Disease relevance of Precancerous Conditions

• To directly examine DNMT1 protein expression levels during human hepatocarcinogenesis, 16 histologically normal liver tissues, 51 noncancerous liver tissues exhibiting chronic hepatitis or cirrhosis, which are considered to be precancerous conditions, and 53 hepatocellular carcinomas (HCCs) were subjected to immunohistochemic examination [1].
• OBJECTIVE: To examine whether diet intervention can promote increased vegetable and fruit intake, as reflected in increased plasma carotenoid and decreased plasma total homocysteine concentrations, in premenopausal women with cervical intraepithelial neoplasia, a precancerous condition [2].
• These data confirm the presence of ER and PgR in colonic cancer and colonic adenomas (so-called precancerous disease); in these subjects the finding of steroid receptors also in normal mucosa suggests that the presence of steroid binding could be considered as a marker of a precancerous condition [3].
• To determine at what stage of carcinogenesis cells begin to express hTERT, we analysed hTERT mRNA expression in gastric carcinoma and precancerous conditions, focusing on chronic gastritis with or without intestinal metaplasia [4].
• In humans, ductal lesions, hyperplasias, or dysplasias, with or without mucin hypersecretion, are possible preneoplastic conditions [5].

High impact information on Precancerous Conditions

• These findings are relevant to human tumors and preneoplastic conditions accompanied by altered IGF2 expression [6].
• Indeed, both high and low frequencies of HR as well as high and low levels of RAD51 expression have been reported in tumors and in precancerous conditions [7].
• Urinary N-nitrosoproline excretion: a further evaluation of the nitrosamine hypothesis of gastric carcinogenesis in precancerous conditions [8].
• CpG methylation around the promoter region, which increases during the progression from a precancerous condition to HCC, may participate in hepatocarcinogenesis through reduction of E-cadherin expression, resulting in loss of intercellular adhesiveness and destruction of tissue morphology [9].
• These studies advance the hypothesis that loss of Cx43 function during development may cause cells to acquire a preneoplastic condition [10].

Chemical compound and disease context of Precancerous Conditions

• Evaluation of the nitrosamine hypothesis of gastric carcinogenesis in precancerous conditions [11].
• Since severe epithelial dysplasia may represent a precancerous condition, prolonged use of trifluridine should be avoided [12].
• Therapeutic trials of vitamin A and related compounds have demonstrated activity in several cancerous and precancerous conditions [13].
• After 16 weeks of supplementation, erythrocyte folate levels of subjects with esophageal dysplasia were improved but remained significantly lower than those of normal supplemented subjects, targeting folic acid as a nutrient of particular interest in this precancerous condition [14].
• These results indicate the lack of risk involved in the application of carbamide peroxide even in oral mucosa with a precancerous condition due to the action of initiation agents such as tobacco and alcohol [15].

Biological context of Precancerous Conditions

• Silencing of the E-cadherin gene by DNA hypermethylation around the promoter region occurs frequently, even in precancerous conditions [16].
• The N-nitrosoproline (NPRO) test was used to study whether subjects with precancerous conditions of the stomach have an elevated potential for endogenous nitrosation [17].
• Furthermore, eradication of H. pylori, and for that matter future vaccination, has the theoretical potential of preventing gastric cancer, and the potential use of COX2 inhibiting NSAID in inducing apoptosis may reverse precancerous conditions of the stomach [18].
• Along with studies showing that many tumor promoters increase ODC activity and that a number of preneoplastic conditions and tumor samples show high levels of ODC, these results suggest that ODC may act as an oncogene in an appropriate background [19].

Anatomical context of Precancerous Conditions

• CEA levels in gastric juice in precancerous conditions and cancer [20].
• Alkaline phosphatase activity in relation to LDH5 (L-lactate: NAD+ - oxidoreductase, E.C.1.1.1.27) in patients with precancerous conditions of the endometrium [21].
• No statistically significant differences were found in plasma testosterone levels or in the testosterone/estradiol index between patients with hyperplastic aberrations of the laryngeal mucosa (including precancerous conditions) and the control subjects [22].
• Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas [23].

Gene context of Precancerous Conditions

• Glycoprotein electrophoretic pattern in sera of patients with oral precancerous conditions and upper aerodigestive tract cancer [24].
• Adenomatous hyperplastic nodules (AHNs) in cirrhotic liver are considered a precancerous condition which may lead to hepatocellular carcinoma (HCC) [25].
• An increase in the activity of ornithine decarboxylase in colonic tissue was developed within the same time period and has been seen only in those tissues which were characterized by the development of precancerous conditions [26].
• 4. The presence of C cell hyperplasia should always be reported; however its usefulness for indicating familial risk is limited and its role as a preneoplastic condition in patients without RET-protooncogene mutations remains to be elucidated [27].
• Neither B72.3 nor MA5 was specific for breast cancer cells: both also reacted with cells from benign and precancerous conditions [28].

Analytical, diagnostic and therapeutic context of Precancerous Conditions

• The aim of this study was to determine whether changes in serum free radicals may be useful for the early detection of precancerous conditions in the rat colon after treatment with a direct carcinogen (N-Methyl-N'-Nitro-N-Nitrosoguanidine, MNNG) and a secondary bile acid (deoxycholic acid, DCA) as a tumor promoter [29].

References