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Gene Review

Pecam1  -  platelet/endothelial cell adhesion molecule 1

Rattus norvegicus

Synonyms: CD31, PECAM-1, Pecam, Platelet endothelial cell adhesion molecule
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Disease relevance of Pecam


High impact information on Pecam

  • Platelet-endothelial cell adhesion molecule-1 (PECAM-1, CD31) plays an active role in the process of leukocyte migration through cultured endothelial cells in vitro and anti-PECAM-1 antibodies (Abs) inhibit accumulation of leukocytes into sites of inflammation in vivo [6].
  • To address this point directly, we studied the effect of an anti-PECAM-1 Ab, recognizing rat PECAM-1, on leukocyte responses within rat mesenteric microvessels using intravital microscopy [6].
  • Further, our findings provide the first in vivo indication that PECAM-1 may have an important role in triggering the passage of leukocytes through the perivascular basement membrane [6].
  • Histology showed iron-labeled cells around the tumor rim in labeled mice, which expressed CD31 and von Willebrand factor, indicating the transplanted cells detected in the tumor have differentiated into endothelial-like cells [7].
  • The PSMA-positive cell-outlined channels are CD31 negative and mutually exclusive of CD31-positive cell-lined channels elsewhere in the tumor consistent with tumor cells adapted to a pseudoendothelial phenotype in vasculogenic mimicry [8].

Chemical compound and disease context of Pecam


Biological context of Pecam

  • Nevertheless, the gene expression of c/EBPalpha, GATA-2, and most of the CYP genes was dramatically reduced (up to 90%) in cell cultures lacking PECAM-1 expression; in strong contrast, expression of the silencer Oct-1 was massively increased (approximately 14-fold) [11].
  • Systemic sBG treatment significantly reduced tumor microvessel density detected with histological analyses and CD-31 immunostainings, as well as tumor blood volume measured with hemoglobin content [12].
  • Frozen sections were examined histologically and stained for vascular cellular adhesion molecule-1 (VCAM-1), platelet-endothelial cell adhesion molecule-1 (PECAM-1), major histocompatibility complex (MHC) class II, tissue factor, leukocyte function associated molecule-1 (LFA-1), very late antigen-4 (VLA-4), as well as for inflammatory cells [13].
  • ICAM-1 and PECAM-1 showed similar kinetics and a diffuse distribution [14].
  • Further, expression of the disease markers beta-MHC and VCAM-1 was repressed (P<0.05), as was expression of the myocyte enhancer factor MEF2c [15].

Anatomical context of Pecam

  • There was also no increase in the number of intravascular neutrophils within the bronchial vessels after treatment with anti-PECAM-1 antibody [1].
  • RESULTS: In experimental rats, an increased PECAM-1 mRNA expression was seen from 4 to 8 h of AEP in peripheral circulation (0.77+/-0.25%, 0.76+/-0.28%, 0.89+/-0.30%, 1.00+/-0.21%), while in pancreatic microcirculation, expression decreased from 2 h and reached the lowest level at 6 h of AEP (0.78+/-0.29%, 0.75+/-0.26%, 0.62+/-0.28%, 0.66+/-0.20%) [2].
  • PECAM-1 expression on PMNs from splenic vein and inferior vena cava was determined by RT-PCR at mRNA level and determined by flow cytometry at protein level [2].
  • OBJECTIVE: To study the changes of platelet endothelial cell adhesion molecule-1 (PECAM-1) expression on polymorphonuclear leukocytes (PMNs) in peripheral circulation and pancreatic microcirculation in rats with acute edematous pancreatitis (AEP) [16].
  • Mural precursor cells (MPCs) isolated with a nonenzymatic method from the intimal aspect of the rat aorta were positive for smooth muscle cell markers (alpha-smooth muscle actin and calponin) and negative for endothelial markers (factor-VIII-related antigen and CD31) [17].

Associations of Pecam with chemical compounds

  • Histological analysis of Calu-6 tumors treated with 50 mg/kg/day ZD6474 for 24 days showed a significant reduction (>70%) in CD31 (endothelial cell) staining in nonnecrotic regions [18].
  • In addition, SU5416 administration significantly inhibited the formation of portal-systemic collateral vessels (52% inhibition), as well as the splanchnic CD31 and VEGF receptor-2 protein expressions in portal hypertensive rats, compared with those receiving vehicle [19].
  • Both platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) and the integrin alphavbeta3 have been implicated in this process, and in vitro studies have identified alphavbeta3 as a heterotypic ligand for PECAM-1 [20].
  • RESULTS: Treatment of donor and recipient animals significantly increased blood and heart tissue vitamin E levels (P<0.05) [15].
  • Staining for VEGF correlated with CD-31 vessel counts (no./mm2: C, 53.1 +/- 16.1; G, 166 +/- 32; NAG, 183 +/- 32; P < 0.05) [21].

Regulatory relationships of Pecam


Other interactions of Pecam

  • Protein expressions of CD31, VEGF receptor-2 and VEGF were also determined by Western blotting [19].
  • RESULTS: Semiquantitative analysis revealed that the capillary density and mRNA expression of PECAM-1, VCAM-1 and VEGF were significantly lower in the one-kidney group compared to the two-kidney group on day 14 [23].
  • Administration of insulin reversed the delay in ulcer healing and significantly decreased the expression of IL-1 beta and TNF-alpha, while producing the rise in the expression of VEGF and PECAM [24].
  • The acceleration of ulcer healing by PPAR-gamma ligand was accompanied by a significant increase in the expression of PECAM-1 protein, a marker of angiogenesis [25].
  • RMLEC express known endothelial- and lymphatic-specific markers as well as the following adhesion molecules: N-cadherin, E-cadherin, PECAM-1, alpha-catenin, beta-catenin, gamma-catenin, p120, and a variety of integrins [26].

Analytical, diagnostic and therapeutic context of Pecam


  1. Platelet endothelial cell adhesion molecule-1 in neutrophil emigration during acute bacterial pneumonia in mice and rats. Tasaka, S., Qin, L., Saijo, A., Albelda, S.M., DeLisser, H.M., Doerschuk, C.M. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  2. Differences in platelet endothelial cell adhesion molecule-1 expression between peripheral circulation and pancreatic microcirculation in cerulein-induced acute edematous pancreatitis. Gao, H.K., Zhou, Z.G., Han, F.H., Chen, Y.Q., Yan, W.W., He, T., Wang, C., Wang, Z. World J. Gastroenterol. (2005) [Pubmed]
  3. Effect of dietary energy restriction on vascular density during mammary carcinogenesis. Thompson, H.J., McGinley, J.N., Spoelstra, N.S., Jiang, W., Zhu, Z., Wolfe, P. Cancer Res. (2004) [Pubmed]
  4. A prostate secretory protein94-derived synthetic peptide PCK3145 inhibits VEGF signalling in endothelial cells: implication in tumor angiogenesis. Lamy, S., Ruiz, M.T., Wisniewski, J., Garde, S., Rabbani, S.A., Panchal, C., Wu, J.J., Annabi, B. Int. J. Cancer (2006) [Pubmed]
  5. Vascular density profile of rat mammary carcinomas induced by 1-methyl-1-nitrosourea: implications for the investigation of angiogenesis. Thompson, H.J., McGinley, J.N., Knott, K.K., Spoelstra, N.S., Wolfe, P. Carcinogenesis (2002) [Pubmed]
  6. An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane. Wakelin, M.W., Sanz, M.J., Dewar, A., Albelda, S.M., Larkin, S.W., Boughton-Smith, N., Williams, T.J., Nourshargh, S. J. Exp. Med. (1996) [Pubmed]
  7. Noninvasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model. Anderson, S.A., Glod, J., Arbab, A.S., Noel, M., Ashari, P., Fine, H.A., Frank, J.A. Blood (2005) [Pubmed]
  8. Prostate-specific membrane antigen directed selective thrombotic infarction of tumors. Liu, C., Huang, H., Doñate, F., Dickinson, C., Santucci, R., El-Sheikh, A., Vessella, R., Edgington, T.S. Cancer Res. (2002) [Pubmed]
  9. Effects of inhibition of the polyol pathway during chronic peritoneal exposure to a dialysis solution. van Westrhenen, R., Aten, J., Aberra, M., Dragt, C.A., Deira, G., Krediet, R.T. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. (2005) [Pubmed]
  10. Multimodal management - of value in fulminant acute pancreatitis? Haraldsen, P., Sun, Z.W., Börjesson, A., Olanders, K., Lasson, A., Andersson, R. Pancreatology (2003) [Pubmed]
  11. Cellular dedifferentiation of endothelium is linked to activation and silencing of certain nuclear transcription factors: implications for endothelial dysfunction and vascular biology. Thum, T., Haverich, A., Borlak, J. FASEB J. (2000) [Pubmed]
  12. Antitumor activity of a recombinant soluble betaglycan in human breast cancer xenograft. Bandyopadhyay, A., López-Casillas, F., Malik, S.N., Montiel, J.L., Mendoza, V., Yang, J., Sun, L.Z. Cancer Res. (2002) [Pubmed]
  13. Prolonged cold preservation augments vascular injury independent of renal transplant immunogenicity and function. Dragun, D., Hoff, U., Park, J.K., Qun, Y., Schneider, W., Luft, F.C., Haller, H. Kidney Int. (2001) [Pubmed]
  14. Ischemia-reperfusion injury in renal transplantation is independent of the immunologic background. Dragun, D., Hoff, U., Park, J.K., Qun, Y., Schneider, W., Luft, F.C., Haller, H. Kidney Int. (2000) [Pubmed]
  15. Vitamin E in heart transplantation: effects on cardiac gene expression. Schulte, I., Bektas, H., Klempnauer, J., Borlak, J. Transplantation (2006) [Pubmed]
  16. Expression of platelet endothelial cell adhesion molecule-1 between pancreatic microcirculation and peripheral circulation in rats with acute edematous pancreatitis. Gao, H.K., Zhou, Z.G., Chen, Y.Q., Han, F.H., Wang, C. HBPD INT (2003) [Pubmed]
  17. Rat aorta-derived mural precursor cells express the Tie2 receptor and respond directly to stimulation by angiopoietins. Iurlaro, M., Scatena, M., Zhu, W.H., Fogel, E., Wieting, S.L., Nicosia, R.F. J. Cell. Sci. (2003) [Pubmed]
  18. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Wedge, S.R., Ogilvie, D.J., Dukes, M., Kendrew, J., Chester, R., Jackson, J.A., Boffey, S.J., Valentine, P.J., Curwen, J.O., Musgrove, H.L., Graham, G.A., Hughes, G.D., Thomas, A.P., Stokes, E.S., Curry, B., Richmond, G.H., Wadsworth, P.F., Bigley, A.L., Hennequin, L.F. Cancer Res. (2002) [Pubmed]
  19. Inhibition of VEGF receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats. Fernandez, M., Mejias, M., Angermayr, B., Garcia-Pagan, J.C., Rodés, J., Bosch, J. J. Hepatol. (2005) [Pubmed]
  20. Divergent effects of platelet-endothelial cell adhesion molecule-1 and beta 3 integrin blockade on leukocyte transmigration in vivo. Thompson, R.D., Wakelin, M.W., Larbi, K.Y., Dewar, A., Asimakopoulos, G., Horton, M.A., Nakada, M.T., Nourshargh, S. J. Immunol. (2000) [Pubmed]
  21. Correlating structure with solute and water transport in a chronic model of peritoneal inflammation. Flessner, M.F., Choi, J., Vanpelt, H., He, Z., Credit, K., Henegar, J., Hughson, M. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  22. Co-expression of beta-endorphin with adhesion molecules in a model of inflammatory pain. Mousa, S.A., Machelska, H., Schäfer, M., Stein, C. J. Neuroimmunol. (2000) [Pubmed]
  23. Impairment of vascular regeneration precedes progressive glomerulosclerosis in anti-Thy 1 glomerulonephritis. Wada, Y., Morioka, T., Oyanagi-Tanaka, Y., Yao, J., Suzuki, Y., Gejyo, F., Arakawa, M., Oite, T. Kidney Int. (2002) [Pubmed]
  24. Impaired gastric ulcer healing in diabetic rats: role of heat shock protein, growth factors, prostaglandins and proinflammatory cytokines. Harsch, I.A., Brzozowski, T., Bazela, K., Konturek, S.J., Kukharsky, V., Pawlik, T., Pawlowski, E., Hahn, E.G., Konturek, P.C. Eur. J. Pharmacol. (2003) [Pubmed]
  25. Agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma): a new compound with potent gastroprotective and ulcer healing properties. Brzozowski, T., Konturek, P.C., Pajdo, R., Kwiecień, S.N., Konturek, S., Targosz, A., Burnat, G., Cieszkowski, J., Pawlik, W.W., Hahn, E.G. Inflammopharmacology. (2005) [Pubmed]
  26. Development and characterization of endothelial cells from rat microlymphatics. Hayes, H., Kossmann, E., Wilson, E., Meininger, C., Zawieja, D. Lymphatic research and biology. (2003) [Pubmed]
  27. Investigation of laser-induced choroidal neovascularization in the rat. Semkova, I., Peters, S., Welsandt, G., Janicki, H., Jordan, J., Schraermeyer, U. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  28. Expression of integrins and MMPs during alkaline-burn-induced corneal angiogenesis. Zhang, H., Li, C., Baciu, P.C. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  29. Lung uptake of antibodies to endothelial antigens: key determinants of vascular immunotargeting. Danilov, S.M., Gavrilyuk, V.D., Franke, F.E., Pauls, K., Harshaw, D.W., McDonald, T.D., Miletich, D.J., Muzykantov, V.R. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  30. Fate of autologous dermal stem cells transplanted into the spinal cord after traumatic injury (TSCI). Gorio, A., Torrente, Y., Madaschi, L., Di Stefano, A.B., Pisati, F., Marchesi, C., Belicchi, M., Di Giulio, A.M., Bresolin, N. Neuroscience (2004) [Pubmed]
  31. Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation. DeLeve, L.D., Wang, X., Hu, L., McCuskey, M.K., McCuskey, R.S. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
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