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Gene Review

Prl3d1  -  prolactin family 3, subfamily d, member 1

Mus musculus

Synonyms: AI325057, Chorionic somatomammotropin hormone 1, Csh1, PL-I, PL-I-alpha, ...
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Disease relevance of Prl3d1


High impact information on Prl3d1


Biological context of Prl3d1


Anatomical context of Prl3d1


Associations of Prl3d1 with chemical compounds


Regulatory relationships of Prl3d1


Other interactions of Prl3d1

  • Oligonucleotides (20-23 bp) corresponding to regions of nucleotide homology between mouse PL-I (mPL-I) and rat PL-I (rPL-I) along with midgestation hamster placental RNA were used in 3' rapid amplification of cDNA ends (RACE) methodology to generate PRL-like cDNA [18].
  • To determine whether lipopolysaccharides (LPS) regulate mouse placental lactogen-I (mPL-I), mPL-II, and mouse GHRF (mGHRF) secretion, mouse placental tissue from days 7, 9, and 12 of pregnancy was dispersed with collagenase and the purified trophoblast cells were cultured in a serum-free medium with or without LPS for 5 days [19].
  • After 24 h, the medium was replaced with fresh medium with/or without mouse PRL (mPRL), mouse placental lactogen-I (mPL-I), mPL-II, mouse GH (mGH), IGF-I, and IGF-II, either alone or in combinations [20].
  • Transforming growth factor-alpha regulates subpopulation of giant cells which secrete mouse placental lactogen-I (mPL-I) and/or mPL-II at midpregnancy [17].

Analytical, diagnostic and therapeutic context of Prl3d1


  1. Rcho-1 trophoblast cell placental lactogens: complementary deoxyribonucleic acids, heterologous expression, and biological activities. Dai, G., Imagawa, W., Liu, B., Szpirer, C., Levan, G., Kwok, S.C., Soares, M.J. Endocrinology (1996) [Pubmed]
  2. Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Cross, J.C., Flannery, M.L., Blanar, M.A., Steingrimsson, E., Jenkins, N.A., Copeland, N.G., Rutter, W.J., Werb, Z. Development (1995) [Pubmed]
  3. Gene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpins. Sun, J., Rose, J.B., Bird, P. J. Biol. Chem. (1995) [Pubmed]
  4. Identification and characterization of a new member of the prolactin family, placental lactogen-I variant. Deb, S., Faria, T.N., Roby, K.F., Larsen, D., Kwok, S.C., Talamantes, F., Soares, M.J. J. Biol. Chem. (1991) [Pubmed]
  5. Trophoblast-specific transcription from the mouse placental lactogen-I gene promoter. Shida, M.M., Ng, Y.K., Soares, M.J., Linzer, D.I. Mol. Endocrinol. (1993) [Pubmed]
  6. Construction of the nuclear matrix at the transition from maternal to zygotic control of development in the mouse: an immunocytochemical study. Prather, R.S., Schatten, G. Mol. Reprod. Dev. (1992) [Pubmed]
  7. Transcription factors underlying the development and endocrine functions of the placenta. Cross, J.C., Anson-Cartwright, L., Scott, I.C. Recent Prog. Horm. Res. (2002) [Pubmed]
  8. Recombinant mouse placental lactogen-I binds to lactogen receptors in mouse liver and ovary: partial characterization of the ovarian receptor. MacLeod, K.R., Smith, W.C., Ogren, L., Talamantes, F. Endocrinology (1989) [Pubmed]
  9. Pituitary-placental interaction: hypophysectomy modulates the secretion of mouse placental lactogen-I. Lopez, M.F., Carrion, F.A., Talamantes, F. Endocrinology (1991) [Pubmed]
  10. Initiation of placental lactogen-I production by blastocysts growing on a two-dimensional surface and in hanging drops. Nieder, G.L., Nagy, F. J. Exp. Zool. (1991) [Pubmed]
  11. Purification and partial characterization of two prolactin-like glycoprotein hormone complexes from the midpregnant mouse conceptus. Colosi, P., Ogren, L., Thordarson, G., Talamantes, F. Endocrinology (1987) [Pubmed]
  12. Modulation of mouse placental lactogen-I secretion in vitro: effects of progesterone and mouse placental lactogen-II. Yamaguchi, M., Endo, H., Thordarson, G., Ogren, L., Talamantes, F. Endocrinology (1992) [Pubmed]
  13. Cyclic adenosine-3',5'-monophosphate stimulates mouse placental lactogen-I (mPL-I) secretion but inhibits mPL-II secretion at midpregnancy. Yamaguchi, M., Imai, T., Maeda, T., Sakata, M., Miyake, A. Endocrinology (1995) [Pubmed]
  14. Regulation of the hepatic growth hormone receptor and serum growth hormone-binding protein during pregnancy in the mouse: effects of litter size. Cramer, S.D., Wong, L., Kensinger, R.S., Ogren, L., Talamantes, F. Endocrinology (1992) [Pubmed]
  15. Cyclic adenosine 3',5'-monophosphate stimulation of placental proliferin and proliferin-related protein secretion. Yamaguchi, M., Imai, T., Maeda, T., Sakata, M., Miyake, A., Linzer, D.I. Endocrinology (1995) [Pubmed]
  16. Localization of placental lactogen-I in trophoblast giant cells of the mouse placenta. Faria, T.N., Ogren, L., Talamantes, F., Linzer, D.I., Soares, M.J. Biol. Reprod. (1991) [Pubmed]
  17. Transforming growth factor-alpha regulates subpopulation of giant cells which secrete mouse placental lactogen-I (mPL-I) and/or mPL-II at midpregnancy. Yamaguchi, M., Ogura, K., Sakata, M., Miyake, A. J. Endocrinol. Invest. (1996) [Pubmed]
  18. Identification, characterization, and expression of a new prolactin-like molecule in the hamster placenta. Barnes, S.W., Renegar, R.H. Biol. Reprod. (1996) [Pubmed]
  19. Lipopolysaccharides selectively inhibit mouse placental lactogen-II secretion through stimulation of interleukin-1 alpha (IL-1 alpha) and IL-6 production. Yamaguchi, M., Sawada, K., Miyake, A. J. Endocrinol. Invest. (1996) [Pubmed]
  20. Expression of a lactogen-dependent insulin-like growth factor-binding protein in cultured mouse mammary epithelial cells. Fielder, P.J., Thordarson, G., English, A., Rosenfeld, R.G., Talamantes, F. Endocrinology (1992) [Pubmed]
  21. Cytokines that use gp130 as a signal transducer stimulate mouse placental lactogen-I (mPL-I) but inhibit mPL-II production in vitro. Yamaguchi, M., Taga, T., Kishimoto, T., Miyake, A. Biol. Reprod. (1995) [Pubmed]
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