The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Middle Ear Ventilation

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Middle Ear Ventilation


High impact information on Middle Ear Ventilation

  • Subjects who had tympanostomy tube surgery for COME/ROM (probands) and their families were recruited for the present study, and an ear examination was performed, without knowledge of the subject's history, to determine presence of OM sequelae [5].
  • Oral prednisolone is an effective adjuvant therapy for acute otitis media with discharge through tympanostomy tubes [6].
  • STUDY DESIGN: In a randomized, double-blind, placebo-controlled study, children with acute discharge (<48 hours) through tympanostomy tubes received either prednisolone (2 mg/kg/d; n = 23) or placebo (n = 27) for 3 days [6].
  • OBJECTIVE: The aim of this study was to determine the cost-effectiveness hreshold of a ciprofloxacin 0.3% and dexamethasone 0.1% (CD) otic suspension relative to olfloxacin otic solution (OFX) for the treatment of acute otitis media in pediatric patients with tympanostomy tubes (AOMT) [7].
  • Ofloxacin applied topically in children with tympanostomy tubes in place and purulent otorrhea is as efficacious as oral amoxicillin/clavulanate (Augmentin) therapy [8].

Chemical compound and disease context of Middle Ear Ventilation


Biological context of Middle Ear Ventilation


Anatomical context of Middle Ear Ventilation


Associations of Middle Ear Ventilation with chemical compounds

  • At the 2-year end point, the rate of attrition was 42.2% in the amoxicillin group, 45.5% in the placebo group and 26.7% in the tympanostomy tube group [9].
  • A course of prednisone for 7 days plus TMP/SMZ for 30 days with monthly follow-up should be considered in children with MEE persisting beyond 6-8 weeks before referral for tympanostomy tube placement [15].
  • Five of 35 (14%) patients treated with prednisone plus TMP/SMZ and one of six (17%) patients treated with TMP/SMZ alone who had complete resolution at 4 weeks required subsequent referrals for tympanostomy tubes [15].
  • RESULTS: Topical ciprofloxacin application after tympanostomy tube insertion was associated with a significantly lower incidence of early posttympanostomy otorrhea [16].
  • CONCLUSION: The use of phenylephrine following tympanostomy tube insertion greatly reduces the incidence of tube obstruction [17].

Gene context of Middle Ear Ventilation

  • TGF-beta1 levels were elevated in association with a history of previous tympanostomy tube placements (TTPs) (P = .029) and mucoid effusions (P = .042) [18].
  • Children undergoing tympanostomy on multiple occasions had average MEE TNF levels (234.2 +/- 109.1 pg/mg total protein) that were nearly 14 times higher (P less than .005) than those from children undergoing their first tympanostomy (16.9 +/- 3.0 pg/mg total protein) [19].
  • PATIENTS: Seventeen children with MRSA otorrhea after bilateral myringotomy with tympanostomy tube insertion (BM&T) and 19 age- and sex-matched control subjects who demonstrated MSSA otorrhea [20].
  • The levels of cathepsin B activity and alpha-2-macroglobulin during the course of clinical therapies (myringotomy and tympanostomy tubing) were analyzed in 10 chronic OME cases where follow-up evaluation was possible [21].
  • As an initial test of this hypothesis, EGF and TGF-alpha concentrations were measured in 82 middle ear effusions of children undergoing tympanostomy tube placement [22].

Analytical, diagnostic and therapeutic context of Middle Ear Ventilation


  1. Effect of early or delayed insertion of tympanostomy tubes for persistent otitis media on developmental outcomes at the age of three years. Paradise, J.L., Feldman, H.M., Campbell, T.F., Dollaghan, C.A., Colborn, D.K., Bernard, B.S., Rockette, H.E., Janosky, J.E., Pitcairn, D.L., Sabo, D.L., Kurs-Lasky, M., Smith, C.G. N. Engl. J. Med. (2001) [Pubmed]
  2. Tube placement: a prospective, randomized double-blind study. Derkay, C.S., Wadsworth, J.T., Darrow, D.H., Strasnick, B., Thompson, G.K., O'Master, J. Laryngoscope (1998) [Pubmed]
  3. Penetration of trimethoprim--sulfadiazine into middle ear fluid in secretory otitis media. Kohonen, A., Palmgren, O., Renkonen, O.V. Int. J. Pediatr. Otorhinolaryngol. (1983) [Pubmed]
  4. A study of the complications of grommet insertion for secretory otitis media in the presence of nasopharyngeal carcinoma. Skinner, D.W., van Hasselt, C.A. Clinical otolaryngology and allied sciences. (1991) [Pubmed]
  5. Chronic and recurrent otitis media: a genome scan for susceptibility loci. Daly, K.A., Brown, W.M., Segade, F., Bowden, D.W., Keats, B.J., Lindgren, B.R., Levine, S.C., Rich, S.S. Am. J. Hum. Genet. (2004) [Pubmed]
  6. Oral prednisolone is an effective adjuvant therapy for acute otitis media with discharge through tympanostomy tubes. Ruohola, A., Heikkinen, T., Jero, J., Puhakka, T., Juvén, T., Närkiö-Mäkelä, M., Saxén, H., Ruuskanen, O. J. Pediatr. (1999) [Pubmed]
  7. A cost threshold analysis of ciprofloxacin-dexamethasone versus ofloxacin for acute otitis media in pediatric patients with tympanostomy tubes. Roland, P.S., Pontius, A., Michael Wall, G., Waycaster, C.R. Clinical therapeutics. (2004) [Pubmed]
  8. Efficacy of ofloxacin and other otic preparations for acute otitis media in patients with tympanostomy tubes. Goldblatt, E.L. Pediatr. Infect. Dis. J. (2001) [Pubmed]
  9. Efficacy of antimicrobial prophylaxis and of tympanostomy tube insertion for prevention of recurrent acute otitis media: results of a randomized clinical trial. Casselbrant, M.L., Kaleida, P.H., Rockette, H.E., Paradise, J.L., Bluestone, C.D., Kurs-Lasky, M., Nozza, R.J., Wald, E.R. Pediatr. Infect. Dis. J. (1992) [Pubmed]
  10. Xylitol in preventing acute otitis media. Uhari, M., Tapiainen, T., Kontiokari, T. Vaccine (2000) [Pubmed]
  11. Direct evidence of bacterial biofilms in otitis media. Post, J.C. Laryngoscope (2001) [Pubmed]
  12. Grommets, tonsillectomies, and deprivation in Scotland. Bisset, A.F., Russell, D. BMJ (1994) [Pubmed]
  13. Impact of pneumococcal polysaccharide vaccine (Prevnar) on middle ear fluid in children undergoing tympanostomy tube insertion. Caspary, H., Welch, J.C., Lawson, L., Darrow, D., Buescher, S., Shahab, S., Derkay, C.S. Laryngoscope (2004) [Pubmed]
  14. Tympanostomy tubes and otic drops. Meyerhoff, W.L., Morizono, T., Wright, C.G., Shaddock, L.C., Shea, D.A., Sikora, M.A. Laryngoscope (1983) [Pubmed]
  15. Management of chronic middle ear effusion with prednisone combined with trimethoprim-sulfamethoxazole. Berman, S., Grose, K., Nuss, R., Huber-Navin, C., Roark, R., Gabbard, S.A., Bagnall, T. Pediatr. Infect. Dis. J. (1990) [Pubmed]
  16. The effect of topical ciprofloxacin on postoperative otorrhea after tympanostomy tube insertion. Zipfel, T.E., Wood, W.E., Street, D.F., Wulffman, J., Tipirneni, A., Frey, C., Gibson, W.S. The American journal of otology. (1999) [Pubmed]
  17. Phenylephrine and the prevention of postoperative tympanostomy tube obstruction. Altman, J.S., Haupert, M.S., Hamaker, R.A., Belenky, W.M. Arch. Otolaryngol. Head Neck Surg. (1998) [Pubmed]
  18. Transforming growth factor-beta expression in otitis media with effusion. Cooter, M.S., Eisma, R.J., Burleson, J.A., Leonard, G., Lafreniere, D., Kreutzer, D.L. Laryngoscope (1998) [Pubmed]
  19. Characterization of cytokines present in middle ear effusions. Yellon, R.F., Leonard, G., Marucha, P.T., Craven, R., Carpenter, R.J., Lehmann, W.B., Burleson, J.A., Kreutzer, D.L. Laryngoscope (1991) [Pubmed]
  20. Methicillin-resistant Staphylococcus aureus otorrhea after tympanostomy tube placement. Coticchia, J.M., Dohar, J.E. Arch. Otolaryngol. Head Neck Surg. (2005) [Pubmed]
  21. Kinetics of lysosomal protease activity in human otitis media with effusion. Hamaguchi, Y., Sakakura, Y., Majima, Y., Juhn, S.K. American journal of otolaryngology. (1987) [Pubmed]
  22. Epidermal growth factor and transforming growth factor-alpha in middle ear effusion. Nassif, P.S., Simpson, S.Q., Izzo, A.A., Nicklaus, P.J. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1998) [Pubmed]
  23. Otorrhea after insertion of silver oxide-impregnated silastic tympanostomy tubes. Gourin, C.G., Hubbell, R.N. Arch. Otolaryngol. Head Neck Surg. (1999) [Pubmed]
  24. Lemon-flavored cod liver oil and a multivitamin-mineral supplement for the secondary prevention of otitis media in young children: pilot research. Linday, L.A., Dolitsky, J.N., Shindledecker, R.D., Pippenger, C.E. The Annals of otology, rhinology, and laryngology. (2002) [Pubmed]
WikiGenes - Universities