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Gene Review

CMKLR1  -  chemokine-like receptor 1

Homo sapiens

Synonyms: CHEMERINR, CHEMR23, ChemR23, Chemokine-like receptor 1, DEZ, ...
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Disease relevance of CMKLR1

  • In a panel of 27 HIV-1 isolates tested, 12 isolates could use CMKLR1/ChemR23 [1].
  • Freshly isolated macrophages from human ascites fluid express CMKLR1 and are chemerin responsive, as well [2].
  • Characterization of the human chemerin receptor - ChemR23/CMKLR1 - as co-receptor for human and simian immunodeficiency virus infection, and identification of virus-binding receptor domains [1].
  • Given the increasing number of chemoattractant receptors used by HIV-1, HIV-2 and SIV as coreceptors, ChemR23 was tested in fusion assays for potential coreceptor activity by a range of viral strains [3].
  • HHV-8-GPCR is a chemokine-like receptor encoded by KSHV, the etiologic agent of KS [4].

High impact information on CMKLR1


Biological context of CMKLR1


Anatomical context of CMKLR1


Associations of CMKLR1 with chemical compounds

  • We report the cloning of a novel human gene encoding an orphan receptor (ChemR23) related to the C3a, C5a and formyl Met-Leu-Phe receptors, and more distantly to the subfamilies of chemokine receptors [3].
  • To address this concern, we used a biotin-avidin linkage to conjugate rAd vectors to ligands which bind with high affinity to selected receptors on DC (ChemR23, alpha(v)beta3 integrin, and DC-SIGN) [11].

Other interactions of CMKLR1


Analytical, diagnostic and therapeutic context of CMKLR1


  1. Characterization of the human chemerin receptor - ChemR23/CMKLR1 - as co-receptor for human and simian immunodeficiency virus infection, and identification of virus-binding receptor domains. M??rtensson, U.E., Maria Feny??, E., Olde, B., Owman, C. Virology (2006) [Pubmed]
  2. Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands. Zabel, B.A., Ohyama, T., Zuniga, L., Kim, J.Y., Johnston, B., Allen, S.J., Guido, D.G., Handel, T.M., Butcher, E.C. Exp. Hematol. (2006) [Pubmed]
  3. ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains. Samson, M., Edinger, A.L., Stordeur, P., Rucker, J., Verhasselt, V., Sharron, M., Govaerts, C., Mollereau, C., Vassart, G., Doms, R.W., Parmentier, M. Eur. J. Immunol. (1998) [Pubmed]
  4. Insights into the viral G protein-coupled receptor encoded by human herpesvirus type 8 (HHV-8). Couty, J.P., Gershengorn, M.C. Biol. Cell (2004) [Pubmed]
  5. Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. Arita, M., Bianchini, F., Aliberti, J., Sher, A., Chiang, N., Hong, S., Yang, R., Petasis, N.A., Serhan, C.N. J. Exp. Med. (2005) [Pubmed]
  6. Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. Wittamer, V., Franssen, J.D., Vulcano, M., Mirjolet, J.F., Le Poul, E., Migeotte, I., Brézillon, S., Tyldesley, R., Blanpain, C., Detheux, M., Mantovani, A., Sozzani, S., Vassart, G., Parmentier, M., Communi, D. J. Exp. Med. (2003) [Pubmed]
  7. Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. Zabel, B.A., Allen, S.J., Kulig, P., Allen, J.A., Cichy, J., Handel, T.M., Butcher, E.C. J. Biol. Chem. (2005) [Pubmed]
  8. Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood. Zabel, B.A., Silverio, A.M., Butcher, E.C. J. Immunol. (2005) [Pubmed]
  9. Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors. Gantz, I., Konda, Y., Yang, Y.K., Miller, D.E., Dierick, H.A., Yamada, T. Cytogenet. Cell Genet. (1996) [Pubmed]
  10. Genomic organization and promoter analysis of the gene encoding the mouse chemoattractant-like receptor, CMKLR1. Mårtensson, U.E., Owman, C., Olde, B. Gene (2004) [Pubmed]
  11. Recombinant adenovirus type 5 vectors that target DC-SIGN, ChemR23 and alpha(v)beta3 integrin efficiently transduce human dendritic cells and enhance presentation of vectored antigens. Maguire, C.A., Sapinoro, R., Girgis, N., Rodriguez-Colon, S.M., Ramirez, S.H., Williams, J., Dewhurst, S. Vaccine (2006) [Pubmed]
  12. HIV-1 co-receptor expression on trophoblastic cells from early placentas and permissivity to infection by several HIV-1 primary isolates. Mognetti, B., Moussa, M., Croitoru, J., Menu, E., Dormont, D., Roques, P., Chaouat, G. Clin. Exp. Immunol. (2000) [Pubmed]
  13. A three-step purification strategy for isolation of hamster TIG2 from CHO cells: characterization of two processed endogenous forms. Busmann, A., Walden, M., Wendland, M., Kutzleb, C., Forssmann, W.G., John, H. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2004) [Pubmed]
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