Gene Review:
KCNMA1 - potassium channel, calcium activated large...
Homo sapiens
Synonyms:
BK channel, BKCA alpha, BKTM, Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel, subfamily M subunit alpha-1, ...
Garcia,
Liebmann,
Wilhelmsen,
Weiger,
Rossi,
Mann,
Bahamonde,
Patt,
Rojas,
Orio,
Tavalin,
Wake,
ten Kate,
Gao,
Blankenstein,
Feiler,
Vázquez,
Bourget-Ponzio,
Schuckit,
van Dijk,
Westerman,
Sentí,
Toro,
Vergara,
Jin,
Leegwater,
Oudejans,
Jung,
Latorre,
Pals,
Rezzonico,
Kraft,
Loubat,
Fernández-Fernández,
Levitan,
Marrugat,
Matsuda,
Smith,
Kalmijn,
Lachmeijer,
Valverde,
Rocchi,
Cosmelli,
Marrion,
Kato,
Lange,
Belhacene,
Mulders,
Bolz,
Lind,
Romey,
van Wijk,
Dekker,
Könst,
Krause,
Schmid-Antomarchi,
Tomás,
Cayatte,
Meera,
Amigo,
Girault,
Basrai,
Elosua,
Van Obberghen,
Valverde,
Wallner,
- Focal adhesion kinase pp125FAK interacts with the large conductance calcium-activated hSlo potassium channel in human osteoblasts: potential role in mechanotransduction. Rezzonico, R., Cayatte, C., Bourget-Ponzio, I., Romey, G., Belhacene, N., Loubat, A., Rocchi, S., Van Obberghen, E., Girault, J.A., Rossi, B., Schmid-Antomarchi, H. J. Bone Miner. Res. (2003)
- Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder. Du, W., Bautista, J.F., Yang, H., Diez-Sampedro, A., You, S.A., Wang, L., Kotagal, P., Lüders, H.O., Shi, J., Cui, J., Richerson, G.B., Wang, Q.K. Nat. Genet. (2005)
- Hypoxia inhibits human recombinant large conductance, Ca(2+)-activated K(+) (maxi-K) channels by a mechanism which is membrane delimited and Ca(2+) sensitive. Lewis, A., Peers, C., Ashford, M.L., Kemp, P.J. J. Physiol. (Lond.) (2002)
- Cloning and characterization of glioma BK, a novel BK channel isoform highly expressed in human glioma cells. Liu, X., Chang, Y., Reinhart, P.H., Sontheimer, H., Chang, Y. J. Neurosci. (2002)
- Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk. Sentí, M., Fernández-Fernández, J.M., Tomás, M., Vázquez, E., Elosua, R., Marrugat, J., Valverde, M.A. Circ. Res. (2005)
- KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer. Bloch, M., Ousingsawat, J., Simon, R., Schraml, P., Gasser, T.C., Mihatsch, M.J., Kunzelmann, K., Bubendorf, L. Oncogene (2007)
- Biochemical variants of Smith-Lemli-Opitz syndrome. Neklason, D.W., Andrews, K.M., Kelley, R.I., Metherall, J.E. Am. J. Med. Genet. (1999)
- The first human trial for gene transfer therapy for the treatment of erectile dysfunction: preliminary results. Melman, A., Bar-Chama, N., McCullough, A., Davies, K., Christ, G. Eur. Urol. (2005)
- Selective activation of Ca2+-activated K+ channels by co-localized Ca2+ channels in hippocampal neurons. Marrion, N.V., Tavalin, S.J. Nature (1998)
- Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation. White, R.E., Lee, A.B., Shcherbatko, A.D., Lincoln, T.M., Schonbrunn, A., Armstrong, D.L. Nature (1993)
- Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit. Valverde, M.A., Rojas, P., Amigo, J., Cosmelli, D., Orio, P., Bahamonde, M.I., Mann, G.E., Vergara, C., Latorre, R. Science (1999)
- Prostaglandin E2 induces interaction between hSlo potassium channel and Syk tyrosine kinase in osteosarcoma cells. Rezzonico, R., Schmid-Alliana, A., Romey, G., Bourget-Ponzio, I., Breuil, V., Breittmayer, V., Tartare-Deckert, S., Rossi, B., Schmid-Antomarchi, H. J. Bone Miner. Res. (2002)
- Effects of nitric oxide on expressions of nitrosocysteine and calcium-activated potassium channels in the supraoptic nuclei and neural lobe of dehydrated rats. Kadekaro, M., Su, G., Chu, R., Lei, Y., Li, J., Fang, L. Neurosci. Lett. (2007)
- BK channel openers inhibit migration of human glioma cells. Kraft, R., Krause, P., Jung, S., Basrai, D., Liebmann, L., Bolz, J., Patt, S. Pflugers Arch. (2003)
- Interacting effects of N-terminal variation and strex exon splicing on slo potassium channel regulation by calcium, phosphorylation, and oxidation. Erxleben, C., Everhart, A.L., Romeo, C., Florance, H., Bauer, M.B., Alcorta, D.A., Rossie, S., Shipston, M.J., Armstrong, D.L. J. Biol. Chem. (2002)
- Diversity of Ca(2+)-activated K(+) channel transcripts in inner ear hair cells. Beisel, K.W., Rocha-Sanchez, S.M., Ziegenbein, S.J., Morris, K.A., Kai, C., Kawai, J., Carninci, P., Hayashizaki, Y., Davis, R.L. Gene (2007)
- Coupling of c-Src to large conductance voltage- and Ca2+-activated K+ channels as a new mechanism of agonist-induced vasoconstriction. Alioua, A., Mahajan, A., Nishimaru, K., Zarei, M.M., Stefani, E., Toro, L. Proc. Natl. Acad. Sci. U.S.A. (2002)
- The parent-of-origin effect of 10q22 in pre-eclamptic females coincides with two regions clustered for genes with down-regulated expression in androgenetic placentas. Oudejans, C.B., Mulders, J., Lachmeijer, A.M., van Dijk, M., Könst, A.A., Westerman, B.A., van Wijk, I.J., Leegwater, P.A., Kato, H.D., Matsuda, T., Wake, N., Dekker, G.A., Pals, G., ten Kate, L.P., Blankenstein, M.A. Mol. Hum. Reprod. (2004)
- Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current. Brainard, A.M., Miller, A.J., Martens, J.R., England, S.K. Am. J. Physiol., Cell Physiol. (2005)
- Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension. Fernández-Fernández, J.M., Tomás, M., Vázquez, E., Orio, P., Latorre, R., Sentí, M., Marrugat, J., Valverde, M.A. J. Clin. Invest. (2004)
- Caveolae targeting and regulation of large conductance Ca(2+)-activated K+ channels in vascular endothelial cells. Wang, X.L., Ye, D., Peterson, T.E., Cao, S., Shah, V.H., Katusic, Z.S., Sieck, G.C., Lee, H.C. J. Biol. Chem. (2005)
- Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels. Jin, P., Weiger, T.M., Levitan, I.B. J. Biol. Chem. (2002)
- Cilostazol enhances casein kinase 2 phosphorylation and suppresses tumor necrosis factor-alpha-induced increased phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and apoptotic cell death in SK-N-SH cells. Kim, K.Y., Shin, H.K., Lee, J.H., Kim, C.D., Lee, W.S., Rhim, B.Y., Shin, Y.W., Hong, K.W. J. Pharmacol. Exp. Ther. (2004)
- Anti-apoptotic action of (2S,3S,4R)-N"-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine (KR-31378) by suppression of the phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and increased phosphorylation of casein kinase2/Akt/ cyclic AMP response element binding protein via maxi-K channel opening in neuronal cells. Kim, K.Y., Lee, J.H., Park, J.H., Yoo, M.A., Kwak, Y.G., Kim, S.O., Yoo, S.E., Hong, K.W. Eur. J. Pharmacol. (2004)
- Cilostazol prevents remnant lipoprotein particle-induced monocyte adhesion to endothelial cells by suppression of adhesion molecules and monocyte chemoattractant protein-1 expression via lectin-like receptor for oxidized low-density lipoprotein receptor activation. Park, S.Y., Lee, J.H., Kim, Y.K., Kim, C.D., Rhim, B.Y., Lee, W.S., Hong, K.W. J. Pharmacol. Exp. Ther. (2005)
- Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: selectivity between voltage-gated and Maxi-K channels. Gao, Y.D., Garcia, M.L. Proteins (2003)
- Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog. Wallner, M., Meera, P., Toro, L. Proc. Natl. Acad. Sci. U.S.A. (1999)
- The role of membrane-bound LBP, endotoxin aggregates, and the MaxiK channel in LPS-induced cell activation. Müller, M., Scheel, O., Lindner, B., Gutsmann, T., Seydel, U. J. Endotoxin Res. (2003)
- Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages. Scheel, O., Papavlassopoulos, M., Blunck, R., Gebert, A., Hartung, T., Zähringer, U., Seydel, U., Schromm, A.B. Infect. Immun. (2006)
- 17-beta-estradiol activates maxi-K channels through a non-genomic pathway in human breast cancer cells. Coiret, G., Matifat, F., Hague, F., Ouadid-Ahidouch, H. FEBS Lett. (2005)
- Extracellular ATP induces oscillations of intracellular Ca2+ and membrane potential and promotes transcription of IL-6 in macrophages. Hanley, P.J., Musset, B., Renigunta, V., Limberg, S.H., Dalpke, A.H., Sus, R., Heeg, K.M., Preisig-Müller, R., Daut, J. Proc. Natl. Acad. Sci. U.S.A. (2004)
- hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family. Behrens, R., Nolting, A., Reimann, F., Schwarz, M., Waldschütz, R., Pongs, O. FEBS Lett. (2000)
- A novel MaxiK splice variant exhibits dominant-negative properties for surface expression. Zarei, M.M., Zhu, N., Alioua, A., Eghbali, M., Stefani, E., Toro, L. J. Biol. Chem. (2001)
- Autosomal linkage analysis for the level of response to alcohol. Schuckit, M.A., Wilhelmsen, K., Smith, T.L., Feiler, H.S., Lind, P., Lange, L.A., Kalmijn, J. Alcohol. Clin. Exp. Res. (2005)
- Daily rhythmicity of large-conductance Ca2+ -activated K+ currents in suprachiasmatic nucleus neurons. Pitts, G.R., Ohta, H., McMahon, D.G. Brain Res. (2006)
- Identification of a novel tetramerization domain in large conductance K(ca) channels. Quirk, J.C., Reinhart, P.H. Neuron (2001)
- Determinant for beta-subunit regulation in high-conductance voltage-activated and Ca(2+)-sensitive K+ channels: an additional transmembrane region at the N terminus. Wallner, M., Meera, P., Toro, L. Proc. Natl. Acad. Sci. U.S.A. (1996)