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Chemical Compound Review

Aviomarin     2-benzhydryloxy-N,N-dimethyl- ethanamine; 8...

Synonyms: Anautine, Diamarin, Dimenest, Dramalen, Dramamin, ...
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Disease relevance of Gravol


Psychiatry related information on Gravol


High impact information on Gravol


Chemical compound and disease context of Gravol


Biological context of Gravol

  • An investigation of the influence of the recommended vehicle on the bioavailability and clearance of dimenhydrinate in isolated rabbit liver microsomes revealed that vehicle at concentrations > 0.68 mg/ml significantly decreased the percent of drug metabolized [16].
  • METHODS: For this study, 128 American Society of Anesthesiology (ASA) physical statuses I, II, and III patients were randomly assigned to receive either ondansetron 4 mg intravenously (IV) at $17 per dose (group 1) or dimenhydrinate 50 mg IV at $2.50 per dose (group 2) before induction of anesthesia [13].
  • The goal was to evaluate the efficiency of intraperitoneal administration of dimethylthioampal (DIMATE), a cellular apoptosis inducer, combined, or not, with cytoreductive surgery on rats with peritoneal adenocarcinomatosis [17].
  • The use of dimenhydrinate in conjunction with dexamethasone for induction of parturition in beef cattle [18].
  • STUDY OBJECTIVES: To examine the psychometric and cardiac effects of dimenhydrinate at 1 and 3 atmospheres (atm) of pressure (0 and 66 feet of sea water, respectively), and to make recommendations about the drug's safety in the diving environment [19].

Anatomical context of Gravol


Associations of Gravol with other chemical compounds

  • Spectral analysis of spontaneous EEG showed slight and similar decreases in the power in the a-band under dimenhydrinate and ARL (p = 0.07 and p = 0.03 with respect to baseline, respectively), but basically no change under betahistine [22].
  • The objective of this guideline is to assist poison center personnel in the appropriate out-of-hospital triage and initial management of patients with a suspected ingestion of diphenhydramine or dimenhydrinate, or a dermal exposure to diphenhydramine [23].
  • RESULTS: 62.5% of the patients undergoing chemotherapy responded completely to granisetron, whereas 10% responded to metoclopramide plus dimenhydrinate (p < 0.0001) [24].
  • PATIENTS AND METHODS: Three hundred patients (165 men and 135 women, ranging in age from 18 to 89 [mean 62] years) undergoing noncoronary arteriography received dimenhydrinate or placebo before the injection of the low-osmolality contrast material ioxaglate (Hexabrix) [25].
  • During whole-body motion in darkness, there was little placebo-drug difference in the vestibular response under alert conditions; under relaxed conditions, dimenhydrinate and promethazine hydrochloride produced significant declines in the vestibular eye movements [26].

Gene context of Gravol


Analytical, diagnostic and therapeutic context of Gravol


  1. Transdermal scopolamine in the prevention of motion sickness at sea. Price, N.M., Schmitt, L.G., McGuire, J., Shaw, J.E., Trobough, G. Clin. Pharmacol. Ther. (1981) [Pubmed]
  2. Reduction of postoperative nausea and vomiting by dimenhydrinate suppositories after strabismus surgery in children. Welters, I.D., Menges, T., Gräf, M., Beikirch, C., Menzebach, A., Hempelmann, G. Anesth. Analg. (2000) [Pubmed]
  3. Intravenous Lorazepam versus dimenhydrinate for treatment of vertigo in the emergency department: a randomized clinical trial. Marill, K.A., Walsh, M.J., Nelson, B.K. Annals of emergency medicine. (2000) [Pubmed]
  4. Fixed drug eruption caused by dimenhydrinate. Saenz de San Pedro, B., Quiralte, J., Florido, J.F. Allergy (2000) [Pubmed]
  5. Fatality secondary to massive overdose of dimenhydrinate. Winn, R.E., McDonnell, K.P. Annals of emergency medicine. (1993) [Pubmed]
  6. Central nervous system effects of meclizine and dimenhydrinate: evidence of acute tolerance to antihistamines. Manning, C., Scandale, L., Manning, E.J., Gengo, F.M. Journal of clinical pharmacology. (1992) [Pubmed]
  7. The effects of dimenhydrinate, cinnarizine and transdermal scopolamine on performance. Gordon, C.R., Gonen, A., Nachum, Z., Doweck, I., Spitzer, O., Shupak, A. J. Psychopharmacol. (Oxford) (2001) [Pubmed]
  8. Effects of aspirin and dimenhydrinate (Dramamine) on visual processes. Luria, S.M., Kinney, J.A., McKay, C.L., Paulson, H.M., Ryan, A.P. British journal of clinical pharmacology. (1979) [Pubmed]
  9. Novel competitive irreversible inhibitors of aldehyde dehydrogenase (ALDH1): restoration of chemosensitivity of L1210 cells overexpressing ALDH1 and induction of apoptosis in BAF(3) cells overexpressing bcl(2). Quash, G., Fournet, G., Chantepie, J., Gore, J., Ardiet, C., Ardail, D., Michal, Y., Reichert, U. Biochem. Pharmacol. (2002) [Pubmed]
  10. Peripheral nerve injection injury with antiemetic agents. Strasberg, J.E., Atchabahian, A., Strasberg, S.R., Watanabe, O., Hunter, D.A., Mackinnon, S.E. J. Neurotrauma (1999) [Pubmed]
  11. Efficacy and tolerability of a fixed low-dose combination of cinnarizine and dimenhydrinate in the treatment of vertigo: A 4-week, randomized, double-blind, active- and placebo-controlled, parallel-group, outpatient study. Pytel, J., Nagy, G., Tóth, A., Spellenberg, S., Schwarz, M., Répassy, G. Clinical therapeutics (2007) [Pubmed]
  12. Prophylaxis of postoperative vomiting in children undergoing tonsillectomy: a systematic review and meta-analysis. Bolton, C.M., Myles, P.S., Nolan, T., Sterne, J.A. British journal of anaesthesia. (2006) [Pubmed]
  13. Antiemetic efficacy of prophylactic dimenhydrinate (Dramamine) vs ondansetron (Zofran): a randomized, prospective trial inpatients undergoing laparoscopic cholecystectomy. Kothari, S.N., Boyd, W.C., Bottcher, M.L., Lambert, P.J. Surgical endoscopy. (2000) [Pubmed]
  14. Methotrimeprazine versus meperidine and dimenhydrinate in the treatment of severe migraine: a randomized, controlled trial. Stiell, I.G., Dufour, D.G., Moher, D., Yen, M., Beilby, W.J., Smith, N.A. Annals of emergency medicine. (1991) [Pubmed]
  15. Intramuscular droperidol versus intramuscular dimenhydrinate for the treatment of acute peripheral vertigo in the emergency department: a randomized clinical trial. Irving, C., Richman, P., Kaiafas, C., Eskin, B., Allegra, J. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. (2002) [Pubmed]
  16. Effect of propylene glycol on the disposition of Dramamine in the rabbit. Walters, K.M., Mason, W.D., Badr, M.Z. Drug Metab. Dispos. (1993) [Pubmed]
  17. Intraperitoneal treatment with dimethylthioampal (DIMATE) combined with surgical debulking is effective for experimental peritoneal carcinomatosis in a rat model. Monneuse, O., Mestrallet, J.P., Quash, G., Gilly, F.N., Glehen, O. J. Gastrointest. Surg. (2005) [Pubmed]
  18. The use of dimenhydrinate in conjunction with dexamethasone for induction of parturition in beef cattle. Morrison, D.G., Humes, P.E., Godke, R.A. Theriogenology (1983) [Pubmed]
  19. The psychometric and cardiac effects of dimenhydrinate in the hyperbaric environment. Taylor, D.M., O'Toole, K.S., Auble, T.E., Ryan, C.M., Sherman, D.R. Pharmacotherapy (2000) [Pubmed]
  20. Diagnostic delay after dimenhydrinate use in vomiting children. Anquist, K.W., Panchanathan, S., Rowe, P.C., Peterson, R.G., Sirnick, A. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. (1991) [Pubmed]
  21. A reduction of vestibulo-visual integration during transdermally administered scopolamine and dimenhydrinate. A presentation of gain control theory in motion sickness. Pyykkö, I., Schalén, L., Jäntti, V., Magnusson, M. Acta oto-laryngologica. Supplementum. (1984) [Pubmed]
  22. Influence of 3 antivertiginous medications on the vigilance of healthy volunteers. Schneider, D., Kiessling, B., Wieczorek, M., Bognar-Steinberg, I., Schneider, L., Claussen, C.F. International journal of clinical pharmacology and therapeutics. (2003) [Pubmed]
  23. Diphenhydramine and dimenhydrinate poisoning: an evidence-based consensus guideline for out-of-hospital management. Scharman, E.J., Erdman, A.R., Wax, P.M., Chyka, P.A., Caravati, E.M., Nelson, L.S., Manoguerra, A.S., Christianson, G., Olson, K.R., Woolf, A.D., Keyes, D.C., Booze, L.L., Troutman, W.G. Clinical toxicology (Philadelphia, Pa.) (2006) [Pubmed]
  24. Contribution to the treatment of nausea and emesis induced by chemotherapy in children and adolescents with osteosarcoma. Luisi, F.A., Petrilli, A.S., Tanaka, C., Caran, E.M. São Paulo medical journal = Revista paulista de medicina. (2006) [Pubmed]
  25. Dimenhydrinate pretreatment in patients receiving intra-arterial ioxaglate: effect on nausea and vomiting. Smith, D.C., Taylor, F.C., McKinney, J.M. Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes. (1995) [Pubmed]
  26. A comparison of some effects of three antimotion sickness drugs on nystagmic responses to angular accelerations and to optokinetic stimuli. Collins, W.E., Schroeder, D.J., Elam, G.W. Aviation, space, and environmental medicine. (1982) [Pubmed]
  27. Dimenhydrinate decreases vomiting after strabismus surgery in children. Vener, D.F., Carr, A.S., Sikich, N., Bissonnette, B., Lerman, J. Anesth. Analg. (1996) [Pubmed]
  28. Response of life threatening dimenhydrinate intoxication to sodium bicarbonate administration. Farrell, M., Heinrichs, M., Tilelli, J.A. J. Toxicol. Clin. Toxicol. (1991) [Pubmed]
  29. Influence of an antivertiginous combination preparation of cinnarizine and dimenhydrinate on event-related potentials, reaction time and psychomotor performance--a randomized, double-blind, 3-way crossover study in healthy volunteers. Philipova, D., Tzenova, B., Iwanowitsch, A., Bognar-Steinberg, I. International journal of clinical pharmacology and therapeutics. (2004) [Pubmed]
  30. Simultaneous monitoring of both phases in the solvent extraction/flow injection analysis of Dramamine tablets. Fossey, L., Cantwell, F.F. Anal. Chem. (1983) [Pubmed]
  31. Prophylaxis of postoperative nausea and vomiting with oral, long-acting dimenhydrinate in gynecologic outpatient laparoscopy. Turner, K.E., Parlow, J.L., Avery, N.D., Tod, D.A., Day, A.G. Anesth. Analg. (2004) [Pubmed]
  32. Rectally administered dimenhydrinate reduces postoperative vomiting in children after strabismus surgery. Schlager, A., Mitterschiffthaler, G., Pühringer, F. British journal of anaesthesia. (2000) [Pubmed]
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