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Chemical Compound Review

CHEMBL1772     2-(4-hydroxyphenyl)ethanoic acid

Synonyms: PubChem22193, SureCN75700, AGN-PC-00G6EL, H50004_ALDRICH, AG-B-75453, ...
 
 
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Disease relevance of p-Hydroxyphenyl acetic acid

 

High impact information on p-Hydroxyphenyl acetic acid

 

Chemical compound and disease context of p-Hydroxyphenyl acetic acid

 

Biological context of p-Hydroxyphenyl acetic acid

  • The hydroxylase has a molecular mass of 59,000 Da, uses NADH as a cosubstrate, and was tentatively classified as a 4-hydroxyphenylacetic acid hydroxylase, albeit it exhibited a rather broad substrate specificity acting on different monohydric and dihydric phenols [14].
  • The concentrations of PAA were increased ten-fold by hydrolysis, pHPAA increased two-fold, and mHPAA was unaffected [15].
 

Anatomical context of p-Hydroxyphenyl acetic acid

 

Associations of p-Hydroxyphenyl acetic acid with other chemical compounds

 

Gene context of p-Hydroxyphenyl acetic acid

 

Analytical, diagnostic and therapeutic context of p-Hydroxyphenyl acetic acid

References

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  2. p-Hydroxyphenylacetic Acid Metabolism in Pseudomonas putida F6. O'Connor, K.E., Witholt, B., Duetz, W. J. Bacteriol. (2001) [Pubmed]
  3. Polymer production by Klebsiella pneumoniae 4-hydroxyphenylacetic acid hydroxylase genes cloned in Escherichia coli. Gibello, A., Ferrer, E., Sanz, J., Martin, M. Appl. Environ. Microbiol. (1995) [Pubmed]
  4. Regulation of the 4-hydroxyphenylacetic acid meta-cleavage pathway in an Acinetobacter sp. Barbour, M.G., Bayly, R.C. Biochem. Biophys. Res. Commun. (1977) [Pubmed]
  5. p-Cresol formation by cell-free extracts of Clostridium difficile. D'Ari, L., Barker, H.A. Arch. Microbiol. (1985) [Pubmed]
  6. Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. Szabó, C., Ferrer-Sueta, G., Zingarelli, B., Southan, G.J., Salzman, A.L., Radi, R. J. Biol. Chem. (1997) [Pubmed]
  7. Molecular characterization of 4-hydroxyphenylacetate 3-hydroxylase of Escherichia coli. A two-protein component enzyme. Prieto, M.A., Garcia, J.L. J. Biol. Chem. (1994) [Pubmed]
  8. Kinetics and metabolism of p-tyramine during monoamine oxidase inhibition by mofegiline. Huebert, N.D., Dulery, B.D., Schoun, J., Schwach, V., Hinze, C., Haegele, K.D. Clin. Pharmacol. Ther. (1994) [Pubmed]
  9. Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster. Prieto, M.A., Díaz, E., García, J.L. J. Bacteriol. (1996) [Pubmed]
  10. Effects of monoamine oxidase inhibitors on the acid metabolites of some trace amines and of dopamine in the rat striatum. Dyck, L.E., Durden, D.A., Boulton, A.A. Biochem. Pharmacol. (1993) [Pubmed]
  11. Catabolism of aromatics in Pseudomonas putida U. Formal evidence that phenylacetic acid and 4-hydroxyphenylacetic acid are catabolized by two unrelated pathways. Olivera, E.R., Reglero, A., Martínez-Blanco, H., Fernández-Medarde, A., Moreno, M.A., Luengo, J.M. Eur. J. Biochem. (1994) [Pubmed]
  12. Urinary p-tyramine in hereditary tyrosinemia: II. Origin of urinary p-tyramine. Hoag, G.N., Hill, A., Zaleski, W. Clin. Biochem. (1977) [Pubmed]
  13. Tyrosyluria in marasmus. Dhatt, P.S., Saini, A.S., Gupta, I., Mehta, H.C., Singh, H. Br. J. Nutr. (1979) [Pubmed]
  14. Characterization of an Escherichia coli aromatic hydroxylase with a broad substrate range. Prieto, M.A., Perez-Aranda, A., Garcia, J.L. J. Bacteriol. (1993) [Pubmed]
  15. Conjugation of phenylacetic acid and m- and p-hydroxyphenylacetic acids in the rat striatum. Dyck, L.E., Durden, D.A., Boulton, A.A. Life Sci. (1993) [Pubmed]
  16. Determination of p-hydroxyphenylacetic acid in cerebrospinal fluid by high-performance liquid chromatography with electrochemical detection. Kobayashi, K., Koide, Y., Shohmori, T. Clin. Chim. Acta (1982) [Pubmed]
  17. Human salivary peroxidase-catalyzed oxidation of nitrite and nitration of salivary components 4-hydroxyphenylacetic acid and proteins. Takahama, U., Hirota, S., Nishioka, T., Oniki, T. Arch. Oral Biol. (2003) [Pubmed]
  18. Inhibition of inflammatory species by titanium surfaces. Suzuki, R., Frangos, J.A. Clin. Orthop. Relat. Res. (2000) [Pubmed]
  19. The role of hydroxyl radicals for the decomposition of p-hydroxy phenylacetic acid in aqueous solutions. Benitez, F.J., Acero, J.L., Real, F.J., Rubio, F.J., Leal, A.I. Water Res. (2001) [Pubmed]
  20. The effects of amiflamine, a reversible MAO-A inhibitor, on the first pass metabolism of tyramine in dog intestine. Yasuhara, H., Kiuchi, Y., Oguchi, K., Davies, D.S., Dollery, C.T. Jpn. J. Pharmacol. (1986) [Pubmed]
  21. Simultaneous determination by GC-MS-SIM of o-, m-, p-hydroxyphenylacetic acid, 3:4-dihydroxyphenylacetic acid and homovanillic acid in biological samples using a common selected ion. Narasimhachari, N., Prakash, U., Helgeson, E., Davis, J.M. Journal of chromatographic science. (1978) [Pubmed]
  22. Optimising hydrogen peroxide measurement in exhaled breath condensate. Brooks, W.M., Lash, H., Kettle, A.J., Epton, M.J. Redox Rep. (2006) [Pubmed]
  23. A novel phenol hydroxylase and catechol 2,3-dioxygenase from the thermophilic Bacillus thermoleovorans strain A2: nucleotide sequence and analysis of the genes. Duffner, F.M., Müller, R. FEMS Microbiol. Lett. (1998) [Pubmed]
  24. Determination of purine nucleosides and their bases by high-performance liquid chromatography using co-immobilized enzyme reactors. Kito, M., Tawa, R., Takeshima, S., Hirose, S. J. Chromatogr. (1990) [Pubmed]
  25. The enzymatic spectrofluorimetric determination of uric acid in microsamples of plasma by using p-hydroxyphenylacetic acid as a fluorophor. Sumi, T., Umeda, Y., Kishi, Y., Takahashi, K., Kakimoto, F. Clin. Chim. Acta (1976) [Pubmed]
  26. A fluorometric assay of acyl-CoA oxidase activity by a coupled peroxidatic reaction: elimination of interfering side reactions. Kvannes, J., Flatmark, T. J. Biochem. Biophys. Methods (1991) [Pubmed]
  27. Fluorimetric analysis of hydrogen peroxide with automated measurement. van Beurden, W.J., van den Bosch, M.J., Janssen, W.C., Smeenk, F.W., Dekhuijzen, P.N., Harff, G.A. Clin. Lab. (2003) [Pubmed]
 
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