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MeSH Review

Glomus Tumor

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Disease relevance of Glomus Tumor


High impact information on Glomus Tumor

  • Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations ("glomangiomas") [6].
  • We hypothesize that cutaneous venous anomalies (i.e., glomangiomas) are caused by mutations in a novel gene that may act to regulate angiogenesis, in concert with the TIE-2 signaling pathway [7].
  • Here we show that VMs with glomus cells (known as "glomangiomas"), inherited as an autosomal dominant trait in five families, are not linked to 9p21 but, instead, link to a new locus, on 1p21-p22, called "VMGLOM" (LOD score 12.70 at recombination fraction.00) [7].
  • Muscle actins were found in 14 of 16 tumors, and desmin was found in three of 16 of the glomus tumors [8].
  • Thick (myosin) filaments in a glomus tumor [9].

Chemical compound and disease context of Glomus Tumor


Biological context of Glomus Tumor


Anatomical context of Glomus Tumor


Gene context of Glomus Tumor


Analytical, diagnostic and therapeutic context of Glomus Tumor


  1. Undiagnosed chronic monarthritis. Clinical and evolutionary profile. Blocka, K.L., Sibley, J.T. Arthritis Rheum. (1987) [Pubmed]
  2. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Kahn, H.J., Bailey, D., Marks, A. Mod. Pathol. (2002) [Pubmed]
  3. Repositioning the hereditary paraganglioma critical region on chromosome band 11q23. Baysal, B.E., van Schothorst, E.M., Farr, J.E., Grashof, P., Myssiorek, D., Rubinstein, W.S., Taschner, P., Cornelisse, C.J., Devlin, B., Devilee, P., Richard, C.W. Hum. Genet. (1999) [Pubmed]
  4. MRI of mastoid and middle ear disease. Holliday, R.A., Reede, D.L. Radiol. Clin. North Am. (1989) [Pubmed]
  5. Venous hemangioma. An immunohistochemical and ultrastructural study. Ichikawa, M.M., Ishida-Yamamoto, A., Hashimoto, Y., Matsuo, S., Iizuka, H. Acta Derm. Venereol. (1997) [Pubmed]
  6. Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations ("glomangiomas"). Brouillard, P., Boon, L.M., Mulliken, J.B., Enjolras, O., Ghassibé, M., Warman, M.L., Tan, O.T., Olsen, B.R., Vikkula, M. Am. J. Hum. Genet. (2002) [Pubmed]
  7. A gene for inherited cutaneous venous anomalies ("glomangiomas") localizes to chromosome 1p21-22. Boon, L.M., Brouillard, P., Irrthum, A., Karttunen, L., Warman, M.L., Rudolph, R., Mulliken, J.B., Olsen, B.R., Vikkula, M. Am. J. Hum. Genet. (1999) [Pubmed]
  8. The immunophenotype of hemangiopericytomas and glomus tumors, with special reference to muscle protein expression: an immunohistochemical study and review of the literature. Porter, P.L., Bigler, S.A., McNutt, M., Gown, A.M. Mod. Pathol. (1991) [Pubmed]
  9. Thick (myosin) filaments in a glomus tumor. di Sant'Agnese, P.A., De Mesy Jensen, K.L. Am. J. Clin. Pathol. (1983) [Pubmed]
  10. Hypertension and a tumor of the glomus jugulare region. Evidence for epinephrine biosynthesis. Blumenfeld, J., Cohen, N., Anwar, M., Teitelman, G., Laragh, J.H., Ruggiero, D.A. Am. J. Hypertens. (1993) [Pubmed]
  11. Glomus tumor treated by prostaglandin inhibition. Report of a case. Rask, M.R., Barnes, A.G., Kopf, E.H. Clin. Orthop. Relat. Res. (1979) [Pubmed]
  12. Imaging jugulotympanic glomus tumors. Phelps, P.D., Cheesman, A.D. Arch. Otolaryngol. Head Neck Surg. (1990) [Pubmed]
  13. Glomangioma of the ankle simulating injury to the flexor hallucis longus: a case report. Miyano, J.A., Fitzgibbons, T.C. Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society. (1996) [Pubmed]
  14. Glomus tumors of the temporal bone: electron microscopic and immunohistochemical evaluation. Farrior, J.B., Packer, J.T. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1991) [Pubmed]
  15. Glomus tumor cells: evaluation of smooth muscle and endothelial cell properties. Miettinen, M., Lehto, V.P., Virtanen, I. Virchows Arch., B, Cell Pathol. (1983) [Pubmed]
  16. Histochemical evidence of adenosine triphosphatase activity in glomus tumor--report of a case. Machinami, R., Adachi, S. Pathol. Res. Pract. (1984) [Pubmed]
  17. Infiltrative glomus tumor arising from a benign glomus tumor: a distinctive immunohistochemical pattern in the infiltrative component. Skelton, H.G., Smith, K.J. The American Journal of dermatopathology. (1999) [Pubmed]
  18. Major basement membrane components in Kaposi's sarcoma, angiosarcoma and benign vascular neogenesis. Dictor, M., Bendsöe, N., Runke, S., Witte, M. J. Cutan. Pathol. (1995) [Pubmed]
  19. p53 and p16INK4A mutations during the progression of glomus tumor. Güran, S., Tali, E.T. Pathol. Oncol. Res. (1999) [Pubmed]
  20. Local and systemic expression of basic fibroblast growth factor in a patient with familial glomangioma. Kapur, N., Lambiase, P., Rakhit, R.D., Pearce, J., Orchard, G., Calonje, E., Dowd, P.M. Br. J. Dermatol. (2002) [Pubmed]
  21. CD34-positive glomus tumor: clinicopathologic and immunohistochemical analysis of six cases with myxoid stromal changes. Mentzel, T., Hügel, H., Kutzner, H. J. Cutan. Pathol. (2002) [Pubmed]
  22. Immunohistochemistry in the differential diagnosis of nodular hidradenoma and glomus tumor. Haupt, H.M., Stern, J.B., Berlin, S.J. The American Journal of dermatopathology. (1992) [Pubmed]
  23. Cutaneous glomus tumor. A comparative immunohistochemical study with pseudoangiomatous intradermal melanocytic nevi. Kaye, V.M., Dehner, L.P. The American Journal of dermatopathology. (1991) [Pubmed]
  24. Multiple hereditary glomangiomas: successful treatment with sclerotherapy. Parsi, K., Kossard, S. Australas. J. Dermatol. (2002) [Pubmed]
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