Disease relevance of SLC6A14

• Do allelic variants of SLC6A14 predispose to obesity [1]?
• Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans [2].

Psychiatry related information on SLC6A14

• Many of the behavioral effects of OBX resemble psychomotor agitation [3].
• Locomotor activity in response to novelty and footshock stress was elevated in OBX rats [3].
• We examined the effects of chronic activity wheel running and imipramine administration on appetitive behavior after olfactory bulbectomy (OBX) [4].

High impact information on SLC6A14

• Significant evidence was observed for association for an SNP in the 3'-untranslated region of the solute carrier family 6 member 14 (SLC6A14) gene (P = 0.0002) and for SNP haplotypes of the SLC6A14 gene (P = 0.0007-0.006) [5].
• Positional candidate gene analysis of the obesity-linked chromosome Xq24 locus identified two obesity-associated single nucleotide polymorphisms (SNPs) in the membrane amino acid transporter encoding the SLC6A14 (solute carrier family 6 [neurotransmitter transporter], member 14) gene in the Finnish population [6].
• The largest increase in 5-HT synthesis after OBX was observed in the sensory-motor cortex (67%) [7].
• They were significantly (p < 0.05) increased in the frontal (50%) and parietal (40%) cortices, superior olive (over 30%), and the substantia nigra (30%) in the OBX rats as compared to the sham operated animals [7].
• 5-HT synthesis rates were significantly decreased in the dorsal and medial raphe nuclei, but there was no significant change the ventral tegmental area and the locus coeruleus following OBX [7].

Chemical compound and disease context of SLC6A14

• The SLC6A14 gene is an interesting novel candidate for obesity because it encodes an amino acid transporter, which potentially regulates tryptophan availability for serotonin synthesis and thus possibly affects appetite control [5].

Biological context of SLC6A14

• Up-regulation of the amino acid transporter ATB(0,+) (SLC6A14) in carcinoma of the cervix [8].
• The reduction in macrophage numbers was accompanied by significant decreases in OE thickness (22% and 21%, P < 0.05), the number of mOSNs (1.2- and 1.9-fold, P < 0.05), and basal cell proliferation (7.6- and 3.8-fold, P < 0.005) in sham and OBX mice, respectively, compared to liposome-treated controls [9].
• Apoptosis of olfactory sensory neurons (OSNs) induced by olfactory bulbectomy (OBX) leads to the activation of resident macrophages within the olfactory epithelium (OE) [9].
• OBX led to upregulation of cerebrocortical alpha4beta2 nAChRs and downregulation of striatal alpha7 nAChRs as compared to either the sham-operated or unoperated groups [10].
• Estrus cyclicity of both adults and weanlings were affected consequent to OBX [11].

Anatomical context of SLC6A14

• These behavioral contrasts were accompanied by greater atrophy of the frontal/parietal cortex and midbrain in aged OBX [12].
• At 48 hours after surgery the numbers of macrophages in the OE of both sham and OBX clodronate-treated mice were significantly reduced compared to liposome-treated controls (38% and 35%, respectively, P < 0.05) [9].
• Serotonin transporter sites were increased in the cortex and hippocampus of young OBX rats, but were decreased in the aged OBX group [12].
• Previous experiments have demonstrated that OBX leads to increased expression of the preproenkephalin (ENK) gene in the olfactory tubercle (OT) portion of the ventral striatum in rats [13].
• Bulbectomized (OBX) birds had incresaed thyroid follicular activity and had greater developed testes than sham-operated controls [14].

Associations of SLC6A14 with chemical compounds

• ATB(0,+) (SLC6A14) is a Na(+)/Cl(-)-coupled arginine transporter expressed at low levels in normal colon [2].
• In the current study, we evaluated expression of MAO subtypes in brain regions of young and aged rats subjected to olfactory bulbectomy (OBX), a procedure that reproduces many of the biochemical and functional changes associated with human depression [15].
• These results suggest that 10 mg/(kg day) of buspirone for 14 days in the OBX rats did not produce a significant alteration in 5-HT synthesis, but 20 mg/(kg day) for 14 days resulted in an overall significant reduction in brain 5-HT synthesis [16].
• These results suggest that the gonadal hormone milieu of the animal plays a role in modulating sucrose preference and activity levels following OBX [17].
• OBX rats exhibited significantly higher basal DA levels (192%) and lower NE levels (12%) than sham-operated controls [3].

Analytical, diagnostic and therapeutic context of SLC6A14

• OBX may provide a useful animal model with which to test therapeutic interventions for geriatric depression [12].
• Basal levels of DA, norepinephrine (NE), homovanillic acid, dihydroxyphenylacetic acid, and 5-hydroxyindoleacetic acid were examined in the striatum of OBX and sham-operated controls using in vivo microdialysis [3].
• We compared the quality and adequacy of biopsy tissue and complication rates in children with NB who underwent open (OBX) and image-guided needle biopsy (NBX) at our center [18].

References