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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Pouchitis


High impact information on Pouchitis


Chemical compound and disease context of Pouchitis


Biological context of Pouchitis


Anatomical context of Pouchitis


Gene context of Pouchitis

  • These findings, if borne out in prospective analyses, suggest that CARD15 mutations, particularly L1007fsinsC, may predispose to the development of pouchitis after IPAA for UC [24].
  • IL-6 and IL-8 were present in all pouchitis specimens, in 70% of the specimens from nonpouchitis and only 30% of specimens from controls [25].
  • Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3) [26].
  • The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis [26].
  • IL-1 beta was detected in all tissue homogenates from patients with pouchitis compared with only 29% from pouches without pouchitis and none from controls [25].

Analytical, diagnostic and therapeutic context of Pouchitis


  1. Fecal lactoferrin for diagnosis of symptomatic patients with ileal pouch-anal anastomosis. Parsi, M.A., Shen, B., Achkar, J.P., Remzi, F.F., Goldblum, J.R., Boone, J., Lin, D., Connor, J.T., Fazio, V.W., Lashner, B.A. Gastroenterology (2004) [Pubmed]
  2. Restorative proctocolectomy and pouch anal anastomosis for ulcerative colitis following orthotopic liver transplantation. Rowley, S., Candinas, D., Mayer, A.D., Buckels, J.A., McMaster, P., Keighley, M.R. Gut (1995) [Pubmed]
  3. Distribution of mucosal pathology and an assessment of colonic phenotypic change in the pelvic ileal reservoir. Shepherd, N.A., Healey, C.J., Warren, B.F., Richman, P.I., Thomson, W.H., Wilkinson, S.P. Gut (1993) [Pubmed]
  4. Increased state of activation of CD4 positive T cells and elevated interferon gamma production in pouchitis. Stallmach, A., Schäfer, F., Hoffmann, S., Weber, S., Müller-Molaian, I., Schneider, T., Köhne, G., Ecker, K.W., Feifel, G., Zeitz, M. Gut (1998) [Pubmed]
  5. Review article: antibiotics and probiotics in inflammatory bowel disease. Kruis, W. Aliment. Pharmacol. Ther. (2004) [Pubmed]
  6. Topical administration of 5-aminosalicylic acid: a therapeutic proposal for the treatment of pouchitis. Miglioli, M., Barbara, L., Di Febo, G., Gozzetti, G., Lauri, A., Paganelli, G.M., Poggioli, G., Santucci, R. N. Engl. J. Med. (1989) [Pubmed]
  7. Prevention is the best defense: Probiotic prophylaxis of pouchitis. Katz, J.A. Gastroenterology (2003) [Pubmed]
  8. Smoking benefits celiac sprue and pouchitis: implications for nicotine therapy? Snook, J.A., Dwyer, L., Lee-Elliott, C., Knan, S., Wheeler, D.W., Nicholas, D.S., Merrett, M.N., Mortensen, N., Kettlewell, n.u.l.l., Jewell, D.P. Gastroenterology (1997) [Pubmed]
  9. Evaluation of the inflammatory infiltrate in pouchitis with 111In-labeled granulocytes. Kmiot, W.A., Hesslewood, S.R., Smith, N., Thompson, H., Harding, L.K., Keighley, M.R. Gastroenterology (1993) [Pubmed]
  10. Short-chain fatty acids in pouch contents from patients with and without pouchitis after ileal pouch-anal anastomosis. Clausen, M.R., Tvede, M., Mortensen, P.B. Gastroenterology (1992) [Pubmed]
  11. Presence of PAF-acether in stool of patients with pouch ileoanal anastomosis and pouchitis. Chaussade, S., Denizot, Y., Valleur, P., Nicoli, J., Raibaud, P., Guerre, J., Hautefeuille, P., Couturier, D., Benveniste, J. Gastroenterology (1991) [Pubmed]
  12. Impairment of epithelial transport but not of barrier function in idiopathic pouchitis after ulcerative colitis. Kroesen, A.J., Stockmann, M., Ransco, C., Schulzke, J.D., Fromm, M., Buhr, H.J. Gut (2002) [Pubmed]
  13. Increased leukotriene B4 release from ileal pouch mucosa in ulcerative colitis compared with familial adenomatous polyposis. Gertner, D.J., Rampton, D.S., Madden, M.V., Talbot, I.C., Nicholls, R.J., Lennard-Jones, J.E. Gut (1994) [Pubmed]
  14. Diagnosis and treatment of patients with pouchitis. Shen, B. Drugs (2003) [Pubmed]
  15. Bismuth carbomer foam enemas for active chronic pouchitis: a randomized, double-blind, placebo-controlled trial. Tremaine, W.J., Sandborn, W.J., Wolff, B.G., Carpenter, H.A., Zinsmeister, A.R., Metzger, P.P. Aliment. Pharmacol. Ther. (1997) [Pubmed]
  16. Long term metabolic consequences of ileal pouch-anal anastomosis for ulcerative colitis. Kuisma, J., Nuutinen, H., Luukkonen, P., Järvinen, H., Kahri, A., Färkkilä, M. Am. J. Gastroenterol. (2001) [Pubmed]
  17. Functional results after restorative proctocolectomy complicated by pouchitis. Keränen, U., Luukkonen, P., Järvinen, H. Dis. Colon Rectum (1997) [Pubmed]
  18. Intestinal flora and mucosal immune responses. Heller, F., Duchmann, R. Int. J. Med. Microbiol. (2003) [Pubmed]
  19. Substance P- and vasoactive intestinal polypeptide-immunoreactive innervation in normal and inflamed pouches after restorative proctocolectomy for ulcerative colitis. Keränen, U., Järvinen, H., Kiviluoto, T., Kivilaakso, E., Soinila, S. Dig. Dis. Sci. (1996) [Pubmed]
  20. Tropomyosin expression in the ileal pouch: a relationship with the development of pouchitis in ulcerative colitis. Biancone, L., Palmieri, G., Lombardi, A., Colantoni, A., Tonelli, F., Das, K.M., Pallone, F. Am. J. Gastroenterol. (2003) [Pubmed]
  21. Laparoscopic management of urolithiasis in a continent urostomy. Coleman, R.L., Mahoney, N.M., Hatch, K.D. Gynecol. Oncol. (2002) [Pubmed]
  22. Substance P--an underlying factor for pouchitis? Prospective study of substance P- and vasoactive intestinal polypeptide-immunoreactive innervation and mast cells. Keränen, U., Järvinen, H., Kärkkäinen, P., Kiviluoto, T., Kivilaakso, E., Soinila, S. Dig. Dis. Sci. (1996) [Pubmed]
  23. Crypt cell proliferation and HLA-DR expression in pelvic ileal pouches. de Silva, H.J., Gatter, K.C., Millard, P.R., Kettlewell, M., Mortensen, N.J., Jewell, D.P. J. Clin. Pathol. (1990) [Pubmed]
  24. Innate immune receptor genetic polymorphisms in pouchitis: is CARD15 a susceptibility factor? Meier, C.B., Hegazi, R.A., Aisenberg, J., Legnani, P.E., Nilubol, N., Cobrin, G.M., Duerr, R.H., Gorfine, S.R., Bauer, J.J., Sachar, D.B., Plevy, S.E. Inflamm. Bowel Dis. (2005) [Pubmed]
  25. Mucosal concentrations of interleukin-1 beta, interleukin-6, interleukin-8, and tumor necrosis factor-alpha in pelvic ileal pouches. Gionchetti, P., Campieri, M., Belluzzi, A., Bertinelli, E., Ferretti, M., Brignola, C., Poggioli, G., Miglioli, M., Barbara, L. Dig. Dis. Sci. (1994) [Pubmed]
  26. Combined carriership of TLR9-1237C and CD14-260T alleles enhances the risk of developing chronic relapsing pouchitis. Lammers, K.M., Ouburg, S., Morré, S.A., Crusius, J.B., Gionchett, P., Rizzello, F., Morselli, C., Caramelli, E., Conte, R., Poggioli, G., Campieri, M., Peña, A.S. World J. Gastroenterol. (2005) [Pubmed]
  27. Ulcer associated cell lineage glands expressing trefoil peptide genes are induced by chronic ulceration in ileal pouch mucosa. Pera, M., Heppell, J., Poulsom, R., Teixeira, F.V., Williams, J. Gut (2001) [Pubmed]
  28. Assessment of ileoanal pouch inflammation by interleukin 1beta and interleukin 8 concentrations in the gut lumen. Evgenikos, N., Bartolo, D.C., Hamer-Hodges, D.W., Ghosh, S. Dis. Colon Rectum (2002) [Pubmed]
  29. Biliary lactoferrin concentrations are increased in active inflammatory bowel disease: a factor in the pathogenesis of primary sclerosing cholangitis? Pereira, S.P., Rhodes, J.M., Campbell, B.J., Kumar, D., Bain, I.M., Murphy, G.M., Dowling, R.H. Clin. Sci. (1998) [Pubmed]
  30. Double-blind crossover trial of metronidazole versus placebo in chronic unremitting pouchitis. Madden, M.V., McIntyre, A.S., Nicholls, R.J. Dig. Dis. Sci. (1994) [Pubmed]
  31. Allopurinol as prophylaxis against pouchitis following ileal pouch-anal anastomosis for ulcerative colitis. A randomized placebo-controlled double-blind study. Joelsson, M., Andersson, M., Bark, T., Gullberg, K., Hallgren, T., Jiborn, H., Magnusson, I., Raab, Y., Sjödahl, R., Ojerskog, B., Oresland, T. Scand. J. Gastroenterol. (2001) [Pubmed]
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