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Chemical Compound Review

p-ABA     4-aminobenzenecarboximidamide

Synonyms: Lopac-A-7148, CHEMBL124632, SureCN150756, CHEBI:308520, CCG-204165, ...
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Disease relevance of p-Aminobenzamidine


High impact information on p-Aminobenzamidine

  • Plasmin-treated F.IX did not bind the active site probe, p-aminobenzamidine, or form an SDS-stable complex with antithrombin [5].
  • Furthermore, HNE-treated F.IX was unable to (1) bind the active site probe p-aminobenzamidine; (2) hydrolyze the synthetic peptide substrate CH3SO2-Leu-Gly-Arg-p-nitroanilide; and (3) activate human factor X (F.X) [6].
  • However, aberrant binding of the active site probe p-aminobenzamidine was observed for factor XIa-activated factor IXG207E, indicating that the active site pocket of the heavy chain of factor IXaG207E was abnormal [7].
  • We used a mutated form of plasminogen activator inhibitor type 1 to conform a correlation between the inactivation of uPA and tumor size; we have compared these results with the action of p-aminobenzamidine and amiloride, known inhibitors of uPA [8].
  • The ligand-receptor interaction involves the catalytic site of UK, since the binding was completely impaired by preincubation of UK:ferritin with p-aminobenzamidine, a competitive inhibitor of the catalytic site of UK [9].

Chemical compound and disease context of p-Aminobenzamidine


Biological context of p-Aminobenzamidine


Anatomical context of p-Aminobenzamidine


Associations of p-Aminobenzamidine with other chemical compounds


Gene context of p-Aminobenzamidine


Analytical, diagnostic and therapeutic context of p-Aminobenzamidine


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  2. The urokinase inhibitor p-aminobenzamidine inhibits growth of a human prostate tumor in SCID mice. Billström, A., Hartley-Asp, B., Lecander, I., Batra, S., Astedt, B. Int. J. Cancer (1995) [Pubmed]
  3. Characterization of the mutant-unc D-gene product in a strain of Escherichia coli K12. An altered beta-subunit of the magnesium ion-stimulated adenosine triphosphatase. Fayle, D.R., Downie, J.A., Cox, G.B., Gibson, F., Radik, J. Biochem. J. (1978) [Pubmed]
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  5. Proteolytic processing of human coagulation factor IX by plasmin. Samis, J.A., Ramsey, G.D., Walker, J.B., Nesheim, M.E., Giles, A.R. Blood (2000) [Pubmed]
  6. Neutrophil elastase cleavage of human factor IX generates an activated factor IX-like product devoid of coagulant function. Samis, J.A., Kam, E., Nesheim, M.E., Giles, A.R. Blood (1998) [Pubmed]
  7. Characterization of a factor IX variant with a glycine207 to glutamic acid mutation. Lin, S.W., Lin, C.N., Hamaguchi, N., Smith, K.J., Shen, M.C. Blood (1994) [Pubmed]
  8. Inhibitors of urokinase reduce size of prostate cancer xenografts in severe combined immunodeficient mice. Jankun, J., Keck, R.W., Skrzypczak-Jankun, E., Swiercz, R. Cancer Res. (1997) [Pubmed]
  9. Receptors for plasminogen activator, urokinase, in normal and Rous sarcoma virus-transformed mouse fibroblasts. Del Rosso, M., Dini, G., Fibbi, G. Cancer Res. (1985) [Pubmed]
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  11. Functional consequences of an arginine180 to glutamine mutation in factor IX Hilo. Monroe, D.M., McCord, D.M., Huang, M.N., High, K.A., Lundblad, R.L., Kasper, C.K., Roberts, H.R. Blood (1989) [Pubmed]
  12. Transient kinetics of heparin-catalyzed protease inactivation by antithrombin III. Characterization of assembly, product formation, and heparin dissociation steps in the factor Xa reaction. Craig, P.A., Olson, S.T., Shore, J.D. J. Biol. Chem. (1989) [Pubmed]
  13. Identification of a binding site for quaternary amines in factor Xa. Monnaie, D., Arosio, D., Griffon, N., Rose, T., Rezaie, A.R., Di Cera, E. Biochemistry (2000) [Pubmed]
  14. In vitro regulation of pericellular proteolysis in prostatic tumor cells treated with bombesin. Festuccia, C., Guerra, F., D'Ascenzo, S., Giunciuglio, D., Albini, A., Bologna, M. Int. J. Cancer (1998) [Pubmed]
  15. A domain-specific 50-kilodalton structural protein of the acrosomal matrix is processed and released during the acrosome reaction in the guinea pig. Westbrook-Case, V.A., Winfrey, V.P., Olson, G.E. Biol. Reprod. (1994) [Pubmed]
  16. Localization of proteolytic activity in the outer membrane of Escherichia coli. MacGregor, C.H., Bishop, C.W., Blech, J.E. J. Bacteriol. (1979) [Pubmed]
  17. p-Aminobenzamidine, an acrosin inhibitor, inhibits mouse sperm penetration of the zona pellucida but not the acrosome reaction. Fraser, L.R. J. Reprod. Fertil. (1982) [Pubmed]
  18. Trypsin-like enzymes during fertilization in the shrimp Rhynchocinetes typus. Rios, M., Barros, C. Mol. Reprod. Dev. (1997) [Pubmed]
  19. Time sequence of germinal vesicle breakdown in pig oocytes after cycloheximide and P-aminobenzamidine block. Kubelka, M., Motík, J., Fulka, J., Procházka, R., Rimkevicová, Z., Fulka, J. Gamete research. (1988) [Pubmed]
  20. Kinetic analysis of a unique direct prothrombinase, fgl2, and identification of a serine residue critical for the prothrombinase activity. Chan, C.W., Chan, M.W., Liu, M., Fung, L., Cole, E.H., Leibowitz, J.L., Marsden, P.A., Clark, D.A., Levy, G.A. J. Immunol. (2002) [Pubmed]
  21. Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity. Poe, M., Bennett, C.D., Biddison, W.E., Blake, J.T., Norton, G.P., Rodkey, J.A., Sigal, N.H., Turner, R.V., Wu, J.K., Zweerink, H.J. J. Biol. Chem. (1988) [Pubmed]
  22. Conformational transitions linked to active site ligation in human thrombin: effect on the interaction with fibrinogen and the cleavable platelet receptor. De Cristofaro, R., De Candia, E., Picozzi, M., Landolfi, R. J. Mol. Biol. (1995) [Pubmed]
  23. Increased migration of murine keratinocytes under hypoxia is mediated by induction of urokinase plasminogen activator. Daniel, R.J., Groves, R.W. J. Invest. Dermatol. (2002) [Pubmed]
  24. The catalytic domain of endogenous urokinase-type plasminogen activator is required for the mitogenic activity of platelet-derived and basic fibroblast growth factors in human vascular smooth muscle cells. Padró, T., Mesters, R.M., Dankbar, B., Hintelmann, H., Bieker, R., Kiehl, M., Berdel, W.E., Kienast, J. J. Cell. Sci. (2002) [Pubmed]
  25. Inhibition of urokinase-type plasminogen activator delays expression of c-jun, activated transforming growth factor beta 1, and matrix metalloproteinase 2 during post-hepatectomy liver regeneration in mice. Nomura, K., Miyagawa, S., Ayukawa, K., Soeda, J., Taniguchi, S., Kawasaki, S. J. Hepatol. (2002) [Pubmed]
  26. 4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors. Spencer, J.R., McGee, D., Allen, D., Katz, B.A., Luong, C., Sendzik, M., Squires, N., Mackman, R.L. Bioorg. Med. Chem. Lett. (2002) [Pubmed]
  27. Mutagenesis studies toward understanding the mechanism of the cofactor function of thrombomodulin. Rezaie, A.R., Yang, L. Biophys. Chem. (2005) [Pubmed]
  28. The thrombin-like enzyme from Bothrops atrox snake venom. Properties of the enzyme purified by affinity chromatography on p-aminobenzamidine-substituted agarose. Holleman, W.H., Weiss, L.J. J. Biol. Chem. (1976) [Pubmed]
  29. Bovine enterokinase. Purification, specificity, and some molecular properties. Anderson, L.E., Walsh, K.A., Neurath, H. Biochemistry (1977) [Pubmed]
  30. High-performance liquid affinity chromatography with phenylboronic acid, benzamidine, tri-L-alanine, and concanavalin A immobilized on 3-isothiocyanatopropyltriethoxysilane-activated nonporous monodisperse silicas. Anspach, F.B., Wirth, H.J., Unger, K.K., Stanton, P., Davies, J.R., Hearn, M.T. Anal. Biochem. (1989) [Pubmed]
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