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Gene Review

Tbcb  -  tubulin folding cofactor B

Mus musculus

Synonyms: 2410007D12Rik, AU041393, CG22, CKAPI, Ckap1, ...
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Disease relevance of Tbcb


High impact information on Tbcb


Biological context of Tbcb


Anatomical context of Tbcb


Associations of Tbcb with chemical compounds

  • A cytoskeleton-associated glycoprotein of 130-kilodalton molecular mass (GP 130) was purified from a nonionic detergent-insoluble fraction of 10-16-d-old chicken embryo brains [21].
  • Two-dimensional phosphopeptide map analyses of NF-M phosphorylated in vitro by individual purified or endogenous axonal cytoskeleton-associated protein kinases showed that five peptides (M9-M13) were substrates for the heparin-sensitive second messenger-independent protein kinase(s) [22].
  • Phalloidin almost completely destroyed actin microfilament bundles, but the amount of polymerized cytoskeleton-associated actin was increased approximately two-fold and the amount of monomeric (Triton X-100 extractable) actin was significantly reduced [23].
  • Interestingly, some of the down-regulated genes in the irradiated group, such as DNA repair and stress response genes and cytoskeleton-associated genes, which are markers of cellular damage after irradiation, were maintained at close to normal expression levels after soybean isoflavone treatment [24].
  • The gPr80env in the TX-100-soluble fraction of the cell was the endoglycosidase H (Endo-H) sensitive mannose-rich form, whereas the cytoskeleton-associated gPr80env was the partially Endo-H-resistant complex carbohydrate form [25].

Regulatory relationships of Tbcb


Other interactions of Tbcb


Analytical, diagnostic and therapeutic context of Tbcb


  1. Immunomorphological characterization and effects of 12-(S)-HETE on a dynamic intracellular pool of the alpha IIb beta 3-integrin in melanoma cells. Tímár, J., Bazaz, R., Kimler, V., Haddad, M., Tang, D.G., Robertson, D., Tovari, J., Taylor, J.D., Honn, K.V. J. Cell. Sci. (1995) [Pubmed]
  2. Cytoskeleton-associated Pr65gag and retrovirus assembly. Edbauer, C.A., Naso, R.B. Virology (1983) [Pubmed]
  3. Podocyte changes upon induction of albuminuria in Thy-1.1 transgenic mice. Smeets, B., Dijkman, H.B., te Loeke, N.A., van Son, J.P., Steenbergen, E.J., Assmann, K.J., Wetzels, J.F., Groenen, P.J. Nephrol. Dial. Transplant. (2003) [Pubmed]
  4. alpha2-chimaerin, a Cdc42/Rac1 regulator, is selectively expressed in the rat embryonic nervous system and is involved in neuritogenesis in N1E-115 neuroblastoma cells. Hall, C., Michael, G.J., Cann, N., Ferrari, G., Teo, M., Jacobs, T., Monfries, C., Lim, L. J. Neurosci. (2001) [Pubmed]
  5. Changes in cytoskeleton-associated molecules in cells with different degrees of proliferation and metastatic ability. Morasso, M.I., Rieber, M.S., Urbina, C., Rieber, M. Cell Biol. Int. Rep. (1989) [Pubmed]
  6. Sequence and domain structure of talin. Rees, D.J., Ades, S.E., Singer, S.J., Hynes, R.O. Nature (1990) [Pubmed]
  7. Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ. Arber, S., Caroni, P. Genes Dev. (1996) [Pubmed]
  8. Shared and unique roles of CAP23 and GAP43 in actin regulation, neurite outgrowth, and anatomical plasticity. Frey, D., Laux, T., Xu, L., Schneider, C., Caroni, P. J. Cell Biol. (2000) [Pubmed]
  9. Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function. Gimond, C., van Der Flier, A., van Delft, S., Brakebusch, C., Kuikman, I., Collard, J.G., Fässler, R., Sonnenberg, A. J. Cell Biol. (1999) [Pubmed]
  10. Cytoskeleton-associated plectin: in situ localization, in vitro reconstitution, and binding to immobilized intermediate filament proteins. Foisner, R., Leichtfried, F.E., Herrmann, H., Small, J.V., Lawson, D., Wiche, G. J. Cell Biol. (1988) [Pubmed]
  11. Diversity and phylogeny of gephyrin: tissue-specific splice variants, gene structure, and sequence similarities to molybdenum cofactor-synthesizing and cytoskeleton-associated proteins. Ramming, M., Kins, S., Werner, N., Hermann, A., Betz, H., Kirsch, J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  12. Kinesin-73 in the nervous system of Drosophila embryos. Li, H.P., Liu, Z.M., Nirenberg, M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  13. Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation of the focal adhesion-associated protein paxillin in Swiss 3T3 cells. Zachary, I., Sinnett-Smith, J., Turner, C.E., Rozengurt, E. J. Biol. Chem. (1993) [Pubmed]
  14. Brain beta-spectrin phosphorylation: phosphate analysis and identification of threonine-347 as a heparin-sensitive protein kinase phosphorylation site. Sihag, R.K. J. Neurochem. (1998) [Pubmed]
  15. Developmental association of the synaptic activity-regulated protein arc with the mouse acrosomal organelle and the sperm tail. Maier, B., Medrano, S., Sleight, S.B., Visconti, P.E., Scrable, H. Biol. Reprod. (2003) [Pubmed]
  16. Coprecipitation of heat shock proteins with a cell surface glycoprotein. Hughes, E.N., August, J.T. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  17. Normal T cells express two T cell antigen receptor populations, one of which is linked to the cytoskeleton via zeta chain and displays a unique activation-dependent phosphorylation pattern. Caplan, S., Baniyash, M. J. Biol. Chem. (1996) [Pubmed]
  18. The actin binding domain of the epidermal growth factor receptor is required for EGF-stimulated tissue invasion. van der Heyden, M.A., Van Bergen en Henegouwen, P.M., de Ruiter, N., Verdaasdonk, M.A., van den Tweel, J.G., Rijksen, G., Boonstra, J., Joling, P. Exp. Cell Res. (1997) [Pubmed]
  19. Annexin II is associated with mRNAs which may constitute a distinct subpopulation. Vedeler, A., Hollås, H. Biochem. J. (2000) [Pubmed]
  20. Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts. Wang, F., Nobes, C.D., Hall, A., Spiegel, S. Biochem. J. (1997) [Pubmed]
  21. A neuronal surface glycoprotein associated with the cytoskeleton. Ranscht, B., Moss, D.J., Thomas, C. J. Cell Biol. (1984) [Pubmed]
  22. Phosphorylation of the amino-terminal head domain of the middle molecular mass 145-kDa subunit of neurofilaments. Evidence for regulation by second messenger-dependent protein kinases. Sihag, R.K., Nixon, R.A. J. Biol. Chem. (1990) [Pubmed]
  23. Stimulation of actin synthesis in phalloidin-treated cells. Evidence for autoregulatory control. Serpinskaya, A.S., Denisenko, O.N., Gelfand, V.I., Bershadsky, A.D. FEBS Lett. (1990) [Pubmed]
  24. Gene expression profiles in the liver of mice irradiated with (60)Co gamma rays and treated with soybean isoflavone. Song, L.H., Yan, H.L., Cai, D.L. European journal of nutrition. (2006) [Pubmed]
  25. Role of cell cytoskeleton in Mo-MuLV env transport and processing: implications in ts1 neuropathology. Soong, M.M., Tompkins, W.A. Exp. Mol. Pathol. (1987) [Pubmed]
  26. A 52 kD cytoskeletal protein from retinal rod photoreceptors is related to erythrocyte dematin. Roof, D., Hayes, A., Hardenbergh, G., Adamian, M. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
  27. Inhibition of anchorage-independent growth of transformed NIH3T3 cells by epithelial protein lost in neoplasm (EPLIN) requires localization of EPLIN to actin cytoskeleton. Song, Y., Maul, R.S., Gerbin, C.S., Chang, D.D. Mol. Biol. Cell (2002) [Pubmed]
  28. The activity-regulated cytoskeleton-associated (Arc) gene is a new light-inducible early gene in the mouse suprachiasmatic nucleus. Nishimura, M., Yamagata, K., Sugiura, H., Okamura, H. Neuroscience (2003) [Pubmed]
  29. Identification and characterization of a cytoskeleton-associated, epidermal growth factor sensitive pp60c-src substrate. Maa, M.C., Wilson, L.K., Moyers, J.S., Vines, R.R., Parsons, J.T., Parsons, S.J. Oncogene (1992) [Pubmed]
  30. The motility-associated proteins GAP-43, MARCKS, and CAP-23 share unique targeting and surface activity-inducing properties. Wiederkehr, A., Staple, J., Caroni, P. Exp. Cell Res. (1997) [Pubmed]
  31. Molecular cloning and characterization of profilin-3: a novel cytoskeleton-associated gene expressed in rat kidney and testes. Hu, E., Chen, Z., Fredrickson, T., Zhu, Y. Exp. Nephrol. (2001) [Pubmed]
  32. Effect of magnetic bead agglomeration on Cytomagnetometric measurements. Möller, W., Nemoto, I., Heyder, J. IEEE transactions on nanobioscience. (2003) [Pubmed]
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