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Gene Review

Hoxb7  -  homeobox B7

Mus musculus

Synonyms: AI325018, Homeobox protein Hox-2.3, Homeobox protein Hox-B7, Homeobox protein MH-22B, Homeobox protein MuB1, ...
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Disease relevance of Hoxb7


High impact information on Hoxb7

  • To study the differential activities of the two RET isoforms further, we generated transgenic mice expressing ligand-dependent and constitutively active forms of RET9 or RET51 under the control of the Hoxb7 regulatory sequences [4].
  • They derive from the Hox 1.1, Hox 2.3, Hox 6.1 genes and two previously undescribed genes, one of a type (paired) not found before in vertebrates [5].
  • LoxP sites were inserted into AQP2 introns 2 and 3, and transgenic mice were bred with strains expressing Cre recombinase under the control of CD-specific Hoxb7- or global EIIa promoter [6].
  • Expression of a Hoxb7/RET-PTC2 transgene, encoding a ligand-independent form of RET kinase, caused the development of abnormal nodules, outside the kidney or at its periphery, containing branched epithelial tubules apparently formed by deregulated growth of the ureteric bud [7].
  • We show that elements driving A-P restricted gene expression are located within the 3.5 kb proximal upstream sequences of the Hoxb-7 gene [8].

Biological context of Hoxb7


Anatomical context of Hoxb7


Associations of Hoxb7 with chemical compounds

  • Hox-2.3, MM-3, and HuC1 also share a stretch of six glutamic acid residues followed by a stop codon 15-20 amino acids 3' of the homeo domain [14].
  • Embryonic day 11.5 metanephroi were microdissected from Hoxb7-green fluorescence protein mice and grown for 48 h in serum-free medium in the presence or absence of Ang II [15].
  • Hox 2.3 was also super-induced by serum, in the presence of cycloheximide, in cells rested previously in serum-free media, suggesting that new protein synthesis was not required for expressive augmentation [16].

Other interactions of Hoxb7

  • When crossed to RET knockout mice, the Hoxb7/RET transgene, which encoded the RET9 isoform, supported normal kidney development in some RET-/- animals, indicating that the other major isoform, RET51, is not required in this organ [7].
  • The induction of Hox 2.3, moreover, was not specific for tubular epithelium, since the gene could be activated in tubulointerstitial fibroblasts after treatment with EGF [16].
  • This study reports the expression pattern of the murine homeobox-containing gene Hox-2.3 during development [13].
  • Treatment of the cells to Hox 2.3 antisense oligodeoxynucleotides led to a selective inhibition of myeloid colony formation, both in size and in numbers, but without significant effect on erythroid and megakaryocytic haematopoiesis [17].
  • This AP expression pattern is distinct from those reported for the expression of GD3, nestin, Hox 2.3, and Wnt-1 during brain development [18].


  1. Ectopic expression of Hox-2.3 induces craniofacial and skeletal malformations in transgenic mice. McLain, K., Schreiner, C., Yager, K.L., Stock, J.L., Potter, S.S. Mech. Dev. (1992) [Pubmed]
  2. DNA-binding activity of the murine homeodomain protein Hox-2.3 produced by a hybrid phage T7/vaccinia virus system. de Jong, R., de Laaf, L., Vennema, H., Meijlink, F. Gene (1992) [Pubmed]
  3. Decreased amiloride-sensitive Na+ absorption in collecting duct principal cells isolated from BPK ARPKD mice. Veizis, E.I., Carlin, C.R., Cotton, C.U. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  4. Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis. de Graaff, E., Srinivas, S., Kilkenny, C., D'Agati, V., Mankoo, B.S., Costantini, F., Pachnis, V. Genes Dev. (2001) [Pubmed]
  5. Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages. Kongsuwan, K., Webb, E., Housiaux, P., Adams, J.M. EMBO J. (1988) [Pubmed]
  6. Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice. Rojek, A., Füchtbauer, E.M., Kwon, T.H., Frøkiaer, J., Nielsen, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. Dominant effects of RET receptor misexpression and ligand-independent RET signaling on ureteric bud development. Srinivas, S., Wu, Z., Chen, C.M., D'Agati, V., Costantini, F. Development (1999) [Pubmed]
  8. Proximal cis-acting elements cooperate to set Hoxb-7 (Hox-2.3) expression boundaries in transgenic mice. Vogels, R., Charité, J., de Graaff, W., Deschamps, J. Development (1993) [Pubmed]
  9. New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. Lonai, P., Arman, E., Czosnek, H., Ruddle, F.H., Blatt, C. DNA (1987) [Pubmed]
  10. Exogenous BMP-4 amplifies asymmetric ureteric branching in the developing mouse kidney in vitro. Cain, J.E., Nion, T., Jeulin, D., Bertram, J.F. Kidney Int. (2005) [Pubmed]
  11. Hox-2.3 upstream sequences mediate lacZ expression in intermediate mesoderm derivatives of transgenic mice. Kress, C., Vogels, R., De Graaff, W., Bonnerot, C., Meijlink, F., Nicolas, J.F., Deschamps, J. Development (1990) [Pubmed]
  12. Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae. Chen, F., Greer, J., Capecchi, M.R. Mech. Dev. (1998) [Pubmed]
  13. Expression of the murine homeobox-containing gene Hox-2.3 suggests multiple time-dependent and tissue-specific roles during development. Vogels, R., de Graaff, W., Deschamps, J. Development (1990) [Pubmed]
  14. Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons. Hart, C.P., Fainsod, A., Ruddle, F.H. Genomics (1987) [Pubmed]
  15. Angiotensin II type 1 receptor-EGF receptor cross-talk regulates ureteric bud branching morphogenesis. Yosypiv, I.V., Schroeder, M., El-Dahr, S.S. J. Am. Soc. Nephrol. (2006) [Pubmed]
  16. Expression of homeobox genes in a proximal tubular cell line derived from adult mice. Wolf, G., Kuncio, G.S., Sun, M.J., Neilson, E.G. Kidney Int. (1991) [Pubmed]
  17. Selective inhibition of normal murine myelopoiesis "in vitro" by a Hox 2.3 antisense oligodeoxynucleotide. Wu, J., Zhu, J.Q., Zhu, D.X., Scharfman, A., Lamblin, G., Han, K.K. Cell. Mol. Biol. (1992) [Pubmed]
  18. Stage-specific expression of alkaline phosphatase during neural development in the mouse. Narisawa, S., Hasegawa, H., Watanabe, K., Millán, J.L. Dev. Dyn. (1994) [Pubmed]
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