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Chemical Compound Review

HYDROXYFASUDIL     5-(1,4-diazepan-1- ylsulfonyl)-2H...

Synonyms: SureCN123699, CHEMBL1233300, SureCN1827528, CHEBI:43149, AK-55619, ...
 
 
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Disease relevance of HYDROXYFASUDIL

 

High impact information on HYDROXYFASUDIL

 

Chemical compound and disease context of HYDROXYFASUDIL

 

Biological context of HYDROXYFASUDIL

 

Anatomical context of HYDROXYFASUDIL

 

Associations of HYDROXYFASUDIL with other chemical compounds

 

Gene context of HYDROXYFASUDIL

 

Analytical, diagnostic and therapeutic context of HYDROXYFASUDIL

References

  1. Beneficial effect of hydroxyfasudil, a specific Rho-kinase inhibitor, on ischemia/reperfusion injury in canine coronary microcirculation in vivo. Yada, T., Shimokawa, H., Hiramatsu, O., Kajita, T., Shigeto, F., Tanaka, E., Shinozaki, Y., Mori, H., Kiyooka, T., Katsura, M., Ohkuma, S., Goto, M., Ogasawara, Y., Kajiya, F. J. Am. Coll. Cardiol. (2005) [Pubmed]
  2. Inhibition of rho-kinase by hydroxyfasudil prevents vasopressin-induced myocardial ischemia in Donryu rats by attenuating coronary vasoconstriction. Vincelette, J., Pagila, R., Kawai, K., Ishii, M., Horimizu, Y., Vergona, R., Sullivan, M.E., Morser, J., Dole, W.P., Wang, Y.X. Pharmacology (2005) [Pubmed]
  3. Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. Takemoto, M., Sun, J., Hiroki, J., Shimokawa, H., Liao, J.K. Circulation (2002) [Pubmed]
  4. Cardioprotective effect of hydroxyfasudil as a specific Rho-kinase inhibitor, on ischemia-reperfusion injury in canine coronary microvessels in vivo. Yada, T., Shimokawa, H., Kajiya, F. Clin. Hemorheol. Microcirc. (2006) [Pubmed]
  5. Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase. Nakamura, K., Nishimura, J., Hirano, K., Ibayashi, S., Fujishima, M., Kanaide, H. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  6. Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Abe, K., Shimokawa, H., Morikawa, K., Uwatoku, T., Oi, K., Matsumoto, Y., Hattori, T., Nakashima, Y., Kaibuchi, K., Sueishi, K., Takeshit, A. Circ. Res. (2004) [Pubmed]
  7. Protein kinase A as another mediator of ischemic preconditioning independent of protein kinase C. Sanada, S., Asanuma, H., Tsukamoto, O., Minamino, T., Node, K., Takashima, S., Fukushima, T., Ogai, A., Shinozaki, Y., Fujita, M., Hirata, A., Okuda, H., Shimokawa, H., Tomoike, H., Hori, M., Kitakaze, M. Circulation (2004) [Pubmed]
  8. Effects of hydroxyfasudil administered to the nucleus tractus solitarii on blood pressure and heart rate in spontaneously hypertensive rats. Ito, K., Hirooka, Y., Kimura, Y., Shimokawa, H., Takeshita, A. Clin. Exp. Hypertens. (2005) [Pubmed]
  9. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Rikitake, Y., Kim, H.H., Huang, Z., Seto, M., Yano, K., Asano, T., Moskowitz, M.A., Liao, J.K. Stroke (2005) [Pubmed]
  10. Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Shimokawa, H., Seto, M., Katsumata, N., Amano, M., Kozai, T., Yamawaki, T., Kuwata, K., Kandabashi, T., Egashira, K., Ikegaki, I., Asano, T., Kaibuchi, K., Takeshita, A. Cardiovasc. Res. (1999) [Pubmed]
  11. Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction. Satoh, S., Yamaguchi, T., Hitomi, A., Sato, N., Shiraiwa, K., Ikegaki, I., Asano, T., Shimokawa, H. Eur. J. Pharmacol. (2002) [Pubmed]
  12. Remnant lipoproteins from patients with sudden cardiac death enhance coronary vasospastic activity through upregulation of Rho-kinase. Oi, K., Shimokawa, H., Hiroki, J., Uwatoku, T., Abe, K., Matsumoto, Y., Nakajima, Y., Nakajima, K., Takeichi, S., Takeshita, A. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
  13. Statins prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway. Kozai, T., Eto, M., Yang, Z., Shimokawa, H., Lüscher, T.F. Cardiovasc. Res. (2005) [Pubmed]
  14. Essential role of rho kinase in the Ca2+ sensitization of prostaglandin F(2alpha)-induced contraction of rabbit aortae. Ito, K., Shimomura, E., Iwanaga, T., Shiraishi, M., Shindo, K., Nakamura, J., Nagumo, H., Seto, M., Sasaki, Y., Takuwa, Y. J. Physiol. (Lond.) (2003) [Pubmed]
  15. Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. Wolfrum, S., Dendorfer, A., Rikitake, Y., Stalker, T.J., Gong, Y., Scalia, R., Dominiak, P., Liao, J.K. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
  16. Evidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm. Kandabashi, T., Shimokawa, H., Miyata, K., Kunihiro, I., Eto, Y., Morishige, K., Matsumoto, Y., Obara, K., Nakayama, K., Takahashi, S., Takeshita, A. Arterioscler. Thromb. Vasc. Biol. (2003) [Pubmed]
  17. The involvement of the rho-kinase pathway and its regulation in cytokine-induced collagen gel contraction by hyalocytes. Hirayama, K., Hata, Y., Noda, Y., Miura, M., Yamanaka, I., Shimokawa, H., Ishibashi, T. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  18. Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts. Ohnaka, K., Shimoda, S., Nawata, H., Shimokawa, H., Kaibuchi, K., Iwamoto, Y., Takayanagi, R. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  19. Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits. Furuyama, T., Komori, K., Shimokawa, H., Matsumoto, Y., Uwatoku, T., Hirano, K., Maehara, Y. J. Vasc. Surg. (2006) [Pubmed]
  20. Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice. Hattori, T., Shimokawa, H., Higashi, M., Hiroki, J., Mukai, Y., Kaibuchi, K., Takeshita, A. Circ. Res. (2004) [Pubmed]
 
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