P.G., Watanakunakorn, C. Am. J. Med. (1985) [Pubmed]
  5. Acquired von Willebrand factor abnormalities in myeloproliferative disorders and other hematologic diseases: a retrospective analysis by a single institution. Sánchez-Luceros, A., Meschengieser, S.S., Woods, A.I., Blanco, A.N., Kempfer, A.C., Casais, P., Salviú, M.J., Lazzari, M.A. Haematologica (2002) [Pubmed]
  6. Electrophysiological and neuropsychological functions in patients treated with interferon-beta. Liberati, A.M., Biagini, S., Perticoni, G., Ricci, S., D'Alessandro, P., Senatore, M., Cinieri, S. J. Interferon Res. (1990) [Pubmed]
  7. In utero hematopoietic stem cell transplantation. A status report. Flake, A.W., Zanjani, E.D. JAMA (1997) [Pubmed]
  8. Systemic lupus erythematosus: emerging concepts. Part 1: Renal, neuropsychiatric, cardiovascular, pulmonary, and hematologic disease. Boumpas, D.T., Austin, H.A., Fessler, B.J., Balow, J.E., Klippel, J.H., Lockshin, M.D. Ann. Intern. Med. (1995) [Pubmed]
  9. ADAMTS13 turns 3. Levy, G.G., Motto, D.G., Ginsburg, D. Blood (2005) [Pubmed]
  10. FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model. Kelly, L.M., Liu, Q., Kutok, J.L., Williams, I.R., Boulton, C.L., Gilliland, D.G. Blood (2002) [Pubmed]
  11. Dose-escalation trial of cladribine using five daily intravenous infusions in patients with advanced hematologic malignancies. Larson, R.A., Mick, R., Spielberger, R.T., O'Brien, S.M., Ratain, M.J. J. Clin. Oncol. (1996) [Pubmed]
  12. The effect of thalidomide on non-small cell lung cancer (NSCLC) cell lines: possible involvement in the PPARgamma pathway. DeCicco, K.L., Tanaka, T., Andreola, F., De Luca, L.M. Carcinogenesis (2004) [Pubmed]
  13. PCNA immunopositivity index as a substitute to 3H-thymidine pulse-labeling index (TLI) in methanol-fixed human lymphocytes. Galand, P., Del Bino, G., Morret, M., Capel, P., Degraef, C., Fokan, D., Feremans, W. Leukemia (1995) [Pubmed]
  14. Allogeneic bone marrow transplantation for hematological malignancies following therapy with high doses of busulphan and cyclophosphamide. Angelucci, E., Polchi, P., Lucarelli, G., Galimberti, M., Baronciani, D., Giardini, C., Durazzi, S.M., Moretti, L., Donati, M. Haematologica (1989) [Pubmed]
  15. Adriamycin-induced cardiomyocyte and endothelial cell apoptosis: in vitro and in vivo studies. Wu, S., Ko, Y.S., Teng, M.S., Ko, Y.L., Hsu, L.A., Hsueh, C., Chou, Y.Y., Liew, C.C., Lee, Y.S. J. Mol. Cell. Cardiol. (2002) [Pubmed]
  16. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Peeters, P., Raynaud, S.D., Cools, J., Wlodarska, I., Grosgeorge, J., Philip, P., Monpoux, F., Van Rompaey, L., Baens, M., Van den Berghe, H., Marynen, P. Blood (1997) [Pubmed]
  17. Genetic instability and hematologic disease risk in Werner syndrome patients and heterozygotes. Moser, M.J., Bigbee, W.L., Grant, S.G., Emond, M.J., Langlois, R.G., Jensen, R.H., Oshima, J., Monnat, R.J. Cancer Res. (2000) [Pubmed]
  18. Chronic myeloproliferative disorders: a tyrosine kinase tale. De Keersmaecker, K., Cools, J. Leukemia (2006) [Pubmed]
  19. Splenectomy in hematology. Current practice and new perspectives. Baccarani, U., Terrosu, G., Donini, A., Zaja, F., Bresadola, F., Baccarani, M. Haematologica (1999) [Pubmed]
  20. Human and mouse chromosomal mapping of the myeloid cell leukemia-1 gene: MCL1 maps to human chromosome 1q21, a region that is frequently altered in preneoplastic and neoplastic disease. Craig, R.W., Jabs, E.W., Zhou, P., Kozopas, K.M., Hawkins, A.L., Rochelle, J.M., Seldin, M.F., Griffin, C.A. Genomics (1994) [Pubmed]
  21. 1998 results of the first series of follow-up studies on Japanese thorotrast patients and their relationships to an autopsy series. Mori, T., Fukutomi, K., Kato, Y., Hatakeyama, S., Machinami, R., Tanooka, H., Ishikawa, Y., Kumatori, T. Radiat. Res. (1999) [Pubmed]
  22. Human cord blood progenitors: kinetics, regulation and their use for hemopoietic reconstitution. Gabutti, V., Timeus, F., Ramenghi, U., Saracco, P., Fassio, D., Giubellino, M.C., Miniero, R., Madon, E. Bone Marrow Transplant. (1993) [Pubmed]
  23. Nerve growth factor (NGF) is present in human placenta and semen, but undetectable in normal and Paget's disease blood: measurements with an anti-mouse-NGF enzyme immunoassay using a recombinant human NGF reference. Heinrich, G., Meyer, T.E. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  24. Surface expression of the alpha 2-macroglobulin receptor on human malignant blood cells. Moestrup, S.K., Hokland, P. Leuk. Res. (1992) [Pubmed]
  25. Antitumoral activity of a xanthate compound. I. Cytotoxicity studies with neoplastic cell lines in vitro. Schick, H.D., Amtmann, E., Berdel, W.E., Danhauser-Riedl, S., Reichert, A., Steinhauser, G., Rastetter, J., Sauer, G. Cancer Lett. (1989) [Pubmed]
  26. Identification of a novel fusion gene in a pre-B acute lymphoblastic leukemia with t(1;19)(q23;p13). Yuki, Y., Imoto, I., Imaizumi, M., Hibi, S., Kaneko, Y., Amagasa, T., Inazawa, J. Cancer Sci. (2004) [Pubmed]
  27. Clinical analysis of 78 cases of paroxysmal nocturnal hemoglobinuria diagnosed in the past ten years. Zhao, M., Shao, Z., Li, K., Chen, G., Liu, H., Zhang, Y., He, H., Shi, J., He, G., Chu, Y., Yang, T. Chin. Med. J. (2002) [Pubmed]
  28. Treatment with recombinant interferon (alpha-2b) early after bone marrow transplantation in patients at high risk for relapse [corrected]. Klingemann, H.G., Grigg, A.P., Wilkie-Boyd, K., Barnett, M.J., Eaves, A.C., Reece, D.E., Shepherd, J.D., Phillips, G.L. Blood (1991) [Pubmed]
  29. Stem cell transplantation for severe autoimmune diseases: progress and problems. Marmont, A.M. Haematologica (1998) [Pubmed]
  30. Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS. Leone, G., Voso, M.T., Teofili, L., Lübbert, M. Clin. Immunol. (2003) [Pubmed]
  31. Low-dose total-body irradiation and fludarabine followed by hematopoietic cell transplantation from HLA-identical sibling donors do not induce complete T-cell donor engraftment in most patients with progressive hematologic diseases. Fernández-Avilés, F., Urbano-Ispizua, A., Aymerich, M., Rovira, M., Martínez, C., Talarn, C., Jiménez, M., Carreras, E., Montserrat, E. Exp. Hematol. (2003) [Pubmed]
  32. Poor antibody response to pneumococcal polysaccharide vaccination suggests increased susceptibility to pneumococcal infection in splenectomized patients with hematological diseases. Cherif, H., Landgren, O., Konradsen, H.B., Kalin, M., Björkholm, M. Vaccine (2006) [Pubmed]
  33. Persistent parvovirus B19 infections in immunocompromised children. Flunker, G., Peters, A., Wiersbitzky, S., Modrow, S., Seidel, W. Med. Microbiol. Immunol. (Berl.) (1998) [Pubmed]
  34. Flunitrazepam-fentanyl-induced sedation and analgesia for bone marrow aspiration and needle biopsy in children. Maunuksela, E.L., Rajantie, J., Siimes, M.A. Acta anaesthesiologica Scandinavica. (1986) [Pubmed]
  35. Alternative viral envelopes for oncoretroviruses to increase gene transfer into hematopoietic stem cells. Barrette, S., Orlic, D. Curr. Opin. Mol. Ther. (2000) [Pubmed]
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