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MeSH Review


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Disease relevance of Uvula


High impact information on Uvula

  • Uvula and oesophageal ulcerations with foscarnet [6].
  • We postulate that a GABA-mediated disturbance affecting the cerebellar nodulus and uvula was responsible for the PAGD in these patients [7].
  • Neither the metabotropic glutamate receptor 1 nor delta2 glutamate receptor in flocculus and uvula/nodulus was affected by a hypergravity load for 2 h to 1 week [8].
  • Dopamine D1-3 receptors, tyrosine hydroxylase and dopamine transporter mRNA was detected in the uvula and nodulus (lobules 9 and 10, respectively) of the vermis of cerebellum from normal individuals [9].
  • In the lower folia of the uvula and nodulus, Purkinje cell expression of PKC-delta is uniformly high, and the sagittal banding for PKC-delta expression is absent [10].

Biological context of Uvula

  • The distribution of vestibular neurons projecting to the flocculus and the nodulus and uvula of the caudal vermis (Larsell's lobules X and IX) was investigated with retrograde axonal transport of horseradish peroxidase and the fluorescent tracers Fast Blue, Nuclear Yellow and Diamindino Yellow [11].
  • No difference was found for the muscles of mastication, levator and tensor veli palatini muscles, styloglossus muscle, genioglossus muscle, intrinsic muscles of the tongue, digastric muscles, mucosal surface of the lateral and posterior pharyngeal wall, uvula, valleculae, parapharyngeal space and larynx [12].
  • Twelve normal fetuses underwent surgical cleft creation by excision of a 20 x 3 mm full-thickness midline section of the secondary palate extending from the alveolus to the uvula, at 85 days of gestation [13].

Anatomical context of Uvula

  • From P4 through P21, several Purkinje cells in the uvula, nodule, and flocculus of the cerebellum demonstrated ChAT-like immunoreactivity [14].
  • We used the juxtacellular recording and labeling technique of Pinault (1996) in the uvula/nodulus of the ketamine anesthetized rat in an attempt to link different patterns of spontaneous activity with different types of morphologically identified cerebellar cortical interneurons [15].
  • Four human soft palate muscles, and palatopharyngeus, the uvula, the levator and tensor veli palatini were examined using enzyme-histochemical, immunohistochemical and biochemical methods and compared with human limb and facial muscles [16].
  • Seventeen patients had a diagnosis of submucous cleft palate made preoperatively and of these thirteen presented with the classic triad of a bifid uvula, a palpable abnormality of the hard palate and diastasis of the soft palate musculature [17].
  • In contrast, MDM2 protein is always detectable in basal and parabasal cells of morphologically normal epithelium outside the invasively growing tumour, as well as in a normal uvula sample [18].

Associations of Uvula with chemical compounds

  • The ventral uvula of the mouse cerebellum: a neural target of ethanol and vestibular stimuli [19].
  • Microinjections of fluorescent tracers (Nuclear Yellow and Fast Blue) were used to study the organization of olivary cells in nucleus beta which give rise to climbing fibers to the medial zone of the uvula and the intermediate zone of the pyramis [20].
  • To identify the cells of origin of these branching climbing fibers, a pair of retrograde fluorescent tracers, propidium iodide in combination with 4', 6-diamidino-2-phenylindole or diamidino yellow, were injected into two sites in the flocculus, nodulus and uvula [21].
  • The rostrolateral part of the MAO projects to the most lateral zone (rostrolateral MAO zone) of the uvula [22].
  • Olivocerebellar branching projections to the flocculus, nodulus and uvula were studied electrophysiologically in pigmented rabbits anesthetized with pentobarbital and halothane [23].

Gene context of Uvula

  • We conclude that immunoreactive NEP is significantly decreased in the uvula epithelium of patients with OSA [24].
  • Injections made in or adjacent to the midline of the uvula resulted in the retrograde labeling of cells, bilaterally in the caudal portion of the medial accessory olive (MAO) [25].
  • Carcinoma of the uvula and midline soft palate: indication for neck treatment [26].
  • The fibre type and MyHC composition indicate that the palatopharyngeus and uvula muscles are functionally involved in quick movements whereas the levator and tensor veli palatini muscles perform slower and more continuous contractions [16].
  • Van der Woude syndrome (VWS) is an autosomal dominant disorder characterized by clefts of the lip and/or palate (CL+/-P), lip pits, bifid uvula and hypodontia [27].

Analytical, diagnostic and therapeutic context of Uvula


  1. Morphologic significance of bifid uvula. Shprintzen, R.J., Schwartz, R.H., Daniller, A., Hoch, L. Pediatrics (1985) [Pubmed]
  2. Emergency stenting of malignant obstruction of the upper airways: long-term follow-up with two types of silicone prostheses. Wassermann, K., Eckel, H.E., Michel, O., Müller, R.P. J. Thorac. Cardiovasc. Surg. (1996) [Pubmed]
  3. Van der Woude syndrome. A case report. Vignale, R., Araujo, J., Pascal, G., Reissenweber, N., Abulafia, J., Quadrelli, R., Vaglio, A., Larrandaburo, M., Reyno, S. Pediatric dermatology. (1998) [Pubmed]
  4. A complication of the use of the laser in ENT surgery. Brightwell, A.P. The Journal of laryngology and otology. (1983) [Pubmed]
  5. A girl with pervasive developmental disorder and complex chromosome rearrangement involving 8p and 10p. Zwaigenbaum, L., Sonnenberg, L.K., Heshka, T., Eastwood, S., Xu, J. Journal of autism and developmental disorders. (2005) [Pubmed]
  6. Uvula and oesophageal ulcerations with foscarnet. Saint-Marc, T., Fournier, F., Touraine, J.L., Marneff, E. Lancet (1992) [Pubmed]
  7. Reversible periodic alternating gaze deviation in hepatic encephalopathy. Averbuch-Heller, L., Meiner, Z. Neurology (1995) [Pubmed]
  8. Quantitative changes in mRNA expression of glutamate receptors in the rat peripheral and central vestibular systems following hypergravity. Uno, Y., Horii, A., Uno, A., Fuse, Y., Fukushima, M., Doi, K., Kubo, T. J. Neurochem. (2002) [Pubmed]
  9. Markers for dopaminergic neurotransmission in the cerebellum in normal individuals and patients with Parkinson's disease examined by RT-PCR. Hurley, M.J., Mash, D.C., Jenner, P. Eur. J. Neurosci. (2003) [Pubmed]
  10. Regional and cellular distribution of protein kinase C in rat cerebellar Purkinje cells. Barmack, N.H., Qian, Z., Yoshimura, J. J. Comp. Neurol. (2000) [Pubmed]
  11. Secondary vestibulocerebellar projections to the flocculus and uvulo-nodular lobule of the rabbit: a study using HRP and double fluorescent tracer techniques. Epema, A.H., Gerrits, N.M., Voogd, J. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1990) [Pubmed]
  12. Ear pain in patients with oropharynx carcinoma: how MRI contributes to the explanation of a prognostic and predictive symptom. Thoeny, H.C., Beer, K.T., Vock, P., Greiner, R.H. European radiology. (2004) [Pubmed]
  13. The fetal cleft palate: II. Scarless healing after in utero repair of a congenital model. Weinzweig, J., Panter, K.E., Pantaloni, M., Spangenberger, A., Harper, J.S., Lui, F., James, L.F., Edstrom, L.E. Plast. Reconstr. Surg. (1999) [Pubmed]
  14. Transient expression of choline acetyltransferase-like immunoreactivity in Purkinje cells of the developing rat cerebellum. Gould, E., Butcher, L.L. Brain Res. (1987) [Pubmed]
  15. Between in and out: linking morphology and physiology of cerebellar cortical interneurons. Simpson, J.I., Hulscher, H.C., Sabel-Goedknegt, E., Ruigrok, T.J. Prog. Brain Res. (2005) [Pubmed]
  16. Characterisation of human soft palate muscles with respect to fibre types, myosins and capillary supply. Stål, P.S., Lindman, R. J. Anat. (2000) [Pubmed]
  17. Velopharyngeal incompetency in the absence of overt cleft palate: anatomic and surgical considerations. Trier, W.C. The Cleft palate journal. (1983) [Pubmed]
  18. Loss of MDM2 expression in human head and neck squamous cell carcinomas and clinical significance. Millon, R., Muller, D., Schultz, I., Salvi, R., Ghnassia, J.P., Frebourg, T., Wasylyk, B., Abecassis, J. Oral Oncol. (2001) [Pubmed]
  19. The ventral uvula of the mouse cerebellum: a neural target of ethanol and vestibular stimuli. Eisenman, L.M., Scott Donovan, H. Brain Res. (2004) [Pubmed]
  20. A double label retrograde tracing study of the olivocerebellar projection to the pyramis and uvula in the rat. Eisenman, L.M., Goracci, G.P. Neurosci. Lett. (1983) [Pubmed]
  21. Olivary branching projections to the flocculus, nodulus and uvula in the rabbit. II. Retrograde double labeling study with fluorescent dyes. Takeda, T., Maekawa, K. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1989) [Pubmed]
  22. Zonal organization of olivocerebellar projections to the uvula in rabbits. Sato, Y., Barmack, N.H. Brain Res. (1985) [Pubmed]
  23. Olivary branching projections to the flocculus, nodulus and uvula in the rabbit. I. An electrophysiological study. Takeda, T., Maekawa, K. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1989) [Pubmed]
  24. Decrease in immunoreactive neutral endopeptidase in uvula epithelium of patients with obstructive sleep apnea. Zakkar, M., Sekosan, M., Wenig, B., Olopade, C.O., Rubinstein, I. The Annals of otology, rhinology, and laryngology. (1997) [Pubmed]
  25. The olivocerebellar projection to the uvula in the mouse. Eisenman, L.M., Sieger, D.D., Blatt, G.J. J. Comp. Neurol. (1983) [Pubmed]
  26. Carcinoma of the uvula and midline soft palate: indication for neck treatment. Har-El, G., Shaha, A., Chaudry, R., Hadar, T., Krespi, Y.P., Lucente, F.E. Head & neck. (1992) [Pubmed]
  27. Van Der Woude syndrome: variable penetrance of a novel mutation (p.Arg 84Gly) of the IRF6 gene in a Turkish family. Item, C.B., Turhani, D., Thurnher, D., Yerit, K., Sinko, K., Wittwer, G., Adeyemo, W.L., Frei, K., Erginel-Unaltuna, N., Watzinger, F., Ewers, R. Int. J. Mol. Med. (2005) [Pubmed]
  28. Laser-assisted uvula-palatoplasty for snoring. Krespi, Y.P., Pearlman, S.J., Keidar, A. The Journal of otolaryngology. (1994) [Pubmed]
  29. Bilateral peritonsillar abscesses: not your usual sore throat. Fasano, C.J., Chudnofsky, C., Vanderbeek, P. The Journal of emergency medicine. (2005) [Pubmed]
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