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Chemical Compound Review

2-Chlorethanol     2-chloroethanol

Synonyms: Chloroalcohol, Chloroethanol, CCRIS 859, AGN-PC-00KE4A, CHEMBL191244, ...
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Disease relevance of Ethylene chlorohydrin


High impact information on Ethylene chlorohydrin

  • Lipophilin dissolved in 2-chloroethanol is, compared to the protein in a lipid environment, richer in the alpha-helical conformation but still contains a sizable amount of beta-structure [6].
  • The [ Phe1 ] analogue although less soluble behaved similarly to native glucagon, while the [ Ala1 ] and [des- His1 ] derivatives exhibited an increased helical content in 0.01 N HCl as a result of an increased propensity of these derivatives to self-associate in the absence of 2-chloroethanol [7].
  • Sulfhydryl assays on whole myelin in 2-chloroethanol indicated that the occurrence of -SH groups in the proteolipid component was at least as high as in the purified apoprotein [8].
  • From FTIR spectroscopy, it is found that, when reconstituted into membranes by dialysis from 2-chloroethanol, the peptide has a predominantly beta-strand secondary structure in which the peptide backbone is oriented at an angle of approximately 56 degrees relative to the membrane normal in dry films of phosphatidylcholines [9].
  • The possibility that on treatment buried thiol groups became exposed was essentially excluded because (1) similar results were obtained in 2-chloroethanol, a solvent in which acylated and deacylated PLP have the same conformation, and (2) small PLP peptides were labeled only in the presence of hydroxylamine [10].

Chemical compound and disease context of Ethylene chlorohydrin


Biological context of Ethylene chlorohydrin


Anatomical context of Ethylene chlorohydrin


Associations of Ethylene chlorohydrin with other chemical compounds


Gene context of Ethylene chlorohydrin

  • Phospholipids did not dissociate from opsin even in 80% 2-chloroethanol [27].
  • Cattle and squid opsins were found to be associated with phospholipids after extensive dialysis of the salt-free digitonin extract of rhodopsin against 30% aqueous 2-chloroethanol (v/v) at pH 2 [27].
  • The S-carboxymethyl derivative lacks the concentration-dependent aggregation characteristic of glucagon at pH 10.2 as does the S-methyl derivative but increases its helical content in 30% 2-chloroethanol to the same extent as native and S-methyl hormone [28].

Analytical, diagnostic and therapeutic context of Ethylene chlorohydrin


  1. Crystallographic and fluorescence studies of the interaction of haloalkane dehalogenase with halide ions. Studies with halide compounds reveal a halide binding site in the active site. Verschueren, K.H., Kingma, J., Rozeboom, H.J., Kalk, K.H., Janssen, D.B., Dijkstra, B.W. Biochemistry (1993) [Pubmed]
  2. Influence of organic nutrients and cocultures on the competitive behavior of 1,2-dichloroethane-degrading bacteria. van den Wijngaard, A.J., van der Kleij, R.G., Doornweerd, R.E., Janssen, D.B. Appl. Environ. Microbiol. (1993) [Pubmed]
  3. Genetic adaptation of bacteria to halogenated aliphatic compounds. Janssen, D.B., van der Ploeg, J.R., Pries, F. Environ. Health Perspect. (1995) [Pubmed]
  4. Studies on the structure of filamentous bacteriophage fd. III. A stable intermediate of the 2-chloroethanol-induced disassembly. Ikehara, K., Utiyama, H. Virology (1975) [Pubmed]
  5. Mechanistic relationship among mutagenicity, skin sensitization, and skin carcinogenicity. Ashby, J., Hilton, J., Dearman, R.J., Callander, R.D., Kimber, I. Environ. Health Perspect. (1993) [Pubmed]
  6. Secondary structure of the hydrophobic myelin protein in a lipid environment as determined by Fourier-transform infrared spectrometry. Surewicz, W.K., Moscarello, M.A., Mantsch, H.H. J. Biol. Chem. (1987) [Pubmed]
  7. Semisynthetic derivatives of glucagon. The contribution of histidine-1 to hormone conformation and activity. Flanders, K.C., Horwitz, E.M., Gurd, R.S. J. Biol. Chem. (1984) [Pubmed]
  8. Nature of the cysteinyl residues in lipophilin from human myelin. Cockle, S.A., Epand, R.M., Stollery, J.G., Moscarello, M.A. J. Biol. Chem. (1980) [Pubmed]
  9. Peptides modeled on the transmembrane region of the slow voltage-gated IsK potassium channel: structural characterization of peptide assemblies in the beta-strand conformation. Aggeli, A., Boden, N., Cheng, Y.L., Findlay, J.B., Knowles, P.F., Kovatchev, P., Turnbull, P.J. Biochemistry (1996) [Pubmed]
  10. Myelin proteolipid protein contains thioester-linked fatty acids. Bizzozero, O.A., Good, L.K. J. Neurochem. (1990) [Pubmed]
  11. Commensal interactions in a dual-species biofilm exposed to mixed organic compounds. Cowan, S.E., Gilbert, E., Liepmann, D., Keasling, J.D. Appl. Environ. Microbiol. (2000) [Pubmed]
  12. The use of suicide substrates to select mutants of Escherichia coli lacking enzymes of alcohol fermentation. Cunningham, P.R., Clark, D.P. Mol. Gen. Genet. (1986) [Pubmed]
  13. Adaptation of Pseudomonas sp. GJ1 to 2-bromoethanol caused by overexpression of an NAD-dependent aldehyde dehydrogenase with low affinity for halogenated aldehydes. Van der Ploeg, J.R., Kingma, J., De Vries, E.J., Van der Ven, J.G., Janssen, D.B. Arch. Microbiol. (1996) [Pubmed]
  14. Phase I pharmacokinetics study of high-dose fotemustine and its metabolite 2-chloroethanol in patients with high-grade gliomas. Tranchand, B., Lucas, C., Biron, P., Giroux, B., Gordon, B., Richards, R., Solere, P., Roux, N., Evene, E., Mornex, F. Cancer Chemother. Pharmacol. (1993) [Pubmed]
  15. Acute ethylene chlorohydrin poisoning: experience of a poison control center. Deng, J.F., Yang, C.C., Tsai, W.J., Ger, J., Wu, M.L. J. Toxicol. Clin. Toxicol. (2001) [Pubmed]
  16. Cholesterol ester hydrolase mediated conjugation of haloethanols with fatty acids. Bhat, H.K., Ansari, G.A. Chem. Res. Toxicol. (1990) [Pubmed]
  17. Toxicokinetics of chloroethanol in the rat after single oral administration. Grunow, W., Altmann, H.J. Arch. Toxicol. (1982) [Pubmed]
  18. 2-chloroethyl fatty acid esters as indicators of 2-chloroethanol in black walnuts, seasoning mixes, and spices. Yurawecz, M.P. Journal - Association of Official Analytical Chemists. (1987) [Pubmed]
  19. Characterization of the immunoprotective antigen of ribosomal preparations from Haemophilus influenzae. Tewari, R.P., Lynn, M., Birnbaum, A.J., Solotorovsky, M. Infect. Immun. (1978) [Pubmed]
  20. Specific labeling of glycoproteins in yeast plasma membrane with concanavalin A. Maurer, A., Mühlethaler, K. Eur. J. Cell Biol. (1981) [Pubmed]
  21. A 13C nuclear magnetic resonance study of histone H1 in 2-chloroethanol and aqueous solutions. Identification of peaks characteristic of secondary folding. Saitô, H., Kameyama, M., Kodama, M., Nagata, C. J. Biochem. (1982) [Pubmed]
  22. Rat liver microsomal palmitoyl-CoA synthetase: subunit structure. Maes, E., Bar-Tana, J. Biochim. Biophys. Acta (1977) [Pubmed]
  23. Effects of pH during recombination of human erythrocyte membrane apoprotein and lipid. Wehrli, E., Moser, S., Zahler, P. Biochim. Biophys. Acta (1976) [Pubmed]
  24. Chemistry of nitrosoureas. Intermediacy of 4,5-dihydro-1,2,3-oxadiazole in 1,3-bis(2-chloroethyl)-1-nitrosourea decomposition. Brundrett, R.B. J. Med. Chem. (1980) [Pubmed]
  25. Mediation of hypersensitivity reactions during hemodialysis by IgE antibodies against ethylene oxide. Lemke, H.D. Artificial organs. (1987) [Pubmed]
  26. Recombinant models of lipoproteins. Apolipoprotein A-I/phosphatidylcholine/cholesterol complexes formed in a 2-chloroethanol-water mixture. Antonov, I.V., Medvedeva, N.V., Misharin AJu, n.u.l.l., Morozkin, A.D., Ruuge, E.K. Biochim. Biophys. Acta (1985) [Pubmed]
  27. Properties of opsin-lipid complex in aqueous 2-chloroethanol. Ikai, A. J. Biochem. (1977) [Pubmed]
  28. Structure-function relationships of S-carboxymethyl methionine27 glucagon. Cornely, K.A., Shelter, K.A., England, R.D., Horwitz, E.M., Gurd, R.S. Arch. Biochem. Biophys. (1985) [Pubmed]
  29. Investigations on metabolism and carcinogenicity of 1,1,2-trichloroethane. Norpoth, K., Heger, M., Müller, G., Mohtashamipur, E., Kemena, A., Witting, C. J. Cancer Res. Clin. Oncol. (1988) [Pubmed]
  30. Characterization and purification of a mycoplasma membrane-derived macrophage-activating factor. Caplan, S., Gallily, R., Barenholz, Y. Cancer Immunol. Immunother. (1994) [Pubmed]
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