Disease relevance of Urethral Stricture

• Cushing's syndrome: complication of triamcinolone injection for urethral strictures in children [1].
• Complications in 8 cases (23.5%) included 4 glans disruption in 4, coronal grove fistula in 2, urethral diverticulum in 1 and urethral stenosis due to balanitis xerotica obliterans in 1 [2].
• The overall complication rate was 17.5% and included meatal stenosis (n = 1), bulbar urethral stricture (n = 1), refractory detrusor hyperreflexia (n = 1), dystrophic bladder neck calcification (n = 1), prostatic synechial formation requiring revision (n = 2), and residual prostatic tissue requiring revision (n = 1) [3].
• We have identified 6 structural fetal anomalies which we postulate may have cocaine-induced vascular accidents as the teratogenic mechanism: 2 complex choroid plexus cysts, gastroschisis, meconium peritonitis, urethral stenosis, and radial hypoplasia [4].
• The toxicity of proline analogues has prevented human testing; BAPN presently is being tested or has been tested in patients with scleroderma, flexor tendon adhesions, posterior urethral strictures, and surface keloids [5].

High impact information on Urethral Stricture

• Recurrent traumatic urethral strictures near the external sphincter: treatment with a covered, retrievable, expandable nitinol stent--initial results [6].
• CONCLUSIONS: Urethral stricture formation is a fibrotic process associated with significant changes in NOS metabolism [7].
• The use of halofuginone in limiting urethral stricture formation and recurrence: an experimental study in rabbits [8].
• Core-through urethrotomy using the neodymium: YAG laser for obliterative urethral strictures after traumatic urethral disruption and/or distraction defects: long-term outcome [9].
• Extracellular matrix changes in urethral stricture disease [10].

Chemical compound and disease context of Urethral Stricture

• A review of steroid management of urethral strictures is presented [11].
• Norfloxacin as prophylaxis against urethral strictures following transurethral resection of the prostate: an open, prospective, randomized study [12].
• A total of 5 patients with recurrent posterior urethral strictures underwent endoscopic placement of an expandable endourethral stent made of titanium [13].
• The present findings explain the etiology of the long urethral stricture epidemics seen in open-heart surgery in the early 1980s by showing the interference between indwelling latex catheters and reduced local blood flow [14].
• Administration of beta-aminopropionitrile to human beings with urethral strictures: A prelimary report [15].

Anatomical context of Urethral Stricture

• The objective findings were vesicoureteral reflux in 29 children, urinary tract infection in 20 and distal urethral stenosis in 8 [16].
• We report a case of primary genitourinary tuberculosis associated with severe progressive scarring, and obstruction of the left collecting system and proximal ureter, a contracted bladder with persistent vesicoureteral reflux and a bulbar urethral stricture [17].
• It is suggested that large amounts of estrogen cause atrophy and fibrosis of the spongy and cavernous bodies of the penis, depriving the urethra of its normal elasticity, which results in urethral stricture [18].

Gene context of Urethral Stricture

• Use of cyclooxygenase-2 inhibitor for prevention of urethral strictures secondary to transurethral resection of the prostate [19].
• At 1 year of follow-up, a urethral stricture had been diagnosed in 8.3% of all cases; in particular, in 17% and 0% of cases in the no COX inhibitor group and COX-2 inhibitor group, respectively [19].
• CONCLUSIONS: We suggest that limited postoperative treatment with a COX-2 inhibitor can effectively prevent post-TURP urethral stricture development by specifically interfering with the inflammatory processes that can precede scar formation [19].
• Eighty-four urethral stricture patients and 73 controls were studied prospectively over a 6 months period in Tikur Anbessa Hospital from April to August 2000 [20].
• Re: Congenital bulbar urethral stricture occurring in a father and son [21].

Analytical, diagnostic and therapeutic context of Urethral Stricture

• With the method described, neodymium: YAG laser phototherapy of urethral strictures appears to offer no treatment advantages over conventional therapy and is associated with a high recurrence rate [22].
• Because latex rubber catheters have been implicated in urethral stricture formation, the incidence of urethral strictures following transurethral prostatectomy (TUP) and subsequent catheterisation with latex rubber or polyvinyl chloride catheters was compared [23].

References