Disease relevance of Gastroschisis

• The effects of this BP metabolite were very specific and malformations such as exencephaly, thoraco- and gastroschisis, phocomelia, and edema were found [1].
• Pneumatic reduction bag for treatment of gastroschisis and omphalocele. A 10-year experience [2].
• Six fetuses with neural tube defects (2 with gastroschisis and 3 where one twin was dead) were detected and found to have elevated AChE, TChE and 2 bands by electrophoresis [3].
• In this article, we report a case of Leuconostoc bacteremia in a 7-month-old infant who had short-gut syndrome after a gastroschisis repair and who was dependent on total parenteral nutrition through a central venous catheter [4].
• We report on a boy who presented at birth with gastroschisis and thereafter developed the characteristic clinical symptoms of infantile sialic acid storage disease within the first two months of life [5].

High impact information on Gastroschisis

• Gastroschisis and alpha-fetoprotein [6].
• Although pseudoephedrine has previously been shown to increase gastroschisis risk, findings of this study raise questions about interactions between medications and possible confounding by underlying illness [7].
• Ten infants had previous surgical correction of abdominal wall defects (gastroschisis/omphalocele); 10 infants had previous surgical correction of congenital diaphragmatic hernia; and 18 infants had no thoracic or abdominal surgery [8].
• CONCLUSION: The mutation rate for MTHFR did not differ in children with and without gastroschisis when mothers were matched by race and age [9].
• RESULTS: Of children with gastroschisis, 6.45% were heterozygous for Factor V Leiden. No infants with gastroschisis had prothrombin gene mutations [9].

Chemical compound and disease context of Gastroschisis

• SETTING: The South West Region of England. POPULATION: All known cases of gastroschisis were identified from the regional fetal medicine, ultrasound, pathology and neonatal surgery, databases [10].
• An increased phosphorylation of two proteins and a shift in one glycoprotein were observed in the skin of irradiated foetuses with gastroschisis compared with the unirradiated normal controls [11].
• The present study evaluates the effects of dexamethasone on intestinal function in a rabbit fetal gastroschisis model [12].
• However, there was only mild thickening in the gastroschisis pretreated with L-NAME group [13].
• Carbimazole-related gastroschisis [14].

Biological context of Gastroschisis

• RESULTS: As reported previously, median AFP levels were significantly higher in pregnancies with gastroschisis and omphalocele compared to unaffected pregnancies (9.42 and 4.18 multiples of the unaffected population median [MoM], respectively) [15].
• Effect of intraamniotic dexamethasone administration on intestinal absorption in a rabbit gastroschisis model [12].

Anatomical context of Gastroschisis

• When amniotic fluid samples from cases of fetal gastroschisis were stained with CD15, analysis by flow cytometry showed a clear positive population [16].
• Nitric oxide synthase inhibition prevents intestinal damage in gastroschisis: a morphological evaluation in chick embryos [13].
• Oral administration of 800 mg/kg/day of mevinolin to rats from days 6 through 17 of gestation produced fetal malformations of the vertebrae and ribs in 29% of the litters, and there was a treatment-related increase in the incidence of gastroschisis [17].
• Size of the abdominal wall defect, viscera exposed or herniated, birth weight, associated medical conditions and congenital anomalies, mode and complications of treatment, and the use of total parenteral alimentation was reviewed in 79 cases of omphalocele and 44 cases of gastroschisis treated in the past 10 yr [18].

Gene context of Gastroschisis

• We have previously shown that the p53 gene plays a crucial role in the development of malformations (exencephaly, gastroschisis, polydactyly, cleft palate and dwarfism) in control and irradiated mouse embryos [19].
• STUDY DESIGN: Thirty-one children born with gastroschisis were tested for Factor V Leiden, prothrombin, and methylene tetrahydrofolate reductase (MTHFR) mutations [9].
• A single case of gastroschisis was also found in a rat exposed to the selective COX-2 inhibitor [20].
• In this series of 30 infants with gastroschisis (20% mortality) significant gastroesophageal reflux was identified in seven of 10 infants with the appropriate barium study [21].
• Mutational analysis of the BMP-1 gene in patients with gastroschisis [22].

Analytical, diagnostic and therapeutic context of Gastroschisis

• Prenatal diagnosis of two cases of gastroschisis following alpha-fetoprotein (AFP) screening [23].
• A 19-week-old fetus with craniosynostosis, renal agenesis and gastroschisis: case report and differential diagnosis [24].
• CONCLUSIONS: Enterally administered erythromycin at a dose of 3 mg/kg 4 times daily conferred no advantage in the time taken to achieve full enteral feeding after primary repair of uncomplicated gastroschisis [25].
• CONCLUSIONS: Our study identified no benefit from cisapride therapy in babies with gastroschisis and also there was no benefit from elective Caesarean section for babies with antenatal diagnosis of gastroschisis [26].
• METHODS: Twenty-seven time-mated rabbits, on gestational day 25, were submitted to a midline laparotomy; the gravid bicornuate uterus was exposed and opened, and the more distal fetuses relative to the vaginal opening had the abdominal wall opened by a small incision to produce gastroschisis (n = 29) [27].

References