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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

dtpa(5-)     2-[2-[2- (bis(carboxylatomethyl)amino) ethyl...

Synonyms: CHEBI:35745, CTK0H9309, AC1MO30W, 14047-41-7, QPCDCPDFJACHGM-UHFFFAOYSA-, ...
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Disease relevance of Detapac


High impact information on Detapac


Biological context of Detapac

  • We also demonstrate exchange of iron between DTPA and holo-transferrin, or at least movement from the chelator to the protein, which may have lost its iron to the cell in advance, providing new binding sites for mobilized iron [6].
  • Ventilation tomography after inhalation of 30 MBq (99m)Tc-diethylenetriaminepentaacetate (DTPA) aerosol was, without patient movement, followed by perfusion tomography after an intravenous injection of 100 MBq (99m)Tc-labeled macroaggregated albumin (MAA) [7].
  • Using 99Tcm-diethylenetriaminepentaacetate (DTPA) an acceptable estimate of glomerular filtration rate (GFR) can be obtained in adult patients by the equation GF (ml/min) = (0.14 x W + 5) x 1000 x k, where W is the 'ideal' body mass (kg) and k the slope determined by two plasma samples [8].
  • A technique for estimating fractional renal blood flow (RBF) from the early part of the 99Tcm-diethylenetriaminepentaacetate (DTPA) renogram has been described previously and its reproducibility validated in the pig model [9].

Anatomical context of Detapac

  • DESIGN: Endothelial cells were maintained in low-serum medium or grown in culture media containing selected chelators, ie, diethylenetriaminepentaacetate or N,N,N', N'-tetrakis(2-pyridylmethyl)-ethylenediamine (TPEN), with or without zinc supplementation [10].
  • It has been generally assumed that clearance of solute follows a simple first-order process and that DTPA clearance through the respiratory epithelium and into blood and lymphatic channels is complete within a few hours [11].
  • Gel chromatographic studies of the distribution of Cd among the proteins of the liver cytosol in treated and untreated animals indicate that neither DTPA nor Puchel was able to release Cd from the metallothionein complex [12].
  • This finding deserves attention since it is generally believed that DTPA is not indicated for early treatment, i.e. while the toxic metals or radionuclides are still in the gastrointestinal tract [13].
  • Liposomes containing diethylenetriaminepentaacetate daunorubicin conjugate (maximum emission wavelength: 590 nm) allow the discrimination of phagocytes and non-phagocytic cells [14].

Associations of Detapac with other chemical compounds

  • The methyl esters of palmitic, nitrilotriacetic, and ethylenediaminetetraacetic acids are first separated from diethylenetriaminepentaacetate by silicic acid column chromatography and are subsequently quantitated by gas-liquid chromatography [15].
  • The whole body retention determined on the second, fourth, and sixth days of the experiment showed that DTPA greatly decreased cadmium retention in all age groups being about four times more effective in older than younger animals [16].
  • In the presence of physiological concentrations of phosphate and bicarbonate in cell culture medium, Eu was precipitated from most complexes (at 1:2 and 1:5 Eu:ligand ratio) except DTPA and albumin [17].
  • 115mCd was administered intraperitoneally, followed immediately and after 24 hr by an intraperitoneal injection of trisodium calcium diethylenetriaminepentaacetate (DTPA) (600 mumole/kg body wt) [16].
  • The purpose of the present investigation was to evaluate 99Tcm-labelled alpha-D-glucose 1-phosphate (GP) aerosols for single photon emission computed tomographic (SPECT) ventilation lung imaging in comparison to 99Tcm-diethylenetriaminepentaacetate (DTPA) aerosols [18].

Gene context of Detapac

  • 99mTc-labeled diethylenetriaminepentaacetate (DPTA) and 125I-labeled bovine serum albumin (BSA) were selectively instilled into localized airway regions of anesthetized rats exposed to 0.8 ppm 03 or clean air for 2 h [19].
  • Co-incubation with the metal chelator diethylenetriaminepentaacetate inhibited these losses, whilst minimal inhibition was seen with superoxide dismutase and catalase treatment [20].

Analytical, diagnostic and therapeutic context of Detapac


  1. Does technetium-99m diethylenetriaminepentaacetate clearance predict the clinical course of idiopathic pulmonary fibrosis? Mura, M., Belmonte, G., Fanti, S., Pacilli, A.M., Fasano, L., Zompatori, M., Schiavina, M., Fabbri, M. Can. Respir. J. (2004) [Pubmed]
  2. Comparative antidotal effects of diethyldithiocarbamate, dimercaptosuccinate, and diethylenetriaminepentaacetate against cadmium-induced testicular toxicity in mice. Walker, E.M., Gale, G.R., Fody, E.P., Atkins, L.M., Smith, A.B., Jones, M.M. Res. Commun. Chem. Pathol. Pharmacol. (1986) [Pubmed]
  3. Chelation therapy of incorporated plutonium-238 and americium-241: comparison of LICAM(C), DTPA and DFOA in rats, hamsters and mice. Volf, V. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. (1986) [Pubmed]
  4. Quantitative measurement of regional blood flow with gadolinium diethylenetriaminepentaacetate bolus track NMR imaging in cerebral infarcts in rats: validation with the iodo[14C]antipyrine technique. Wittlich, F., Kohno, K., Mies, G., Norris, D.G., Hoehn-Berlage, M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  5. The susceptibility of tumors to the antivascular drug combretastatin A4 phosphate correlates with vascular permeability. Beauregard, D.A., Hill, S.A., Chaplin, D.J., Brindle, K.M. Cancer Res. (2001) [Pubmed]
  6. The surface of rat hepatocytes can transfer iron from stable chelates to external acceptors. Scheiber, B., Goldenberg, H. Hepatology (1998) [Pubmed]
  7. Comprehensive ventilation/perfusion SPECT. Palmer, J., Bitzén, U., Jonson, B., Bajc, M. J. Nucl. Med. (2001) [Pubmed]
  8. A simplified determination of glomerular filtration rate with 99Tcm-DTPA. Galli, G., Rufini, V., Meduri, G. Nuclear medicine communications. (1994) [Pubmed]
  9. 99Tcm-DMSA as a dynamic imaging agent for estimating renal blood flow. A comparison with 99Tcm-DTPA. Bunce, C.J., Godley, M.L., Snell, M.E. Nuclear medicine communications. (1994) [Pubmed]
  10. Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. Meerarani, P., Ramadass, P., Toborek, M., Bauer, H.C., Bauer, H., Hennig, B. Am. J. Clin. Nutr. (2000) [Pubmed]
  11. Retention of soluble 99mTc-DTPA in the human lung: 24-h postdeposition. Foster, W.M., Stetkiewicz, P.T., Freed, A.N. J. Appl. Physiol. (1997) [Pubmed]
  12. Influence of chelating agents on the distribution and excretion of cadmium in rats. Planas-Bohne, F., Lehmann, M. Toxicol. Appl. Pharmacol. (1983) [Pubmed]
  13. Oral Zn-DTPA treatment reduces cadmium absorption and retention in rats. Kostial, K., Kargacin, B., Landeka, M. Toxicol. Lett. (1987) [Pubmed]
  14. Identification of two macrophage populations by flow cytometry monitoring of oxidative burst and phagocytic functions. Lepoivre, M., Roche, A.C., Tenu, J.P., Petit, J.F., Nolibe, D., Monsigny, M. Biol. Cell (1986) [Pubmed]
  15. Quantitative chromatographic method for the determination of low levels of nitrilotriacetic and ethylenediaminetetraacetic acids in diethylenetriaminepentaacetic acid. Blank, M.L., Snyder, F. J. Chromatogr. (1979) [Pubmed]
  16. Lower efficiency of DTPA in reducing cadmium retention in suckling rats. Kostial, K., Kargacin, B., Blanusa, M., Landeka, M. Environmental research. (1984) [Pubmed]
  17. Binding of lanthanides to cell membranes in the presence of ligands. Bingham, D., Dobrota, M. J. Inorg. Biochem. (1995) [Pubmed]
  18. Evaluation of 99Tcm-labelled alpha-D-glucose 1-phosphate aerosols for SPECT ventilation lung imaging. Ercan, M.T., Ulutunçel, N., Naldöken, S. Nuclear medicine communications. (1993) [Pubmed]
  19. Relative permeability of nasal, tracheal, and bronchoalveolar mucosa to macromolecules in rats exposed to ozone. Bhalla, D.K., Mannix, R.C., Kleinman, M.T., Crocker, T.T. Journal of toxicology and environmental health. (1986) [Pubmed]
  20. Combustion of dried animal dung as biofuel results in the generation of highly redox active fine particulates. Mudway, I.S., Duggan, S.T., Venkataraman, C., Habib, G., Kelly, F.J., Grigg, J. Particle and fibre toxicology [electronic resource]. (2005) [Pubmed]
  21. A novel view of pH titration in biomolecules. Onufriev, A., Case, D.A., Ullmann, G.M. Biochemistry (2001) [Pubmed]
  22. 99mTc-DTPA gamma-camera renography: normal values and rapid determination of single-kidney glomerular filtration rate. Rehling, M., Møller, M.L., Lund, J.O., Jensen, K.B., Thamdrup, B., Trap-Jensen, J. European journal of nuclear medicine. (1985) [Pubmed]
  23. Scintigraphic patterns of lymphocele in post-renal transplant. Kumar, R., Bharathi Dasan, J., Choudhury, S., Guleria, S., Padhy, A.K., Malhotra, A. Nuclear medicine communications. (2003) [Pubmed]
  24. Biological effects of the enhanced excretion of zinc after calcium diethylenetriaminepentaacetate chelation therapy. Cohen, N., Guilmette, R. Bioinorganic chemistry. (1976) [Pubmed]
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