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Chemical Compound Review

Vectrine     2-[(2-oxothiolan-3- yl)carbamoylmethylsulfa...

Synonyms: Erdotin, Edirel, Erdosteine, Erdosteinum, Dithiosteine, ...
 
 
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Disease relevance of RV 144

 

High impact information on RV 144

 

Chemical compound and disease context of RV 144

 

Biological context of RV 144

 

Anatomical context of RV 144

 

Associations of RV 144 with other chemical compounds

 

Gene context of RV 144

  • The effects of NAC on apoptosis, the increases in the local production of TNF-alpha and VEGF, were weaker than the effects of erdosteine [12].
  • The erythrocyte catalase (CAT) activity of Dxr plus erdosteine group was higher than control and Dxr groups [22].
  • Erdosteine also reduced depletion in the tissue CAT, GSH-Px, and SOD activities [23].
  • On the other hand, administration of erdosteine to INH-treated group significantly increased NR2A receptors and decreased MDA production [24].
  • We aimed to investigate adverse effects of INH on rat hippocampal NMDAR receptors, and to elucidate whether erdosteine prevents possible adverse effects of INH [24].
 

Analytical, diagnostic and therapeutic context of RV 144

References

  1. Erdosteine. Dechant, K.L., Noble, S. Drugs (1996) [Pubmed]
  2. Appropriate use of antitussives and protussives. A practical review. Irwin, R.S., Curley, F.J., Bennett, F.M. Drugs (1993) [Pubmed]
  3. Effects of aminoguanidine and antioxidant erdosteine on bleomycin-induced lung fibrosis in rats. Yildirim, Z., Turkoz, Y., Kotuk, M., Armutcu, F., Gurel, A., Iraz, M., Ozen, S., Aydogdu, I., Akyol, O. Nitric Oxide (2004) [Pubmed]
  4. Comparison of the effects of erdosteine and N-acetylcysteine on apoptosis regulation in endotoxin-induced acute lung injury. Demiralay, R., Gürsan, N., Ozbilim, G., Erdogan, G., Demirci, E. Journal of applied toxicology : JAT. (2006) [Pubmed]
  5. Influence of erdosteine, a mucolytic agent, on amoxycillin penetration into sputum in patients with an infective exacerbation of chronic bronchitis. Ricevuti, G., Mazzone, A., Uccelli, E., Gazzani, G., Fregnan, G.B. Thorax (1988) [Pubmed]
  6. Protective effects of erdosteine on rotenone-induced oxidant injury in liver tissue. Terzi, A., Iraz, M., Sahin, S., Ilhan, A., Idiz, N., Fadillioglu, E. Toxicology and industrial health. (2004) [Pubmed]
  7. Erdosteine prevents bleomycin-induced pulmonary fibrosis in rats. Sogut, S., Ozyurt, H., Armutcu, F., Kart, L., Iraz, M., Akyol, O., Ozen, S., Kaplan, S., Temel, I., Yildirim, Z. Eur. J. Pharmacol. (2004) [Pubmed]
  8. Cisplatin-induced acute renal failure is ameliorated by erdosteine in a dose-dependent manner. Ozyurt, H., Yildirim, Z., Kotuk, M., Yilmaz, H.R., Yağmurca, M., Iraz, M., Söğüt, S., Gergerlioglu, S. Journal of applied toxicology : JAT. (2004) [Pubmed]
  9. Erdosteine against acetaminophen induced renal toxicity. Isik, B., Bayrak, R., Akcay, A., Sogut, S. Mol. Cell. Biochem. (2006) [Pubmed]
  10. The effects of erdosteine on the activities of some metabolic enzymes during cisplatin-induced nephrotoxicity in rats. Yilmaz, H.R., Iraz, M., Sogut, S., Ozyurt, H., Yildirim, Z., Akyol, O., Gergerlioglu, S. Pharmacol. Res. (2004) [Pubmed]
  11. In vivo evidences suggesting the role of oxidative stress in pathogenesis of vancomycin-induced nephrotoxicity: protection by erdosteine. Oktem, F., Arslan, M.K., Ozguner, F., Candir, O., Yilmaz, H.R., Ciris, M., Uz, E. Toxicology (2005) [Pubmed]
  12. Regulation of sepsis-induced apoptosis of pulmonary cells by posttreatment of erdosteine and N-aceylcysteine. Demiralay, R., G??rsan, N., Erdem, H. Toxicology (2006) [Pubmed]
  13. Effects of erdosteine on sputum biochemical and rheologic properties: pharmacokinetics in chronic obstructive lung disease. Marchioni, C.F., Moretti, M., Muratori, M., Casadei, M.C., Guerzoni, P., Scuri, R., Fregnan, G.B. Lung (1990) [Pubmed]
  14. A combination of budesonide and the SH-metabolite I of erdosteine acts synergistically in reducing chemiluminescence during human neutrophil respiratory burst. Dal Sasso, M., Culici, M., Guffanti, E.E., Bianchi, T., Fonti, E., Braga, P.C. Pharmacology (2005) [Pubmed]
  15. Protection of erdosteine on smoke-induced peripheral neutrophil dysfunction both in healthy and in bronchitic smokers. Ciaccia, A., Papi, A., Tschirky, B., Fregnan, B. Fundamental & clinical pharmacology. (1992) [Pubmed]
  16. Erdosteine ameliorates neurological outcome and oxidative stress due to ischemia/reperfusion injury in rabbit spinal cord. Ege, E., Ilhan, A., Gurel, A., Akyol, O., Ozen, S. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. (2004) [Pubmed]
  17. Bacterial adhesiveness: effects of the SH metabolite of erdosteine (mucoactive drug) plus clarithromycin versus clarithromycin alone. Braga, P.C., Zuccotti, T., Dal Sasso, M. Chemotherapy. (2001) [Pubmed]
  18. The protective role of erdosteine on testicular tissue after testicular torsion and detorsion. Koc, A., Narci, A., Duru, M., Gergerlioglu, H.S., Akaydin, Y., Sogut, S. Mol. Cell. Biochem. (2005) [Pubmed]
  19. Effects of erdosteine on bleomycin-induced lung fibrosis in rats. Boyaci, H., Maral, H., Turan, G., Başyiğit, I., Dillioğlugil, M.O., Yildiz, F., Tugay, M., Pala, A., Erçin, C. Mol. Cell. Biochem. (2006) [Pubmed]
  20. The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of pulmonary cells. Demiralay, R., Gürsan, N., Erdem, H. Toxicology (2006) [Pubmed]
  21. Clinical effects of erdosteine in the treatment of acute respiratory tract diseases in children. Balli, F., Bergamini, B., Calistru, P., Ciofu, E.P., Domenici, R., Doros, G., Dragomir, D., Gherghina, I., Iordachescu, F., Murgoci, G., Orasanu, D., Plesca, D., Vaccaro, A., Assereto, R. International journal of clinical pharmacology and therapeutics (2007) [Pubmed]
  22. Effects of erdosteine treatment against doxorubicin-induced toxicity through erythrocyte and plasma oxidant/antioxidant status in rats. Fadillioğlu, E., Erdoğan, H. Pharmacol. Res. (2003) [Pubmed]
  23. Oral erdosteine administration attenuates cisplatin-induced renal tubular damage in rats. Yildirim, Z., Sogut, S., Odaci, E., Iraz, M., Ozyurt, H., Kotuk, M., Akyol, O. Pharmacol. Res. (2003) [Pubmed]
  24. The effects of isoniazid on hippocampal NMDA receptors: protective role of erdosteine. Cicek, E., Sutcu, R., Gokalp, O., Yilmaz, H.R., Ozer, M.K., Uz, E., Ozcelik, N., Delibas, N. Mol. Cell. Biochem. (2005) [Pubmed]
  25. Protective effects of erdosteine against doxorubicin-induced cardiomyopathy in rats. Fadillioğlu, E., Erdoğan, H., Söğüt, S., Kuku, I. Journal of applied toxicology : JAT. (2003) [Pubmed]
  26. The effect of long-term treatment with erdosteine on chronic obstructive pulmonary disease: the EQUALIFE Study. Moretti, M., Bottrighi, P., Dallari, R., Da Porto, R., Dolcetti, A., Grandi, P., Garuti, G., Guffanti, E., Roversi, P., De Gugliemo, M., Potena, A. Drugs under experimental and clinical research. (2004) [Pubmed]
  27. HPLC with on-line mass spectrometry detection application to elucidate erdosteine metabolism: preliminary study. Savu, S., Mitrea, M., Silvestro, L., Mancini, C. International journal of clinical pharmacology and therapeutics. (2000) [Pubmed]
 
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