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Gene Review

Ccl20  -  chemokine (C-C motif) ligand 20

Mus musculus

Synonyms: Beta-chemokine exodus-1, C-C motif chemokine 20, CC chemokine LARC, CC chemokine ST38, CKb4, ...
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Disease relevance of Ccl20

  • These results suggest that in chronic DSS-induced colitis, both MAdCAM-1 and mLARC/CCL20 may play important roles in T and B lymphocyte adhesion in the inflamed colon under flow conditions [1].
  • However, coexpression of the Herpes Simplex Virus thymidine kinase gene (HSVtk) and CCL20, cured large established tumors where HSVtk expression alone was not sufficient [2].
  • CCL3 and CCL20 expression alone did not significantly inhibit the development of the B16 melanoma tumor [2].
  • Control of Salmonella dissemination in vivo by macrophage inflammatory protein (MIP)-3alpha/CCL20 [3].
  • Together, these results demonstrate an important role for CCL20 in the control of bacterial infection and more specifically in the regulation of cell-mediated immunity against intracellular bacteria such as S. enteritidis [3].

High impact information on Ccl20


Biological context of Ccl20


Anatomical context of Ccl20


Associations of Ccl20 with chemical compounds


Other interactions of Ccl20

  • In some of the experiments antibodies against the adhesion molecules or anti-mLARC/CCL20 were administered, or CC chemokine receptor 6 (CCR6) of the lymphocytes was desensitized with excess amounts of mLARC/CCL20 [1].
  • They did not migrate to inducible chemokines--CCL3 [macrophage inflammatory protein (MIP)-1alpha], CCL5 [regulated upon activation, normal T cell expressed and secreted (RANTES)], or CCL20 (MIP-3alpha) [13].
  • When epithelial cells were treated with the Toll-like receptor (TLR) agonists Pam3Cys (TLR2/1), peptidoglycan (TLR2/6) or lipopolysaccharide (LPS; TLR4), CCL20/MIP-3 alpha increased rapidly (4 hr) in both apical and basolateral secretions [12].

Analytical, diagnostic and therapeutic context of Ccl20


  1. Increased lymphocyte trafficking to colonic microvessels is dependent on MAdCAM-1 and C-C chemokine mLARC/CCL20 in DSS-induced mice colitis. Teramoto, K., Miura, S., Tsuzuki, Y., Hokari, R., Watanabe, C., Inamura, T., Ogawa, T., Hosoe, N., Nagata, H., Ishii, H., Hibi, T. Clin. Exp. Immunol. (2005) [Pubmed]
  2. Expression of inflammatory chemokines combined with local tumor destruction enhances tumor regression and long-term immunity. Crittenden, M., Gough, M., Harrington, K., Olivier, K., Thompson, J., Vile, R.G. Cancer Res. (2003) [Pubmed]
  3. Control of Salmonella dissemination in vivo by macrophage inflammatory protein (MIP)-3alpha/CCL20. Fahy, O.L., Townley, S.L., Coates, N.J., Clark-Lewis, I., McColl, S.R. Lab. Invest. (2004) [Pubmed]
  4. Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Merad, M., Hoffmann, P., Ranheim, E., Slaymaker, S., Manz, M.G., Lira, S.A., Charo, I., Cook, D.N., Weissman, I.L., Strober, S., Engleman, E.G. Nat. Med. (2004) [Pubmed]
  5. Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo. Le Borgne, M., Etchart, N., Goubier, A., Lira, S.A., Sirard, J.C., van Rooijen, N., Caux, C., Aït-Yahia, S., Vicari, A., Kaiserlian, D., Dubois, B. Immunity (2006) [Pubmed]
  6. CC chemokine ligand 20 partially controls adhesion of naive B cells to activated endothelial cells under shear stress. Meissner, A., Zilles, O., Varona, R., Jozefowski, K., Ritter, U., Marquez, G., Hallmann, R., Korner, H. Blood (2003) [Pubmed]
  7. Changes in the lymph node microenvironment induced by oncostatin M. Louis, I., Dulude, G., Corneau, S., Brochu, S., Boileau, C., Meunier, C., Côté, C., Labrecque, N., Perreault, C. Blood (2003) [Pubmed]
  8. Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52. Radeke, H.H., von Wenckstern, H., Stoidtner, K., Sauer, B., Hammer, S., Kleuser, B. J. Immunol. (2005) [Pubmed]
  9. CCR6 has a non-redundant role in the development of inflammatory bowel disease. Varona, R., Cadenas, V., Flores, J., Martínez-A, C., Márquez, G. Eur. J. Immunol. (2003) [Pubmed]
  10. A role for macrophage inflammatory protein-3 alpha/CC chemokine ligand 20 in immune priming during T cell-mediated inflammation of the central nervous system. Kohler, R.E., Caon, A.C., Willenborg, D.O., Clark-Lewis, I., McColl, S.R. J. Immunol. (2003) [Pubmed]
  11. CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. Zhao, X., Sato, A., Dela Cruz, C.S., Linehan, M., Luegering, A., Kucharzik, T., Shirakawa, A.K., Marquez, G., Farber, J.M., Williams, I., Iwasaki, A. J. Immunol. (2003) [Pubmed]
  12. Effect of oestradiol on PAMP-mediated CCL20/MIP-3 alpha production by mouse uterine epithelial cells in culture. Soboll, G., Crane-Godreau, M.A., Lyimo, M.A., Wira, C.R. Immunology (2006) [Pubmed]
  13. CCR and CC chemokine expression in relation to Flt3 ligand-induced renal dendritic cell mobilization. Coates, P.T., Colvin, B.L., Ranganathan, A., Duncan, F.J., Lan, Y.Y., Shufesky, W.J., Zahorchak, A.F., Morelli, A.E., Thomson, A.W. Kidney Int. (2004) [Pubmed]
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