The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Adrb2  -  adrenoceptor beta 2, surface

Rattus norvegicus

Synonyms: Adrb2r, Beta-2 adrenergic receptor, Beta-2 adrenoceptor, Beta-2 adrenoreceptor
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Adrb2


Psychiatry related information on Adrb2


High impact information on Adrb2


Chemical compound and disease context of Adrb2


Biological context of Adrb2


Anatomical context of Adrb2


Associations of Adrb2 with chemical compounds

  • Addition of the beta2-adrenoceptor antagonist ICI 118,551 (55 nmol/liter) did not influence the hypertrophic effect of norepinephrine [25].
  • For the beta 2-adrenergic receptor (beta 2AR) system, which is coupled to adenylyl cyclase via the stimulatory guanine nucleotide-binding regulatory (G5) protein, homologous desensitization is mediated in part by a receptor-specific kinase (beta ARK) and a soluble cofactor (beta-arrestin) [26].
  • Intracerebroventricular, but not intravenous, administration of the beta 2-adrenergic receptor antagonist ICI 118551 (30 micrograms) prevented the increased renal sympathetic nerve activity and antinatriuretic responses to air stress [27].
  • Enalaprilat treatment increased total beta-adrenoceptor density, whereas both treatments restored the binding affinity and beta1- and beta2-adrenoceptor proportions to normal in SHR [28].
  • Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712A (a selective beta 1-adrenergic receptor antagonist) did not change the plasma ACTH response to insulin injection, while pretreatment with 2.5 mg/kg ICI 118551 (a selective beta 2-adrenergic receptor antagonist) resulted in a significant decrease of the IIH-induced stimulation of ACTH secretion [29].

Regulatory relationships of Adrb2


Other interactions of Adrb2


Analytical, diagnostic and therapeutic context of Adrb2


  1. Activation of beta2-adrenergic receptor plays a pivotal role in generating the protective effect of ischemic preconditioning in rat hearts. Mieno, S., Horimoto, H., Sawa, Y., Watanabe, F., Furuya, E., Horimoto, S., Kishida, K., Sasaki, S. Scand. Cardiovasc. J. (2005) [Pubmed]
  2. Structural and functional analysis of the 5'-flanking region of the rat beta 2-adrenergic receptor gene. McGraw, D.W., Jacobi, S.E., Hiller, F.C., Cornett, L.E. Biochim. Biophys. Acta (1996) [Pubmed]
  3. Regulation of beta-adrenergic receptor mRNA in rat C6 glioma cells is sensitive to the state of microtubule assembly. Hough, C., Fukamauchi, F., Chuang, D.M. J. Neurochem. (1994) [Pubmed]
  4. Salmeterol, a long-acting beta 2-adrenoceptor agonist mediating cyclic AMP accumulation in a neuronal cell line. McCrea, K.E., Hill, S.J. Br. J. Pharmacol. (1993) [Pubmed]
  5. Regulation of tumour necrosis factor and interleukin-6 gene transcription by beta2-adrenoceptor in the rat astrocytes. Nakamura, A., Johns, E.J., Imaizumi, A., Abe, T., Kohsaka, T. J. Neuroimmunol. (1998) [Pubmed]
  6. The role of beta1 and beta2 adrenoceptors in isoproterenol-induced drinking. Kirby, R.F., Novak, C.M., Thunhorst, R.L., Johnson, A.K. Brain Res. (1994) [Pubmed]
  7. Comparative effects of beta 2-adrenoceptor agonists on intracranial self-stimulation, Sidman avoidance, and motor activity in rats. Liebman, J.M., Hall, N.R., Prowse, J., Gerhardt, S., Noreika, L., Fenton, H.M. Psychopharmacology (Berl.) (1984) [Pubmed]
  8. Effects of the beta 2-adrenoceptor agonist, clenbuterol, on muscle atrophy due to food deprivation in the rat. Choo, J.J., Horan, M.A., Little, R.A., Rothwell, N.J. Metab. Clin. Exp. (1990) [Pubmed]
  9. Combined effects of adrenaline and insulin on active electrogenic Na+-K+ transport in rat soleus muscle. Flatman, J.A., Clausen, T. Nature (1979) [Pubmed]
  10. Transformation of the beta2 adrenoceptor in normal rat liver into a beta1 type in Zajdela hepatoma. Lacombe, M.L., Rene, E., Guellaen, G., Hanoune, J. Nature (1976) [Pubmed]
  11. Nitric oxide-mediated beta 2-adrenoceptor relaxation is impaired in mesenteric veins from portal-hypertensive rats. Martínez-Cuesta, M.A., Moreno, L., Piqué, J.M., Bosch, J., Rodrigo, J., Esplugues, J.V. Gastroenterology (1996) [Pubmed]
  12. Beta-adrenergic control of motility in the rat colon. II. Proportions of beta 1- and beta 2-adrenoceptors identified with 125I-(-)pindolol binding. Ek, B.A., Nahorski, S.R. Gastroenterology (1986) [Pubmed]
  13. Comparison of terbutaline and dobutamine in rats with endotoxemia. Wu, J.Y., Liaw, W.J., Tzao, C., Chen, S.J., Wang, J.H., Wu, C.C. The Chinese journal of physiology. (2002) [Pubmed]
  14. Clenbuterol induces hypertrophy of the latissimus dorsi muscle and heart in the rat with molecular and phenotypic changes. Petrou, M., Wynne, D.G., Boheler, K.R., Yacoub, M.H. Circulation (1995) [Pubmed]
  15. In vivo transfer of a beta 2-adrenergic receptor gene into the pressure-overloaded rat heart enhances cardiac response to beta-adrenergic agonist. Kawahira, Y., Sawa, Y., Nishimura, M., Sakakida, S., Ueda, H., Kaneda, Y., Matsuda, H. Circulation (1998) [Pubmed]
  16. Hemodynamic effects of terbutaline, a beta 2-adrenoceptor agonist, in conscious rats with secondary biliary cirrhosis. Poo, J.L., Braillon, A., Hadengue, A., Gaudin, C., Lebrec, D. Hepatology (1992) [Pubmed]
  17. Comparison of duration of agonist action at beta 1- and beta 2- adrenoceptors in C6 glioma cells: evidence that the long duration of action of salmeterol is specific to the beta 2-adrenoceptor. McCrea, K.E., Hill, S.J. Mol. Pharmacol. (1996) [Pubmed]
  18. Substance P induces a cardiovascular defense reaction in the rat: pharmacological characterization. Unger, T., Carolus, S., Demmert, G., Ganten, D., Lang, R.E., Maser-Gluth, C., Steinberg, H., Veelken, R. Circ. Res. (1988) [Pubmed]
  19. Beta-adrenoceptor blockade and sympathetic neurotransmission in the pithed rat. Majewski, H., Murphy, T.V. J. Hypertens. (1989) [Pubmed]
  20. Purified rat hepatic beta 2-adrenergic receptor. Structural similarities to the rat fat cell beta 1-adrenergic receptor. Graziano, M.P., Moxham, C.P., Malbon, C.C. J. Biol. Chem. (1985) [Pubmed]
  21. Mammalian beta-adrenergic receptors. Structural differences in beta 1 and beta 2 subtypes revealed by peptide maps. Stiles, G.L., Strasser, R.H., Caron, M.G., Lefkowitz, R.J. J. Biol. Chem. (1983) [Pubmed]
  22. Characterisation of beta 1 and beta 2 adrenoceptor subtypes in the atrioventricular node of diabetic rat hearts by quantitative autoradiography. Saito, K., Kuroda, A., Tanaka, H. Cardiovasc. Res. (1991) [Pubmed]
  23. Characterization of beta 1- and beta 2-adrenoceptors in rat skeletal muscles. Kim, Y.S., Sainz, R.D., Molenaar, P., Summers, R.J. Biochem. Pharmacol. (1991) [Pubmed]
  24. The in vitro pharmacology of xamoterol (ICI 118,587). Malta, E., Mian, M.A., Raper, C. Br. J. Pharmacol. (1985) [Pubmed]
  25. Beta-adrenoceptor stimulation attenuates the hypertrophic effect of alpha-adrenoceptor stimulation in adult rat ventricular cardiomyocytes. Schäfer, M., Pönicke, K., Heinroth-Hoffmann, I., Brodde, O.E., Piper, H.M., Schlüter, K.D. J. Am. Coll. Cardiol. (2001) [Pubmed]
  26. Beta-adrenergic receptor kinase-like activity and beta-arrestin are expressed in osteoblastic cells. Bliziotes, M., Murtagh, J., Wiren, K. J. Bone Miner. Res. (1996) [Pubmed]
  27. Central adrenergic receptor control of renal function in conscious hypertensive rats. Koepke, J.P., DiBona, G.F. Hypertension (1986) [Pubmed]
  28. Effects of renin-angiotensin blockade on sympathetic reactivity and beta-adrenergic pathway in the spontaneously hypertensive rat. K-Laflamme, A., Oster, L., Cardinal, R., de Champlain, J. Hypertension (1997) [Pubmed]
  29. Ontogeny of insulin-induced hypoglycemia stimulation of adrenocorticotropin secretion in the rat: role of catecholamines. Grino, M., Oliver, C. Endocrinology (1992) [Pubmed]
  30. Up-regulation of oxytocin receptors in non-pregnant rat myometrium by isoproterenol: effects of steroids. Engstrom, T., Bratholm, P., Christensen, N.J., Vilhardt, H. J. Endocrinol. (1999) [Pubmed]
  31. The beta 3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes. Gettys, T.W., Harkness, P.J., Watson, P.M. Endocrinology (1996) [Pubmed]
  32. Beta-adrenoceptor blockade in rats enhances the ambulation induced by 5-HT1A receptor agonists. Kalkman, H.O. Eur. J. Pharmacol. (1989) [Pubmed]
  33. Insulin secretion induced by glucose and by stimulation of beta 2 -adrenoceptors in the rat. Different sensitivity to somatostatin. Ahrén, B., Järhult, J., Lundquist, I. Acta Physiol. Scand. (1981) [Pubmed]
  34. Characterization of neurotransmitters and dopamine attenuation of inducible nitric oxide synthase in glioma cells. Mazzio, E., Becker, A., Soliman, K.F. J. Neuroimmunol. (2002) [Pubmed]
  35. Halothane facilitates the translocation of GRK-2 and phosphorylation of beta2-adrenergic receptor in rat synaptosomes. Saito, S., Kadoi, Y., Ohyama, A., Goto, F. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (2000) [Pubmed]
  36. The beta-adrenoceptor selectivity profile of BRL 37344 in the pithed rat. Oriowo, M.A., Sennitt, M.V., Smith, S.A., Ruffolo, R.R., Cawthorne, M.A. Journal of autonomic pharmacology. (1994) [Pubmed]
  37. Sequence of the 5' regulatory domain of the gene encoding the rat beta 2-adrenergic receptor. Jiang, L., Kunos, G. Gene (1995) [Pubmed]
  38. Pharmacological characterization and anatomical localization of prejunctional beta-adrenoceptors in the rat kidney. Lakhlani, P.P., Amenta, F., Napoleone, P., Felici, L., Eikenburg, D.C. Br. J. Pharmacol. (1994) [Pubmed]
WikiGenes - Universities