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Chemical Compound Review

DETOMIDINE     4-[(2,3- dimethylphenyl)methyl]-3H- imidazole

Synonyms: Detomidina, Detomidinum, SureCN247340, SureCN2626815, AC1Q4WOG, ...
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Disease relevance of DETOMIDINE

  • The functional alpha2-adrenoceptor antagonistic effect of MPV-1743 A III was demonstrated by studying the ability of orally administered MPV-1743 A III to reverse and prevent the alpha2-adrenoceptor agonist detomidine-induced mydriasis in rat [1].
  • Prazosin somewhat inhibited but did not eliminate the hyperthermia seen with the very high doses of detomidine [2].
  • Bradycardia (heart rate < 145 beats/min) was detected at each evaluation time in cats treated orally with detomidine and ketamine and in all cats treated i.m. Minimal differences among groups were detected for heart and respiratory rates, rectal temperature, and hemoglobin oxygen saturation [3].
  • The BIS was calculated before (awake) and after (sedated) administration of detomidine (0.01 mg/kg of body weight, IV) and butorphanol (0.01 mg/kg, IV) [4].
  • Results indicate that use of detomidine for CEA and CSA in mares probably induces local spinal and CNS effects, marked sedation, moderate ataxia, mild cardiopulmonary depression, and renal diuresis [5].

Psychiatry related information on DETOMIDINE

  • Development and characterization of an equine behaviour chamber and the effects of amitraz and detomidine on spontaneous locomotor activity [6].
  • Detomidine was a good analgesic in control animals; their pain thresholds were significantly elevated for about 60 minutes [7].
  • Several alpha-2 adrenoceptor agonists reduce wakefulness and inhibit paradoxical sleep, whereas novel imidazoline derivatives, such as detomidine, display sedative and analgesic properties which have been related to the activation of central alpha-2 adrenoceptors [8].

High impact information on DETOMIDINE


Chemical compound and disease context of DETOMIDINE


Biological context of DETOMIDINE


Anatomical context of DETOMIDINE


Associations of DETOMIDINE with other chemical compounds


Gene context of DETOMIDINE


Analytical, diagnostic and therapeutic context of DETOMIDINE

  • Evaluation of detomidine-induced analgesia in horses with chronic hoof pain [29].
  • Detomidine produced a dose-dependent increase in HCT and a decrease in the subjective grade of hoof withdrawal response through 55 min after treatment [29].
  • Slow injection (particularly of the low dose rates) and premedication with detomidine resulted in a longer time to collapse (median 46 seconds) [30].
  • Radioimmunoassay of detomidine, a new benzylimidazole drug with analgesic sedation properties [28].
  • METHODS: Six healthy, mature horses were sedated with an i.v. bolus of detomidine (0.02 mg/kg bwt) and butorphanol (0.02 mg/kg bwt) and instrumented to determine the changes in cardiopulmonary function, haematology, serum chemistry and PF values during and after pneumoperitoneum with CO2 to 15 mmHg pressure for standing laparoscopy [31].


  1. Anti-obesity effect of MPV-1743 A III, a novel imidazoline derivative, in genetic obesity. Savontaus, E., Raasmaja, A., Rouru, J., Koulu, M., Pesonen, U., Virtanen, R., Savola, J.M., Huupponen, R. Eur. J. Pharmacol. (1997) [Pubmed]
  2. Comparison of the effects of detomidine and xylazine on some alpha 2-adrenoceptor-mediated responses in the central and peripheral nervous systems. Virtanen, R., MacDonald, E. Eur. J. Pharmacol. (1985) [Pubmed]
  3. Sedative and physiologic effects of orally administered alpha 2-adrenoceptor agonists and ketamine in cats. Grove, D.M., Ramsay, E.C. J. Am. Vet. Med. Assoc. (2000) [Pubmed]
  4. Evaluation of the bispectral index as an indicator of degree of central nervous system depression in isoflurane-anesthetized horses. Haga, H.A., Dolvik, N.I. Am. J. Vet. Res. (2002) [Pubmed]
  5. Caudal analgesia induced by epidural or subarachnoid administration of detomidine hydrochloride solution in mares. Skarda, R.T., Muir, W.W. Am. J. Vet. Res. (1994) [Pubmed]
  6. Development and characterization of an equine behaviour chamber and the effects of amitraz and detomidine on spontaneous locomotor activity. Harkins, J.D., Queiroz-Neto, A., Mundy, G.D., West, D., Tobin, T. J. Vet. Pharmacol. Ther. (1997) [Pubmed]
  7. Analgesic effects of detomidine in thoroughbred horses with chronic tendon injury. Chambers, J.P., Livingston, A., Waterman, A.E., Goodship, A.E. Res. Vet. Sci. (1993) [Pubmed]
  8. Central alpha-2 adrenoceptors regulate central and peripheral functions. Fornai, F., Blandizzi, C., del Tacca, M. Pharmacol. Res. (1990) [Pubmed]
  9. Depression of NMDA receptor-mediated synaptic transmission by four alpha2 adrenoceptor agonists on the in vitro rat spinal cord preparation. Faber, E.S., Chambers, J.P., Evans, R.H. Br. J. Pharmacol. (1998) [Pubmed]
  10. Analysis of detomidine in horse blood, plasma and urine samples utilizing a sensitive gas chromatography-mass spectrometry method. Singh, A.K., Mishra, U., Ashraf, M., Abdennebi, E.H., Granley, K., Dombrovskis, D., Hewetson, D., Stowe, C.M. J. Chromatogr. (1987) [Pubmed]
  11. Cardiovascular action of detomidine, a sedative and analgesic imidazole derivative with alpha-agonistic properties. Savola, J.M., Ruskoaho, H., Puurunen, J., Kärki, N.T. Eur. J. Pharmacol. (1985) [Pubmed]
  12. Continuous alpha 2-adrenoceptor blockade by atipamezole decreases neocortical high-voltage spindle activity in rats. Jäkälä, P., Viitamaa, T., Sirviö, J., Riekkinen, P., Salonen, J., Haapalinna, A., Virtanen, R., Riekkinen, P. Eur. J. Pharmacol. (1992) [Pubmed]
  13. Cardiorespiratory and metabolic effects of xylazine, detomidine, and a combination of xylazine and acepromazine administered after exercise in horses. Hubbell, J.A., Hinchcliff, K.W., Schmall, L.M., Muir, W.W., Robertson, J.T., Sams, R.A. Am. J. Vet. Res. (1999) [Pubmed]
  14. Comparison of detomidine and romifidine as premedicants before ketamine and halothane anesthesia in horses undergoing elective surgery. Taylor, P.M., Bennett, R.C., Brearley, J.C., Luna, S.P., Johnson, C.B. Am. J. Vet. Res. (2001) [Pubmed]
  15. Effects of alpha-adrenoceptor antagonists on the mydriatic and bradycardic effects of detomidine. Hanson, C.E., Hsu, W.H. Archives internationales de pharmacodynamie et de thérapie. (1987) [Pubmed]
  16. The influence of detomidine and epinephrine on heart rate, arterial blood pressure, and cardiac arrhythmia in horses. Raekallio, M., Vainio, O., Karjalainen, J. Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons. (1991) [Pubmed]
  17. Some effects of multiple administration of detomidine during the last trimester of equine pregnancy. Luukkanen, L., Katila, T., Koskinen, E. Equine Vet. J. (1997) [Pubmed]
  18. Pleuropulmonary and cardiovascular consequences of thoracoscopy performed in healthy standing horses. Peroni, J.F., Robinson, N.E., Stick, J.A., Derksen, F.J. Equine Vet. J. (2000) [Pubmed]
  19. The effect of detomidine (Domosedan) on the maintenance of equine pregnancy and foetal development: ten cases. Katila, T., Oijala, M. Equine Vet. J. (1988) [Pubmed]
  20. Influence of detomidine and buprenorphine on motor-evoked potentials in horses. Nollet, H., Van Ham, L., Gasthuys, F., Dewulf, J., Vanderstraeten, G., Deprez, P. Vet. Rec. (2003) [Pubmed]
  21. Evaluation of the alpha 1- and alpha 2-adrenoceptor effects of detomidine, a novel veterinary sedative analgesic. Virtanen, R., Nyman, L. Eur. J. Pharmacol. (1985) [Pubmed]
  22. Alpha 2-adrenoceptor-mediated inhibitory and excitatory effects of detomidine on rat gastric acid secretion. Blandizzi, C., Bernardini, M.C., Natale, G., del Tacca, M. J. Pharm. Pharmacol. (1990) [Pubmed]
  23. In vitro effects of oxytocin, acepromazine, detomidine, xylazine, butorphanol, terbutaline, isoproterenol, and dantrolene on smooth and skeletal muscles of the equine esophagus. Wooldridge, A.A., Eades, S.C., Hosgood, G.L., Moore, R.M. Am. J. Vet. Res. (2002) [Pubmed]
  24. Effects of an alveolar recruitment maneuver on cardiovascular and respiratory parameters during total intravenous anesthesia in ponies. Wettstein, D., Moens, Y., Jaeggin-Schmucker, N., Böhm, S.H., Rothen, H.U., Mosing, M., Kästner, S.B., Schatzmann, U. Am. J. Vet. Res. (2006) [Pubmed]
  25. Reversal of sedative and clinicophysiological effects of epidural xylazine and detomidine with atipamezole and yohimbine in buffaloes (Bubalus bubalis). Tiwari, S.K., Kumar, A., Vainio, O. Vet. Rec. (1998) [Pubmed]
  26. Comparison of intraoperative pain responses following intratesticular or mesorchial injection of lidocaine in standing horses undergoing laparoscopic cryptorchidectomy. Joyce, J., Hendrickson, D.A. J. Am. Vet. Med. Assoc. (2006) [Pubmed]
  27. Sedative and analgesic effects of detomidine and romifidine in horses. Hamm, D., Turchi, P., Jöchle, W. Vet. Rec. (1995) [Pubmed]
  28. Radioimmunoassay of detomidine, a new benzylimidazole drug with analgesic sedation properties. Vakkuri, O., Salonen, J.S., Leppäluoto, J., Anttila, M., Karjalainen, A., Järvensivu, P. Life Sci. (1987) [Pubmed]
  29. Evaluation of detomidine-induced analgesia in horses with chronic hoof pain. Owens, H.G., Kamerling, S.G., Stanton, S.R., Keowen, M.L. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  30. Humane destruction of horses with a mixture of quinalbarbitone and cinchocaine. Knottenbelt, D.C., Jones, R.S., Brazil, T.J., Proudman, C.J., Edwards, S.R., Harrison, L.J. Vet. Rec. (1994) [Pubmed]
  31. Cardiopulmonary, blood and peritoneal fluid alterations associated with abdominal insufflation of carbon dioxide in standing horses. Latimer, F.G., Eades, S.C., Pettifer, G., Tetens, J., Hosgood, G., Moore, R.M. Equine Vet. J. (2003) [Pubmed]
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