Disease relevance of Takayasu's Arteritis

• OBJECTIVE: Granulomatous inflammation is a typical feature of Takayasu arteritis (TA), and tumor necrosis factor (TNF) is important in the formation of granulomas [1].
• Inflammatory aortitis may occur in isolation or as part of a systemic inflammatory disorder such as Takayasu arteritis, systemic lupus erythematosus, rheumatoid arthritis, and giant cell arteritis [2].
• Pyoderma gangrenosum associated with Takayasu's arteritis responding to cyclosporin [3].
• In the absence of other vasculitis or inflammation markers, Takayasu's arteritis was diagnosed and steroid therapy was started [4].
• In the late occlusive or pulseless phase Takayasu arteritis, angiography usually demonstrates luminal changes such as such as stenosis, occlusion, or aneurysmal dilatation of the aorta and pulmonary artery and of their branches [5].

High impact information on Takayasu's Arteritis

• Mycophenolate mofetil for the treatment of Takayasu arteritis: report of three cases [6].
• Images in Cardiovascular Medicine. Ultrasonographic images of Takayasu's arteritis [7].
• The cells subjected to sera from patients with Takayasu arteritis demonstrated specific immunofluorescent staining of their plasma membrane and cytosol [8].
• Treatment of glucocorticoid-resistant or relapsing Takayasu arteritis with methotrexate [9].
• Thrombomodulin in patients with Takayasu's arteritis [10].

Chemical compound and disease context of Takayasu's Arteritis

• CONCLUSION: CT angiography clearly depicts both luminal and mural changes in the thoracic aorta and its major branches and has a high accuracy in the diagnosis of Takayasu arteritis [11].
• Plasma levels of PF4, beta TG, TAT, FPA and D-dimer, but not PIC, in patients with Takayasu's arteritis were substantially higher than those in normal control subjects [12].
• A 42 year old woman with Takayasu's arteritis responded to treatment with prednisone (60 mg daily) but developed severe side effects [13].
• One of the characteristic problems in Takayasu's arteritis is the necessity for prednisolone administration in some patients preoperatively or postoperatively, or both [14].
• Thallium-201 stress scintigraphy in Takayasu arteritis [15].

Biological context of Takayasu's Arteritis

• To further define the HLA-linked genes controlling the susceptibility to Takayasu's arteritis, polymorphisms in five microsatellites around the HLA-B and MICA genes, C1-2-A, MIB, C1-4-1, C1-2-5, and C1-3-1, were investigated in 91 Japanese patients with Takayasu's arteritis and 248 healthy Japanese controls [16].
• This finding suggests that the disease susceptibility gene of Takayasu arteritis is located between the HLA-B locus and HLA-DR, DQ loci [17].

Anatomical context of Takayasu's Arteritis

• Expression of heat shock protein (HSP)-65 as well as infiltration of T-cells in arterial lesions and raised levels of circulating antibodies against mycobacterial HSP65 (mHSP65) led us to the concept that mHSP65 or its human homologue (hHSP60) might be involved in the etiopathogenesis of Takayasu's arteritis (TA) [18].
• Incubating cells with IgG aggregates caused reduction of EA-RFC and these lymphocytes restored their ability to form rosettes with EA by rinsing cells with medium at 37 degrees C. In conclusion, we could confirm the presence of IC both in sera and on lymphocyte Fc receptors in some cases of Takayasu's arteritis [19].
• Stroke related to carotid artery dissection in a young patient with Takayasu arteritis, systemic lupus erythematosus and antiphospholipid antibody syndrome [20].
• Autoantibodies against cardiolipin and endothelial cells in Takayasu's arteritis: prevalence and isotype distribution [21].
• A significant positive correlation was evident between plasma ET-1 levels and erythrocyte sedimentation rates (ESRs) in patients with Takayasu's arteritis (r = 0.53, p < 0.005) [22].

Gene context of Takayasu's Arteritis

• Plasma levels of vWF:Ag in patients with Takayasu's arteritis did not differ significantly from those in normal subjects, and plasma levels of TM were significantly lower than those in normal subjects [12].
• Because two HLA-B alleles, HLA-B51 and B39.1, which are similar but different at the epitope from HLA-B52 and B39.2, respectively, are not associated with Takayasu arteritis, 63Glu and 67Ser are supposed to be involved in the pathogenesis [23].
• The distribution of HLA-A, B, C and DR antigens was determined in a cohort of 104 unrelated Indian patients with Takayasu arteritis (TA) belonging to the North Indian states of Punjab, Haryana, Uttar Pradesh and Delhi [24].
• High TNF-alpha and low IL-2 producing T cells characterize active disease in Takayasu's arteritis [25].
• Interleukin-8 in Takayasu's arteritis: plasma levels and relationship with disease activity [26].

Analytical, diagnostic and therapeutic context of Takayasu's Arteritis

• Induction of remission in a patient with Takayasu's arteritis by low dose pulses of methotrexate [13].
• DNA typing of HLA-B gene in Takayasu's arteritis [23].
• Multiple percutaneous transluminal angioplasties and low dose pulse methotrexate for Takayasu's arteritis [27].
• We conclude that the provocative upright test with 99Tcm-HMPAO brain SPET can detect abnormal patterns of cerebral perfusion in patients with Takayasu arteritis that might be missed by brain SPET using 123I-IMP and acetazolamide [28].
• The peripheral venous plasma levels of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) were determined by radioimmunoassay in 23 control subjects, 14 patients with essential hypertension, 19 patients with cerebrovascular disease (CVD) not taking aspirin, 12 patients with DVD taking aspirin, and 12 patients with Takayasu's arteritis [29].

References