Disease relevance of Many1

• BACKGROUND: Many studies have suggested that the renin-angiotensin system plays an important role in the development of pressure overload-induced cardiac hypertrophy [1].
• Brain tumors in children are diverse: Many have neuronal characteristics, whereas others have glial features [2].
• BACKGROUND: Many birth defects are believed to involve gene-environment interactions, although the mechanisms involved are poorly understood [3].
• Most were of large follicular center cells and are considered typical of the type formerly designated as "reticulum cell sarcoma, type B." Many lymphomas contained a large proportion of nonneoplastic cells which partially obscured their neoplastic component [4].
• INTRODUCTION: Many common bone diseases such as osteoporosis, Paget's disease, and cancer-associated bone disease are characterized by excessive bone loss caused by increased osteoclastic activity [5].

High impact information on Many1

• BACKGROUND: Many critical cellular functions such as mitosis, cell movement, and maintenance of cell structure are performed by microtubules [6].
• BACKGROUND: Many breast cancers are estrogen independent, and even in patients who initially respond to estrogen suppression therapy, the regression is often temporary [7].
• CONCLUSIONS: Many homeobox genes are expressed in human adult small intestinal mucosa, and some are found predominantly in one region [8].
• Type I cells were flattened epithelial-like cells, much like normal mammary epithelial cells, which when stained with actin antibody displayed many brightly fluorescent parallel cables or "stress fibers." Many microtubules and microfilament bundles were observed in type I cells when examined by transmission electron microscopy [9].
• RECENT FINDINGS: Many quantitative trait loci have been found that regulate plasma levels for HDL cholesterol (37 in mice and 30 in humans), LDL cholesterol (25 in mice and 20 in humans) and triglycerides (19 in mice and 30 in humans) [10].

Chemical compound and disease context of Many1

• (2) Many drugs such as erythromycin, cephalosporin etc. showed apparent toxicity in 10(-5) - 10(-4)M [11].

Biological context of Many1

• BACKGROUND: Many studies suggest that long term potentiation (LTP) has a role in learning and memory [12].
• INTRODUCTION: Many skeletal studies have reported strong correlations between phenotypes for muscle, bone, and body size, and these correlations add to the difficulty in identifying genetic influence on skeletal traits that are not mediated through overall body size [13].
• CONCLUSIONS: Many genes and chromosomes are involved in the genetic control over mechanical integrity of cortical bone [14].
• RESULTS: Many genes involved in inflammatory alterations were upregulated in db/db mice on HF/S compared with LF in parallel with phosphorylation of c-Jun N-terminal kinase (JNK) [15].
• Best activity was observed for compounds having linkages of the type -CH2CONH-, -CH2N(COR)-, and -CH2NHCO-. Many of these compounds inhibit PAF-induced platelet aggregation with IC50's under 1 microM [16].

Anatomical context of Many1

• BACKGROUND: Many differentiating tissues contain progenitor cells that differ in their commitment states but cannot be readily distinguished or segregated [17].
• Cardiac hypertrophy and heart failure remain leading causes of death in the United States. Many studies have suggested that, under stress, myocardium releases factors triggering protein synthesis and stimulating myocyte growth [18].
• BACKGROUND: Many forms of glomerular diseases are characterized by injury to the glomerular visceral epithelial cell, or podocyte, which usually results in depletion of podocyte number [19].
• BACKGROUND: Many studies have shown that interstitial inflammation in human and experimental renal disease is characterized by T-cell infiltration, but published data on the involvement of inflammatory cell subsets in progressive tubulointerstitial lesions are often conflicting [20].
• BACKGROUND/AIMS: Many pathogenic organisms, including hepatotrophic viruses enter the liver and induce an immune response, but there is little information about the immunogenic resident antigen-presenting cells [21].

Associations of Many1 with chemical compounds

• RATIONALE: Many of the biochemical, physiological, and behavioral effects of ethanol are known to be mediated by ionotropic glutamate receptors [22].
• Background Many different types of phthalate ester are used as plasticizers and are thus found in the air [23].
• Atipamezole was without effect on ethanol's locomotor stimulant effect in the holeboard but L 659,066 attenuated this effect at doses less than 3 mg/kg Many alpha-2 adrenoceptor ligands also have affinity for nonadrenergic imidazoline-binding sites [24].
• These polyanionic ligands are capable of raising the temperature at which the protein unfolds by 15-30 degrees C. Many commonly used excipients were also observed to stabilize aFGF in both the presence and the absence of heparin [25].
• INTRODUCTION: Many fluorinated analogues of adenosine nucleoside have been synthesized and studied as potential antitumor and antiviral agents [26].

Analytical, diagnostic and therapeutic context of Many1

• PURPOSE: Many current clinical trials involve vaccination of patients with vaccines directed against tumor-associated antigens, which are, in actuality, "self-antigens" overexpressed in tumors as compared with normal tissues [27].
• PURPOSE: Many epidemiologic studies indicate an increased incidence of certain vision threatening conditions in postmenopausal women [28].
• OBJECTIVE: Many clinical gene therapy trials have described poor engraftment of retrovirally transduced CD34(+) cells [29].
• BACKGROUND: Many of the procedures used in handling neutrophils may affect the expression of surface antigens, and hence their quantitation by flow cytometry [30].
• CONCLUSION: Many genes implicated in intrahepatic inflammation, fibrosis and proliferation were up-regulated in activated HSC. cDNA microarray is an effective technique in screening for differentially expressed genes between two different situations of the HSC [31].

References