Chemical Compound Review:
Antisedan 4-(2-ethyl-1,3-dihydroinden- 2-yl)-3H...
Synonyms:
Atipamezol, Atipamezole, Atipamezolum, antipamezole, Antisedan (TN), ...
Jager,
De Graaf,
Widjaja-Greefkes,
Ihalainen,
Tanila,
Puurunen,
Jolkkonen,
Sirviö,
Haapalinna,
Sivenius,
Puurunen,
Sirviö,
Koistinaho,
Miettinen,
Haapalinna,
Riekkinen,
Sivenius,
Stone,
Zhang,
Hiller,
Simon,
Hillman,
Dodge,
Badura,
Sjöholm,
Lähdesmäki,
Pyykkö,
Hillilä,
Scheinin,
Haapalinna,
Sirviö,
MacDonald,
Virtanen,
Heinonen,
Haapalinna,
Leino,
Heinonen,
Scheinin,
Aantaa,
Anttila,
Hakola,
Helminen,
Karhuvaara,
- Inhibition of intestinal motility and reversal of postlaparotomy ileus by selective alpha 2-adrenergic drugs in the rat. Tanila, H., Kauppila, T., Taira, T. Gastroenterology (1993)
- Studies on the influence of enriched-environment housing combined with systemic administration of an alpha2-adrenergic antagonist on spatial learning and hyperactivity after global ischemia in rats. Puurunen, K., Sirviö, J., Koistinaho, J., Miettinen, R., Haapalinna, A., Riekkinen, P., Sivenius, J. Stroke (1997)
- An alpha(2)-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats. Puurunen, K., Jolkkonen, J., Sirviö, J., Haapalinna, A., Sivenius, J. Neuropharmacology (2001)
- Evidence for central alpha-2 adrenoceptors, not imidazoline binding sites, mediating the ethanol-attenuating properties of alpha-2 adrenoceptor antagonists. Durcan, M.J., Lister, R.G., Linnoila, M. J. Pharmacol. Exp. Ther. (1991)
- Dexmedetomidine injection into the locus ceruleus produces antinociception. Guo, T.Z., Jiang, J.Y., Buttermann, A.E., Maze, M. Anesthesiology (1996)
- Systemic administration of atipamezole, a selective antagonist of alpha-2 adrenoceptors, facilitates behavioural activity but does not influence short-term or long-term memory in trimethyltin-intoxicated and control rats. Niittykoski, M., Lappalainen, R., Jolkkonen, J., Haapalinna, A., Riekkinen, P., Sirviö, J. Neuroscience and biobehavioral reviews. (1998)
- Alpha-1-noradrenergic neurotransmission, corticosterone, and behavioral depression. Stone, E.A., Quartermain, D. Biol. Psychiatry (1999)
- Alpha-2 adrenoceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats. Marrs, W., Kuperman, J., Avedian, T., Roth, R.H., Jentsch, J.D. Neuropsychopharmacology (2005)
- Antinociceptive response to nitrous oxide is mediated by supraspinal opiate and spinal alpha 2 adrenergic receptors in the rat. Guo, T.Z., Poree, L., Golden, W., Stein, J., Fujinaga, M., Maze, M. Anesthesiology (1996)
- Comparative effects of alpha-2 receptor agents and THA on the performance of adult and aged rats in the delayed non-matching to position task. Sirviö, J., Harju, M., Riekkinen, P., Haapalinna, A., Riekkinen, P.J. Psychopharmacology (Berl.) (1992)
- Buccal delivery of an alpha 2-adrenergic receptor antagonist, atipamezole, in humans. Huupponen, R., Karhuvaara, S., Anttila, M., Vuorilehto, L., Scheinin, H. Clin. Pharmacol. Ther. (1995)
- In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse nucleus accumbens. Ihalainen, J.A., Tanila, H. J. Neurochem. (2004)
- Noradrenergic modulation of cognitive function in rat medial prefrontal cortex as measured by attentional set shifting capability. Lapiz, M.D., Morilak, D.A. Neuroscience (2006)
- Alpha2-adrenergic drug effects on brain monoamines, locomotion, and body temperature are largely abolished in mice lacking the alpha2A-adrenoceptor subtype. Lähdesmäki, J., Sallinen, J., MacDonald, E., Sirviö, J., Scheinin, M. Neuropharmacology (2003)
- Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole. Hoffman, W.E., Kochs, E., Werner, C., Thomas, C., Albrecht, R.F. Anesthesiology (1991)
- Antagonist precipitated clonidine withdrawal in rat: effects on locus coeruleus neurons, sympathetic nerves and cardiovascular parameters. Grubb, M.C., Stornetta, R.L., Pence, R., Baertschi, A.J., Guyenet, P.G. J. Auton. Nerv. Syst. (1998)
- The effects of alpha-2 agonist, medetomidine and its antagonist, atipamezole on reaction and movement times in a visual choice reaction time task in monkeys. Rämä, P., Linnankoski, I., Carlson, S. Brain Res. Bull. (1997)
- Antagonistic effect of atipamezole on xylazine-induced sedation, bradycardia, and ruminal atony in calves. Thompson, J.R., Kersting, K.W., Hsu, W.H. Am. J. Vet. Res. (1991)
- Antagonism of detomidine sedation in the horse using intravenous tolazoline or atipamezole. Hubbell, J.A., Muir, W.W. Equine Vet. J. (2006)
- Reversal of the sedative and sympatholytic effects of dexmedetomidine with a specific alpha2-adrenoceptor antagonist atipamezole: a pharmacodynamic and kinetic study in healthy volunteers. Scheinin, H., Aantaa, R., Anttila, M., Hakola, P., Helminen, A., Karhuvaara, S. Anesthesiology (1998)
- Modulation of the hypothermic and hyperglycaemic effects of 8-OH-DPAT by alpha 2-adrenoceptor antagonists. Durcan, M.J., Wozniak, K.M., Linnoila, M. Br. J. Pharmacol. (1991)
- Potentiation of the anti-obesity effect of the selective beta 3-adrenoceptor agonist BRL 35135 in obese Zucker rats by exercise. Santti, E., Huupponen, R., Rouru, J., Hänninen, V., Pesonen, U., Jhanwar-Uniyal, M., Koulu, M. Br. J. Pharmacol. (1994)
- The alpha 2-adrenoceptor antagonist atipamezole potentiates anti-Parkinsonian effects and can reduce the adverse cardiovascular effects of dopaminergic drugs in rats. Haapalinna, A., Leino, T., Heinonen, E. Naunyn Schmiedebergs Arch. Pharmacol. (2003)
- The effects of a specific alpha(2)-adrenoceptor antagonist, atipamezole, on cognitive performance and brain neurochemistry in aged Fisher 344 rats. Haapalinna, A., Sirviö, J., MacDonald, E., Virtanen, R., Heinonen, E. Eur. J. Pharmacol. (2000)
- Differentially altered cerebral metabolism in ischemic rats by alpha2-adrenoceptor blockade and its relation to improved limb-placing reactions. Barbelivien, A., Jolkkonen, J., Rutkauskaite, E., Sirviö, J., Sivenius, J. Neuropharmacology (2002)
- Non-adrenergic binding of [3H]atipamezole in rat kidney--regional distribution and comparison to alpha2-adrenoceptors. Sjöholm, B., Lähdesmäki, J., Pyykkö, K., Hillilä, M., Scheinin, M. Br. J. Pharmacol. (1999)
- Involvement of supraspinal and spinal segmental alpha-2-adrenergic mechanisms in the medetomidine-induced antinociception. Pertovaara, A., Kauppila, T., Jyväsjärvi, E., Kalso, E. Neuroscience (1991)
- Activation of fos in mouse amygdala by local infusion of norepinephrine or atipamezole. Stone, E.A., Zhang, Y., Hiller, J.M., Simon, E.J., Hillman, D.E. Brain Res. (1997)
- Effect of alpha2 antagonists and an agonist on EEG slowing induced by scopolamine and lesion of the nucleus basalis. Riekkinen, P., Sirviö, J., Jäkälä, P., Lammintausta, R., Riekkinen, P. Neuropharmacology (1990)
- Effects of a selective alpha 2-adrenoceptor antagonist, atipamezole, on hypothalamic histamine and noradrenaline release in vivo. Laitinen, K.S., Tuomisto, L., MacDonald, E. Eur. J. Pharmacol. (1995)
- Effects of atipamezole, detomidine and medetomidine on release of steroid hormones by porcine adrenocortical cells in vitro. Jager, L.P., De Graaf, G.J., Widjaja-Greefkes, H.C. Eur. J. Pharmacol. (1998)
- Alpha-adrenergic stimulation of ERK phosphorylation in astrocytes is alpha(2)-specific and may be mediated by transactivation. Peng, L., Yu, A.C., Fung, K.Y., Prévot, V., Hertz, L. Brain Res. (2003)
- Dexmedetomidine inhibits osmotic water permeability in the rat cortical collecting duct. Rouch, A.J., Kudo, L.H., Hébert, C. J. Pharmacol. Exp. Ther. (1997)
- Infusion of alpha-2-adrenergic agents into the paraventricular and arcuate nuclei of the hypothalamus in the Siberian hamster: opposing effects on basal prolactin. Dodge, J.C., Badura, L.L. Neuroendocrinology (2002)
- A fully noninvasive and robust experimental protocol for longitudinal fMRI studies in the rat. Weber, R., Ramos-Cabrer, P., Wiedermann, D., van Camp, N., Hoehn, M. Neuroimage (2006)
- Acetylcholine release in the rat prefrontal cortex in vivo: modulation by alpha 2-adrenoceptor agonists and antagonists. Tellez, S., Colpaert, F., Marien, M. J. Neurochem. (1997)
- Dexmedetomidine decreases seizure threshold in a rat model of experimental generalized epilepsy. Mirski, M.A., Rossell, L.A., McPherson, R.W., Traystman, R.J. Anesthesiology (1994)
- The effect of medetomidine, an alpha 2-adrenoceptor agonist, in various pain tests. Pertovaara, A., Kauppila, T., Tukeva, T. Eur. J. Pharmacol. (1990)