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Chemical Compound Review

Dipidolor     1-(3-cyano-3,3-diphenyl- propyl)-4-(1...

Synonyms: Pirdolan, Dipydolor, Piridolan, Piritramid, Piritramida, ...
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Disease relevance of Piritramide


Psychiatry related information on Piritramide


High impact information on Piritramide


Chemical compound and disease context of Piritramide


Biological context of Piritramide


Anatomical context of Piritramide


Associations of Piritramide with other chemical compounds


Gene context of Piritramide

  • In an open prospective study the pharmacokinetics of piritramide were investigated in four groups: newborns (NB, age: 1-28 days) (n=8), infants 1 (IF1, age: 2-4 months) (n=7), infants 2 (IF2, age: 5-12 months) (n=14) and young children (YC, age: 2-4 years) (n=10) [22].
  • Combined dichotomous data on pain intensity and relief, and the need for rescue analgesics from eight morphine, one pethidine, one piritramide, and one nalbuphine trial (691 patients), were in favour of PCA (RR 1.22 (1.00 to 1.50), NNT 8) [23].
  • A visual analogue scale (VAS) for pain, the Glasgow Coma Score, a modified Aldrete Score, arterial carbon dioxide tension (PaCO2) and piritramide consumption were evaluated every half an hour postoperatively [18].
  • Pipamperone and its internal standard (piritramide or 1'-(3-cyano-3,3-diphenylpropyl)-[1,4'-bipiperidine]-4'-carbo xamide) were extracted from alkalinized plasma by liquid-liquid extraction and analysed on a reversed-phase (C18) column [24].

Analytical, diagnostic and therapeutic context of Piritramide


  1. Auricular acupuncture for pain relief after total hip arthroplasty - a randomized controlled study. Usichenko, T.I., Dinse, M., Hermsen, M., Witstruck, T., Pavlovic, D., Lehmann, C.h. Pain (2005) [Pubmed]
  2. Pulmonary venodilation by isoflurane improves gas exchange during Escherichia coli bacteremia. Fretschner, R., Klöss, T., Guggenberger, H., Deusch, H., Schmid, H.J. Crit. Care Med. (1993) [Pubmed]
  3. Focal myopathy associated with chronic intramuscular injection of piritramide. Van den Bergh, P.Y., Guettat, L., Vande Berg, B.C., Martin, J.J. Muscle Nerve (1997) [Pubmed]
  4. No pulmonary edema or congestion after central venous injection of conventional and newer contrast media in dogs. Böck, J., Heilbron, D.C., Hoeft, A., Korb, H., Hellige, G. Investigative radiology. (1988) [Pubmed]
  5. Comparison of continuous epidural infusion of ropivacaine and sufentanil with intravenous patient-controlled analgesia after total hip replacement. Kampe, S., Randebrock, G., Kiencke, P., Hünseler, U., Cranfield, K., König, D.P., Diefenbach, C. Anaesthesia. (2001) [Pubmed]
  6. Intracranial self-stimulation in rats as a function of various stimulus parameters. VI. Influence of fentanyl, piritramide, and morphine on medial forebrain bundle stimulation with monopolar electrodes. Wauquier, A., Niemegeers, C.J. Psychopharmacologia. (1976) [Pubmed]
  7. Population pharmacokinetics of piritramide in surgical patients. Bouillon, T., Kietzmann, D., Port, R., Meineke, I., Hoeft, A. Anesthesiology (1999) [Pubmed]
  8. Deliberate arterial hypotension does not reduce intraocular pressure in pigs. Jantzen, J.P., Hennes, H.J., Rochels, R., Wallenfang, T. Anesthesiology (1992) [Pubmed]
  9. Increased numbers of opioid expressing inflammatory cells do not affect intra-articular morphine analgesia. Likar, R., Mousa, S.A., Philippitsch, G., Steinkellner, H., Koppert, W., Stein, C., Schäfer, M. British journal of anaesthesia. (2004) [Pubmed]
  10. Effect of celecoxib and dexamethasone on postoperative pain after lumbar disc surgery. Karst, M., Kegel, T., Lukas, A., Lüdemann, W., Hussein, S., Piepenbrock, S. Neurosurgery (2003) [Pubmed]
  11. Protein binding of piritramide: influence of various protein concentrations and the postoperative acute phase response. Wiesner, G., Gruber, M., Wild, K., Hoerauf, K., Taeger, K. Eur. J. Clin. Pharmacol. (1999) [Pubmed]
  12. Subarachnoid and intravenous PCA versus bolus administration for postoperative pain relief in orthopaedic patients. Rundshagen, I., Kochs, E., Standl, T., Schnabel, K., Schulte am Esch, J. Acta anaesthesiologica Scandinavica. (1998) [Pubmed]
  13. The direct myocardial effects of xenon in the dog heart in vivo. Preckel, B., Ebel, D., Müllenheim, J., Frässdorf, J., Thämer, V., Schlack, W. Anesth. Analg. (2002) [Pubmed]
  14. Death during patient-controlled analgesia: piritramide overdose and tissue distribution of the drug. Musshoff, F., Padosch, S.A., Madea, B. Forensic Sci. Int. (2005) [Pubmed]
  15. Effect of dopamine and atrial pacing on stunned myocardium. Schad, H., Heimisch, W., Eising, G.P., Mendler, N. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (1998) [Pubmed]
  16. Quantitative determination of piritramide in human serum applying liquid chromatography-two-stage mass spectrometry. Martens-Lobenhoffer, J., Römhild, W. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2003) [Pubmed]
  17. Arrhythmogenic, antiarrhythmic and inotropic properties of opioids. Effects of piritramide, pethidine and morphine compared on heart muscle isolated from rats. Helgesen, K.G., Refsum, H. Pharmacology (1987) [Pubmed]
  18. Postoperative condition after the use of remifentanil with a small dose of piritramide compared with a fentanyl-based protocol in patients undergoing craniotomy. van der Zwan, T., Baerts, W.D., Perez, R.S., de Lange, J.J. European journal of anaesthesiology. (2005) [Pubmed]
  19. Postoperative pain control following remifentanil-based anaesthesia for major abdominal surgery. Albrecht, S., Fechner, J., Geisslinger, G., Maass, A.B., Upadhyaya, B., Moecke, H., Haigh, C., Schüttler, J. Anaesthesia. (2000) [Pubmed]
  20. Clinical experimental studies of postoperative infusion analgesia. Knoche, E., Dick, W., Bowdler, I., Gundlach, G. Clinical therapeutics. (1983) [Pubmed]
  21. Postoperative analgesia with no motor block by continuous epidural infusion of ropivacaine 0.1% and sufentanil after total hip replacement. Kampe, S., Weigand, C., Kaufmann, J., Klimek, M., König, D.P., Lynch, J. Anesth. Analg. (1999) [Pubmed]
  22. Pharmacokinetics of piritramide in newborns, infants and young children in intensive care units. Müller, C., Kremer, W., Harlfinger, S., Doroshyenko, O., Jetter, A., Hering, F., Hünseler, C., Roth, B., Theisohn, M. Eur. J. Pediatr. (2006) [Pubmed]
  23. Efficacy and safety of patient-controlled opioid analgesia for acute postoperative pain. A quantitative systematic review. Walder, B., Schafer, M., Henzi, I., Tramèr, M.R. Acta anaesthesiologica Scandinavica. (2001) [Pubmed]
  24. Determination of pipamperone in human plasma by high performance liquid chromatography. Luhmann, I., Szathmary, S.C., Grünert, I. Arzneimittel-Forschung. (1992) [Pubmed]
  25. Coronary microcirculation during halothane, enflurane, isoflurane, and adenosine in dogs. Conzen, P.F., Habazettl, H., Vollmar, B., Christ, M., Baier, H., Peter, K. Anesthesiology (1992) [Pubmed]
  26. Continuous wound infiltration with ropivacaine reduces pain and analgesic requirement after shoulder surgery. Gottschalk, A., Burmeister, M.A., Radtke, P., Krieg, M., Farokhzad, F., Kreissl, S., Strauss, M., Standl, T. Anesth. Analg. (2003) [Pubmed]
  27. Quantitative determination of piritramide in human plasma and urine by off- and on-line solid-phase extraction liquid chromatography coupled to tandem mass spectrometry. Kahlich, R., Gleiter, C.H., Laufer, S., Kammerer, B. Rapid Commun. Mass Spectrom. (2006) [Pubmed]
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