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MeSH Review

Glomerular Mesangium

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Disease relevance of Glomerular Mesangium


High impact information on Glomerular Mesangium

  • In the course of glomerular development, small groups of PDGF-Rbeta and desmin-expressing cells collected in the 'S'-shaped and early cup-shaped vesicles, and at later stages such cells were found in the glomerular mesangium [6].
  • Among non-central nervous system tissues and tumors, GMEM was found by peroxidase-antiperoxidase immunohistology in normal liver sinusoids, spleen red pulp sinusoids, kidney medullary tubule interstitium, and glomerular mesangium and in association with vascular and stromal elements of several undifferentiated tumors [7].
  • Western blot analysis demonstrated increased PKC beta in diabetic animals, localized by immunofluorescence to the glomerular mesangium [8].
  • MCBM width did not correlate with age, duration of diabetes, creatinine clearance, urinary albumin excretion, or fractional volume of the glomerular mesangium [9].
  • Uptake of polyvinyl alcohol by macrophages in the glomerular mesangium of rats. Histologic and functional studies [10].

Biological context of Glomerular Mesangium


Anatomical context of Glomerular Mesangium


Associations of Glomerular Mesangium with chemical compounds


Gene context of Glomerular Mesangium


  1. Increased phosphorylation of focal adhesion kinase in diabetic rat kidney glomeruli. Clark, S., Muggli, E., La Greca, N., Dunlop, M.E. Diabetologia (1995) [Pubmed]
  2. Delayed treatment with lithospermate B attenuates experimental diabetic renal injury. Lee, G.T., Ha, H., Jung, M., Li, H., Hong, S.W., Cha, B.S., Lee, H.C., Cho, Y.D. J. Am. Soc. Nephrol. (2003) [Pubmed]
  3. The development of an acth-induced renal glomerular lesion in Mus musculus. An ultrastructural study. Feldman, D.L., Christian, J.J. J. Pathol. (1981) [Pubmed]
  4. Combined glomerular deposition of polymeric rat IgA and IgG aggravates renal inflammation. van Dixhoorn, M.G., Sato, T., Muizert, Y., van Gijlswijk-Janssen, D.J., De Heer, E., Daha, M.R. Kidney Int. (2000) [Pubmed]
  5. Increased and prolonged production of specific polymeric IgA after systemic immunization with tetanus toxoid in IgA nephropathy. Layward, L., Allen, A.C., Harper, S.J., Hattersley, J.M., Feehally, J. Clin. Exp. Immunol. (1992) [Pubmed]
  6. Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli. Lindahl, P., Hellström, M., Kalén, M., Karlsson, L., Pekny, M., Pekna, M., Soriano, P., Betsholtz, C. Development (1998) [Pubmed]
  7. Human glioma-mesenchymal extracellular matrix antigen defined by monoclonal antibody. Bourdon, M.A., Wikstrand, C.J., Furthmayr, H., Matthews, T.J., Bigner, D.D. Cancer Res. (1983) [Pubmed]
  8. Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension. Kelly, D.J., Zhang, Y., Hepper, C., Gow, R.M., Jaworski, K., Kemp, B.E., Wilkinson-Berka, J.L., Gilbert, R.E. Diabetes (2003) [Pubmed]
  9. Relationship of muscle capillary basement membrane to renal structure and function in diabetes mellitus. Ellis, E.N., Mauer, S.M., Goetz, F.C., Sutherland, D.E., Steffes, M.W. Diabetes (1986) [Pubmed]
  10. Uptake of polyvinyl alcohol by macrophages in the glomerular mesangium of rats. Histologic and functional studies. Sterzel, R.B., Eisenbach, G.M., Seiler, M.W., Hoyer, J.R. Am. J. Pathol. (1983) [Pubmed]
  11. Simvastatin inhibits the cellular signaling and proliferative action of arginine vasopressin in cultured rat glomerular mesangial cells. Ishikawa, S., Kawasumi, M., Saito, T. Endocrinology (1995) [Pubmed]
  12. Angiotensin II binding sites on micro-organisms contaminating cell cultures. Whitebread, S., Pfeilschifter, J., Ramjoué, H., de Gasparo, M. Regul. Pept. (1993) [Pubmed]
  13. Transforming growth factor-beta1 regulation of laminin gamma1 and fibronectin expression and survival of mouse mesangial cells. Jiang, Y., Cheng, D.W., Crook, E.D., Singh, L.P. Mol. Cell. Biochem. (2005) [Pubmed]
  14. Monoclonal antibodies to human glomerular antigens. Nakamura, T., Oite, T., Kazama, T., Suzuki, S., Orikasa, M., Arakawa, M., Shimizu, F. Virchows Archiv. A, Pathological anatomy and histopathology. (1988) [Pubmed]
  15. Extracellular matrix metabolism in diabetic nephropathy. Mason, R.M., Wahab, N.A. J. Am. Soc. Nephrol. (2003) [Pubmed]
  16. Localization of decay accelerating factor in normal and diseased kidneys. Cosio, F.G., Sedmak, D.D., Mahan, J.D., Nahman, N.S. Kidney Int. (1989) [Pubmed]
  17. Three-dimensional matrix primes mesangial cells to down-regulation of alpha-smooth muscle actin via deactivation of CArG box elements. Kitamura, M., Ishikawa, Y. Kidney Int. (1998) [Pubmed]
  18. The GATA-3 gene is expressed during human kidney embryogenesis. Labastie, M.C., Catala, M., Gregoire, J.M., Peault, B. Kidney Int. (1995) [Pubmed]
  19. Differentiation of smooth muscle phenotypes in mouse mesangial cells. Iehara, N., Takeoka, H., Tsuji, H., Imabayashi, T., Foster, D.N., Strauch, A.R., Yamada, Y., Kita, T., Doi, T. Kidney Int. (1996) [Pubmed]
  20. Glomerular mesangium: its function and relationship to angiotensin II. Raij, L., Keane, W.F. Am. J. Med. (1985) [Pubmed]
  21. Serotonin and the glomerular mesangium. Mechanisms of intracellular signaling. Menè, P., Pugliese, F., Cinotti, G.A. Hypertension (1991) [Pubmed]
  22. Localization of mRNAs for insulin-like growth factor binding proteins 1 to 6 in rat kidney. Price, G.J., Berka, J.L., Edmondson, S.R., Werther, G.A., Bach, L.A. Kidney Int. (1995) [Pubmed]
  23. Neutral proteinase activity produced in vitro by cells of the glomerular mesangium. Lovett, D.H., Sterzel, R.B., Kashgarian, M., Ryan, J.L. Kidney Int. (1983) [Pubmed]
  24. Mesangial glomerulonephropathy with deposition of IgG, IgM, and C3 induced by mercuric chloride: a new model. Makker, S.P., Aikawa, M. Lab. Invest. (1979) [Pubmed]
  25. Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3' untranslated region of the Megsin gene. Li, Y.J., Du, Y., Li, C.X., Guo, H., Leung, J.C., Lam, M.F., Yang, N., Huang, F., Chen, Y., Fang, J.Q., Maxwell, P.H., Lai, K.N., Wang, Y. J. Am. Soc. Nephrol. (2004) [Pubmed]
  26. Cell adhesion molecule expression in murine lupus-like nephritis induced by lipopolysaccharide. Baran, D., Vendeville, B., Ogborn, M., Katz, N. Nephron (2000) [Pubmed]
  27. Osteopontin expression and microvascular injury in cyclosporine nephrotoxicity. Lim, B.J., Kim, P.K., Hong, S.W., Jeong, H.J. Pediatr. Nephrol. (2004) [Pubmed]
  28. Adhesion molecule interactions in human glomerulonephritis: importance of the tubulointerstitium. Roy-Chaudhury, P., Wu, B., King, G., Campbell, M., Macleod, A.M., Haites, N.E., Simpson, J.G., Power, D.A. Kidney Int. (1996) [Pubmed]
  29. Cellular receptors for matrix proteins in normal human kidney and human mesangial cells. Cosio, F.G., Sedmak, D.D., Nahman, N.S. Kidney Int. (1990) [Pubmed]
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