The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Bcl3  -  B cell leukemia/lymphoma 3

Mus musculus

Synonyms: AI528691, B-cell lymphoma 3 protein homolog, BCL-3, Bcl-3
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Bcl3


High impact information on Bcl3


Chemical compound and disease context of Bcl3

  • We propose that E2 withdrawal may initiate selection for hormone independence in breast cancer cells by activation of NF-kappaB and Bcl-3, which could then supplant E2 by providing both survival and growth signals [9].
  • No changes in the levels of nuclear I kappa B alpha or Bcl-3 occurred after hemorrhage when xanthine oxidase activity was inhibited [10].

Biological context of Bcl3


Anatomical context of Bcl3


Associations of Bcl3 with chemical compounds

  • Nuclear localization of Bcl-3 was associated with inhibition of LPS-induced TNF-alpha production [13].
  • Tumors derived from MCF-7 cells ectopically expressing Bcl-3 remain E2 dependent but display a markedly higher tumor establishment and growth rate compared to controls [9].
  • Transfer of the N-terminal domain of IkappaB alpha to the ankyrin domain of the related oncoprotein Bcl-3 or to the unrelated protein glutathione S-transferase confers signal-induced phosphorylation on the resulting chimeric proteins [14].
  • Estrogen withdrawal increases both NF-kappaB DNA binding activity and expression of Bcl-3 in MCF-7 and LCC1 cells in vitro and in vivo [9].
  • These results demonstrate that blood loss, at least partly through xanthine oxidase-dependent mechanisms, produces alterations in the levels of both I kappa B alpha and Bcl-3 in lung mononuclear cell populations [10].
  • Platelets from wild-type mice synthesize Bcl-3 in response to activation, as do human platelets, and platelets from mice with targeted deletion of Bcl-3 have defective retraction of fibrin in platelet-fibrin clots mimicking treatment of human platelets with rapamycin [15].

Physical interactions of Bcl3

  • Remarkably, constitutive expression of Bcl-3 in these cells augments the DNA binding activity of p52 homodimers [16].

Regulatory relationships of Bcl3


Other interactions of Bcl3

  • The results indicate that Bcl-3 is associated with endogenous p50 and p52 in nuclear extracts from transgenic animals [16].
  • These genes included nuclear IkappaB proteins such as Bcl-3 and IkappaBNS [17].
  • Overexpression of Jun family proteins transactivates the promoter and restores Bcl-3 expression in the absence of IL-4 stimulation [18].
  • To characterize the IL-4-induced regulation of murine Bcl-3 expression, we cloned the promoter of this gene [18].
  • The time courses of expression suggest that Bcl-2 and Bcl-x(L) promote survival early in the response, whereas Bcl-3 acts later in the response [19].

Analytical, diagnostic and therapeutic context of Bcl3


  1. Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy. Hunter, R.B., Kandarian, S.C. J. Clin. Invest. (2004) [Pubmed]
  2. The IkappaB protein Bcl-3 negatively regulates transcription of the IL-10 gene in macrophages. Riemann, M., Endres, R., Liptay, S., Pfeffer, K., Schmid, R.M. J. Immunol. (2005) [Pubmed]
  3. Increased expression of p50-NF-kappaB and constitutive activation of NF-kappaB transcription factors during mouse skin carcinogenesis. Budunova, I.V., Perez, P., Vaden, V.R., Spiegelman, V.S., Slaga, T.J., Jorcano, J.L. Oncogene (1999) [Pubmed]
  4. Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions. Franzoso, G., Carlson, L., Scharton-Kersten, T., Shores, E.W., Epstein, S., Grinberg, A., Tran, T., Shacter, E., Leonardi, A., Anver, M., Love, P., Sher, A., Siebenlist, U. Immunity (1997) [Pubmed]
  5. The putative oncoprotein Bcl-3 induces cyclin D1 to stimulate G(1) transition. Westerheide, S.D., Mayo, M.W., Anest, V., Hanson, J.L., Baldwin, A.S. Mol. Cell. Biol. (2001) [Pubmed]
  6. Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Massoumi, R., Chmielarska, K., Hennecke, K., Pfeifer, A., Fässler, R. Cell (2006) [Pubmed]
  7. Expression of the Bcl-3 proto-oncogene suppresses p53 activation. Kashatus, D., Cogswell, P., Baldwin, A.S. Genes Dev. (2006) [Pubmed]
  8. Immunological defects in mice with a targeted disruption in Bcl-3. Schwarz, E.M., Krimpenfort, P., Berns, A., Verma, I.M. Genes Dev. (1997) [Pubmed]
  9. Estrogen withdrawal-induced NF-kappaB activity and bcl-3 expression in breast cancer cells: roles in growth and hormone independence. Pratt, M.A., Bishop, T.E., White, D., Yasvinski, G., Ménard, M., Niu, M.Y., Clarke, R. Mol. Cell. Biol. (2003) [Pubmed]
  10. Systemic blood loss affects NF-kappa B regulatory mechanisms in the lungs. Moine, P., Shenkar, R., Kaneko, D., Le Tulzo, Y., Abraham, E. Am. J. Physiol. (1997) [Pubmed]
  11. Abnormal organogenesis of Peyer's patches in mice deficient for NF-kappaB1, NF-kappaB2, and Bcl-3. Paxian, S., Merkle, H., Riemann, M., Wilda, M., Adler, G., Hameister, H., Liptay, S., Pfeffer, K., Schmid, R.M. Gastroenterology (2002) [Pubmed]
  12. The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells. Bauer, A., Villunger, A., Labi, V., Fischer, S.F., Strasser, A., Wagner, H., Schmid, R.M., Häcker, G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  13. IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages. Kuwata, H., Watanabe, Y., Miyoshi, H., Yamamoto, M., Kaisho, T., Takeda, K., Akira, S. Blood (2003) [Pubmed]
  14. The signal response of IkappaB alpha is regulated by transferable N- and C-terminal domains. Brown, K., Franzoso, G., Baldi, L., Carlson, L., Mills, L., Lin, Y.C., Gerstberger, S., Siebenlist, U. Mol. Cell. Biol. (1997) [Pubmed]
  15. mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets. Weyrich, A.S., Denis, M.M., Schwertz, H., Tolley, N.D., Foulks, J., Spencer, E., Kraiss, L.W., Albertine, K.H., McIntyre, T.M., Zimmerman, G.A. Blood (2007) [Pubmed]
  16. Constitutive expression of Bc1-3 in thymocytes increases the DNA binding of NF-kappaB1 (p50) homodimers in vivo. Caamaño, J.H., Perez, P., Lira, S.A., Bravo, R. Mol. Cell. Biol. (1996) [Pubmed]
  17. The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria. Hirotani, T., Lee, P.Y., Kuwata, H., Yamamoto, M., Matsumoto, M., Kawase, I., Akira, S., Takeda, K. J. Immunol. (2005) [Pubmed]
  18. Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and AP1-like transcription factors. Rebollo, A., Dumoutier, L., Renauld, J.C., Zaballos, A., Ayllón, V., Martínez-A, C. Mol. Cell. Biol. (2000) [Pubmed]
  19. Cutting edge: Bcl-3 up-regulation by signal 3 cytokine (IL-12) prolongs survival of antigen-activated CD8 T cells. Valenzuela, J.O., Hammerbeck, C.D., Mescher, M.F. J. Immunol. (2005) [Pubmed]
  20. Gene array analysis reveals changes in peripheral nervous system gene expression following stimuli that result in reactivation of latent herpes simplex virus type 1: induction of transcription factor Bcl-3. Tsavachidou, D., Podrzucki, W., Seykora, J., Berger, S.L. J. Virol. (2001) [Pubmed]
  21. Beta2 integrin modulates platelet caspase activation and life span in mice. Piguet, P.F., Vesin, C., Rochat, A. Eur. J. Cell Biol. (2001) [Pubmed]
WikiGenes - Universities