Gene Review:
Stat4 - signal transducer and activator of...
Mus musculus
Synonyms:
Signal transducer and activator of transcription 4
- Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis. Matsukawa, A., Kaplan, M.H., Hogaboam, C.M., Lukacs, N.W., Kunkel, S.L. J. Exp. Med. (2001)
- Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice. Jacob, C.O., Zang, S., Li, L., Ciobanu, V., Quismorio, F., Mizutani, A., Satoh, M., Koss, M. J. Immunol. (2003)
- Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response. Kaplan, M.H., Whitfield, J.R., Boros, D.L., Grusby, M.J. J. Immunol. (1998)
- Stat4-null non-obese diabetic mice: protection from diabetes and experimental allergic encephalomyelitis, but with concomitant epitope spread. Boyton, R.J., Davies, S., Marden, C., Fantino, C., Reynolds, C., Portugal, K., Dewchand, H., Altmann, D.M. Int. Immunol. (2005)
- Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Kaplan, M.H., Sun, Y.L., Hoey, T., Grusby, M.J. Nature (1996)
- GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet. Usui, T., Nishikomori, R., Kitani, A., Strober, W. Immunity (2003)
- Effect of targeted disruption of signal transducer and activator of transcription (Stat)4 and Stat6 genes on the autoimmune diabetes development induced by multiple low doses of streptozotocin. Cetkovic-Cvrlje, M., Uckun, F.M. Clin. Immunol. (2005)
- Dysfunction of Stat4 leads to accelerated incidence of chemical-induced thymic lymphomas in mice. Zhang, S.S., Welte, T., Fu, X.Y. Exp. Mol. Pathol. (2001)
- Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection. Shen, X.D., Ke, B., Zhai, Y., Gao, F., Anselmo, D., Lassman, C.R., Busuttil, R.W., Kupiec-Weglinski, J.W. Hepatology (2003)
- Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways. Lawless, V.A., Zhang, S., Ozes, O.N., Bruns, H.A., Oldham, I., Hoey, T., Grusby, M.J., Kaplan, M.H. J. Immunol. (2000)
- Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M. Broxmeyer, H.E., Bruns, H.A., Zhang, S., Cooper, S., Hangoc, G., McKenzie, A.N., Dent, A.L., Schindler, U., Naeger, L.K., Hoey, T., Kaplan, M.H. Immunity (2002)
- Involvement of connective tissue-type mast cells in Th1 immune responses via Stat4 expression. Kataoka, T.R., Komazawa, N., Morii, E., Oboki, K., Nakano, T. Blood (2005)
- A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells. Kaplan, M.H., Wurster, A.L., Grusby, M.J. J. Exp. Med. (1998)
- Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. Jacobson, N.G., Szabo, S.J., Weber-Nordt, R.M., Zhong, Z., Schreiber, R.D., Darnell, J.E., Murphy, K.M. J. Exp. Med. (1995)
- Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells. White, S.J., Underhill, G.H., Kaplan, M.H., Kansas, G.S. J. Immunol. (2001)
- Unexpected characteristics of the IFN-gamma reporters in nontransformed T cells. Zhu, H., Yang, J., Murphy, T.L., Ouyang, W., Wagner, F., Saparov, A., Weaver, C.T., Murphy, K.M. J. Immunol. (2001)
- The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-gamma expression. Zhang, S., Kaplan, M.H. J. Immunol. (2000)
- Distinct requirements for Stat4 and Stat6 in hematopoietic progenitor cell responses to growth factors and chemokines. Kaplan, M.H., Chang, H.C., Cooper, S., Lee, Y., Broxmeyer, H.E. J. Hematother. Stem Cell Res. (2003)
- Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. Tarleton, R.L., Grusby, M.J., Zhang, L. J. Immunol. (2000)
- Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Zhong, Z., Wen, Z., Darnell, J.E. Proc. Natl. Acad. Sci. U.S.A. (1994)
- The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals. Kamezaki, K., Shimoda, K., Numata, A., Matsuda, T., Nakayama, K., Harada, M. Int. Immunol. (2004)
- Interleukin 13 gene transfer in liver ischemia and reperfusion injury: role of Stat6 and TLR4 pathways in cytoprotection. Ke, B., Shen, X.D., Gao, F., Busuttil, R.W., Kupiec-Weglinski, J.W. Hum. Gene Ther. (2004)
- Jaks and Stats in cytokine signaling. Ihle, J.N., Nosaka, T., Thierfelder, W., Quelle, F.W., Shimoda, K. Stem Cells (1997)
- Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses. Hoey, T., Zhang, S., Schmidt, N., Yu, Q., Ramchandani, S., Xu, X., Naeger, L.K., Sun, Y.L., Kaplan, M.H. EMBO J. (2003)
- The mouse transcription factor Stat4 is expressed in haploid male germ cells and is present in the perinuclear theca of spermatozoa. Herrada, G., Wolgemuth, D.J. J. Cell. Sci. (1997)
- Role of Stat4-Mediated Signal Transduction Events in the Generation of Aggressor CD4(+) T Cells in Herpetic Stromal Keratitis Pathogenesis. Banerjee, K., Biswas, P.S., Rouse, B.T. J. Interferon Cytokine Res. (2007)