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MeSH Review

Spinal Fusion

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Disease relevance of Spinal Fusion


High impact information on Spinal Fusion


Chemical compound and disease context of Spinal Fusion


Biological context of Spinal Fusion


Anatomical context of Spinal Fusion

  • Preclinical and clinical studies have shown that BMP-2 can be utilized in various therapeutic interventions such as bone defects, non-union fractures, spinal fusion, osteoporosis and root canal surgery [18].
  • Red blood cell indices in four adolescent and preadolescent patients with documented inappropriate antidiuretic hormone secretion (SIADH) following spinal fusion were examined for evidence of dilution [19].
  • In the future, a series of vectors with multiple genes that are regulated by physiologic cues might be used to enhance spinal fusion, restore IVD tissue, or support spinal cord healing [20].
  • This study is a retrospective review of 43 adult patients with idiopathic or congenital scoliosis who had spinal fusion from T11 or above to the sacrum [21].
  • To summarise, the presented clinical and radiological study shows the cancellous bone tissue filled, titanium implant to be a meaningful and useable alternative to conventional methods of spinal fusion [22].

Associations of Spinal Fusion with chemical compounds

  • Further study is necessary to determine whether coralline hydroxyapatite used as a bone graft extender in lumbar spinal fusion may help to obviate the need for secondary site graft harvesting [23].
  • Syndrome of inappropriate antidiuretic hormone secretion in children following spinal fusion [24].
  • METHODS: Forty-four patients scheduled to undergo elective spinal fusion were randomly assigned to receive either 100 mg/kg tranexamic acid before incision followed by an infusion of 10 mg . kg . h during surgery (tranexamic acid group) or 0.9% saline (placebo group) [25].
  • To document the analgesic properties of intravenous clonidine during the postoperative period, 50 ASA physical status 1 patients, immediately after spinal fusion, were randomly assigned to two groups, blindly administered either clonidine (5 micrograms/kg infused the 1st h and then 0.3 during 11 h) or a placebo [26].
  • Threaded lumbar interbody spinal fusion devices (TIBFD) made from titanium have been reported to be 90% effective for single-level lumbar interbody fusion, although radiographic determination of fusion has been intensely debated in the literature [27].

Gene context of Spinal Fusion


Analytical, diagnostic and therapeutic context of Spinal Fusion


  1. A study of desmopressin and blood loss during spinal fusion for neuromuscular scoliosis: a randomized, controlled, double-blinded study. Theroux, M.C., Corddry, D.H., Tietz, A.E., Miller, F., Peoples, J.D., Kettrick, R.G. Anesthesiology (1997) [Pubmed]
  2. Captopril reduces the dose requirement for sodium nitroprusside induced hypotension. Woodside, J., Garner, L., Bedford, R.F., Sussman, M.D., Miller, E.D., Longnecker, D.E., Epstein, R.M. Anesthesiology (1984) [Pubmed]
  3. The effect of cyclooxygenase-2 inhibition on analgesia and spinal fusion. Reuben, S.S., Ekman, E.F. The Journal of bone and joint surgery. American volume. (2005) [Pubmed]
  4. Use of intramuscular butorphanol for the treatment of postoperative orthopedic pain in adolescents: a pilot study. Steg, N.L. Clinical therapeutics. (1988) [Pubmed]
  5. 1-Desamino-8-D-arginine vasopressin (desmopressin) decreases operative blood loss in patients having Harrington rod spinal fusion surgery. A randomized, double-blinded, controlled trial. Kobrinsky, N.L., Letts, R.M., Patel, L.R., Israels, E.D., Monson, R.C., Schwetz, N., Cheang, M.S. Ann. Intern. Med. (1987) [Pubmed]
  6. Application of bone morphogenetic proteins in spinal fusion. Gupta, M.C., Khan, S.N. Cytokine Growth Factor Rev. (2005) [Pubmed]
  7. Hematogenous candida osteomyelitis. Report of three cases and review of the literature. Edwards, J.E., Turkel, S.B., Elder, H.A., Rand, R.W., Guze, L.B. Am. J. Med. (1975) [Pubmed]
  8. Rofecoxib: a review of its use in the management of osteoarthritis, acute pain and rheumatoid arthritis. Matheson, A.J., Figgitt, D.P. Drugs (2001) [Pubmed]
  9. Nicardipine versus nitroprusside for controlled hypotension during spinal surgery in adolescents. Hersey, S.L., O'Dell, N.E., Lowe, S., Rasmussen, G., Tobias, J.D., Deshpande, J.K., Mencio, G., Green, N. Anesth. Analg. (1997) [Pubmed]
  10. Determination of intraoperative plasma catecholamine concentrations using liquid chromatography with electrochemical detection. Salzman, S.K., Sellers, M.S., Beckman, A.L., Naidu, R., Macewen, G.D. J. Chromatogr. (1985) [Pubmed]
  11. Mesh cages in idiopathic scoliosis in adolescents. Lenke, L.G., Bridwell, K.H. Clin. Orthop. Relat. Res. (2002) [Pubmed]
  12. Hyponatremia after spinal fusion caused by inappropriate secretion of antidiuretic hormone (SIADH). Elster, A.D. Clin. Orthop. Relat. Res. (1985) [Pubmed]
  13. Vertebral osteomyelitis secondary to Streptococcus agalactiae. Fasano, F.J., Graham, D.R., Stauffer, E.S. Clin. Orthop. Relat. Res. (1990) [Pubmed]
  14. Dose-response of ketorolac as an adjunct to patient-controlled analgesia morphine in patients after spinal fusion surgery. Reuben, S.S., Connelly, N.R., Lurie, S., Klatt, M., Gibson, C.S. Anesth. Analg. (1998) [Pubmed]
  15. The effects of propofol, small-dose isoflurane, and nitrous oxide on cortical somatosensory evoked potential and bispectral index monitoring in adolescents undergoing spinal fusion. Clapcich, A.J., Emerson, R.G., Roye, D.P., Xie, H., Gallo, E.J., Dowling, K.C., Ramnath, B., Heyer, E.J. Anesth. Analg. (2004) [Pubmed]
  16. One-stage versus two-stage anterior and posterior spinal reconstruction in adults. Comparison of outcomes including nutritional status, complications rates, hospital costs, and other factors. Dick, J., Boachie-Adjei, O., Wilson, M. Spine. (1992) [Pubmed]
  17. Prospective evaluation of trunk range of motion in adolescents with idiopathic scoliosis undergoing spinal fusion surgery. Engsberg, J.R., Lenke, L.G., Reitenbach, A.K., Hollander, K.W., Bridwell, K.H., Blanke, K. Spine. (2002) [Pubmed]
  18. Bone morphogenetic proteins. Chen, D., Zhao, M., Mundy, G.R. Growth Factors (2004) [Pubmed]
  19. The syndrome of inappropriate antidiuretic hormone secretion and its effect on blood indices following spinal fusion. Mason, R.J., Betz, R.R., Orlowski, J.P., Bell, G.R. Spine. (1989) [Pubmed]
  20. Gene therapy for spinal applications. Hidaka, C., Khan, S.N., Farmer, J.C., Sandhu, H.S. Orthop. Clin. North Am. (2002) [Pubmed]
  21. Fusion to the sacrum for nonparalytic scoliosis in the adult. Balderston, R.A., Winter, R.B., Moe, J.H., Bradford, D.S., Lonstein, J.E. Spine. (1986) [Pubmed]
  22. Cervical monosegmental interbody fusion using titanium implants in degenerative, intervertebral disc disease. al-Hami, S. Minimally invasive neurosurgery : MIN. (1999) [Pubmed]
  23. Use of autologous growth factors in lumbar spinal fusion. Lowery, G.L., Kulkarni, S., Pennisi, A.E. Bone (1999) [Pubmed]
  24. Syndrome of inappropriate antidiuretic hormone secretion in children following spinal fusion. Lieh-Lai, M.W., Stanitski, D.F., Sarnaik, A.P., Uy, H.G., Rossi, N.F., Simpson, P.M., Stanitski, C.L. Crit. Care Med. (1999) [Pubmed]
  25. Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery. Sethna, N.F., Zurakowski, D., Brustowicz, R.M., Bacsik, J., Sullivan, L.J., Shapiro, F. Anesthesiology (2005) [Pubmed]
  26. Postoperative analgesia by intravenous clonidine. Bernard, J.M., Hommeril, J.L., Passuti, N., Pinaud, M. Anesthesiology (1991) [Pubmed]
  27. Polyetheretherketone as a biomaterial for spinal applications. Toth, J.M., Wang, M., Estes, B.T., Scifert, J.L., Seim, H.B., Turner, A.S. Biomaterials (2006) [Pubmed]
  28. Bone morphogenetic protein-2: biology and applications. Riley, E.H., Lane, J.M., Urist, M.R., Lyons, K.M., Lieberman, J.R. Clin. Orthop. Relat. Res. (1996) [Pubmed]
  29. De novo osteogenesis from human ligamentum flavum by adenovirus-mediated bone morphogenetic protein-2 gene transfer. Yang, I.H., Kim, H., Kwon, U.H., Lee, K.I., Jun, J.A., Kim, J.H., Yun, C.O., Park, S.Y., Lee, H.M., Moon, S.H. Spine. (2005) [Pubmed]
  30. Use of bone morphogenetic protein-9 gene therapy to induce spinal arthrodesis in the rodent. Helm, G.A., Alden, T.D., Beres, E.J., Hudson, S.B., Das, S., Engh, J.A., Pittman, D.D., Kerns, K.M., Kallmes, D.F. J. Neurosurg. (2000) [Pubmed]
  31. The effect of cyclooxygenase-2 inhibition on acute and chronic donor-site pain after spinal-fusion surgery. Reuben, S.S., Ekman, E.F., Raghunathan, K., Steinberg, R.B., Blinder, J.L., Adesioye, J. Regional anesthesia and pain medicine. (2006) [Pubmed]
  32. How does recombinant human bone morphogenetic protein-4 enhance posterior spinal fusion? Cheng, J.C., Guo, X., Law, L.P., Lee, K.M., Chow, D.H., Rosier, R. Spine. (2002) [Pubmed]
  33. Recombinant human bone morphogenetic protein-2 enhances anterior spinal fusion in a thoracoscopically instrumented animal model. Sucato, D.J., Hedequist, D., Zhang, H., Pierce, W.A., O'Brien, S.E., Welch, R.D. The Journal of bone and joint surgery. American volume. (2004) [Pubmed]
  34. Evaluation of 70/30 poly (L-lactide-co-D,L-lactide) for use as a resorbable interbody fusion cage. Toth, J.M., Estes, B.T., Wang, M., Seim, H.B., Scifert, J.L., Turner, A.S., Cornwall, G.B. J. Neurosurg. (2002) [Pubmed]
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