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MeSH Review

Language Development

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Disease relevance of Language Development


Psychiatry related information on Language Development


High impact information on Language Development


Chemical compound and disease context of Language Development

  • Succinic semialdehyde dehydrogenase (SSADH) deficiency has predominantly neurological consequences, affecting psychomotor, speech and language development [16].
  • This induction resulted in lower testosterone and estrogen levels, interfering with brain development in the vulnerable period of language development and the development of visuo-spatial abilities [17].
  • However, significant language performance differences were noted between androgen- vs. estrogen-exposed patients, regardless of genetic sex or diagnosis of the patient, indicating a hormonal effect on language development over time [18].
  • Mebendazole had a positive effect on motor and language development, but this was not statistically significant [19].
  • Using identical procedures for children and mothers, PROP sensitivity and sucrose preferences were assessed by using forced-choice procedures that were embedded in the context of games that minimized the impact of language development and were sensitive to the cognitive limitations of pediatric populations [20].

Biological context of Language Development

  • CONCLUSIONS: Exposure to tricyclic antidepressants or fluoxetine throughout gestation does not appear to adversely affect cognition, language development, or the temperament of preschool and early-school children [12].

Anatomical context of Language Development

  • The topography of the brain-stem (ABR), middle latency (MLR) and cortical (ACR) evoked responses was investigated in children with normal speech and language development and those with either a language or motor speech disorder [21].

Gene context of Language Development


Analytical, diagnostic and therapeutic context of Language Development


  1. Primary degeneration of the granular layer of the cerebellum. A study of 14 patients and review of the literature. Pascual-Castroviejo, I., Gutierrez, M., Morales, C., Gonzalez-Mediero, I., Martínez-Bermejo, A., Pascual-Pascual, S.I. Neuropediatrics. (1994) [Pubmed]
  2. Neurodevelopment of adopted children exposed in utero to cocaine: the Toronto Adoption Study. Nulman, I., Rovet, J., Greenbaum, R., Loebstein, M., Wolpin, J., Pace-Asciak, P., Koren, G. Clinical and investigative medicine. Médecine clinique et experimentale. (2001) [Pubmed]
  3. History of in utero cocaine exposure in language-delayed children. Angelilli, M.L., Fischer, H., Delaney-Black, V., Rubinstein, M., Ager, J.W., Sokol, R.J. Clinical pediatrics. (1994) [Pubmed]
  4. Language dysfunction in epileptic conditions. Wheless, J.W., Simos, P.G., Butler, I.J. Seminars in pediatric neurology. (2002) [Pubmed]
  5. Sensorineural hearing loss in sporadic congenital hypothyroidism. Vanderschueren-Lodeweyckx, M., Debruyne, F., Dooms, L., Eggermont, E., Eeckels, R. Arch. Dis. Child. (1983) [Pubmed]
  6. Clinical course of hearing and language development in GJB2 and non-GJB2 deafness following habilitation with hearing aids. Matsunaga, T., Hirota, E., Bito, S., Niimi, S., Usami, S. Audiol. Neurootol. (2006) [Pubmed]
  7. Prenatal exposure to methylmercury and child development: influence of social factors. Davidson, P.W., Myers, G.J., Shamlaye, C., Cox, C., Wilding, G.E. Neurotoxicology and teratology. (2004) [Pubmed]
  8. Results of psychological testing of patients aged 3-6 years. Michel, U., Schmidt, E., Batzler, U. Eur. J. Pediatr. (1990) [Pubmed]
  9. Visual, cognitive, and language assessments at 39 months: a follow-up study of children fed formulas containing long-chain polyunsaturated fatty acids to 1 year of age. Auestad, N., Scott, D.T., Janowsky, J.S., Jacobsen, C., Carroll, R.E., Montalto, M.B., Halter, R., Qiu, W., Jacobs, J.R., Connor, W.E., Connor, S.L., Taylor, J.A., Neuringer, M., Fitzgerald, K.M., Hall, R.T. Pediatrics (2003) [Pubmed]
  10. Critical periods for the transmission of tactual information. Richardson, B.L., Wuillemin, D.B. International journal of rehabilitation research. Internationale Zeitschrift für Rehabilitationsforschung. Revue internationale de recherches de réadaptation. (1981) [Pubmed]
  11. Neurodevelopment of children exposed in utero to phenytoin and carbamazepine monotherapy. Scolnik, D., Nulman, I., Rovet, J., Gladstone, D., Czuchta, D., Gardner, H.A., Gladstone, R., Ashby, P., Weksberg, R., Einarson, T. JAMA (1994) [Pubmed]
  12. Child development following exposure to tricyclic antidepressants or fluoxetine throughout fetal life: a prospective, controlled study. Nulman, I., Rovet, J., Stewart, D.E., Wolpin, J., Pace-Asciak, P., Shuhaiber, S., Koren, G. The American journal of psychiatry. (2002) [Pubmed]
  13. Accelerated protein evolution and origins of human-specific features: Foxp2 as an example. Zhang, J., Webb, D.M., Podlaha, O. Genetics (2002) [Pubmed]
  14. Language acquisition in special populations: a comparison between Down and Williams syndromes. Vicari, S., Caselli, M.C., Gagliardi, C., Tonucci, F., Volterra, V. Neuropsychologia. (2002) [Pubmed]
  15. A prospective evaluation of early language development in children with in utero cocaine exposure and in control subjects. Hurt, H., Malmud, E., Betancourt, L., Brodsky, N.L., Giannetta, J. J. Pediatr. (1997) [Pubmed]
  16. The molecular basis of succinic semialdehyde dehydrogenase deficiency in one family. Bekri, S., Fossoud, C., Plaza, G., Guenne, A., Salomons, G.S., Jakobs, C., Van Obberghen, E. Mol. Genet. Metab. (2004) [Pubmed]
  17. Perinatal dioxin exposure and later effects--a review. ten Tusscher, G.W., Koppe, J.G. Chemosphere (2004) [Pubmed]
  18. Hormonal influence on language development in physically advanced children. McCardle, P., Wilson, B.E. Brain and language. (1990) [Pubmed]
  19. Effects of iron supplementation and anthelmintic treatment on motor and language development of preschool children in Zanzibar: double blind, placebo controlled study. Stoltzfus, R.J., Kvalsvig, J.D., Chwaya, H.M., Montresor, A., Albonico, M., Tielsch, J.M., Savioli, L., Pollitt, E. BMJ (2001) [Pubmed]
  20. Genetic and environmental determinants of bitter perception and sweet preferences. Mennella, J.A., Pepino, M.Y., Reed, D.R. Pediatrics (2005) [Pubmed]
  21. Brain-stem, middle latency and late cortical evoked potentials in children with speech and language disorders. Mason, S.M., Mellor, D.H. Electroencephalography and clinical neurophysiology. (1984) [Pubmed]
  22. Linguistic abilities in children with Williams-Beuren syndrome. Gosch, A., Städing, G., Pankau, R. Am. J. Med. Genet. (1994) [Pubmed]
  23. Early speech and language development in children with velocardiofacial syndrome. Scherer, N.J., D'Antonio, L.L., Kalbfleisch, J.H. Am. J. Med. Genet. (1999) [Pubmed]
  24. Development, behaviour and temperament: a prospective study of infants conceived through in-vitro fertilization. Gibson, F.L., Ungerer, J.A., Leslie, G.I., Saunders, D.M., Tennant, C.C. Hum. Reprod. (1998) [Pubmed]
  25. Atypical "benign" partial epilepsy or pseudo-Lennox syndrome. Part I: symptomatology and long-term prognosis. Hahn, A., Pistohl, J., Neubauer, B.A., Stephani, U. Neuropediatrics. (2001) [Pubmed]
  26. Productive use of the English past tense in children with focal brain injury and specific language impairment. Marchman, V.A., Saccuman, C., Wulfeck, B. Brain and language. (2004) [Pubmed]
  27. Effects of prenatal exposure to cocaine and associated risk factors on language development. Mentis, M., Lundgren, K. Journal of speech and hearing research. (1995) [Pubmed]
  28. Use of Fast ForWord to enhance language development in children with cochlear implants. Schopmeyer, B., Mellon, N., Dobaj, H., Grant, G., Niparko, J.K. The Annals of otology, rhinology & laryngology. Supplement. (2000) [Pubmed]
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