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Gene Review

Drd3  -  dopamine receptor D3

Mus musculus

Synonyms: D(3) dopamine receptor, D3 receptor, D3R, Dopamine D3 receptor
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Disease relevance of Drd3


Psychiatry related information on Drd3


High impact information on Drd3


Chemical compound and disease context of Drd3


Biological context of Drd3


Anatomical context of Drd3


Associations of Drd3 with chemical compounds

  • C57BL/6J mice exhibit reduced dopamine D3 receptor-mediated locomotor-inhibitory function relative to DBA/2J mice [5].
  • The D3 receptor expressed in CHO-K1 and CCL1.3 cells exhibited similar radioligand binding profiles, especially for the D3-selective compound, 7-hydroxy-2-(di-n-propylamino)tetralin (7-OH-DPAT) [17].
  • In conclusion, these data indicate first that rimonabant prevented the enhancement by quinelorane of the appetitive value of food pellets unexpectedly delivered during extinction and second that rimonabant effects might involve D3 receptor-mediated processes [19].
  • CONCLUSIONS: Taken together, these studies suggest that the D2 receptor rather than the D3 receptor is important for the antidepressant-like activity observed for pramipexole in the mouse forced swim test [20].
  • Cocaine-conditioned hyperactivity was inhibited by BP 897 or SB-277011-A, D3R-selective partial agonist and antagonist, respectively [21].

Regulatory relationships of Drd3


Other interactions of Drd3


Analytical, diagnostic and therapeutic context of Drd3


  1. High-fat diet induced adiposity in mice with targeted disruption of the dopamine-3 receptor gene. McQuade, J.A., Benoit, S.C., Xu, M., Woods, S.C., Seeley, R.J. Behav. Brain Res. (2004) [Pubmed]
  2. Human dopamine D3 and D2L receptors couple to inward rectifier potassium channels in mammalian cell lines. Kuzhikandathil, E.V., Yu, W., Oxford, G.S. Mol. Cell. Neurosci. (1998) [Pubmed]
  3. Dopamine D2 receptor knock-out mice are insensitive to the hypolocomotor and hypothermic effects of dopamine D2/D3 receptor agonists. Boulay, D., Depoortere, R., Perrault, G., Borrelli, E., Sanger, D.J. Neuropharmacology (1999) [Pubmed]
  4. Antidepressant-like properties of the anti-Parkinson agent, piribedil, in rodents: mediation by dopamine D2 receptors. Brocco, M., Dekeyne, A., Papp, M., Millan, M.J. Behavioural pharmacology. (2006) [Pubmed]
  5. C57BL/6J mice exhibit reduced dopamine D3 receptor-mediated locomotor-inhibitory function relative to DBA/2J mice. McNamara, R.K., Levant, B., Taylor, B., Ahlbrand, R., Liu, Y., Sullivan, J.R., Stanford, K., Richtand, N.M. Neuroscience (2006) [Pubmed]
  6. Neuroadaptations to hyperdopaminergia in dopamine D3 receptor-deficient mice. Le Foll, B., Diaz, J., Sokoloff, P. Life Sci. (2005) [Pubmed]
  7. BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization. Guillin, O., Diaz, J., Carroll, P., Griffon, N., Schwartz, J.C., Sokoloff, P. Nature (2001) [Pubmed]
  8. Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist. Pilla, M., Perachon, S., Sautel, F., Garrido, F., Mann, A., Wermuth, C.G., Schwartz, J.C., Everitt, B.J., Sokoloff, P. Nature (1999) [Pubmed]
  9. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Xu, F., Gainetdinov, R.R., Wetsel, W.C., Jones, S.R., Bohn, L.M., Miller, G.W., Wang, Y.M., Caron, M.G. Nat. Neurosci. (2000) [Pubmed]
  10. Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension. Asico, L.D., Ladines, C., Fuchs, S., Accili, D., Carey, R.M., Semeraro, C., Pocchiari, F., Felder, R.A., Eisner, G.M., Jose, P.A. J. Clin. Invest. (1998) [Pubmed]
  11. Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors. Xu, M., Koeltzow, T.E., Santiago, G.T., Moratalla, R., Cooper, D.C., Hu, X.T., White, N.M., Graybiel, A.M., White, F.J., Tonegawa, S. Neuron (1997) [Pubmed]
  12. Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor. Joyce, J.N., Woolsey, C., Ryoo, H., Borwege, S., Hagner, D. BMC Biol. (2004) [Pubmed]
  13. Effects of acute "binge" cocaine on mRNA levels of mu opioid receptor and neuropeptides in dopamine D1 or D3 receptor knockout mice. Zhou, Y., Adomako-Mensah, J., Yuferov, V., Ho, A., Zhang, J., Xu, M., Kreek, M.J. Synapse (2007) [Pubmed]
  14. Structural organization of the murine D3 dopamine receptor gene. Park, B.H., Fishburn, C.S., Carmon, S., Accili, D., Fuchs, S. J. Neurochem. (1995) [Pubmed]
  15. Preferential alterations in the mesolimbic dopamine pathway of heterozygous reeler mice: an emerging animal-based model of schizophrenia. Ballmaier, M., Zoli, M., Leo, G., Agnati, L.F., Spano, P. Eur. J. Neurosci. (2002) [Pubmed]
  16. Dopamine D3 receptor agonists produce similar decreases in body temperature and locomotor activity in D3 knock-out and wild-type mice. Boulay, D., Depoortere, R., Rostene, W., Perrault, G., Sanger, D.J. Neuropharmacology (1999) [Pubmed]
  17. Characterization of the human dopamine D3 receptor expressed in transfected cell lines. MacKenzie, R.G., VanLeeuwen, D., Pugsley, T.A., Shih, Y.H., Demattos, S., Tang, L., Todd, R.D., O'Malley, K.L. Eur. J. Pharmacol. (1994) [Pubmed]
  18. Identification of the dopamine D3 receptor in oligodendrocyte precursors: potential role in regulating differentiation and myelin formation. Bongarzone, E.R., Howard, S.G., Schonmann, V., Campagnoni, A.T. J. Neurosci. (1998) [Pubmed]
  19. Blockade by the cannabinoid CB1 receptor antagonist, rimonabant (SR141716), of the potentiation by quinelorane of food-primed reinstatement of food-seeking behavior. Duarte, C., Alonso, R., Bichet, N., Cohen, C., Soubrié, P., Thiébot, M.H. Neuropsychopharmacology (2004) [Pubmed]
  20. The activity of pramipexole in the mouse forced swim test is mediated by D2 rather than D3 receptors. Siuciak, J.A., Fujiwara, R.A. Psychopharmacology (Berl.) (2004) [Pubmed]
  21. Role of the dopamine D3 receptor in reactivity to cocaine-associated cues in mice. Le Foll, B., Francès, H., Diaz, J., Schwartz, J.C., Sokoloff, P. Eur. J. Neurosci. (2002) [Pubmed]
  22. Dose-response analysis of locomotor activity and stereotypy in dopamine D3 receptor mutant mice following acute amphetamine. McNamara, R.K., Logue, A., Stanford, K., Xu, M., Zhang, J., Richtand, N.M. Synapse (2006) [Pubmed]
  23. The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption. Jeanblanc, J., He, D.Y., McGough, N.N., Logrip, M.L., Phamluong, K., Janak, P.H., Ron, D. J. Neurosci. (2006) [Pubmed]
  24. Differential regulation of the dopamine D1, D2 and D3 receptor gene expression and changes in the phenotype of the striatal neurons in mice lacking the dopamine transporter. Fauchey, V., Jaber, M., Caron, M.G., Bloch, B., Le Moine, C. Eur. J. Neurosci. (2000) [Pubmed]
  25. Molecular cloning and characterisation of the gene encoding the murine D4 dopamine receptor. Fishburn, C.S., Carmon, S., Fuchs, S. FEBS Lett. (1995) [Pubmed]
  26. Alterations in dopamine release but not dopamine autoreceptor function in dopamine D3 receptor mutant mice. Koeltzow, T.E., Xu, M., Cooper, D.C., Hu, X.T., Tonegawa, S., Wolf, M.E., White, F.J. J. Neurosci. (1998) [Pubmed]
  27. A novel short isoform of the D3 dopamine receptor generated by alternative splicing in the third cytoplasmic loop. Fishburn, C.S., Belleli, D., David, C., Carmon, S., Fuchs, S. J. Biol. Chem. (1993) [Pubmed]
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