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Gene Review

TMC6  -  transmembrane channel-like 6

Homo sapiens

Synonyms: EV1, EVER1, EVIN1, Epidermodysplasia verruciformis protein 1, LAK-4P, ...
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Disease relevance of TMC6


Psychiatry related information on TMC6

  • CONCLUSIONS: Epidermodysplasia verruciformis is a model not only of cutaneous viral oncogenesis but also of local defense mechanisms in the progression of human papillomavirus-associated cancers [5].
  • Successively younger birth cohorts displayed an increase in prevalence and a decrease in onset-age for all disorders. "Ever" use of mental health services was higher for women with 3 or more comorbid disorders (65%) than for those with no disorder (9.8%), or only 1 disorder (51.4%) [6].
  • RESULTS: Ever smoking a cigarette at baseline had a statistically significant impact on high depressive symptoms at follow-up [7].

High impact information on TMC6


Chemical compound and disease context of TMC6


Biological context of TMC6


Anatomical context of TMC6

  • Our hypothesis is that EVER proteins act as restriction factors for EV-specific HPVs in keratinocytes, and that EV represents a primary deficiency of intrinsic immunity against certain papillomaviruses [17].
  • In addition to natural ligands human echovirus-1 (EV1) gains entry into the cell by binding to alpha 2 beta 1 and taking advantage of alpha 2 beta 1 internalization via caveolae [18].
  • Transient expression assays with keratinocytes and fibroblasts of epidermodysplasia verruciformis patients and controls demonstrated that the NRE activity is not cell specific [19].
  • Epidermodysplasia verruciformis T cells were inhibited in their capacity to respond to allogeneic epidermal cells when they were simultaneously exposed to autologous epidermal cells from HPV-infected lesional epidermis, but not to normal-appearing epidermis [20].
  • In view of the rare incidence of EV, we had a unique opportunity to perform a virologic study of the amniotic fluid and placenta from an EV patient infected with HPV5, HPV8, several other EV HPV, and HPV3 [21].

Associations of TMC6 with chemical compounds


Other interactions of TMC6


Analytical, diagnostic and therapeutic context of TMC6


  1. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. Kurima, K., Yang, Y., Sorber, K., Griffith, A.J. Genomics (2003) [Pubmed]
  2. Evidence for a nonallelic heterogeneity of epidermodysplasia verruciformis with two susceptibility loci mapped to chromosome regions 2p21-p24 and 17q25. Ramoz, N., Taïeb, A., Rueda, L.A., Montoya, L.S., Bouadjar, B., Favre, M., Orth, G. J. Invest. Dermatol. (2000) [Pubmed]
  3. A susceptibility locus for epidermodysplasia verruciformis, an abnormal predisposition to infection with the oncogenic human papillomavirus type 5, maps to chromosome 17qter in a region containing a psoriasis locus. Ramoz, N., Rueda, L.A., Bouadjar, B., Favre, M., Orth, G. J. Invest. Dermatol. (1999) [Pubmed]
  4. Tumour induction in the rodent Mastomys natalensis by activation of endogenous papilloma virus genomes. Amtmann, E., Volm, M., Wayss, K. Nature (1984) [Pubmed]
  5. Epidermodysplasia verruciformis as a model of human papillomavirus-induced genetic cancer of the skin. Majewski, S., Jabłońska, S. Archives of dermatology. (1995) [Pubmed]
  6. Psychiatric disorders and use of mental health services by Ontario women. Frise, S., Steingart, A., Sloan, M., Cotterchio, M., Kreiger, N. Canadian journal of psychiatry. Revue canadienne de psychiatrie. (2002) [Pubmed]
  7. The role of smoking and rebelliousness in the development of depressive symptoms among a cohort of Massachusetts adolescents. Albers, A.B., Biener, L. Preventive medicine. (2002) [Pubmed]
  8. Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. Ramoz, N., Rueda, L.A., Bouadjar, B., Montoya, L.S., Orth, G., Favre, M. Nat. Genet. (2002) [Pubmed]
  9. Oral retinoid treatment of human papillomavirus type 5-induced epidermodysplasia verruciformis. Lutzner, M.A., Blanchet-Bardon, C. N. Engl. J. Med. (1980) [Pubmed]
  10. Breast-feeding and risk of childhood acute leukemia. Shu, X.O., Linet, M.S., Steinbuch, M., Wen, W.Q., Buckley, J.D., Neglia, J.P., Potter, J.D., Reaman, G.H., Robison, L.L. J. Natl. Cancer Inst. (1999) [Pubmed]
  11. Estrogen replacement therapy and risk of fatal colon cancer in a prospective cohort of postmenopausal women. Calle, E.E., Miracle-McMahill, H.L., Thun, M.J., Heath, C.W. J. Natl. Cancer Inst. (1995) [Pubmed]
  12. Structural and functional analysis of integrin alpha2I domain interaction with echovirus 1. Xing, L., Huhtala, M., Pietiäinen, V., Käpylä, J., Vuorinen, K., Marjomäki, V., Heino, J., Johnson, M.S., Hyypiä, T., Cheng, R.H. J. Biol. Chem. (2004) [Pubmed]
  13. Internalization of echovirus 1 in caveolae. Marjomäki, V., Pietiäinen, V., Matilainen, H., Upla, P., Ivaska, J., Nissinen, L., Reunanen, H., Huttunen, P., Hyypiä, T., Heino, J. J. Virol. (2002) [Pubmed]
  14. Envelope glycoprotein nucleotide sequence and genetic characterization of North American ovine lentiviruses. Mwaengo, D.M., Grant, R.F., DeMartini, J.C., Carlson, J.O. Virology (1997) [Pubmed]
  15. A novel type of human papilloma virus DNA from the lesion of epidermodysplasia verruciformis. Adachi, A., Yasue, H., Ohashi, M., Ishibashi, M. Jpn. J. Cancer Res. (1986) [Pubmed]
  16. Epidermodysplasia verruciformis with multiple mucosal carcinomas treated with pegylated interferon alfa and acitretin. Gubinelli, E., Posteraro, P., Cocuroccia, B., Girolomoni, G. The Journal of dermatological treatment. (2003) [Pubmed]
  17. Genetics of epidermodysplasia verruciformis: Insights into host defense against papillomaviruses. Orth, G. Semin. Immunol. (2006) [Pubmed]
  18. Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization. Upla, P., Marjomäki, V., Kankaanpää, P., Ivaska, J., Hyypiä, T., Van Der Goot, F.G., Heino, J. Mol. Biol. Cell (2004) [Pubmed]
  19. Transcriptional silencer of the human papillomavirus type 8 late promoter interacts alternatively with the viral trans activator E2 or with a cellular factor. May, M., Grassmann, K., Pfister, H., Fuchs, P.G. J. Virol. (1994) [Pubmed]
  20. Antigen presentation and T-cell activation in epidermodysplasia verruciformis. Cooper, K.D., Androphy, E.J., Lowy, D., Katz, S.I. J. Invest. Dermatol. (1990) [Pubmed]
  21. A possible vertical transmission of human papillomavirus genotypes associated with epidermodysplasia verruciformis. Favre, M., Majewski, S., De Jesus, N., Malejczyk, M., Orth, G., Jablonska, S. J. Invest. Dermatol. (1998) [Pubmed]
  22. Thyrotoxicosis caused by weight-reducing herbal medicines. Ohye, H., Fukata, S., Kanoh, M., Kubota, S., Kuma, K., Miyauchi, A., Sugawara, M. Arch. Intern. Med. (2005) [Pubmed]
  23. Treatment of epidermodysplasia verruciformis with a combination of acitretin and interferon alfa-2a. Anadolu, R., Oskay, T., Erdem, C., Boyvat, A., Terzi, E., Gürgey, E. J. Am. Acad. Dermatol. (2001) [Pubmed]
  24. Cimetidine therapy for epidermodysplasia verruciformis. Micali, G., Nasca, M.R., Dall'Oglio, F., Musumeci, M.L. J. Am. Acad. Dermatol. (2003) [Pubmed]
  25. Novel mutations of EVER1/TMC6 gene in a Japanese patient with epidermodysplasia verruciformis. Tate, G., Suzuki, T., Kishimoto, K., Mitsuya, T. J. Hum. Genet. (2004) [Pubmed]
  26. TP53 mutations in squamous-cell carcinomas of the conjunctiva: evidence for UV-induced mutagenesis. Ateenyi-Agaba, C., Dai, M., Le Calvez, F., Katongole-Mbidde, E., Smet, A., Tommasino, M., Franceschi, S., Hainaut, P., Weiderpass, E. Mutagenesis (2004) [Pubmed]
  27. TGF beta-1 and TNF alpha expression in the epidermis of patients with epidermodysplasia verruciformis. Majewski, S., Hunzelmann, N., Nischt, R., Eckes, B., Rudnicka, L., Orth, G., Krieg, T., Jablonska, S. J. Invest. Dermatol. (1991) [Pubmed]
  28. Identification of a novel mutation and a genetic polymorphism of EVER1 gene in two families with epidermodysplasia verruciformis. Zuo, Y.G., Ma, D., Zhang, Y., Qiao, J., Wang, B. J. Dermatol. Sci. (2006) [Pubmed]
  29. Identification of an immunologically distinct papillomavirus from lesions of epidermodysplasia verruciformis. Pass, F., Reissig, M., Shah, K.V., Eisinger, M., Orth, G. J. Natl. Cancer Inst. (1977) [Pubmed]
  30. Detection of human papillomavirus type 5 DNA in skin cancers of an immunosuppressed renal allograft recipient. Lutzner, M.A., Orth, G., Dutronquay, V., Ducasse, M.F., Kreis, H., Crosnier, J. Lancet (1983) [Pubmed]
  31. Human papillomavirus DNA in cutaneous primary and metastasized squamous cell carcinomas from patients with epidermodysplasia verruciformis. Ostrow, R.S., Bender, M., Niimura, M., Seki, T., Kawashima, M., Pass, F., Faras, A.J. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  32. Skin autografts in epidermodysplasia verruciformis: human papillomavirus-associated cutaneous changes need over 20 years for malignant conversion. Majewski, S., Jablonska, S. Cancer Res. (1997) [Pubmed]
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