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MeSH Review

Splenic Vein

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Disease relevance of Splenic Vein


High impact information on Splenic Vein

  • Bile acid concentrations in peripheral vein were correlated with the measured portal and splenic vein shunt indexes [5].
  • In the splenic vein, responses solely to LTC4 were very slightly reduced in the presence of L-NAME [6].
  • Reduced hemoglobin (10(-6) and 10(-5) M) inhibited LTC4-evoked splenic vein relaxation and, in a concentration of 10(-5) M, inhibited LTD4-evoked relaxation of the splenic vein [6].
  • Elimination of this sump by adding complete dissection of the splenic vein and division of the splenocolic ligament to DSRS (splenopancreatic disconnection, SPD) could preserve portal perfusion, decrease shunt loss of hepatotrophic factor, and improve survival in alcoholic cirrhotics [7].
  • Infusion of vasopressin (0.3 U/min) significantly decreased the blood flow in the left gastric vein (-56%), portal trunk (-54%), superior mesenteric vein (-54%), and splenic vein (-56%) as a result of decrease of blood velocity in these vessels [8].

Biological context of Splenic Vein

  • We therefore studied muscarinic cholinergic binding sites in a bovine splenic vein preparation by direct radioligand binding techniques using [3H]quinuclidinyl benzilate ([3H]QNB) as radioactive probe [9].

Anatomical context of Splenic Vein


Associations of Splenic Vein with chemical compounds

  • On the other hand, the longitudinal muscle of the splenic vein and the gastric vein responded less well than the circular muscle; for example 0.36 and 0.16 times as responsive to noradrenaline, respectively [15].
  • The hyaluronic acid serum concentration correlated positively with the splenic vein diameter (P=0.004) and marginally with alpha2-macroglobulin (P=0.059) [16].
  • In contrast, splenic vein occlusion caused no changes except for a decrease in biliary bilirubin concentration [17].
  • Plugging of the needle tract by injection of suspensions of small Gelfoam or Ivalon particles resulted in intravasation of these particles into the splenic vein [18].
  • Pulmonary and splenic veins also showed marked relaxation with isoproterenol [19].

Gene context of Splenic Vein

  • PECAM-1 expression on PMNs from splenic vein and inferior vena cava was determined by RT-PCR at mRNA level and determined by flow cytometry at protein level [20].
  • The major peak of NPY-Li in spleen extracts and splenic vein plasma co-eluted with synthetic porcine NPY and a minor peak with larger Stokes radius was also present [21].
  • The splenic vein was shown to be occluded in two patients in the venous phase of celiac angiography and was entirely nonvisualized by percutaneous portography in the third case [22].
  • HT29-5FU cells showed significantly higher adhesion to E-selectin and to matrigel and in vitro invasive properties and significantly increased liver colonization capacity in nude mice following splenic vein injection [23].
  • During experimental trials, dogs received, in addition, glucagon (5 ng/kg/min) infused via a splenic vein catheter [24].

Analytical, diagnostic and therapeutic context of Splenic Vein


  1. Abdominal thrombotic and ischemic manifestations of the antiphospholipid antibody syndrome: CT findings in 42 patients. Kaushik, S., Federle, M.P., Schur, P.H., Krishnan, M., Silverman, S.G., Ros, P.R. Radiology. (2001) [Pubmed]
  2. Splenic rupture following splenic vein thrombosis in a man with protein S deficiency. Williams, N., Gerrand, C., London, N.J., Chapman, C., Bell, P.R. Postgraduate medical journal. (1992) [Pubmed]
  3. Tumor thrombus in the splenic vein originated from gastric carcinoma that produced alpha-fetoprotein. Yamaguchi, M., Midorikawa, T., Saitoh, M., Kadokura, S., Miyagawa, K., Sanada, Y., Kumada, K. Hepatogastroenterology (2003) [Pubmed]
  4. Appleby operation for pancreatic body-tail carcinoma: report of three cases. Yamaguchi, K., Nakano, K., Kobayashi, K., Ogura, Y., Konomi, H., Sugitani, A., Tanaka, M. Surgery today. (2003) [Pubmed]
  5. Role of portal and splenic vein shunts and impaired hepatic extraction in the elevated serum bile acids in liver cirrhosis. Ohkubo, H., Okuda, K., Iida, S., Ohnishi, K., Ikawa, S., Makino, I. Gastroenterology (1984) [Pubmed]
  6. Leukotrienes C4 and D4 are potent endothelium-dependent relaxing agents in canine splanchnic venous capacitance vessels. Pawloski, J.R., Chapnick, B.M. Circ. Res. (1993) [Pubmed]
  7. Splenopancreatic disconnection. Improved selectivity of distal splenorenal shunt. Warren, W.D., Millikan, W.J., Henderson, J.M., Abu-Elmagd, K.M., Galloway, J.R., Shires, G.T., Richards, W.O., Salam, A.A., Kutner, M.H. Ann. Surg. (1986) [Pubmed]
  8. Effects of vasopressin on left gastric venous flow in cirrhotic patients with esophageal varices. Ohnishi, K., Sato, S. Am. J. Gastroenterol. (1990) [Pubmed]
  9. Muscarinic receptors of the vascular bed: radioligand binding studies on bovine splenic veins. Brunner, F., Kukovetz, W.R. J. Cardiovasc. Pharmacol. (1986) [Pubmed]
  10. Mesenteric vein thrombosis: CT identification. Rosen, A., Korobkin, M., Silverman, P.M., Dunnick, N.R., Kelvin, F.M. AJR. American journal of roentgenology. (1984) [Pubmed]
  11. Parenteral glutamine infusion alters insulin-mediated glucose metabolism. Borel, M.J., Williams, P.E., Jabbour, K., Levenhagen, D., Kaizer, E., Flakoll, P.J. JPEN. Journal of parenteral and enteral nutrition. (1998) [Pubmed]
  12. Tuberculosis of the pancreas. Fernández del Castillo, C., González-Ojeda, A., Reyes, E., Quiroz-Ferrari, F., Uribe, M., Robles-Díaz, G. Pancreas (1990) [Pubmed]
  13. Feasibility spectrum for Doppler flowmetry of splanchnic vessels. In normal and cirrhotic populations. Sabbá, C., Ferraioli, G., Sarin, S.K., Lerner, E., Groszmann, R.J., Taylor, K.J. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. (1990) [Pubmed]
  14. Hepatocavopathy and isolated splenic vein thrombosis due to hypercoagulability state. Akarsu, M., Seçil, M., Yener, S., Topalak, O. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. (2005) [Pubmed]
  15. Regional differences of reactivity to stimulants in the dog portal tree. Fujii, K., Fujiwara, M., Kumada, K., Kurahashi, K., Usui, H. Br. J. Pharmacol. (1987) [Pubmed]
  16. Serum hyaluronic acid as a comprehensive marker to assess severity of liver disease in schistosomiasis. Köpke-Aguiar, L.A., Martins, J.R., Passerotti, C.C., Toledo, C.F., Nader, H.B., Borges, D.R. Acta Trop. (2002) [Pubmed]
  17. The effects of temporary occlusion of the superior mesenteric vein or splenic vein on biliary bilirubin and bile acid excretion in rats. Adachi, Y., Kamisako, T., Yamamoto, T. J. Lab. Clin. Med. (1991) [Pubmed]
  18. Improved safety of splenoportography by plugging of the needle tract. Probst, P., Rysavy, J.A., Amplatz, K. AJR. American journal of roentgenology. (1978) [Pubmed]
  19. Regional variation in beta-adrenoceptor-mediated relaxation of canine veins. Furuta, T., Ishikawa, N., Shigei, T. Blood vessels. (1986) [Pubmed]
  20. Differences in platelet endothelial cell adhesion molecule-1 expression between peripheral circulation and pancreatic microcirculation in cerulein-induced acute edematous pancreatitis. Gao, H.K., Zhou, Z.G., Han, F.H., Chen, Y.Q., Yan, W.W., He, T., Wang, C., Wang, Z. World J. Gastroenterol. (2005) [Pubmed]
  21. Radioimmunoassay for neuropeptide Y (NPY): chromatographic characterization of immunoreactivity in plasma and tissue extracts. Theodorsson-Norheim, E., Hemsén, A., Lundberg, J.M. Scand. J. Clin. Lab. Invest. (1985) [Pubmed]
  22. Splenic vein thrombosis as a consequence of chronic pancreatitis: a study of three cases. Nishiyama, T., Iwao, N., Myose, H., Okamoto, T., Fujitomi, Y., Chinen, M., Komichi, Y., Kobayashi, T. Am. J. Gastroenterol. (1986) [Pubmed]
  23. Biological properties and expression of mucins in 5-fluorouracil resistant HT29 human colon cancer cells. Choi, S.R., Cho, M., Kim, H.R., Ahn, D.H., Sleisenger, M.H., Kim, Y.S. Int. J. Oncol. (2000) [Pubmed]
  24. Glucagon lowers canine biliary cholesterol output at physiologic doses. Schirmer, B.D., Kortz, W.J., Miller, R.J., Christian, K.G., Hayes, E., Jones, R.S. Dig. Dis. Sci. (1986) [Pubmed]
  25. Splenic vein thrombosis in patients with acute pancreatitis. Rogers, C., Klatt, E.C. Int. J. Pancreatol. (1989) [Pubmed]
  26. Laparoscopic correction of congenital portosystemic shunt in children. Kimura, T., Soh, H., Hasegawa, T., Sasaki, T., Kuroda, S., Yuri, E., Tomoda, K., Fukuzawa, M. Surgical laparoscopy, endoscopy & percutaneous techniques. (2004) [Pubmed]
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