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Chemical Compound Review

AC1L4NBH     hydrogen peroxide; iron(+2) cation;...

Synonyms: AR-1J0774, AR-1J0775, LS-148219, Fenton's reagent, ferrous; hydrogen peroxide; sulfuric acid, ...
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Disease relevance of Fenton's reagent


Psychiatry related information on Fenton's reagent

  • The effect of operating conditions such as reaction time, pH, H2O2 to Fe(II) molar ratio, Fenton's reagent dosage, initial COD strength, feeding mode, the type of polymer, and temperature on the efficacy of Fenton process was investigated [4].

High impact information on Fenton's reagent

  • Intense lipid peroxidation of brain synaptosomes initiated with Fenton's reagent (H2O2 + Fe2+) began instantly upon addition of Fe2+ and preceded detectable OH. formation [5].
  • Given the fact that methane has a relatively strong C-H bond (ca. 10 kcal/mol stronger than the C-H bonds in the more typical Fenton's reagent substrates), we infer that for many organic substrates oxidation with the ferryl ion as an active intermediate may be a perfectly viable route [6].
  • To quantify antioxidative effects, a newly introduced test system based on the diminution of the ESR signal of DMPO-OH (generated by Fenton's reagent) by the tested compounds was applied [7].
  • HO(*) was generated from Fenton's reagent (1. 5x10(-4)M H(2)O(2) plus 10(-4)M FeSO(4)); generation of HO(*) from H(2)O(2)/FeSO(4) in the superfusate was monitored by electron spin resonance spectroscopy using the spin-trap 5, 5-dimethyl-1-pyrroline-N-oxide throughout the experimental time course [8].
  • We, therefore, investigated the role of oxygen-derived free radicals generated from Fenton's reagent (3 x 10(-4) M H2O2 plus 2 x 10(-4) M FeSO4) on CGRP-mediated neurogenic relaxation of canine lingual artery ring preparations [9].

Chemical compound and disease context of Fenton's reagent


Biological context of Fenton's reagent


Anatomical context of Fenton's reagent


Associations of Fenton's reagent with other chemical compounds


Gene context of Fenton's reagent

  • Further, an increased susceptibility of the apo B-containing lipoproteins (LDL+VLDL) to oxidation in vitro, induced by copper ions and Fenton's reagent, was observed in the untreated CCT diet fed group [27].
  • The first was a chemical model using Fenton's reagent, a mixture of Fe(II)-chelator and H2O2, for which the normal reaction is OH. production, and the second, a preparation from rat liver and brain microsomes containing NADPH and achieving enzymatic oxidation of the solvents [28].
  • Effect of sequestration on PAH degradability with Fenton's reagent: roles of total organic carbon, humin, and soil porosity [29].
  • Approximately, 88% TOC, 85% color and 89% AOX removals were obtained by the Fenton's reagent at pH 5 within 30min [30].
  • Incubation of Trypanosoma cruzi mitochondrial ATPase (Fo-F1) with the xanthine oxidase system (XO), Fenton's reagent (Fe2+ + H2O2) and the ascorbate-Cu system, caused gradual loss of enzyme activity, which increased as a function of incubation time and rate of oxygen radical generation [31].

Analytical, diagnostic and therapeutic context of Fenton's reagent

  • The specific filtration resistance, moisture, and SVI were used to evaluate the influence of pH on the filtration and dewatering efficiencies when applying Fenton's reagent to treat the excess sludge [32].


  1. Optimization of simultaneous chemical and biological mineralization of perchloroethylene. Büyüksönmez, F., Hess, T.F., Crawford, R.L., Paszczynski, A., Watts, R.J. Appl. Environ. Microbiol. (1999) [Pubmed]
  2. Advanced oxidation of commercial textile biocides in aqueous solution: effects on acute toxicity and biomass inhibition. Arslan-Alaton, I., Eremektar, G., Germirli-Babuna, F., Insel, G., Selcuk, H., Ozerkan, B., Teksoy, S. Water Sci. Technol. (2005) [Pubmed]
  3. The effect of chemical pretreatment on the aerobic microbial degradation of PCB congeners in aqueous systems. Aronstein, B.N., Paterek, J.R., Kelley, R.L., Rice, L.E. J. Ind. Microbiol. (1995) [Pubmed]
  4. Optimization of Fenton process for the treatment of landfill leachate. Zhang, H., Choi, H.J., Huang, C.P. Journal of hazardous materials. (2005) [Pubmed]
  5. The involvement of iron in lipid peroxidation. Importance of ferric to ferrous ratios in initiation. Braughler, J.M., Duncan, L.A., Chase, R.L. J. Biol. Chem. (1986) [Pubmed]
  6. Methane-to-methanol oxidation by the hydrated iron(IV) oxo species in aqueous solution: a combined DFT and car-parrinello molecular dynamics study. Ensing, B., Buda, F., Gribnau, M.C., Baerends, E.J. J. Am. Chem. Soc. (2004) [Pubmed]
  7. Hydroxyl radical scavenging and antipsoriatic activity of benzoic acid derivatives. Haseloff, R.F., Blasig, I.E., Meffert, H., Ebert, B. Free Radic. Biol. Med. (1990) [Pubmed]
  8. Differential sensitivity to hydroxyl radicals of pre- and postjunctional neurovascular transmission in the isolated canine mesenteric vein. Hagiwara, T., Lee, C.I., Okabe, E. Neuropharmacology (2000) [Pubmed]
  9. Inhibition by hydroxyl radicals of calcitonin gene-related peptide-mediated neurogenic vasorelaxation in isolated canine lingual artery. Norisue, M., Todoki, K., Okabe, E. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  10. Removal of COD from landfill leachate by electro-Fenton method. Zhang, H., Zhang, D., Zhou, J. J. Hazard. Mater. (2006) [Pubmed]
  11. Treatment of landfill leachate by Fenton's reagent in a continuous stirred tank reactor. Zhang, H., Choi, H.J., Huang, C.P. J. Hazard. Mater. (2006) [Pubmed]
  12. Chemical pathway and kinetics of phenol oxidation by Fenton's reagent. Zazo, J.A., Casas, J.A., Mohedano, A.F., Gilarranz, M.A., Rodríguez, J.J. Environ. Sci. Technol. (2005) [Pubmed]
  13. Indirect electrochemical treatment of bisphenol A in water via electrochemically generated Fenton's reagent. Gözmen, B., Oturan, M.A., Oturan, N., Erbatur, O. Environ. Sci. Technol. (2003) [Pubmed]
  14. Antioxidant activity of piperlactam S: prevention of copper-induced LDL peroxidation and amelioration of free radical-induced oxidative stress of endothelial cells. Tsai, J.Y., Chou, C.J., Chen, C.F., Chiou, W.F. Planta Med. (2003) [Pubmed]
  15. Removal of organophosphate pesticides from wastewater by supercritical carbon dioxide extraction. Yu, J.J. Water Res. (2002) [Pubmed]
  16. Environmental assessment of different advanced oxidation processes applied to a bleaching Kraft mill effluent. Muñoz, I., Rieradevall, J., Torrades, F., Peral, J., Domènech, X. Chemosphere (2006) [Pubmed]
  17. Electron spin resonance study of free radicals produced from ethanol and acetaldehyde after exposure to a Fenton system or to brain and liver microsomes. Gonthier, B., Jeunet, A., Barret, L. Alcohol (1991) [Pubmed]
  18. A study on the reaction of human erythrocytes with hydrogen peroxide. Yamaguchi, T., Fujita, Y., Kuroki, S., Ohtsuka, K., Kimoto, E. J. Biochem. (1983) [Pubmed]
  19. Inhibitory effects of volatile antioxidants found in various beans on malonaldehyde formation in horse blood plasma. Lee, S.J., Lee, K.G. Food Chem. Toxicol. (2005) [Pubmed]
  20. Hydroxyl radical-mediated reduction of Ca(2+)-ATPase activity of masseter muscle sarcoplasmic reticulum. Lee, C., Okabe, E. Jpn. J. Pharmacol. (1995) [Pubmed]
  21. Inhibition of malonaldehyde formation in oxidized calf thymus DNA with synthetic and natural antioxidants. Matsufuji, H., Shibamoto, T. J. Agric. Food Chem. (2004) [Pubmed]
  22. Novel "scavestrogens" and their radical scavenging effects, iron-chelating, and total antioxidative activities: delta 8,9-dehydro derivatives of 17 alpha-estradiol and 17 beta-estradiol. Römer, W., Oettel, M., Droescher, P., Schwarz, S. Steroids (1997) [Pubmed]
  23. Cellobiose oxidase from Phanerochaete chrysosporium as a source of Fenton's reagent. Kremer, S.M., Wood, P.M. Biochem. Soc. Trans. (1992) [Pubmed]
  24. Degradation of ethylene glycol using Fenton's reagent and UV. McGinnis, B.D., Adams, V.D., Middlebrooks, E.J. Chemosphere (2001) [Pubmed]
  25. Inhibitory effects of plant-derived flavonoids and phenolic acids on malonaldehyde formation from ethyl arachidonate. Lee, K.G., Shibamoto, T., Takeoka, G.R., Lee, S.E., Kim, J.H., Park, B.S. J. Agric. Food Chem. (2003) [Pubmed]
  26. Photodegradation of direct yellow-12 using UV/H2O2/Fe2+. Rathi, A., Rajor, H.K., Sharma, R.K. Journal of hazardous materials. (2003) [Pubmed]
  27. Atheroprotective effect of exogenous heparin-derivative treatment on the aortic disturbances and lipoprotein oxidation in hypercholesterolemic diet fed rats. Deepa, P.R., Varalakshmi, P. Clin. Chim. Acta (2005) [Pubmed]
  28. In-vitro spin-trapping of free radicals produced during trichloroethylene and diethylether metabolism. Gonthier, B.P., Barret, L.G. Toxicol. Lett. (1989) [Pubmed]
  29. Effect of sequestration on PAH degradability with Fenton's reagent: roles of total organic carbon, humin, and soil porosity. Bogan, B.W., Trbovic, V. Journal of hazardous materials. (2003) [Pubmed]
  30. Color, TOC and AOX removals from pulp mill effluent by advanced oxidation processes: A comparative study. Catalkaya, E.C., Kargi, F. J. Hazard. Mater. (2007) [Pubmed]
  31. Inactivation of mitochondrial adenosine triphosphatase from Trypanosoma cruzi by oxygen radicals. Cataldi de Flombaum, M.A., Stoppani, A.O. Biochem. Int. (1986) [Pubmed]
  32. Influence of pH on the dewatering of activated sludge by Fenton's reagent. Lu, M.C., Lin, C.J., Liao, C.H., Ting, W.P., Huang, R.Y. Water Sci. Technol. (2001) [Pubmed]
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