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Gene Review

SLC6A14  -  solute carrier family 6 (amino acid...

Homo sapiens

Synonyms: Amino acid transporter ATB0+, Sodium-and chloride-dependent neutral and basic amino acid transporter B(0+), Solute carrier family 6 member 14
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Disease relevance of SLC6A14


Psychiatry related information on SLC6A14


High impact information on SLC6A14

  • Significant evidence was observed for association for an SNP in the 3'-untranslated region of the solute carrier family 6 member 14 (SLC6A14) gene (P = 0.0002) and for SNP haplotypes of the SLC6A14 gene (P = 0.0007-0.006) [5].
  • Positional candidate gene analysis of the obesity-linked chromosome Xq24 locus identified two obesity-associated single nucleotide polymorphisms (SNPs) in the membrane amino acid transporter encoding the SLC6A14 (solute carrier family 6 [neurotransmitter transporter], member 14) gene in the Finnish population [6].
  • The largest increase in 5-HT synthesis after OBX was observed in the sensory-motor cortex (67%) [7].
  • They were significantly (p < 0.05) increased in the frontal (50%) and parietal (40%) cortices, superior olive (over 30%), and the substantia nigra (30%) in the OBX rats as compared to the sham operated animals [7].
  • 5-HT synthesis rates were significantly decreased in the dorsal and medial raphe nuclei, but there was no significant change the ventral tegmental area and the locus coeruleus following OBX [7].

Chemical compound and disease context of SLC6A14

  • The SLC6A14 gene is an interesting novel candidate for obesity because it encodes an amino acid transporter, which potentially regulates tryptophan availability for serotonin synthesis and thus possibly affects appetite control [5].

Biological context of SLC6A14


Anatomical context of SLC6A14

  • These behavioral contrasts were accompanied by greater atrophy of the frontal/parietal cortex and midbrain in aged OBX [12].
  • At 48 hours after surgery the numbers of macrophages in the OE of both sham and OBX clodronate-treated mice were significantly reduced compared to liposome-treated controls (38% and 35%, respectively, P < 0.05) [9].
  • Serotonin transporter sites were increased in the cortex and hippocampus of young OBX rats, but were decreased in the aged OBX group [12].
  • Previous experiments have demonstrated that OBX leads to increased expression of the preproenkephalin (ENK) gene in the olfactory tubercle (OT) portion of the ventral striatum in rats [13].
  • Bulbectomized (OBX) birds had incresaed thyroid follicular activity and had greater developed testes than sham-operated controls [14].

Associations of SLC6A14 with chemical compounds

  • ATB(0,+) (SLC6A14) is a Na(+)/Cl(-)-coupled arginine transporter expressed at low levels in normal colon [2].
  • In the current study, we evaluated expression of MAO subtypes in brain regions of young and aged rats subjected to olfactory bulbectomy (OBX), a procedure that reproduces many of the biochemical and functional changes associated with human depression [15].
  • These results suggest that 10 mg/(kg day) of buspirone for 14 days in the OBX rats did not produce a significant alteration in 5-HT synthesis, but 20 mg/(kg day) for 14 days resulted in an overall significant reduction in brain 5-HT synthesis [16].
  • These results suggest that the gonadal hormone milieu of the animal plays a role in modulating sucrose preference and activity levels following OBX [17].
  • OBX rats exhibited significantly higher basal DA levels (192%) and lower NE levels (12%) than sham-operated controls [3].

Analytical, diagnostic and therapeutic context of SLC6A14


  1. Do allelic variants of SLC6A14 predispose to obesity? Tiwari, H.K., Allison, D.B. J. Clin. Invest. (2003) [Pubmed]
  2. Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans. Gupta, N., Miyauchi, S., Martindale, R.G., Herdman, A.V., Podolsky, R., Miyake, K., Mager, S., Prasad, P.D., Ganapathy, M.E., Ganapathy, V. Biochim. Biophys. Acta (2005) [Pubmed]
  3. Dopamine overflow is increased in olfactory bulbectomized rats: an in vivo microdialysis study. Masini, C.V., Holmes, P.V., Freeman, K.G., Maki, A.C., Edwards, G.L. Physiol. Behav. (2004) [Pubmed]
  4. Effects of chronic activity wheel running and imipramine on masculine copulatory behavior after olfactory bulbectomy. Chambliss, H.O., Van Hoomissen, J.D., Holmes, P.V., Bunnell, B.N., Dishman, R.K. Physiol. Behav. (2004) [Pubmed]
  5. The SLC6A14 gene shows evidence of association with obesity. Suviolahti, E., Oksanen, L.J., Ohman, M., Cantor, R.M., Ridderstrale, M., Tuomi, T., Kaprio, J., Rissanen, A., Mustajoki, P., Jousilahti, P., Vartiainen, E., Silander, K., Kilpikari, R., Salomaa, V., Groop, L., Kontula, K., Peltonen, L., Pajukanta, P. J. Clin. Invest. (2003) [Pubmed]
  6. Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians. Durand, E., Boutin, P., Meyre, D., Charles, M.A., Clement, K., Dina, C., Froguel, P. Diabetes (2004) [Pubmed]
  7. Regional brain serotonin synthesis is increased in the olfactory bulbectomy rat model of depression: an autoradiographic study. Watanabe, A., Tohyama, Y., Nguyen, K.Q., Hasegawa, S., Debonnel, G., Diksic, M. J. Neurochem. (2003) [Pubmed]
  8. Up-regulation of the amino acid transporter ATB(0,+) (SLC6A14) in carcinoma of the cervix. Gupta, N., Prasad, P.D., Ghamande, S., Moore-Martin, P., Herdman, A.V., Martindale, R.G., Podolsky, R., Mager, S., Ganapathy, M.E., Ganapathy, V. Gynecol. Oncol. (2006) [Pubmed]
  9. Macrophage depletion in the murine olfactory epithelium leads to increased neuronal death and decreased neurogenesis. Borders, A.S., Getchell, M.L., Etscheidt, J.T., van Rooijen, N., Cohen, D.A., Getchell, T.V. J. Comp. Neurol. (2007) [Pubmed]
  10. Cholinergic receptor subtypes in the olfactory bulbectomy model of depression. Slotkin, T.A., Seidler, F.J. Brain Res. Bull. (2006) [Pubmed]
  11. Effect of photic changes and olfactory impairment on reproduction in female south Indian gerbil. Thomas, B.B., Oommen, M.M. Indian J. Exp. Biol. (1999) [Pubmed]
  12. Modeling geriatric depression in animals: biochemical and behavioral effects of olfactory bulbectomy in young versus aged rats. Slotkin, T.A., Miller, D.B., Fumagalli, F., McCook, E.C., Zhang, J., Bissette, G., Seidler, F.J. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  13. Herpes virus-mediated preproenkephalin gene transfer in the ventral striatum mimics behavioral changes produced by olfactory bulbectomy in rats. Primeaux, S.D., Wilson, M.A., Wilson, S.P., Guth, A.N., Lelutiu, N.B., Holmes, P.V. Brain Res. (2003) [Pubmed]
  14. The involvement of the olfactory bulbs in the regulation of gonadal and thyroidal activities of male red-winged blackbirds, exposed to short-day light regime. Robinzon, B., Katz, Y., Rogers, J.G. Brain Res. Bull. (1979) [Pubmed]
  15. Regional differences in brain monoamine oxidase subtypes in an animal model of geriatric depression: effects of olfactory bulbectomy in young versus aged rats. Slotkin, T.A., Seidler, F.J., Ritchie, J.C. Brain Res. (2000) [Pubmed]
  16. Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: an autoradiographic study. Watanabe, A., Hasegawa, S., Nishi, K., Nguyen, K.Q., Diksic, M. Brain Res. Bull. (2006) [Pubmed]
  17. Gender and gonadal hormone effects in the olfactory bulbectomy animal model of depression. Stock, H.S., Ford, K., Wilson, M.A. Pharmacol. Biochem. Behav. (2000) [Pubmed]
  18. Analysis of needle versus open biopsy for the diagnosis of advanced stage pediatric neuroblastoma. Gupta, A., Kumar, A., Walters, S., Chait, P., Irwin, M.S., Gerstle, J.T. Pediatric blood & cancer. (2006) [Pubmed]
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