Disease relevance of CPSF4

• The CPSF30 binding site on the NS1A protein of influenza A virus is a potential antiviral target [1].
• Quality of the mother's diet, expressed as a NAR index, was significantly correlated (r = 0.301, P less than 0.05) with birth weight of the infant [2].
• Influenza A virus replication was inhibited in this cell line, whereas no inhibition was observed with influenza B virus, whose NS1B protein lacks a binding site for CPSF30 [1].
• No proteinuria occurred in the UNX male NAR (final value 15 +/- 2 mg/day) [3].
• Both in ovariectomized and orchidectomized NAR, estradiol caused severe hypercholesterolemia (9 to 12 mmol/liter) and hypertriglyceridemia (6 to 8 mmol/liter) after six weeks [4].

Psychiatry related information on CPSF4

• Canonical Discriminant Function Analysis was employed, which resulted in four clinical-diagnostic scales: SA for sleep apnea, NAR for narcolepsy, PSY for psychiatric sleep disorder and PLM for periodic limb movement disorder [5].

High impact information on CPSF4

• Interestingly, this part of the Arabidopsis Fip1 interacts with Arabidopsis homologs of CstF77, CPSF30, CFIm-25, and PabN1 [6].
• We demonstrate that binding of CPSF30 is mediated by two of its zinc fingers, F2F3, and that the CPSF30/F2F3 binding site on the NS1A protein extends from amino acid 144 to amino acid 186 [1].
• In the childhood study in these 31 subjects, six had no response (NAR); six, an early response (EAR); eight, a late (LAR); and eleven subjects, an EAR followed by an LAR (dual asthmatic response [DAR]) to the inhalation of HD [7].
• Reductions in mean NAR were matched by lower rates of net photosynthesis (A) on an area basis in the major photosynthetic source (first trifoliolate) leaf [8].
• These rats, or ovariectomized NAR where the estrogen treatment had been withdrawn, had practically no proteinuria (4 +/- 1, 19 +/- 11, and 13 +/- 4 mg/day, respectively) or renal damage (glomerulosclerosis score 1 +/- 0.4, 5 +/- 3 and 3 +/- 1, respectively) after 24 weeks [4].

Biological context of CPSF4

• Pre-mRNA processing is inhibited via the binding of the NS1A protein to the cellular CPSF30 protein, and mutational inactivation of this NS1A binding site causes severe attenuation of the virus [1].
• Plasma viscosity was higher in female NAR than in male NAR, but there were no differences in blood viscosity [3].
• Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic hypermutation [9].
• Previous analysis of the new antigen receptor gene in nurse sharks (NAR), however, revealed no bias to mutate GC base pairs and the frequency of mutation was comparable to that of mammalian IgG [9].
• The NAR mutational pattern is most similar to that of mammalian IgG and furthermore both are strikingly akin to mutations acquired during the neutral evolution of nuclear pseudogenes, suggesting that a similar mechanism is at work for both processes [9].

Anatomical context of CPSF4

• Deposition of apo B and apo E was observed in the glomerular mesangium of UNX female NAR, particularly in sclerotic lesions [3].
• In liver recipients the absolute number of CD28+ cells fell sharply immediately after transplant, but no significant differences were detected between the AR and NAR groups either in the absolute number or in the percentage of CD28+ lymphocytes [10].
• By contrast, both CD4+CD28+ and CD8+CD28+ T-cell subsets displayed a significant increase in CD28 intensity expression in AR recipients, whereas CD28 expression was significantly downregulated in the NAR recipients [10].
• RESULTS: Clonal immortalized keratinocyte cell lines KEB-1, KEB-2, KEB-3 (using SV40 T antigen) and KEB-4, KEB-7 and NEB-1 (using HPV16 E6/E7) were established [11].
• The present study analyzes the expression of these co-stimulatory molecules in peripheral blood cells from 74 liver recipients and in 16 liver biopsies, which were classified into acute-rejection (AR, n = 27) and nonacute-rejection (NAR, n = 47) groups, as well as their influence on the in vitro response of in vivo allosensitized cells [12].

Associations of CPSF4 with chemical compounds

• Ovariectomized and orchidectomized uninephrectomized NAR were treated with estradiol implants for 24 weeks [4].
• Plasma cholesterol increased from 6.3 +/- 0.4 (week 4) to 11.9 +/- 0.6 mmol/liter (week 37) in the female NAR, and from 4.3 +/- 0.1 to 6.4 +/- 0.5 mmol/liter in the male NAR in the same period [3].
• However, in hyperlipidemic analbuminemic rats (NAR), females are more prone to develop renal injury than males, and ovariectomy tends to decrease triglyceride levels and prevent renal disease [4].
• As seen for all species studied to date, the serine codon AGC/T in NAR was a mutational hotspot [9].
• In this study, pre- and post-operative levels of mHLA-I in peripheral blood lymphocytes (PBL) and serum sHLA-I were analyzed in 86 liver transplants, immunosuppressed with Cyclosporine-A, methylprednisolone and azathioprine, and classified into acute-rejection (AR, n = 28) and non-acute-rejection (NAR, n = 58) groups [13].

Other interactions of CPSF4

• These include two lines from a single individual with Weber-Cockayne EBS (i.e. KEB-3 and KEB-4, mutation K14 V270M), and three cell lines from a second family, two from siblings carrying the same mutation (KEB-1, KEB-2 lines from Dowling-Meara EBS, mutation K5 E475G) and one from an unaffected relative (NEB-1) [11].

Analytical, diagnostic and therapeutic context of CPSF4

• Eight women who reported that they had smoked during pregnancy had infants with significantly lower birth weights (P less than 0.01), gained less weight during prenatal care (P less than 0.01), and had a lower NAR index (P less than 0.10) than 32 women who said they did not smoke during pregnancy [2].
• Myopic sphere and spherical equivalent values were recorded more frequently with the WASS than with the NAR or refined retinoscopy [14].
• ETS-S and ETS-NS subjects differed in correlations between bilateral subjective and objective measures: ETS-S subjects showed significant correlation between baseline congestion and NAR; in contrast, ETS-NS subjects showed significant correlation between baseline congestion and acoustic rhinometry [15].
• New statistical workload indicators, NPR and NAR, for radiotherapy departments [16].
• NAR was assessed in all subjects using posterior rhinomanometry and nasal lavage before the application of the spray and again 10 min later [17].

References