The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

MAGEH1  -  melanoma antigen family H, 1

Homo sapiens

Synonyms: APR-1, APR1, Apoptosis-related protein 1, MAGE-H1 antigen, MAGEH, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of MAGEH1

  • PURPOSE: Apoptosis-related proteins are important molecules for predicting chemotherapy response and prognosis in adult acute myeloid leukemia (AML) [1].
  • Expression of hepatocyte growth factor, transforming growth factor alpha, apoptosis related proteins Bax and Bcl-2, and gastrin in human gastric cancer [2].
  • These findings demonstrate that these mitochondrial diseases harbor unique apoptosis-related changes that differ from caspase 3-dependent apoptosis [3].
  • This study was undertaken to determine whether the frequency of apoptosis-related cell damage and reproductive performance of testicular spermatozoa from men with non-obstructive azoospermia can be improved by in-vitro culture [4].
  • Prognostic significance of apoptosis related proteins Bcl-2 and Bax in node-negative breast cancer patients [5].

Psychiatry related information on MAGEH1


High impact information on MAGEH1

  • At the molecular level, among 589 genes examined, at least 2% of genes including a proto-oncogene, cytokine receptor genes, and apoptosis-related genes were derepressed at inappropriate stages of T-cell development in SATB1-null mice [10].
  • Thus, modulation of apoptosis-related proteins by TH1 and TH2 cytokines controls thyrocyte survival in thyroid autoimmunity [11].
  • HAF-triggered apoptosis was preceded by increased levels of the apoptosis-related proteins c-Myc and c-Rel and cell accumulation in Go/G1 phase of the cell cycle [12].
  • METHODS: Cells of the human cervical carcinoma cell line C33A and normal human cervical epithelial cells were treated with 4HPR and analyzed for survival, induction of apoptosis, generation of reactive oxygen species, and expression of the apoptosis-related proteins Bcl-2 and Bax [13].
  • Doxorubicin disaccharide analogue: apoptosis-related improvement of efficacy in vivo [14].

Chemical compound and disease context of MAGEH1

  • Furthermore, the identification of this specific mechanism underlying the survival-promoting activity of amifostine lends support to the possible use of this agent in apoptosis-related pathologies, such as myelodysplasias [15].
  • Studies from our laboratory and others have shown that genistein can induce apoptosis by regulating the expression of apoptosis-related genes in breast cancer cells [16].
  • Alterations in growth regulatory factors (steroid receptors, proliferation and apoptosis-related proteins) can also be found in a proportion of hyperplasias [17].
  • OBJECTIVE AND METHODS: The present study evaluated the effects of asoprisnil on cell proliferation, the expression of apoptosis-related proteins, and apoptosis in cultured human uterine leiomyoma cells and matched normal myometrial cells [18].
  • Our previous study has demonstrated that aloe-emodin induced a significant change in the expression of lung cancer cell apoptosis-related proteins compared to those of control cells [19].

Biological context of MAGEH1

  • We then studied: (1) Cell death by the TUNEL method, (2) mRNA expression of 96 apoptosis-related genes using DNA microarray, (3) expression of selected apoptosis related proteins by Western blotting [20].
  • CONCLUSIONS: We conclude that apoptosis-related molecules are associated with maturation stage, cytogenetic risk groups, and therapy outcome in childhood de novo AML [1].
  • The flow cytometric protocol thus enables analysis of apoptosis-related proteins at different stages of the disease, which will lead to a better understanding of the role of apoptosis resistance in the emergence of MRD in AML [21].
  • Apoptosis-related gene expression and the bile acid pool were determined in separate experiments up to 6 h after burn [22].
  • A severe thermal injury caused an up-regulation of apoptosis and apoptosis-related genes and down-regulation of bile acid secretion [22].

Anatomical context of MAGEH1


Associations of MAGEH1 with chemical compounds

  • Thirty-five clones were isolated, 28 of which were derived from unknown genes, that tagged 19 individual genes and 7 of which referred to known genes that tagged the apoptosis-related protein (APR)-1, -2 and indoleamine-pyrrole 2,3,-dioxygenase (IDO) [27].
  • To study the regulation of apoptosis in the endometrium during the normal menstrual cycle, the expression of the apoptosis related proteins Bcl-2 and Bax and their correlation to serum estradiol and progesterone, as well as to a replication-related antigen Ki-67 were analyzed [26].
  • Apoptosis-related proteins and steroid hormone receptors in normal, hyperplastic, and neoplastic endometrium [28].
  • The purpose of this study was to evaluate the distribution and frequency of apoptosis-related proteins and their correlation with estrogen, progesterone, and androgen receptors in endometrial tissues [28].
  • The correlation between expression of apoptosis-related proteins and myocardial functional reserve evaluated by dobutamine stress echocardiography in patients with dilated cardiomyopathy [29].

Regulatory relationships of MAGEH1


Other interactions of MAGEH1


Analytical, diagnostic and therapeutic context of MAGEH1

  • We therefore developed a four-color flow cytometry method that enables establishment of apoptosis-related protein expression such as Bcl-2, Bcl-x(L), Mcl-1 and Bax at diagnosis and in MRD [21].
  • Microarray analysis demonstrated that the apoptosis related caspases 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, were all transcribed (caspases 8, 9, and 10 were highly up-regulated) [39].
  • In addition, the gene and protein expressions of apoptosis-related proteins such as Bax and Bcl-2 were investigated by reverse transcription-polymerase chain reaction and Western blot [2].
  • Apoptosis was evaluated by: deoxyribonucleic acid (DNA) fragmentation electrophoresis, DNA content, annexin V binding, apoptosis related markers (Fas, B-cell lymphona leukaemia-2 (Bcl-2), Bax, and CD25), and by electron microscopy [24].
  • We evaluated whether circulating soluble apoptosis-related protein levels change after anthracycline-containing chemotherapy and radiotherapy in relation to cardiac dysfunction or the applied treatment [40].


  1. High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia. Tamm, I., Richter, S., Oltersdorf, D., Creutzig, U., Harbott, J., Scholz, F., Karawajew, L., Ludwig, W.D., Wuchter, C. Clin. Cancer Res. (2004) [Pubmed]
  2. Expression of hepatocyte growth factor, transforming growth factor alpha, apoptosis related proteins Bax and Bcl-2, and gastrin in human gastric cancer. Konturek, P.C., Konturek, S.J., Sulekova, Z., Meixner, H., Bielanski, W., Starzynska, T., Karczewska, E., Marlicz, K., Stachura, J., Hahn, E.G. Aliment. Pharmacol. Ther. (2001) [Pubmed]
  3. Apoptosis-related changes in skeletal muscles of patients with mitochondrial diseases. Umaki, Y., Mitsui, T., Endo, I., Akaike, M., Matsumoto, T. Acta Neuropathol. (2002) [Pubmed]
  4. Assisted reproduction with in-vitro-cultured testicular spermatozoa in cases of severe germ cell apoptosis: a pilot study. Tesarik, J., Greco, E., Mendoza, C. Hum. Reprod. (2001) [Pubmed]
  5. Prognostic significance of apoptosis related proteins Bcl-2 and Bax in node-negative breast cancer patients. Kapranos, N., Karaiosifidi, H., Valavanis, C., Kouri, E., Vasilaros, S. Anticancer Res. (1997) [Pubmed]
  6. Retention of imprinting of the human apoptosis-related gene TSSC3 in human brain tumors. Müller, S., van den Boom, D., Zirkel, D., Köster, H., Berthold, F., Schwab, M., Westphal, M., Zumkeller, W. Hum. Mol. Genet. (2000) [Pubmed]
  7. No difference in expression of apoptosis-related proteins and apoptotic morphology in control, pathologically aged and Alzheimer's disease cases. Woodhouse, A., Dickson, T.C., West, A.K., McLean, C.A., Vickers, J.C. Neurobiol. Dis. (2006) [Pubmed]
  8. Expression pattern of apoptosis-related markers in Huntington's disease. Vis, J.C., Schipper, E., de Boer-van Huizen, R.T., Verbeek, M.M., de Waal, R.M., Wesseling, P., ten Donkelaar, H.J., Kremer, B. Acta Neuropathol. (2005) [Pubmed]
  9. Apoptosis-associated gene expression in HIV-infected patients in response to successful antiretroviral therapy. Balestrieri, E., Grelli, S., Matteucci, C., Minutolo, A., d'Ettorre, G., Di Sora, F., Montella, F., Vullo, V., Vella, S., Favalli, C., Macchi, B., Mastino, A. J. Med. Virol. (2007) [Pubmed]
  10. The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development. Alvarez, J.D., Yasui, D.H., Niida, H., Joh, T., Loh, D.Y., Kohwi-Shigematsu, T. Genes Dev. (2000) [Pubmed]
  11. Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins. Stassi, G., Di Liberto, D., Todaro, M., Zeuner, A., Ricci-Vitiani, L., Stoppacciaro, A., Ruco, L., Farina, F., Zummo, G., De Maria, R. Nat. Immunol. (2000) [Pubmed]
  12. Induction of programmed cell death in Kaposi's sarcoma cells by preparations of human chorionic gonadotropin. Samaniego, F., Bryant, J.L., Liu, N., Karp, J.E., Sabichi, A.L., Thierry, A., Lunardi-Iskandar, Y., Gallo, R.C. J. Natl. Cancer Inst. (1999) [Pubmed]
  13. Involvement of reactive oxygen species in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells. Oridate, N., Suzuki, S., Higuchi, M., Mitchell, M.F., Hong, W.K., Lotan, R. J. Natl. Cancer Inst. (1997) [Pubmed]
  14. Doxorubicin disaccharide analogue: apoptosis-related improvement of efficacy in vivo. Arcamone, F., Animati, F., Berettoni, M., Bigioni, M., Capranico, G., Casazza, A.M., Caserini, C., Cipollone, A., De Cesare, M., Franciotti, M., Lombardi, P., Madami, A., Manzini, S., Monteagudo, E., Polizzi, D., Pratesi, G., Righetti, S.C., Salvatore, C., Supino, R., Zunino, F. J. Natl. Cancer Inst. (1997) [Pubmed]
  15. Amifostine inhibits hematopoietic progenitor cell apoptosis by activating NF-kappaB/Rel transcription factors. Romano, M.F., Lamberti, A., Bisogni, R., Garbi, C., Pagnano, A.M., Auletta, P., Tassone, P., Turco, M.C., Venuta, S. Blood (1999) [Pubmed]
  16. Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells. Gong, L., Li, Y., Nedeljkovic-Kurepa, A., Sarkar, F.H. Oncogene (2003) [Pubmed]
  17. Are all ductal proliferations of the breast premalignant? Walker, R.A. J. Pathol. (2001) [Pubmed]
  18. A novel selective progesterone receptor modulator asoprisnil (J867) inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells. Chen, W., Ohara, N., Wang, J., Xu, Q., Liu, J., Morikawa, A., Sasaki, H., Yoshida, S., Demanno, D.A., Chwalisz, K., Maruo, T. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  19. Release of nucleophosmin from the nucleus: Involvement in aloe-emodin-induced human lung non small carcinoma cell apoptosis. Lee, H.Z., Wu, C.H., Chang, S.P. Int. J. Cancer (2005) [Pubmed]
  20. Identification of specific genes and pathways involved in NSAIDs-induced apoptosis of human colon cancer cells. Huang, R.H., Chai, J., Tarnawski, A.S. World J. Gastroenterol. (2006) [Pubmed]
  21. A flow cytometric method to detect apoptosis-related protein expression in minimal residual disease in acute myeloid leukemia. van Stijn, A., Kok, A., van der Pol, M.A., Feller, N., Roemen, G.M., Westra, A.H., Ossenkoppele, G.J., Schuurhuis, G.J. Leukemia (2003) [Pubmed]
  22. Gut mucosal homeostasis and cellular mediators after severe thermal trauma and the effect of insulin-like growth factor-I in combination with insulin-like growth factor binding protein-3. Jeschke, M.G., Bolder, U., Chung, D.H., Przkora, R., Mueller, U., Thompson, J.C., Wolf, S.E., Herndon, D.N. Endocrinology (2007) [Pubmed]
  23. Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes. Zhu, F., Yan, W., Zhao, Z.L., Chai, Y.B., Lu, F., Wang, Q., Peng, W.D., Yang, A.G., Wang, C.J. BioTechniques (2000) [Pubmed]
  24. Fluticasone induces apoptosis in peripheral T-lymphocytes: a comparison between asthmatic and normal subjects. Melis, M., Siena, L., Pace, E., Gjomarkaj, M., Profita, M., Pirazzoli, A., Todaro, M., Stassi, G., Bonsignore, G., Vignola, A.M. Eur. Respir. J. (2002) [Pubmed]
  25. Effects of uraemia and haemodialysis on neutrophil apoptosis and expression of apoptosis-related proteins. Majewska, E., Baj, Z., Sulowska, Z., Rysz, J., Luciak, M. Nephrol. Dial. Transplant. (2003) [Pubmed]
  26. Apoptosis and apoptosis-related proteins in human endometrium. Vaskivuo, T.E., Stenbäck, F., Karhumaa, P., Risteli, J., Dunkel, L., Tapanainen, J.S. Mol. Cell. Endocrinol. (2000) [Pubmed]
  27. Identification of functional genes during Fas-mediated apoptosis using a randomly fragmented cDNA library. Hassan, M., Mirmohammadsadegh, A., Selimovic, D., Nambiar, S., Tannapfel, A., Hengge, U.R. Cell. Mol. Life Sci. (2005) [Pubmed]
  28. Apoptosis-related proteins and steroid hormone receptors in normal, hyperplastic, and neoplastic endometrium. Bozdoğan, O., Atasoy, P., Erekul, S., Bozdoğan, N., Bayram, M. Int. J. Gynecol. Pathol. (2002) [Pubmed]
  29. The correlation between expression of apoptosis-related proteins and myocardial functional reserve evaluated by dobutamine stress echocardiography in patients with dilated cardiomyopathy. Ho, Y.L., Chen, C.L., Hsu, R.B., Lin, L.C., Huang, P.J. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. (2003) [Pubmed]
  30. Induction of apoptosis in melanoma cell lines by p53 and its related proteins. Yamashita, T., Tokino, T., Tonoki, H., Moriuchi, T., Jin, H.Y., Omori, F., Jimbow, K. J. Invest. Dermatol. (2001) [Pubmed]
  31. Heterogenous susceptibility to CD95-induced apoptosis in melanoma cells correlates with bcl-2 and bcl-x expression and is sensitive to modulation by interferon-gamma. Ugurel, S., Seiter, S., Rappl, G., Stark, A., Tilgen, W., Reinhold, U. Int. J. Cancer (1999) [Pubmed]
  32. p53 dephosphorylation and p21(Cip1/Waf1) translocation correlate with caspase-3 activation in TGF-beta1-induced apoptosis of HuH-7 cells. Fan, G., Ma, X., Wong, P.Y., Rodrigues, C.M., Steer, C.J. Apoptosis (2004) [Pubmed]
  33. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Chan, J.A., Krichevsky, A.M., Kosik, K.S. Cancer Res. (2005) [Pubmed]
  34. Biosynthesis of adipokinetic hormones (AKHs): further characterization of precursors and identification of novel products of processing. Hekimi, S., O'Shea, M. J. Neurosci. (1989) [Pubmed]
  35. Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L. Aragane, Y., Kulms, D., Metze, D., Wilkes, G., Pöppelmann, B., Luger, T.A., Schwarz, T. J. Cell Biol. (1998) [Pubmed]
  36. Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites. Qian, H., Wang, T., Naumovski, L., Lopez, C.D., Brachmann, R.K. Oncogene (2002) [Pubmed]
  37. Loss of expression of death-inducing signaling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification. Shivapurkar, N., Reddy, J., Matta, H., Sathyanarayana, U.G., Huang, C.X., Toyooka, S., Minna, J.D., Chaudhary, P.M., Gazdar, A.F. Oncogene (2002) [Pubmed]
  38. Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells. Satoh, T., Toyoda, M., Hoshino, H., Monden, T., Yamada, M., Shimizu, H., Miyamoto, K., Mori, M., Yamada, M., Mori, M. Oncogene (2002) [Pubmed]
  39. Apoptosis in chronic rejection of human cardiac allografts. Xu, B., Sakkas, L.I., Slachta, C.A., Goldman, B.I., Jeevanandam, V., Oleszak, E.L., Platsoucas, C.D. Transplantation (2001) [Pubmed]
  40. The relation between soluble apoptotic proteins and subclinical cardiotoxicity in adjuvant-treated breast cancer patients. Perik, P.J., De Vries, E.G., Boomsma, F., Messerschmidt, J., Van Veldhuisen, D.J., Sleijfer, D.T., Gietema, J.A., Van der Graaf, W.T. Anticancer Res. (2006) [Pubmed]
WikiGenes - Universities