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MeSH Review

Color Perception

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Disease relevance of Color Perception


Psychiatry related information on Color Perception

  • The Farnsworth D-15 Test, the Lanthony New Color Test, and the City University Color Vision Test were administered to 32 patients with AD (ranging in dementia severity from mild to severe) and 32 age-matched normal control subjects (NCS) [6].
  • These results suggest that low exposure to styrene could affect some psychometric performance and may impair color vision [7].
  • Generally, the T0-T2 difference in MA was associated (Spearman's Rho) with differences in color vision (p < 0.001), simple reaction time (mean and standard deviation), digit span forward, tension, fatigue and the number of symptoms (p < 0.05); aiming precision showed a similar tendency (p < 0.10) [8].

High impact information on Color Perception


Chemical compound and disease context of Color Perception


Biological context of Color Perception


Anatomical context of Color Perception


Associations of Color Perception with chemical compounds


Gene context of Color Perception

  • Toward a physical map of the Xq28 region in man: linking color vision, G6PD, and coagulation factor VIII genes to an X-Y homology region [26].
  • RAD52 or RAD51 recombination-deficient yeast strains stabilize otherwise unstable YACs containing ribosomal DNA or the human color vision locus (Kohno et al., 1994) [27].
  • The gene for the neural cell adhesion molecule L1 (L1CAM) has been shown to be located close to the color vision pigment genes in mouse and man [28].
  • G6PD haplotypes spanning Xq28 from F8C to red/green color vision [29].
  • In addition, systematic analysis of the chromophore-binding pocket in rhodopsin and cone pigments has led to an improved understanding of the mechanism of the opsin shift, and of particular molecular determinants underlying color vision in humans [30].

Analytical, diagnostic and therapeutic context of Color Perception


  1. The red-green visual pigment gene region in adrenoleukodystrophy. Aubourg, P., Feil, R., Guidoux, S., Kaplan, J.C., Moser, H., Kahn, A., Mandel, J.L. Am. J. Hum. Genet. (1990) [Pubmed]
  2. Mutations in the RPGR gene cause X-linked cone dystrophy. Yang, Z., Peachey, N.S., Moshfeghi, D.M., Thirumalaichary, S., Chorich, L., Shugart, Y.Y., Fan, K., Zhang, K. Hum. Mol. Genet. (2002) [Pubmed]
  3. Detection of color vision defects in chloroquine retinopathy. Vu, B.L., Easterbrook, M., Hovis, J.K. Ophthalmology (1999) [Pubmed]
  4. Urinary glucose testing inaccuracies among diabetic patients. Effect of acquired color vision deficiency caused by diabetic retinopathy. Bresnick, G.H., Groo, A., Palta, M., Korth, K. Arch. Ophthalmol. (1984) [Pubmed]
  5. X-linked high myopia associated with cone dysfunction. Young, T.L., Deeb, S.S., Ronan, S.M., Dewan, A.T., Alvear, A.B., Scavello, G.S., Paluru, P.C., Brott, M.S., Hayashi, T., Holleschau, A.M., Benegas, N., Schwartz, M., Atwood, L.D., Oetting, W.S., Rosenberg, T., Motulsky, A.G., King, R.A. Arch. Ophthalmol. (2004) [Pubmed]
  6. Incomplete achromatopsia in Alzheimer's disease. Cronin-Golomb, A., Sugiura, R., Corkin, S., Growdon, J.H. Neurobiol. Aging (1993) [Pubmed]
  7. Impairment of color vision among workers exposed to low concentrations of styrene. Chia, S.E., Jeyaratnam, J., Ong, C.N., Ng, T.P., Lee, H.S. Am. J. Ind. Med. (1994) [Pubmed]
  8. Surveillance of early neurotoxic dysfunction. Mergler, D., Huel, G., Bélanger, S., Bowler, R.M., Truchon, G., Drolet, D., Ostiguy, C. Neurotoxicology (1996) [Pubmed]
  9. Homothorax switches function of Drosophila photoreceptors from color to polarized light sensors. Wernet, M.F., Labhart, T., Baumann, F., Mazzoni, E.O., Pichaud, F., Desplan, C. Cell (2003) [Pubmed]
  10. A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group. Beck, R.W., Cleary, P.A., Anderson, M.M., Keltner, J.L., Shults, W.T., Kaufman, D.I., Buckley, E.G., Corbett, J.J., Kupersmith, M.J., Miller, N.R. N. Engl. J. Med. (1992) [Pubmed]
  11. Spectral tuning of rhodopsin and metarhodopsin in vivo. Britt, S.G., Feiler, R., Kirschfeld, K., Zuker, C.S. Neuron (1993) [Pubmed]
  12. Impaired color vision in cocaine-withdrawn patients. Desai, P., Roy, M., Roy, A., Brown, S., Smelson, D. Arch. Gen. Psychiatry (1997) [Pubmed]
  13. Color vision deficiencies in two cases of digoxin toxicity. Chuman, M.A., LeSage, J. Am. J. Ophthalmol. (1985) [Pubmed]
  14. Optic neuropathy associated with ethambutol in Koreans. Choi, S.Y., Hwang, J.M. Korean journal of ophthalmology : KJO. (1997) [Pubmed]
  15. Visual evoked potentials and ibuprofen (Motrin) toxicity. Hamburger, H.A., Beckman, H., Thompson, R. Annals of ophthalmology. (1984) [Pubmed]
  16. Negative-type electroretinogram from cisplatin toxicity. Marmor, M.F. Documenta ophthalmologica. Advances in ophthalmology. (1993) [Pubmed]
  17. Linezolid-associated toxic optic neuropathy: a report of 2 cases. Lee, E., Burger, S., Shah, J., Melton, C., Mullen, M., Warren, F., Press, R. Clin. Infect. Dis. (2003) [Pubmed]
  18. Transcriptional organization of a 450-kb region of the human X chromosome in Xq28. Bione, S., Tamanini, F., Maestrini, E., Tribioli, C., Poustka, A., Torri, G., Rivella, S., Toniolo, D. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  19. Cone arrestin identified by targeting expression of a functional family. Craft, C.M., Whitmore, D.H., Wiechmann, A.F. J. Biol. Chem. (1994) [Pubmed]
  20. Visual dysfunction in patients receiving vigabatrin: clinical and electrophysiologic findings. Miller, N.R., Johnson, M.A., Paul, S.R., Girkin, C.A., Perry, J.D., Endres, M., Krauss, G.L. Neurology (1999) [Pubmed]
  21. Ethambutol alters spinule-type synaptic connections and induces morphologic alterations in the cone pedicles of the fish retina. Kohler, K., Zrenner, E., Weiler, R. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  22. Ocular effects and safety of antimalarial agents. Easterbrook, M. Am. J. Med. (1988) [Pubmed]
  23. Abnormal color vision and reliable self-monitoring of blood glucose. Lombrail, P., Cathelineau, G., Gervais, P., Thibult, N. Diabetes Care (1984) [Pubmed]
  24. Melatonin regulation in humans with color vision deficiencies. Ruberg, F.L., Skene, D.J., Hanifin, J.P., Rollag, M.D., English, J., Arendt, J., Brainard, G.C. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  25. Color vision tests for early detection of antiepileptic drug toxicity. Bayer, A.U., Thiel, H.J., Zrenner, E., Dichgans, J., Kuehn, M., Paulus, W., Ried, S., Schmidt, D. Neurology (1997) [Pubmed]
  26. Toward a physical map of the Xq28 region in man: linking color vision, G6PD, and coagulation factor VIII genes to an X-Y homology region. Arveiler, B., Vincent, A., Mandel, J.L. Genomics (1989) [Pubmed]
  27. Construction and characterization of a rad51rad52 double mutant as a host for YAC libraries. Kohno, K., Oshiro, T., Kishine, H., Wada, M., Takeda, H., Ihara, N., Imamoto, F., Kano, Y., Schlessinger, D. Gene (1997) [Pubmed]
  28. Completion of the physical map of Xq28: the location of the gene for L1CAM on the human X chromosome. Dietrich, A., Korn, B., Poustka, A. Mamm. Genome (1992) [Pubmed]
  29. G6PD haplotypes spanning Xq28 from F8C to red/green color vision. Filosa, S., Calabrò, V., Lania, G., Vulliamy, T.J., Brancati, C., Tagarelli, A., Luzzatto, L., Martini, G. Genomics (1993) [Pubmed]
  30. Rhodopsin: a prototypical G protein-coupled receptor. Sakmar, T.P. Prog. Nucleic Acid Res. Mol. Biol. (1998) [Pubmed]
  31. A novel ABCR nonsense mutation responsible for late-onset fundus flavimaculatus. Souied, E.H., Ducroq, D., Rozet, J.M., Gerber, S., Perrault, I., Sterkers, M., Benhamou, N., Munnich, A., Coscas, G., Soubrane, G., Kaplan, J. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  32. Peripheral cone dystrophy: a variant of cone dystrophy with predominant dysfunction in the peripheral cone system. Kondo, M., Miyake, Y., Kondo, N., Ueno, S., Takakuwa, H., Terasaki, H. Ophthalmology (2004) [Pubmed]
  33. Pattern dystrophy of the retinal pigment epithelium and geographic atrophy of the macula. Marmor, M.F., McNamara, J.A. Am. J. Ophthalmol. (1996) [Pubmed]
  34. Intervention study on acquired color vision deficiencies in styrene-exposed workers. Triebig, G., Stark, T., Ihrig, A., Dietz, M.C. J. Occup. Environ. Med. (2001) [Pubmed]
  35. Impairment of neurobehavioral function and color vision loss among workers exposed to low concentration of styrene--a review of literatures. Kishi, R., Tozaki, S., Gong, Y.Y. Industrial health. (2000) [Pubmed]
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