Gene Review:
Cxcr4 - chemokine (C-X-C motif) receptor 4
Mus musculus
Synonyms:
C-X-C chemokine receptor type 4, CD184, CXC-R4, CXCR-4, Cmkar4, ...
- Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Nagasawa, T., Nakajima, T., Tachibana, K., Iizasa, H., Bleul, C.C., Yoshie, O., Matsushima, K., Yoshida, N., Springer, T.A., Kishimoto, T. Proc. Natl. Acad. Sci. U.S.A. (1996)
- AMD3465, a novel CXCR4 receptor antagonist, abrogates schistosomal antigen-elicited (type-2) pulmonary granuloma formation. Hu, J.S., Freeman, C.M., Stolberg, V.R., Chiu, B.C., Bridger, G.J., Fricker, S.P., Lukacs, N.W., Chensue, S.W. Am. J. Pathol. (2006)
- Mice deficient in the chemokine receptor CXCR4 exhibit impaired limb innervation and myogenesis. Odemis, V., Lamp, E., Pezeshki, G., Moepps, B., Schilling, K., Gierschik, P., Littman, D.R., Engele, J. Mol. Cell. Neurosci. (2005)
- Functional expression of CXC chemokine recepter-4 mediates the secretion of matrix metalloproteinases from mouse hepatocarcinoma cell lines with different lymphatic metastasis ability. Chu, H., Zhou, H., Liu, Y., Liu, X., Hu, Y., Zhang, J. Int. J. Biochem. Cell Biol. (2007)
- Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Zou, Y.R., Kottmann, A.H., Kuroda, M., Taniuchi, I., Littman, D.R. Nature (1998)
- HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Feng, Y., Broder, C.C., Kennedy, P.E., Berger, E.A. Science (1996)
- Reversing systemic inflammatory response syndrome with chemokine receptor pepducins. Kaneider, N.C., Agarwal, A., Leger, A.J., Kuliopulos, A. Nat. Med. (2005)
- Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Ceradini, D.J., Kulkarni, A.R., Callaghan, M.J., Tepper, O.M., Bastidas, N., Kleinman, M.E., Capla, J.M., Galiano, R.D., Levine, J.P., Gurtner, G.C. Nat. Med. (2004)
- Involvement of chemokine receptors in breast cancer metastasis. Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M.E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S.N., Barrera, J.L., Mohar, A., Verástegui, E., Zlotnik, A. Nature (2001)
- Characterization of antibody responses to purified HIV-1 gp120 glycoproteins fused with the molecular adjuvant C3d. Koch, M., Frazier, J., Sodroski, J., Wyatt, R. Virology (2005)
- The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Bleul, C.C., Farzan, M., Choe, H., Parolin, C., Clark-Lewis, I., Sodroski, J., Springer, T.A. Nature (1996)
- CXCR4 expression increases liver and lung metastasis in a mouse model of pancreatic cancer. Saur, D., Seidler, B., Schneider, G., Algül, H., Beck, R., Senekowitsch-Schmidtke, R., Schwaiger, M., Schmid, R.M. Gastroenterology (2005)
- Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells. Burger, M., Glodek, A., Hartmann, T., Schmitt-Gräff, A., Silberstein, L.E., Fujii, N., Kipps, T.J., Burger, J.A. Oncogene (2003)
- CXCR4 regulates growth of both primary and metastatic breast cancer. Smith, M.C., Luker, K.E., Garbow, J.R., Prior, J.L., Jackson, E., Piwnica-Worms, D., Luker, G.D. Cancer Res. (2004)
- Bone marrow-derived CXCR4+ cells mobilized by macrophage colony-stimulating factor participate in the reduction of infarct area and improvement of cardiac remodeling after myocardial infarction in mice. Morimoto, H., Takahashi, M., Shiba, Y., Izawa, A., Ise, H., Hongo, M., Hatake, K., Motoyoshi, K., Ikeda, U. Am. J. Pathol. (2007)
- Expression of the chemokine receptor Cxcr4 mRNA during mouse brain development. Tissir, F., Wang, C.E., Goffinet, A.M. Brain Res. Dev. Brain Res. (2004)
- CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells. Vasyutina, E., Stebler, J., Brand-Saberi, B., Schulz, S., Raz, E., Birchmeier, C. Genes Dev. (2005)
- Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1). Ara, T., Nakamura, Y., Egawa, T., Sugiyama, T., Abe, K., Kishimoto, T., Matsui, Y., Nagasawa, T. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis. Suratt, B.T., Petty, J.M., Young, S.K., Malcolm, K.C., Lieber, J.G., Nick, J.A., Gonzalo, J.A., Henson, P.M., Worthen, G.S. Blood (2004)
- A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. Lieberam, I., Agalliu, D., Nagasawa, T., Ericson, J., Jessell, T.M. Neuron (2005)
- Expression signature of the mouse prostate. Berquin, I.M., Min, Y., Wu, R., Wu, H., Chen, Y.Q. J. Biol. Chem. (2005)
- Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Allen, C.D., Ansel, K.M., Low, C., Lesley, R., Tamamura, H., Fujii, N., Cyster, J.G. Nat. Immunol. (2004)
- Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. Okada, T., Ngo, V.N., Ekland, E.H., Förster, R., Lipp, M., Littman, D.R., Cyster, J.G. J. Exp. Med. (2002)
- FTY720-enhanced T cell homing is dependent on CCR2, CCR5, CCR7, and CXCR4: evidence for distinct chemokine compartments. Yopp, A.C., Fu, S., Honig, S.M., Randolph, G.J., Ding, Y., Krieger, N.R., Bromberg, J.S. J. Immunol. (2004)
- Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. Miura, K., Uniyal, S., Leabu, M., Oravecz, T., Chakrabarti, S., Morris, V.L., Chan, B.M. Biochem. Cell Biol. (2005)
- A CXCR4-dependent chemorepellent signal contributes to the emigration of mature single-positive CD4 cells from the fetal thymus. Vianello, F., Kraft, P., Mok, Y.T., Hart, W.K., White, N., Poznansky, M.C. J. Immunol. (2005)
- Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes. Tanabe, S., Heesen, M., Yoshizawa, I., Berman, M.A., Luo, Y., Bleul, C.C., Springer, T.A., Okuda, K., Gerard, N., Dorf, M.E. J. Immunol. (1997)
- Lipopolysaccharide-induced maturation of bone marrow-derived dendritic cells is regulated by notch signaling through the up-regulation of CXCR4. Wang, Y.C., Hu, X.B., He, F., Feng, F., Wang, L., Li, W., Zhang, P., Li, D., Jia, Z.S., Liang, Y.M., Han, H. J. Biol. Chem. (2009)
- Stromal cell-derived factor-1alpha associates with heparan sulfates through the first beta-strand of the chemokine. Amara, A., Lorthioir, O., Valenzuela, A., Magerus, A., Thelen, M., Montes, M., Virelizier, J.L., Delepierre, M., Baleux, F., Lortat-Jacob, H., Arenzana-Seisdedos, F. J. Biol. Chem. (1999)
- Redirection of B cell responsiveness by transforming growth factor beta receptor. Roes, J., Choi, B.K., Cazac, B.B. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells. De La Luz Sierra, M., Gasperini, P., McCormick, P.J., Zhu, J., Tosato, G. Blood (2007)
- Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4. Wang, J., Alvarez, R., Roderiquez, G., Guan, E., Norcross, M.A. J. Cell. Biochem. (2004)
- The role of CXCL12 in the organ-specific process of artery formation. Ara, T., Tokoyoda, K., Okamoto, R., Koni, P.A., Nagasawa, T. Blood (2005)
- Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain. Tran, P.B., Banisadr, G., Ren, D., Chenn, A., Miller, R.J. J. Comp. Neurol. (2007)
- Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses. Kim, C.H., Qu, C.K., Hangoc, G., Cooper, S., Anzai, N., Feng, G.S., Broxmeyer, H.E. J. Exp. Med. (1999)
- The stromal cell-derived factor-1alpha/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas. Kayali, A.G., Van Gunst, K., Campbell, I.L., Stotland, A., Kritzik, M., Liu, G., Flodström-Tullberg, M., Zhang, Y.Q., Sarvetnick, N. J. Cell Biol. (2003)
- GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo. Vroon, A., Heijnen, C.J., Raatgever, R., Touw, I.P., Ploemacher, R.E., Premont, R.T., Kavelaars, A. J. Leukoc. Biol. (2004)
- Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4. McGrath, K.E., Koniski, A.D., Maltby, K.M., McGann, J.K., Palis, J. Dev. Biol. (1999)
- Syngenic bone marrow cells restore hepatic function in carbon tetrachloride-induced mouse liver injury. Jung, Y.J., Ryu, K.H., Cho, S.J., Woo, S.Y., Seoh, J.Y., Chun, C.H., Yoo, K., Moon, I.H., Han, H.S. Stem Cells Dev. (2006)
- Renal SDF-1 signals mobilization and homing of CXCR4-positive cells to the kidney after ischemic injury. Tögel, F., Isaac, J., Hu, Z., Weiss, K., Westenfelder, C. Kidney Int. (2005)