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Gene Review

Fut7  -  fucosyltransferase 7

Mus musculus

Synonyms: AI853193, Alpha-(1,3)-fucosyltransferase 7, FTVII, Fuc-TVII, FucT-VII, ...
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Disease relevance of Fut7


High impact information on Fut7

  • These observations demonstrate an essential role for Fuc-TVII in E-, P-, and L-selectin ligand biosynthesis and imply that this locus can control leukocyte trafficking in health and disease [6].
  • The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis [6].
  • The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing [7].
  • We show here that inflammation-dependent leukocyte recruitment retained in FucT-VII deficiency is extinguished in FucT-IV(-/-)/FucT-VII(-/-) mice [7].
  • Fucosylated selectin ligands are essential for all interactions, as rolling was absent in mice doubly deficient in alpha1,3-fucosyltransferase (FucT)-IV and FucT-VII [8].

Biological context of Fut7

  • Influencing the differentiation by varying the priming dose of antigenic peptide results in similar FucT-VII down-regulation only in Ag-specific Th2 cells [5].
  • The deduced amino acid sequence of mFuc-TIX, consisting of 359 residues, indicated a type II membrane protein and shows low degrees of homology to the previously cloned alpha1,3-fucosyltransferases, i.e. mFuc-TIV (48.4%), mouse Fuc-TVII (39.1%), and human Fuc-TIII (43.0%), at the amino acid sequence level [9].
  • FucT-VII expression was induced by T cell activation, and was enhanced by IL-12 independently of Stat4, whereas C2GlcNAcT-I up-regulation was mediated exclusively by IL-12, acting through Stat4 [10].
  • Transplantation of a heart from ICAM-1 -/- or Fuc-TVII/ICAM-1 double-mutated mice into allogeneic recipients resulted in limited (2-2.5 days) but nevertheless significant prolongation of the graft survival (P<0.01 and P<0.01 in log-rank test) compared with the survival of unmodified hearts [11].
  • We also demonstrate that Fuc-TVII overexpression in HAL-24Luc cells is sufficient for the acquisition of the lung colonization phenotype [12].

Anatomical context of Fut7

  • Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes [2].
  • By contrast, defective CHS in Fuc-TVII(-/-) mice or Fuc-TIV(-/-)/Fuc-TVII(-/-) mice is attributed in part to prominent, or nearly complete deficiencies, respectively, in the complement of naive T lymphocytes available in lymph nodes for antigen-dependent activation, expansion, differentiation, and dissemination [2].
  • CONCLUSIONS: FucT-VII-mediated alpha(1,3)fucosylation of selectin ligands is a necessary concomitant to atherogenesis in apoE-/- mice and is required for P-selectin-dependent peripheral blood monocyte adhesion under shear stress [4].
  • FucT-IV also contributes to HEV-born L-selectin ligands, since lymphocyte homing retained in FucT-VII(-/-) mice is revoked in FucT-IV(-/-)/FucT-VII(-/-) mice [7].
  • Neutrophil infiltration in postischemic kidneys of FucT-IV/FucT-VII-deficient mice was also attenuated [13].

Associations of Fut7 with chemical compounds


Regulatory relationships of Fut7

  • In brief, FucT-VII mRNA levels were higher in cultured T lymphoblasts expressing sLe(x)-related epitopes and both selectin ligands than in cells expressing P-selectin ligands alone [16].
  • Previous studies from our laboratories indicated that the alpha(1,3)-fucosyltransferase FucT-VII regulates the synthesis of E-selectin ligands and sialylated Lewis(x)-related epitopes (sLe(x)-related epitopes) in human T lymphoblasts [16].

Other interactions of Fut7


Analytical, diagnostic and therapeutic context of Fut7


  1. L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest. Läubli, H., Stevenson, J.L., Varki, A., Varki, N.M., Borsig, L. Cancer Res. (2006) [Pubmed]
  2. Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes. Smithson, G., Rogers, C.E., Smith, P.L., Scheidegger, E.P., Petryniak, B., Myers, J.T., Kim, D.S., Homeister, J.W., Lowe, J.B. J. Exp. Med. (2001) [Pubmed]
  3. Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart. Cai, Y.H., Alvarez, A., Alcaide, P., Duramad, P., Lim, Y.C., Jarolim, P., Lowe, J.B., Luscinskas, F.W., Lichtman, A.H. J. Immunol. (2006) [Pubmed]
  4. Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- mice. Homeister, J.W., Daugherty, A., Lowe, J.B. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
  5. Alpha(1,3)-fucosyltransferase VII and alpha(2,3)-sialyltransferase IV are up-regulated in activated CD4 T cells and maintained after their differentiation into Th1 and migration into inflammatory sites. Blander, J.M., Visintin, I., Janeway, C.A., Medzhitov, R. J. Immunol. (1999) [Pubmed]
  6. The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Malý, P., Thall, A., Petryniak, B., Rogers, C.E., Smith, P.L., Marks, R.M., Kelly, R.J., Gersten, K.M., Cheng, G., Saunders, T.L., Camper, S.A., Camphausen, R.T., Sullivan, F.X., Isogai, Y., Hindsgaul, O., von Andrian, U.H., Lowe, J.B. Cell (1996) [Pubmed]
  7. The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing. Homeister, J.W., Thall, A.D., Petryniak, B., Malý, P., Rogers, C.E., Smith, P.L., Kelly, R.J., Gersten, K.M., Askari, S.W., Cheng, G., Smithson, G., Marks, R.M., Misra, A.K., Hindsgaul, O., von Andrian, U.H., Lowe, J.B. Immunity (2001) [Pubmed]
  8. Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels. Weninger, W., Ulfman, L.H., Cheng, G., Souchkova, N., Quackenbush, E.J., Lowe, J.B., von Andrian, U.H. Immunity (2000) [Pubmed]
  9. Expression cloning and characterization of a novel murine alpha1, 3-fucosyltransferase, mFuc-TIX, that synthesizes the Lewis x (CD15) epitope in brain and kidney. Kudo, T., Ikehara, Y., Togayachi, A., Kaneko, M., Hiraga, T., Sasaki, K., Narimatsu, H. J. Biol. Chem. (1998) [Pubmed]
  10. Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells. White, S.J., Underhill, G.H., Kaplan, M.H., Kansas, G.S. J. Immunol. (2001) [Pubmed]
  11. Intercellular cell adhesion molecule-1 and selectin ligands in acute cardiac allograft rejection: a study on gene-deficient mouse models. Lácha, J., Bushell, A., Smetana, K., Rossmann, P., Pribylová, P., Wood, K., Malý, P. J. Leukoc. Biol. (2002) [Pubmed]
  12. Overexpression of alpha(1,3)-fucosyltransferase VII is sufficient for the acquisition of lung colonization phenotype in human lung adenocarcinoma HAL-24Luc cells. Martín-Satué, M., de Castellarnau, C., Blanco, J. Br. J. Cancer (1999) [Pubmed]
  13. Pathophysiological contributions of fucosyltransferases in renal ischemia reperfusion injury. Burne, M.J., Rabb, H. J. Immunol. (2002) [Pubmed]
  14. Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant. Natsuka, S., Gersten, K.M., Zenita, K., Kannagi, R., Lowe, J.B. J. Biol. Chem. (1994) [Pubmed]
  15. Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII. Piccio, L., Rossi, B., Colantonio, L., Grenningloh, R., Gho, A., Ottoboni, L., Homeister, J.W., Scarpini, E., Martinello, M., Laudanna, C., D'Ambrosio, D., Lowe, J.B., Constantin, G. J. Immunol. (2005) [Pubmed]
  16. Alpha(1,3)-fucosyltransferase VII-dependent synthesis of P- and E-selectin ligands on cultured T lymphoblasts. Knibbs, R.N., Craig, R.A., Mály, P., Smith, P.L., Wolber, F.M., Faulkner, N.E., Lowe, J.B., Stoolman, L.M. J. Immunol. (1998) [Pubmed]
  17. P-selectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyltransferases Fuc-TIV and Fuc-TVII in mouse neutrophils. Huang, M.C., Zöllner, O., Moll, T., Maly, P., Thall, A.D., Lowe, J.B., Vestweber, D. J. Biol. Chem. (2000) [Pubmed]
  18. Increased expression of alpha(1,3)-fucosyltransferase-VII and P-selectin binding of synovial fluid T cells in juvenile idiopathic arthritis. De Benedetti, F., Pignatti, P., Biffi, M., Bono, E., Wahid, S., Ingegnoli, F., Chang, S.Y., Alexander, H., Massa, M., Pistorio, A., Martini, A., Pitzalis, C., Sinigaglia, F., Rogge, L. J. Rheumatol. (2003) [Pubmed]
  19. Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice. Beck, P.L., Xavier, R., Lu, N., Nanda, N.N., Dinauer, M., Podolsky, D.K., Seed, B. Gastroenterology (2000) [Pubmed]
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