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Gene Review

LGALS8  -  lectin, galactoside-binding, soluble, 8

Homo sapiens

Synonyms: Gal-8, Galectin-8, PCTA-1, PCTA1, Po66 carbohydrate-binding protein, ...
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Disease relevance of LGALS8


High impact information on LGALS8


Chemical compound and disease context of LGALS8


Biological context of LGALS8


Anatomical context of LGALS8


Associations of LGALS8 with chemical compounds

  • When p21 expression was inhibited by cycloheximide, galectin-8 directed the cells toward apoptosis, which involves induction of poly(ADP-ribose) polymerase cleavage [7].
  • Galectin-8 also interacts with other members of the integrin family, like (alpha)(6)(beta)(1 )integrins [11].
  • Pretreatment of the cells with Mn(2+), which increases the affinity of integrins for their ligands, abolished the inhibitory effects of galectin-8 [11].
  • Galectin-8 had much higher affinity for 3'-O-sulfated or 3'-O-sialylated lactose and a Lewis x-containing glycan than for oligosaccharides terminating in Galbeta1-->3/4GlcNAc [14].
  • Cell adhesion is potentiated in the presence of Mn(2+), whereas it is interrupted in the presence of soluble galectin-8, integrin beta(1) inhibitory antibodies, EDTA, or thiodigalactoside but not by RGD peptides [15].
  • In glycan microarray analyses, each CRD of Gal-8 showed different binding, with Gal-8N recognizing sulfated and sialylated glycans and Gal-8C recognizing blood group antigens and polyLacNAc glycans [16].

Physical interactions of LGALS8

  • Gal-8-induced Rac-1 activation and binding to alpha1 and alpha5 integrins have not been described in any other cellular system [12].
  • Affinity purification of galectin-interacting proteins from solubilized neutrophil membrane revealed that N-terminal carbohydrate recognition domain (CRD) of galectin-8 bound promatrix metalloproteinase-9 (proMMP-9), and C-terminal CRD bound integrin alphaM/CD11b and proMMP-9 [13].

Other interactions of LGALS8


Analytical, diagnostic and therapeutic context of LGALS8


  1. Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family. Su, Z.Z., Lin, J., Shen, R., Fisher, P.E., Goldstein, N.I., Fisher, P.B. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Galectin-8 expression decreases in cancer compared with normal and dysplastic human colon tissue and acts significantly on human colon cancer cell migration as a suppressor. Nagy, N., Bronckart, Y., Camby, I., Legendre, H., Lahm, H., Kaltner, H., Hadari, Y., Van Ham, P., Yeaton, P., Pector, J.C., Zick, Y., Salmon, I., Danguy, A., Kiss, R., Gabius, H.J. Gut (2002) [Pubmed]
  3. Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene. Gopalkrishnan, R.V., Roberts, T., Tuli, S., Kang, D., Christiansen, K.A., Fisher, P.B. Oncogene (2000) [Pubmed]
  4. Two messenger RNAs and five isoforms for Po66-CBP, a galectin-8 homolog in a human lung carcinoma cell line. Bidon, N., Brichory, F., Hanash, S., Bourguet, P., Dazord, L., Le Pennec, J.P. Gene (2001) [Pubmed]
  5. The tumor antigen repertoire identified in tumor-bearing Neu transgenic mice predicts human tumor antigens. Lu, H., Knutson, K.L., Gad, E., Disis, M.L. Cancer Res. (2006) [Pubmed]
  6. Galectins are differentially expressed in supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas, and significantly modulate tumor astrocyte migration. Camby, I., Belot, N., Rorive, S., Lefranc, F., Maurage, C.A., Lahm, H., Kaltner, H., Hadari, Y., Ruchoux, M.M., Brotchi, J., Zick, Y., Salmon, I., Gabius, H.J., Kiss, R. Brain Pathol. (2001) [Pubmed]
  7. Cyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8. Arbel-Goren, R., Levy, Y., Ronen, D., Zick, Y. J. Biol. Chem. (2005) [Pubmed]
  8. The effects of calcium antagonists after PTCA. Hoberg, E. Eur. Heart J. (1995) [Pubmed]
  9. Left ventricular dysfunction following transient ischaemia induced by transluminal coronary angioplasty. Beneficial effects of calcium antagonists against post-ischaemic myocardial stunning. Sheiban, I., Tonni, S., Benussi, P., Marini, A., Trevi, G.P. Eur. Heart J. (1993) [Pubmed]
  10. Galectin-8: a complex sub-family of galectins (Review). Bidon, N., Brichory, F., Bourguet, P., Le Pennec, J.P., Dazord, L. Int. J. Mol. Med. (2001) [Pubmed]
  11. Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. Hadari, Y.R., Arbel-Goren, R., Levy, Y., Amsterdam, A., Alon, R., Zakut, R., Zick, Y. J. Cell. Sci. (2000) [Pubmed]
  12. Galectin-8 binds specific beta1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells. Cárcamo, C., Pardo, E., Oyanadel, C., Bravo-Zehnder, M., Bull, P., Cáceres, M., Martínez, J., Massardo, L., Jacobelli, S., González, A., Soza, A. Exp. Cell Res. (2006) [Pubmed]
  13. Galectin-8 modulates neutrophil function via interaction with integrin alphaM. Nishi, N., Shoji, H., Seki, M., Itoh, A., Miyanaka, H., Yuube, K., Hirashima, M., Nakamura, T. Glycobiology (2003) [Pubmed]
  14. The N-terminal carbohydrate recognition domain of galectin-8 recognizes specific glycosphingolipids with high affinity. Ideo, H., Seko, A., Ishizuka, I., Yamashita, K. Glycobiology (2003) [Pubmed]
  15. Galectin-8 functions as a matricellular modulator of cell adhesion. Levy, Y., Arbel-Goren, R., Hadari, Y.R., Eshhar, S., Ronen, D., Elhanany, E., Geiger, B., Zick, Y. J. Biol. Chem. (2001) [Pubmed]
  16. Dimeric Galectin-8 induces phosphatidylserine exposure in leukocytes through polylactosamine recognition by the C-terminal domain. Stowell, S.R., Arthur, C.M., Slanina, K.A., Horton, J.R., Smith, D.F., Cummings, R.D. J. Biol. Chem. (2008) [Pubmed]
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