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Chemical Compound Review

AR-1C0869     7-[2-[(E)-3-hydroxyoct-1- enyl]-5-oxo-1...

Synonyms: AC1NS4O5, AC1Q5W5S, 14152-28-4, 15-hydroxy-9-oxoprosta-10,13-dien-1-oic acid
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Disease relevance of prostaglandin A1


Psychiatry related information on prostaglandin A1

  • Prostaglandin A1 (PGA1) was infused at the rate of 1/microgram/kg/min in 10 patients with decompensated heart failure under conditions of water loading (5 patients) or water deprivation (5 patients) [6].

High impact information on prostaglandin A1


Chemical compound and disease context of prostaglandin A1


Biological context of prostaglandin A1


Anatomical context of prostaglandin A1

  • When prostaglandin A1 was incubated with a Tris/saline suspension of washed human red blood cells, a substantial amount was converted to polar metabolites [21].
  • In this study, we report that the calcium ionophore A23187, a glucose-regulated protein (GRP) inducer, dramatically inhibits HSP70 synthesis and HSP70 mRNA transcription after induction by heat shock, sodium arsenite, or prostaglandin A1 treatment in human K562 cells [22].
  • Moreover, NS2 accumulated in the nucleoli of host cells cultured at 41 degrees C, showing that the export of NS2 was also disturbed at 41 degrees C. However, NS2 was exported normally from the nucleus, irrespective of PGA1 treatment at 37 degrees C, suggesting that HSP70 does not influence NS2 [23].
  • On the basis of this data, we conclude that PGA1 does not act via a generalized alteration of a basic property at the plasma membrane, such as its fluidity; rather, PGA1 acts specifically to inhibit cyclic AMP extrusion [24].
  • Our findings show that PGA1 and PGJ2 induce apoptosis in endothelial cells independent of PPARgamma [25].

Associations of prostaglandin A1 with other chemical compounds


Gene context of prostaglandin A1


Analytical, diagnostic and therapeutic context of prostaglandin A1


  1. Antiproliferative prostaglandins activate heat shock transcription factor. Amici, C., Sistonen, L., Santoro, M.G., Morimoto, R.I. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Inhibition of human malignant melanoma colony-forming cells in vitro by prostaglandin A1. Bregman, M.D., Meyskens, F.L. Cancer Res. (1983) [Pubmed]
  3. Inhibition of herpesvirus-induced HIV-1 replication by cyclopentenone prostaglandins: role of IkappaB kinase (IKK). Amici, C., Belardo, G., Rozera, C., Bernasconi, D., Santoro, M.G. AIDS (2004) [Pubmed]
  4. Selective inhibition of virus protein synthesis by prostaglandin A1: a translational block associated with HSP70 synthesis. Amici, C., Giorgi, C., Rossi, A., Santoro, M.G. J. Virol. (1994) [Pubmed]
  5. Inhibition of rotavirus replication by prostaglandin A: evidence for a block of virus maturation. Superti, F., Amici, C., Tinari, A., Donelli, G., Santoro, M.G. J. Infect. Dis. (1998) [Pubmed]
  6. Effects of prostaglandin A1 on renal handling of salt and water in congestive heart failure. Di Perri, T., Forconi, S., Puccetti, F., Vittoria, A., Guerrini, M. J. Cardiovasc. Pharmacol. (1980) [Pubmed]
  7. Effect of indomethacin and prostaglandin A1 on renal function and plasma renin activity in alcoholic liver disease. Boyer, T.D., Zia, P., Reynolds, T.B. Gastroenterology (1979) [Pubmed]
  8. Inhibition of nuclear factor kappa B by prostaglandin A1: an effect associated with heat shock transcription factor activation. Rossi, A., Elia, G., Santoro, M.G. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  9. Prostaglandin I2 modifies both prolactin binding capacity and fluidity of mouse liver membranes. Dave, J.R., Knazek, R.A. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  10. The effect of prostaglandin A1 on renin and aldosterone in man. Golub, M.S., Speckart, P.F., Zia, P.K., Horton, R. Circ. Res. (1976) [Pubmed]
  11. Management of severe preeclampsia detected in early labor by prostaglandin A1 or dihydralazine infusions. Toppozada, M.K., Darwish, E., Barakat, A.A. Am. J. Obstet. Gynecol. (1991) [Pubmed]
  12. Tumor cell biotransformation products of prostaglandin A1 with growth inhibitory activity. Gouin, E., Vulliez-Le Normand, B., Gouyette, A., Heidet, V., Nagel, N., Dray, F. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  13. Induction of the heat-shock response by antiviral prostaglandins in human cells infected with human immunodeficiency virus type 1. de Marco, A., Carattoli, A., Rozera, C., Fortini, D., Giorgi, C., Belardo, G., Amici, C., Santoro, M.G. Eur. J. Biochem. (1998) [Pubmed]
  14. Failure to prostaglandin A1 to modify renal diatrizoate uptake in experimental acute renal failure. Robinson, P.J., Gaunt, A., Leung, W.K., McLachlan, M.S. Investigative radiology. (1978) [Pubmed]
  15. Enhancement of neuroprotection and heat shock protein induction by combined prostaglandin A1 and lithium in rodent models of focal ischemia. Xu, X.H., Zhang, H.L., Han, R., Gu, Z.L., Qin, Z.H. Brain Res. (2006) [Pubmed]
  16. Induction of the stress response with prostaglandin A1 increases I-kappaBalpha gene expression. Thomas, S.C., Ryan, M.A., Shanley, T.P., Wong, H.R. FASEB J. (1998) [Pubmed]
  17. Potent prostaglandin A1 analogs that suppress tumor cell growth through induction of p21 and reduction of cyclin E. Tanikawa, M., Yamada, K., Tominaga, K., Morisaki, H., Kaneko, Y., Ikeda, K., Suzuki, M., Kiho, T., Tomokiyo, K., Furuta, K., Noyori, R., Nakanishi, M. J. Biol. Chem. (1998) [Pubmed]
  18. Role of the adenosine 3',5'-cyclic monophosphate (cAMP) in enhancing the efficacy of siRNA-mediated gene silencing in neuroblastoma cells. Hanson, A.J., Nahreini, P., Andreatta, C., Yan, X.D., Prasad, K.N. Oncogene (2005) [Pubmed]
  19. Prostaglandin A1 inhibits rotenone-induced apoptosis in SH-SY5Y cells. Wang, X., Qin, Z.H., Leng, Y., Wang, Y., Jin, X., Chase, T.N., Bennett, M.C. J. Neurochem. (2002) [Pubmed]
  20. TEI-3313, a novel prostaglandin A1 derivative, prevents bone loss and enhances bone formation in immobilized male rats. Ohta, T., Azuma, Y., Kanatani, H., Kiyoki, M., Koshihara, Y. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  21. Formation of glutathione conjugates of prostaglandin A1 in human red blood cells. Cagen, L.M., Fales, H.M., Pisano, J.J. J. Biol. Chem. (1976) [Pubmed]
  22. Inhibition of HSP70 expression by calcium ionophore A23187 in human cells. An effect independent of the acquisition of DNA-binding activity by the heat shock transcription factor. Elia, G., De Marco, A., Rossi, A., Santoro, M.G. J. Biol. Chem. (1996) [Pubmed]
  23. Heat shock protein 70 is related to thermal inhibition of nuclear export of the influenza virus ribonucleoprotein complex. Hirayama, E., Atagi, H., Hiraki, A., Kim, J. J. Virol. (2004) [Pubmed]
  24. Export of cyclic AMP from avian red cells. Independence from major membrane transporters and specific inhibition by prostaglandin A. Heasley, L.E., Azari, J., Brunton, L.L. Mol. Pharmacol. (1985) [Pubmed]
  25. Cyclopentenone prostaglandins induce endothelial cell apoptosis independent of the peroxisome proliferator-activated receptor-gamma. Erl, W., Weber, C., Zernecke, A., Neuzil, J., Vosseler, C.A., Kim, H.J., Weber, P.C. Eur. J. Immunol. (2004) [Pubmed]
  26. Inhibition of human melanoma growth by prostaglandin A, D, and J analogues. Bregman, M.D., Funk, C., Fukushima, M. Cancer Res. (1986) [Pubmed]
  27. Putative inhibitor of cyclic AMP efflux: chromatography, amino acid composition, and identification as a prostaglandin A1-glutathione adduct. Heasley, L.E., Watson, M.J., Brunton, L.L. J. Biol. Chem. (1985) [Pubmed]
  28. The effect of sodium restriction and prostaglandin inhibition on the renin-angiotensin system in man. Speckart, P., Zia, P., Zipser, R., Horton, R. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
  29. Metabolism of prostaglandins A and E in the perfused rabbit lung and the effects of selected inhibitors. Gross, K.B., Gillis, C.N. J. Pharmacol. Exp. Ther. (1976) [Pubmed]
  30. Involvement of c-jun N-terminal kinase activation in 15-deoxy-delta12,14-prostaglandin J2-and prostaglandin A1-induced apoptosis in AGS gastric epithelial cells. Liu, J.D., Lin, S.Y., Ho, Y.S., Pan, S., Hung, L.F., Tsai, S.H., Lin, J.K., Liang, Y.C. Mol. Carcinog. (2003) [Pubmed]
  31. Purification and characterization of rat pulmonary cytochrome P-450. Imaoka, S., Funae, Y. J. Biochem. (1990) [Pubmed]
  32. Inhibitory effects of prostaglandin A1 on membrane transport of folates mediated by both the reduced folate carrier and ATP-driven exporters. Assaraf, Y.G., Sierra, E.E., Babani, S., Goldman, I.D. Biochem. Pharmacol. (1999) [Pubmed]
  33. Prostaglandin A1 enhances c-fos expression and activating protein-1 activity. Ishikawa, T., Sekine, N., Hata, K., Igarashi, T., Fujita, T. Mol. Cell. Endocrinol. (2000) [Pubmed]
  34. Specific binding of heat shock protein 70 with HN-protein inhibits the HN-protein assembly in Sendai virus-infected Vero cells. Hirayama, E., Hattori, M., Kim, J. Virus Res. (2006) [Pubmed]
  35. Metabolism of prostaglandins A1 and E1 in man. Golub, M., Zia, P., Matsuno, M., Horton, R. J. Clin. Invest. (1975) [Pubmed]
  36. A radioimmunoassay for prostaglandin A1 in human peripheral blood. Zia, P., Golub, M., Horton, R. J. Clin. Endocrinol. Metab. (1975) [Pubmed]
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