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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Lymphangioma


High impact information on Lymphangioma


Chemical compound and disease context of Lymphangioma


Biological context of Lymphangioma

  • John's Institute of Dermatology from 1996 to 1999 identified three women with vulval lymphangiectasia and two with vulval lymphangioma circumscriptum treated with the CO2 laser [16].

Anatomical context of Lymphangioma

  • CONCLUSIONS: The scant staining for Ki-67 in the majority of the lesions, combined with proliferative rates that were only focally elevated, suggests that lymphangiomas in children and adults are quiescent lesions whose enlargement is due to engorgement by chyle and localized secondary inflammation rather than primary tumoral growth [17].
  • Results: In the oral lymphangiomas and hemangiomas D2-40 was detected in all lymphatics, while all blood vessels were positive for CD34 [18].
  • Carbon dioxide laser ablation for treatment of lymphangioma of the conjunctiva [19].

Gene context of Lymphangioma

  • The results suggest that VEGF-C and its receptors may take active parts in the formation of lymphangioma by autocrine or paracrine regulation [10].
  • The present case of lymphangioma showed strong immunohistochemical reactivity of angiogenin and vWF, while it showed weak reactions of VEGF and PCNA [20].
  • Here we used lymphatic endothelial cells (LEC) derived from experimentally induced murine lymphangiomas to investigate the pattern of chemokine expression by these cells [21].
  • OBJECTIVE: To examine the expression of molecules targeted by imatinib mesylate (STI571;Gleevec) and epidermal growth factor receptor (EGFR) inhibitors in orbital lymphangiomas [22].
  • Senile and cavernous haemangiomas as well as lymphangiomas were negative or exhibited only weak CD40 reactivity [23].

Analytical, diagnostic and therapeutic context of Lymphangioma


  1. Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. Folpe, A.L., Veikkola, T., Valtola, R., Weiss, S.W. Mod. Pathol. (2000) [Pubmed]
  2. Prognosis and management of lesions of the trunk in children with Klippel-Trenaunay syndrome. Telander, R.L., Kaufman, B.H., Gloviczki, P., Stickler, G.B., Hollier, L.H. J. Pediatr. Surg. (1984) [Pubmed]
  3. Fetal ovarian cysts: development and neonatal outcome. Mittermayer, C., Blaicher, W., Grassauer, D., Horcher, E., Deutinger, J., Bernaschek, G., Ulm, B. Ultraschall in der Medizin (Stuttgart, Germany : 1980) (2003) [Pubmed]
  4. Treatment of cystic hygroma and lymphangioma with the use of bleomycin fat emulsion. Tanigawa, N., Shimomatsuya, T., Takahashi, K., Inomata, Y., Tanaka, K., Satomura, K., Hikasa, Y., Hashida, M., Muranishi, S., Sezaki, H. Cancer (1987) [Pubmed]
  5. Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors. Partanen, T.A., Alitalo, K., Miettinen, M. Cancer (1999) [Pubmed]
  6. Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis. Nagy, J.A., Vasile, E., Feng, D., Sundberg, C., Brown, L.F., Detmar, M.J., Lawitts, J.A., Benjamin, L., Tan, X., Manseau, E.J., Dvorak, A.M., Dvorak, H.F. J. Exp. Med. (2002) [Pubmed]
  7. Percutaneous sclerotherapy of lymphangiomas. Molitch, H.I., Unger, E.C., Witte, C.L., vanSonnenberg, E. Radiology. (1995) [Pubmed]
  8. CD9 expression on lymphatic vessels in head and neck mucosa. Erovic, B.M., Neuchrist, C., Kandutsch, S., Woegerbauer, M., Pammer, J. Mod. Pathol. (2003) [Pubmed]
  9. Lymphangioma circumscriptum of the vulva following surgical and radiological therapy of cervical cancer. Jappe, U., Zimmermann, T., Kahle, B., Petzoldt, D. Sexually transmitted diseases. (2002) [Pubmed]
  10. Co-expression of VEGF-C and its receptors, VEGFR-2 and VEGFR-3, in endothelial cells of lymphangioma. Implication in autocrine or paracrine regulation of lymphangioma. Huang, H.Y., Ho, C.C., Huang, P.H., Hsu, S.M. Lab. Invest. (2001) [Pubmed]
  11. Magnetic resonance imaging of orbital lymphangioma with and without gadolinium contrast enhancement. Bond, J.B., Haik, B.G., Taveras, J.L., Francis, B.A., Numaguchi, Y., Mihara, F., Gupta, K.L. Ophthalmology (1992) [Pubmed]
  12. Percutaneous sclerotherapy of lymphangiomas with acetic acid. Won, J.H., Kim, B.M., Kim, C.H., Park, S.W., Kim, M.D. Journal of vascular and interventional radiology : JVIR. (2004) [Pubmed]
  13. Lymphangioma of large intestine: report of ten cases with endoscopic and pathologic correlation. Kim, K.M., Choi, K.Y., Lee, A., Kim, B.K. Gastrointest. Endosc. (2000) [Pubmed]
  14. Immunoelectron microscopic characterization of human dermal lymphatic microvascular endothelial cells. Differential expression of CD31, CD34, and type IV collagen with lymphatic endothelial cells vs blood capillary endothelial cells in normal human skin, lymphangioma, and hemangioma in situ. Sauter, B., Foedinger, D., Sterniczky, B., Wolff, K., Rappersberger, K. J. Histochem. Cytochem. (1998) [Pubmed]
  15. Recurrent gastrointestinal bleeding associated with an abdominal lymphangioma: treatment by parenteral nutrition. Michaud, L., Gottrand, F., Turck, D., Besson, R., Bonnevalle, M., Farriaux, J.P. J. Pediatr. Gastroenterol. Nutr. (1993) [Pubmed]
  16. CO(2) laser therapy of vulval lymphangiectasia and lymphangioma circumscriptum. Huilgol, S.C., Neill, S., Barlow, R.J. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2002) [Pubmed]
  17. Intra-abdominal lymphangiomas in children and adults. Assessment of proliferative activity. Mahle, C., Schwartz, M., Popek, E., Bocklage, T. Arch. Pathol. Lab. Med. (1997) [Pubmed]
  18. Immunohistochemical co-localization of lymphatics and blood vessels in oral squamous cell carcinomas. Xuan, M., Fang, Y.R., Wato, M., Hata, S., Tanaka, A. J. Oral Pathol. Med. (2005) [Pubmed]
  19. Carbon dioxide laser ablation for treatment of lymphangioma of the conjunctiva. Spector, J.A., Zide, B.M. Plast. Reconstr. Surg. (2006) [Pubmed]
  20. Lymphangioma involving the mandible: immunohistochemical expressions for the lymphatic proliferation. Park, Y.W., Kim, S.M., Min, B.G., Park, I.W., Lee, S.K. J. Oral Pathol. Med. (2002) [Pubmed]
  21. Evidence of CXC, CC and C chemokine production by lymphatic endothelial cells. Mancardi, S., Vecile, E., Dusetti, N., Calvo, E., Stanta, G., Burrone, O.R., Dobrina, A. Immunology (2003) [Pubmed]
  22. Growth factor receptor expression in orbital lymphangioma: possible therapeutic implications. Esmaeli, B., Prieto, V.G., Gonnering, R., Hawes, M.J., Diba, R., Saadati, H.G., Shepler, T.R., Karcioglu, Z. Orbit (Amsterdam, Netherlands) (2004) [Pubmed]
  23. Expression of the CD40 antigen on normal endothelial cells and in benign and malignant tumours of vascular origin. Pammer, J., Weninger, W., Mazal, P.R., Horvat, R., Tschachler, E. Histopathology (1996) [Pubmed]
  24. Orbital lymphangioma with positive immunohistochemistry of lymphatic endothelial markers (vascular endothelial growth factor receptor 3 and podoplanin). Cursiefen, C., Schlötzer-Schrehardt, U., Breiteneder-Geleff, S., Holbach, L.M. Graefes Arch. Clin. Exp. Ophthalmol. (2001) [Pubmed]
  25. Treatment of lymphangioma with Nd:YAG laser irradiation: a case report. Harashima, T., Hossain, M., Walverde, D.A., Yamada, Y., Matsumoto, K. Journal of clinical laser medicine & surgery. (2001) [Pubmed]
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